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Anticancer Activities of Mushrooms: A Neglected Source for Drug Discovery
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cncr.29421openalex-snapshotA phase I trial of mushroom powder in patients with biochemically recurrent prostate cancer: Roles of cytokines and myeloid‐derived suppressor cells for Agaricus bisporus–induced prostate‐specific antigen responses
inferredcites →https://doi.org/10.1002/jsfa.7039openalex-snapshotAn appraisal of eighteen commonly consumed edible plants as functional food based on their antioxidant and starch hydrolase inhibitory activities
inferredcites →https://doi.org/10.1002/jsfa.7194openalex-snapshotPurification and characterization of a ∼43 kDa antioxidant protein with antitumor activity from Pholiota nameko
inferredcites →https://doi.org/10.1002/ptr.5402openalex-snapshotPachymic Acid Induces Apoptosis of EJ Bladder Cancer Cells by DR5 Up-Regulation, ROS Generation, Modulation of Bcl-2 and IAP Family Members
inferredcites →https://doi.org/10.1007/s00432-005-0672-1openalex-snapshotSuppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model
inferredcites →https://doi.org/10.1007/s00432-009-0562-zopenalex-snapshotA phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects
inferredcites →https://doi.org/10.1007/s00432-012-1224-0openalex-snapshotSchizophyllan inhibits the development of mammary and hepatic carcinomas induced by 7,12 dimethylbenz(α)anthracene and decreases cell proliferation: comparison with tamoxifen
inferredcites →https://doi.org/10.1007/s11418-016-1061-6openalex-snapshotProtein tyrosine phosphatase 1B inhibitory properties of seco-cucurbitane triterpenes obtained from fruiting bodies of Russula lepida
inferredcites →https://doi.org/10.1016/j.fct.2010.10.031openalex-snapshotAnti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway
inferredcites →https://doi.org/10.1016/j.fct.2018.12.009openalex-snapshotAntrodia salmonea suppresses invasion and metastasis in triple-negative breast cancer cells by reversing EMT through the NF-κB and Wnt/β-catenin signaling pathway
inferredcites →https://doi.org/10.1016/j.jep.2015.08.042openalex-snapshotShotgun proteomic analysis of tiger milk mushroom (Lignosus rhinocerotis) and the isolation of a cytotoxic fungal serine protease from its sclerotium
inferredcites →https://doi.org/10.1016/j.jep.2016.12.018openalex-snapshotAntrodia salmonea induces G2 cell-cycle arrest in human triple-negative breast cancer (MDA-MB-231) cells and suppresses tumor growth in athymic nude mice
inferredcites →https://doi.org/10.1016/j.jep.2020.112851openalex-snapshotEvaluation of anticancer activities of Poria cocos ethanol extract in breast cancer: In vivo and in vitro, identification and mechanism
inferredcites →https://doi.org/10.1016/j.jpba.2015.04.010openalex-snapshotMetabolites identification and multi-component pharmacokinetics of ergostane and lanostane triterpenoids in the anticancer mushroom Antrodia cinnamomea
inferredcites →https://doi.org/10.1016/j.phymed.2012.02.016openalex-snapshotEthanol extracts of fruiting bodies of Antrodia cinnamomea exhibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K/AKT signaling pathways
inferredcites →https://doi.org/10.1021/jf900269ropenalex-snapshotPurification of a Water Extract of Chinese Sweet Tea Plant (Rubus suavissimus S. Lee) by Alcohol Precipitation
inferredcites →https://doi.org/10.1021/tx100318mopenalex-snapshotIdentification of Antrocin from Antrodia camphorata as a Selective and Novel Class of Small Molecule Inhibitor of Akt/mTOR Signaling in Metastatic Breast Cancer MDA-MB-231 Cells
inferredcites →https://doi.org/10.1038/srep36563openalex-snapshotFucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFβ receptor degradation and attenuates breast cancer tumorigenesis
inferredcites →https://doi.org/10.1055/a-0942-2087openalex-snapshotAntcin-A Modulates Epithelial-to-Mesenchymal Transition and Inhibits Migratory and Invasive Potentials of Human Breast Cancer Cells via p53-Mediated miR-200c Activation
inferredcites →https://doi.org/10.1080/01635581.2014.884232openalex-snapshotReduction of Adverse Effects by a Mushroom Product, Active Hexose Correlated Compound (AHCC) in Patients With Advanced Cancer During Chemotherapy—The Significance of the Levels of HHV-6 DNA in Saliva as a Surrogate Biomarker During Chemotherapy
inferredcites →https://doi.org/10.1081/imm-120022979openalex-snapshotEffects of Ganopoly®(AGanoderma lucidumPolysaccharide Extract) on the Immune Functions in Advanced‐Stage Cancer Patients
inferredcites →https://doi.org/10.1089/acm.2016.0136openalex-snapshotCoriolus versicolor ( Yunzhi ) Use as Therapy in Advanced Hepatocellular Carcinoma Patients with Poor Liver Function or Who Are Unfit for Standard Therapy
inferredcites →https://doi.org/10.1089/jmf.2005.8.159openalex-snapshotEffects of Water-Soluble Ganoderma lucidum Polysaccharides on the Immune Functions of Patients with Advanced Lung Cancer
inferredcites →https://doi.org/10.1093/jjco/hyq081openalex-snapshotDietary Administration of Mushroom Mycelium Extracts in Patients with Early Stage Prostate Cancers Managed Expectantly: A Phase II Study
inferredcites →https://doi.org/10.1111/j.1048-891x.2004.14403.xopenalex-snapshotNatural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy
inferredcites →https://doi.org/10.1142/s0192415x11008956openalex-snapshotEfficacy and Safety of Orally Administered Lentinula edodes Mycelia Extract for Patients Undergoing Cancer Chemotherapy: A Pilot Study
inferredcites →https://doi.org/10.1155/2012/702857openalex-snapshotInhibition of Cell Growth and Induction of Apoptosis byAntrodia camphoratain HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway
inferredcites →https://doi.org/10.1155/2012/809614openalex-snapshotSpore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial
inferredcites →https://doi.org/10.1155/2015/718539openalex-snapshotImmunomodulatory Effects of theAgaricus blazeiMurrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study
inferredcites →https://doi.org/10.1186/s12906-016-1312-9openalex-snapshotA preliminary randomised controlled study of short-term Antrodia cinnamomea treatment combined with chemotherapy for patients with advanced cancer
inferredcites →https://doi.org/10.1186/s12906-018-2204-yopenalex-snapshotAntrodia cinnamomea extract inhibits the proliferation of tamoxifen-resistant breast cancer cells through apoptosis and skp2/microRNAs pathway
inferredcites →https://doi.org/10.1189/jlb.0711386openalex-snapshotSoluble β-glucan fromGrifola frondosainduces proliferation and Dectin-1/Syk signaling in resident macrophages via the GM-CSF autocrine pathway
inferredcites →https://doi.org/10.1189/jlb.1a0814-415rropenalex-snapshotSoluble β-glucan from Grifola frondosa induces tumor regression in synergy with TLR9 agonist via dendritic cell-mediated immunity
inferredcites →https://doi.org/10.1200/jco.19.03141openalex-snapshotClinical Cancer Advances 2020: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology
inferredcites →https://doi.org/10.1371/journal.pone.0098370openalex-snapshotPanepoxydone Targets NF-kB and FOXM1 to Inhibit Proliferation, Induce Apoptosis and Reverse Epithelial to Mesenchymal Transition in Breast Cancer
inferredcites →https://doi.org/10.1615/interjmedicmush.v5.i4.40openalex-snapshotA Randomized, Placebo-Controlled, Multicenter Study of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Polysaccharides (Ganopoly) in Patients with Advanced Lung Cancer
inferredcites →https://doi.org/10.18632/oncotarget.4026openalex-snapshotErgosterol purified from medicinal mushroomAmauroderma rudeinhibits cancer growthin vitroandin vivoby up-regulating multiple tumor suppressors
inferredcites →https://doi.org/10.18632/oncotarget.4397openalex-snapshotPurification and identification of a polysaccharide from medicinal mushroomAmauroderma rudewith immunomodulatory activity and inhibitory effect on tumor growth
inferredcites →https://doi.org/10.3389/fphar.2019.00115openalex-snapshotIdentification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro
inferredcites →https://doi.org/10.3390/molecules21101267openalex-snapshotCordycepin Induces Apoptosis and Inhibits Proliferation of Human Lung Cancer Cell Line H1975 via Inhibiting the Phosphorylation of EGFR
inferredcites →https://doi.org/10.3892/ijo_00000122openalex-snapshotPleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway
inferredcites →https://doi.org/10.3892/ol.2018.9475openalex-snapshotGanoderic acid A exerts antitumor activity against MDA‑MB‑231 human breast cancer cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway
inferredcites →https://doi.org/10.3892/or.15.2.417openalex-snapshotIn vitro effects on proliferation, apoptosis and colony inhibition in ER-dependent and ER-independent human breast cancer cells by selected mushroom species
inferredcites →https://doi.org/10.3892/or.15.3.637openalex-snapshotGrowth-inhibitory effects of a β-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: Cell-cycle arrest and apoptosis induction
inferredcites →https://doi.org/10.3892/or.2012.1936openalex-snapshotBreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer
inferredcites →https://doi.org/10.4103/0253-7613.111894openalex-snapshotEffect of Agaricus sylvaticus supplementation on nutritional status and adverse events of chemotherapy of breast cancer: A randomized, placebo-controlled, double-blind clinical trial
inferredcites →https://doi.org/10.4161/cbt.4.6.1721openalex-snapshotDifferential anti-tumor activity of coriolus versicolor (Yunzhi) extract through p53- and/or Bcl-2-dependent apoptotic pathway in human breast cancer cells
inferredcites →https://doi.org/10.4162/nrp.2010.4.3.177openalex-snapshotAnticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells
inferredcites →https://doi.org/10.5414/cp201663openalex-snapshotGanoderic acids suppress growth and angiogenesis by modulating the NF-?B signaling pathway in breast cancer cells
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.3897/pharmacia.72.e143676zenodo-depositor-declaredInvestigation of the promising repurposed, computational, and anticancer candidates to co-deliver with cabazitaxel for hormonal-resistance prostate cancer
inferred← citeshttps://doi.org/10.1002/9781394272266.ch10openalex-snapshotUsing Artificial Intelligence (AI) Analyzing Recent Advancements in the Anti‐Cancerous Properties of Edible Mushrooms and Their Association with the Mode of Action of Polysaccharides
inferred← citeshttps://doi.org/10.1002/cbf.3909openalex-snapshotZnO nanomaterials target mitochondrial apoptosis and mitochondrial autophagy pathways in cancer cells
inferred← citeshttps://doi.org/10.1002/ddr.70131openalex-snapshotTarget‐Specific Potency and Drug‐Ability Profile of Flavonoids Against Lung Cancer: An Integrative Multi‐Omics Approach for Lead Identification
inferred← citeshttps://doi.org/10.1007/s13205-024-03968-xopenalex-snapshotComparative studies on the cultivation, yield, and nutritive value of an edible mushroom, Pleurotus tuber-regium (Rumph. ex Fr.) Singer, grown under different agro waste substrates
inferred← citeshttps://doi.org/10.1007/s42360-026-01005-wopenalex-snapshotImpact of agro-industrial substrates on the proximate composition and secondary metabolites in Pleurotus florida, Pleurotus eous APK1 and Pleurotus ulmarius CO2
inferred← citeshttps://doi.org/10.1016/j.colsurfb.2025.115222openalex-snapshotDevelopment of novel solid lipid nanoparticles for delivery of astrakurkurone with increasing anti-cancer efficacy against non-small cell lung cancer cells
inferred← citeshttps://doi.org/10.1016/j.fbio.2025.107309openalex-snapshotA comprehensive review of the anti-angiogenic potential of edible and medicinal mushrooms: bioactive compounds, mechanisms of action and clinical status
inferred← citeshttps://doi.org/10.1016/j.fitote.2023.105681openalex-snapshotA review for cancer treatment with mushroom metabolites through targeting mitochondrial signaling pathway: In vitro and in vivo evaluations, clinical studies and future prospects for mycomedicine
inferred← citeshttps://doi.org/10.1016/j.jtcms.2022.09.006openalex-snapshotTwo novel compounds, ergosterol and ergosta-5,8-dien-3-ol, from Termitomyces heimii Natarajan demonstrate promising anti-hepatocarcinoma activity
inferred← citeshttps://doi.org/10.1016/j.jtcms.2023.12.008openalex-snapshotNovel wild edible mushroom Astraeus hygrometricus (Pers.) Morgan induces robust apoptosis on human acute lymphoblastic leukemia cells through a RONS-subsisted mitochondria-dependent pathway
inferred← citeshttps://doi.org/10.1016/j.sajb.2024.05.029openalex-snapshotNeoergosterol-rich mushroom extract, resourced from wild edible mushroom Termitomyces heimii Natarajan, induces robust apoptosis against lung cancer
inferred← citeshttps://doi.org/10.1021/acsomega.3c04827openalex-snapshotCombined Deep Learning and Molecular Modeling Techniques on the Virtual Screening of New mTOR Inhibitors from the Thai Mushroom Database
inferred← citeshttps://doi.org/10.1039/d2fo01683dopenalex-snapshotTherapeutic potential and nutritional significance of Ganoderma lucidum – a comprehensive review from 2010 to 2022
inferred← citeshttps://doi.org/10.1186/s12906-025-04984-xopenalex-snapshotComparative study on the therapeutic potential of aqueous extracts from commercially cultivated Agaricus bisporus and Lentinula edodes in Sri Lanka: antioxidant, anticancer, antidiabetic, and antibacterial properties
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5267286/v1openalex-snapshotPreliminary trial of the cultivation of Pleurotus djamor var. fuscopruinosus from southern Thailand using sawdust substrate and applications
inferred← citeshttps://doi.org/10.2298/abs220803030mopenalex-snapshotAnticancer and apoptotic effects of a polysaccharide extract isolated from Lactarius chrysorrheus Fr. in HepG2 and PANC-1 cell lines
inferred← citeshttps://doi.org/10.3389/fphar.2023.1195104openalex-snapshotApplication of natural polysaccharides and their novel dosage forms in gynecological cancers: therapeutic implications from the diversity potential of natural compounds
inferred← citeshttps://doi.org/10.3390/cimb46070450openalex-snapshotMedicinal Mushrooms in Metastatic Breast Cancer: What Is Their Therapeutic Potential as Adjuvant in Clinical Settings?
inferred← citeshttps://doi.org/10.3390/foods15111896openalex-snapshotArtificial Intelligence-Assisted Optimization of Amanita caesarea Extracts for Bioactive Compounds and Functional Food Applications
inferred← citeshttps://doi.org/10.3390/jof9010112openalex-snapshotTermite Mushrooms (Termitomyces), a Potential Source of Nutrients and Bioactive Compounds Exhibiting Human Health Benefits: A Review
inferred← citeshttps://doi.org/10.3390/ph17050600openalex-snapshotBioactivity Profiling of Daedaleopsis confragosa (Bolton) J. Schröt. 1888: Implications for Its Possible Application in Enhancing Women’s Reproductive Health
inferred← citeshttps://doi.org/10.3390/ph17081013openalex-snapshotChemical Content and Cytotoxic Activity on Various Cancer Cell Lines of Chaga (Inonotus obliquus) Growing on Betula pendula and Betula pubescens
inferred← citeshttps://doi.org/10.37349/emed.2024.00222openalex-snapshotA review on mushrooms as a versatile therapeutic agent with emphasis on its bioactive constituents for anticancer and antioxidant potential
inferred← citeshttps://doi.org/10.4103/mjbl.mjbl_1415_23openalex-snapshotAnticancer, Apoptotic, and Mitotic Effectiveness of Lentinula edodes Microwave-Assisted Extract against Certain 2D Monolayer Culture Cancer Cell Lines
inferred← citeshttps://doi.org/10.59324/ejmhr.2024.2(4).19openalex-snapshotEvaluation of the Efficacy of Aqueous and Alcoholic Extract of Cinnamomum zeylanicum Against the Growth of Candida albicans Isolated from Different Clinical Samples
inferred← citeshttps://doi.org/10.5937/kgjsci2401121mopenalex-snapshotExploring Amanita muscaria (L.) Lam.: Cytotoxic, proapoptotic and antiferroptotic effect of acetone extract on JAR choriocarcinoma cell line
inferred← citeshttps://doi.org/10.7150/ijms.93334openalex-snapshotEvaluation of oyster mushroom (Pleurotus ostreatus)-derived anthraquinone on the induction of apoptosis and suppression of MMP-2 and MMP-9 expression in breast cancer cells
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