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Solids Turn into Liquids—Liquid Eutectic Systems of Pharmaceutics to Improve Drug Solubility

https://doi.org/10.3390/ph15030279
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jps.22061openalex-snapshot
Conformational Polymorphism of Tolbutamide: A Structural, Spectroscopic, and Thermodynamic Characterization of Burger’s Forms I–IV
inferredcites →https://doi.org/10.1002/jrs.3012openalex-snapshot
Conformational polymorphism of the antidiabetic drug chlorpropamide
inferredcites →https://doi.org/10.1002/pola.26555openalex-snapshot
Deep eutectic solvents as both active fillers and monomers for frontal polymerization
inferredcites →https://doi.org/10.1007/s10953-018-0793-1openalex-snapshot
Insights into the Nature of Eutectic and Deep Eutectic Mixtures
inferredcites →https://doi.org/10.1007/s10973-007-8822-0openalex-snapshot
Transitions among five polymorphs of chlorpropamide near the melting point
inferredcites →https://doi.org/10.1007/s10973-012-2831-3openalex-snapshot
Phase diagram of ibuprofen with fatty acids
inferredcites →https://doi.org/10.1016/j.drudis.2020.04.016openalex-snapshot
Multiple approaches for achieving drug solubility: an in silico perspective
inferredcites →https://doi.org/10.1016/j.ejpb.2015.11.002openalex-snapshot
Dissolution enhancement of active pharmaceutical ingredients by therapeutic deep eutectic systems
inferredcites →https://doi.org/10.1016/j.ejpb.2017.02.003openalex-snapshot
A comparison between pure active pharmaceutical ingredients and therapeutic deep eutectic solvents: Solubility and permeability studies
inferredcites →https://doi.org/10.1016/j.ejps.2020.105583openalex-snapshot
The role of ionic vs. non-ionic excipients in APIs-based eutectic systems
inferredcites →https://doi.org/10.1016/j.fluid.2017.05.009openalex-snapshot
Liquid pharmaceuticals formulation by eutectic formation
inferredcites →https://doi.org/10.1016/j.ijpharm.2013.10.003openalex-snapshot
Towards the characterization of an in vitro triple co-culture intestine cell model for permeability studies
inferredcites →https://doi.org/10.1016/j.ijpharm.2014.06.003openalex-snapshot
A PAT approach for the on-line monitoring of pharmaceutical co-crystals formation with near infrared spectroscopy
inferredcites →https://doi.org/10.1016/j.ijpharm.2015.06.038openalex-snapshot
Design of controlled release systems for THEDES—Therapeutic deep eutectic solvents, using supercritical fluid technology
inferredcites →https://doi.org/10.1016/j.ijpharm.2016.04.018openalex-snapshot
Investigation on drug solubility enhancement using deep eutectic solvents and their derivatives
inferredcites →https://doi.org/10.1016/j.ijpharm.2018.06.024openalex-snapshot
Pharmaceutical cocrystallization techniques. Advances and challenges
inferredcites →https://doi.org/10.1016/j.ijpharm.2018.12.036openalex-snapshot
Co-former selection for co-amorphous drug-amino acid formulations
inferredcites →https://doi.org/10.1016/j.jconrel.2019.09.019openalex-snapshot
Emerging frontiers of deep eutectic solvents in drug discovery and drug delivery systems
inferredcites →https://doi.org/10.1016/j.jddst.2019.101159openalex-snapshot
Therapeutic deep eutectic system of capric acid and menthol: Characterization and pharmaceutical application
inferredcites →https://doi.org/10.1016/j.jddst.2020.101512openalex-snapshot
Design and characterization of ascorbic acid based therapeutic deep eutectic solvent as a new ion-gel for delivery of sunitinib malate
inferredcites →https://doi.org/10.1016/j.molliq.2020.113727openalex-snapshot
Influence of water of crystallization on the ternary phase behavior of a drug and deep eutectic solvent
inferredcites →https://doi.org/10.1016/j.molliq.2020.114745openalex-snapshot
Formulation, structure, and applications of therapeutic and amino acid-based deep eutectic solvents: An overview
inferredcites →https://doi.org/10.1016/j.molstruc.2020.128226openalex-snapshot
A new salt of clofazimine to improve leprosy treatment
inferredcites →https://doi.org/10.1016/j.saa.2019.117876openalex-snapshot
Considerations on high-throughput cocrystals screening by ultrasound assisted cocrystallization and vibrational spectroscopy
inferredcites →https://doi.org/10.1016/j.supflu.2020.104826openalex-snapshot
Design and processing of drug delivery formulations of therapeutic deep eutectic systems for tuberculosis
inferredcites →https://doi.org/10.1016/j.tca.2015.01.018openalex-snapshot
Characterization of CoQ 10-lauric acid eutectic system
inferredcites →https://doi.org/10.1016/j.xphs.2018.01.029openalex-snapshot
Synthesis of a Glibenclamide Cocrystal: Full Spectroscopic and Thermal Characterization
inferredcites →https://doi.org/10.1016/s0168-3659(97)00153-3openalex-snapshot
Transdermal delivery from eutectic systems: enhanced permeation of a model drug, ibuprofen
inferredcites →https://doi.org/10.1016/s0378-5173(02)00003-0openalex-snapshot
Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formation
inferredcites →https://doi.org/10.1021/acs.jced.0c00715openalex-snapshot
Viscosity of Choline Chloride-Based Deep Eutectic Solvents: Experiments and Modeling
inferredcites →https://doi.org/10.1021/acs.jced.8b00050openalex-snapshot
Solubility of Tolbutamide and Chlorpropamide in Supercritical Carbon Dioxide
inferredcites →https://doi.org/10.1021/acs.jpcb.7b05454openalex-snapshot
Resilience of Malic Acid Natural Deep Eutectic Solvent Nanostructure to Solidification and Hydration
inferredcites →https://doi.org/10.1021/acsmedchemlett.6b00504openalex-snapshot
Transdermal Bioavailability in Rats of Lidocaine in the Forms of Ionic Liquids, Salts, and Deep Eutectic
inferredcites →https://doi.org/10.1021/acssuschemeng.9b05096openalex-snapshot
Looking at the “Water-in-Deep-Eutectic-Solvent” System: A Dilution Range for High Performance Eutectics
inferredcites →https://doi.org/10.1021/sc500096jopenalex-snapshot
Natural Deep Eutectic Solvents – Solvents for the 21st Century
inferredcites →https://doi.org/10.1021/sc500439wopenalex-snapshot
Insights into the Synthesis and Properties of Deep Eutectic Solvents Based on Cholinium Chloride and Carboxylic Acids
inferredcites →https://doi.org/10.1039/c1cc15284jopenalex-snapshot
Synthesis of novel lidocaine-releasing poly(diol-co-citrate) elastomers by using deep eutectic solvents
inferredcites →https://doi.org/10.1039/c2cs35178aopenalex-snapshot
Deep eutectic solvents: syntheses, properties and applications
inferredcites →https://doi.org/10.1039/c5gc02914gopenalex-snapshot
Liquid structure of the choline chloride-urea deep eutectic solvent (reline) from neutron diffraction and atomistic modelling
inferredcites →https://doi.org/10.1039/c5md00551eopenalex-snapshot
Significantly improving the solubility of non-steroidal anti-inflammatory drugs in deep eutectic solvents for potential non-aqueous liquid administration
inferredcites →https://doi.org/10.1039/d1nj03816hopenalex-snapshot
Investigation of NH 3 absorption by protic imidazolium thiocyanate-based deep eutectic solvents with multiple binding sites and low viscosity
inferredcites →https://doi.org/10.1080/17425247.2019.1604680openalex-snapshot
Deep eutectic solvents comprising active pharmaceutical ingredients in the development of drug delivery systems
inferredcites →https://doi.org/10.1080/21691401.2016.1226178openalex-snapshot
Microemulsions based on paeonol-menthol eutectic mixture for enhanced transdermal delivery: formulation development and in vitro evaluation
inferredcites →https://doi.org/10.1186/s40064-016-2575-9openalex-snapshot
Natural deep eutectic solvents: cytotoxic profile
inferredcites →https://doi.org/10.1208/pt0803065openalex-snapshot
Comparison of the effect of tromethamine and polyvinylpyrrolidone on dissolution properties and analgesic effect of nimesulide
inferredcites →https://doi.org/10.1208/s12249-015-0459-xopenalex-snapshot
Evaporation Behavior and Characterization of Eutectic Solvent and Ibuprofen Eutectic Solution
inferredcites →https://doi.org/10.1371/journal.pone.0117934openalex-snapshot
In Vitro and In Vivo Toxicity Profiling of Ammonium-Based Deep Eutectic Solvents
inferredcites →https://doi.org/10.3109/10837450.2016.1163390openalex-snapshot
Amino acids as co-amorphous excipients for tackling the poor aqueous solubility of valsartan
inferredcites →https://doi.org/10.3390/molecules23123263openalex-snapshot
Vibrational Spectroscopy for Cocrystals Screening. A Comparative Study
inferredcites →https://doi.org/10.3390/molecules24010055openalex-snapshot
Properties of Therapeutic Deep Eutectic Solvents of l-Arginine and Ethambutol for Tuberculosis Treatment
inferredcites →https://doi.org/10.3390/pharmaceutics10030098openalex-snapshot
Co-Amorphous Solid Dispersions for Solubility and Absorption Improvement of Drugs: Composition, Preparation, Characterization and Formulations for Oral Delivery
inferredcites →https://doi.org/10.3892/mmr.2017.6147openalex-snapshot
Preparation and evaluation of microemulsion-based transdermal delivery of Cistanche tubulosa phenylethanoid glycosides

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Synergistic Effects of Sulfonylureas with Chemotherapeutics: In Vitro Screening Reveals Enhanced Cytotoxicity of Doxorubicin in Combination with Sulfonylureas
inferred← citeshttps://doi.org/10.1002/slct.202305218openalex-snapshot
Solubility and Stability of Carvedilol in Deep Eutectic Solvents: A Step Towards a Sustainable Pharmaceutical Formulation in the Liquid State
inferred← citeshttps://doi.org/10.1007/s11696-026-04767-9openalex-snapshot
Insights into the crucial role of API based deep eutectic solvents in pharmaceuticals: inception to applications
inferred← citeshttps://doi.org/10.1016/b978-0-443-21962-7.00019-5openalex-snapshot
Therapeutic deep eutectic solvents as drug delivery systems
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.119009openalex-snapshot
Sulfonylureas beyond diabetes: A comprehensive review on anticancer and off-target effects (1956–2025)
inferred← citeshttps://doi.org/10.1016/j.ejps.2026.107484openalex-snapshot
Deep eutectic systems as enabling pharmaceutical formulations: mechanisms and applications
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Green solvents in analytical chemistry: From sustainable innovation to education for a greener future
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e29783openalex-snapshot
Pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in maximising drug delivery
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.123890openalex-snapshot
Thermodynamic solubility measurement without chemical analysis
inferred← citeshttps://doi.org/10.1016/j.jddst.2023.104327openalex-snapshot
Ibuprofen solubility and cytotoxic study of deep eutectic solvents formed by xylitol, choline chloride and water
inferred← citeshttps://doi.org/10.1016/j.molliq.2025.129014openalex-snapshot
The role of water in enhancing the formation and stability of Therapeutic Deep Eutectic Systems (THEDESs) of tolbutamide and chlorpropamide
inferred← citeshttps://doi.org/10.1016/j.xphs.2025.103909openalex-snapshot
Dissolution improvement and solubility enhancement of two tumor-associated enzyme inhibitors via the formation of eutectic mixtures
inferred← citeshttps://doi.org/10.1021/acsomega.5c13008openalex-snapshot
From Chemistry to Clinic: Amorphous Solid-State Modification Strategies for Oral Azole Antifungals
inferred← citeshttps://doi.org/10.3390/app13105980openalex-snapshot
Has the Toxicity of Therapeutic Deep Eutectic Systems Been Assessed?
inferred← citeshttps://doi.org/10.3390/cryst15040350openalex-snapshot
A Novel Formulation of Fosamprenavir Calcium: Therapeutic Deep Eutectic Solvent with Enhanced Properties
inferred← citeshttps://doi.org/10.3390/ijms242115648openalex-snapshot
Therapeutic Liquid Eutectic Solvents in Lipid Nanoparticles as Drug Vehicles—A Proof of Concept
inferred← citeshttps://doi.org/10.3390/ijms26041429openalex-snapshot
Combining Sulfonylureas with Anticancer Drugs: Evidence of Synergistic Efficacy with Doxorubicin In Vitro and In Vivo
inferred← citeshttps://doi.org/10.3390/ijms27073110openalex-snapshot
A Green Innovative Approach for Solubility Enhancement of Poorly Water-Soluble Drugs Using Choline Chloride–Polyol Eutectic Solvents
inferred← citeshttps://doi.org/10.3390/ph17010124openalex-snapshot
A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest
inferred← citeshttps://doi.org/10.3390/ph17101316openalex-snapshot
Exploring Deep Eutectic Solvents as Pharmaceutical Excipients: Enhancing the Solubility of Ibuprofen and Mefenamic Acid
inferred← citeshttps://doi.org/10.70675/9572c4e2zdfafz441dz9d9fz43ffd50079b1openalex-snapshot
A green approach for the development of antitumoral eutectic solvent-based nanoparticles functionalized by hyaluronic acid-derived copolymers : preparation, characterization, and biological evaluation
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