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Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier

https://doi.org/10.3390/pharmaceutics14050987
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Crossing the Blood–Brain Barrier: Recent Advances in Drug Delivery to the Brain
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Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis
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Pharmacokinetic analysis and drug delivery efficiency of the focused ultrasound-induced blood-brain barrier opening in non-human primates
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The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle
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The blood–brain barrier: an overview
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X-ray irradiation induces disruption of the blood–brain barrier with localized changes in claudin-5 and activation of microglia in the mouse brain
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The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
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Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
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Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium
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Detection of Intracerebral Hemorrhage and Transient Blood-Supply Shortage in Focused-Ultrasound-Induced Blood–Brain Barrier Disruption by Ultrasound Imaging
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New Developments in Liposomal Drug Delivery
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Methotrexate-Loaded Extracellular Vesicles Functionalized with Therapeutic and Targeted Peptides for the Treatment of Glioblastoma Multiforme
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Antioxidative Theranostic Iron Oxide Nanoparticles toward Brain Tumors Imaging and ROS Production
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Solid Lipid Nanoparticles Enhanced the Neuroprotective Role of Curcumin against Epilepsy through Activation of Bcl-2 Family and P38 MAPK Pathways
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Gadolinium-Free Contrast Agents for Magnetic Resonance Imaging of the Central Nervous System
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Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease
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Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics
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Surface Functionalization of Exosomes Using Click Chemistry
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Glycopeptide-Membrane Interactions: Glycosyl Enkephalin Analogues Adopt Turn Conformations by NMR and CD in Amphipathic Media
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Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
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Gene therapy put on hold as third child develops cancer
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A phase I/II study of intrathecal idursulfase-IT in children with severe mucopolysaccharidosis II
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Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice
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Regulation of Aminopeptidase A in Human Brain Tumor Vasculature: Evidence for a Role of Transforming Growth Factor-β
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Efficient CNS gene delivery by intravenous injection
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From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery
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Astrocyte–endothelial interactions at the blood–brain barrier
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Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics
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Revisiting the role of ABC transporters in multidrug-resistant cancer
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Strategies for delivering therapeutics across the blood–brain barrier
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Engineering hybrid exosomes by membrane fusion with liposomes
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An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles
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Transporter protein and drug-conjugated gold nanoparticles capable of bypassing the blood-brain barrier
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Multimodality MRI assessment of grey and white matter injury and blood-brain barrier disruption after intracerebral haemorrhage in mice
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Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease
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A microfluidic model of the blood–brain barrier to study permeabilization by pulsed electric fields
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Nanoparticles as contrast agents for brain nuclear magnetic resonance imaging in Alzheimer's disease diagnosis
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Learning the ABCs one at a time: structure and mechanism of ABC transporters
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Enzyme-Replacement Therapy in Mucopolysaccharidosis I
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Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice
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Dual role of ALCAM in neuroinflammation and blood–brain barrier homeostasis
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Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice
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A comprehensive review on recent preparation techniques of liposomes
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International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
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Structural and Mechanistic Principles of ABC Transporters
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Reversibility of increased microvessel permeability in response to VE-cadherin disassembly
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Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology
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Influence of the Surface Properties on Nanoparticle-Mediated Transport of Drugs to the Brain
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Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [ 11 C]erlotinib
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Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
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Characteristics of compounds that cross the blood-brain barrier
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Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors
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Adenosine receptor signaling: a key to opening the blood–brain door
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Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human
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A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity
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Exploring different approaches to improve the success of drug discovery and development projects: a review
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Delivery of Small Interfering RNA to Inhibit Vascular Endothelial Growth Factor in Zebrafish Using Natural Brain Endothelia Cell-Secreted Exosome Nanovesicles for the Treatment of Brain Cancer
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Evidence Indicating that Renal Tubular Metabolism of Leptin Is Mediated by Megalin But Not by the Leptin Receptors
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DCE-MRI blood–brain barrier assessment in acute ischemic stroke
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370 Magnetic Resonance-Guided Focused Ultrasound Delivery of Polymeric Brain-Penetrating Nanoparticle MicroRNA Conjugates in Glioblastoma
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MRI Study on Reversible and Irreversible Electroporation Induced Blood Brain Barrier Disruption
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Peripheral Nervous System Neuropathology and Progressive Sensory Impairments in a Mouse Model of Mucopolysaccharidosis IIIB
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Effects on P-Glycoprotein Expression after Blood-Brain Barrier Disruption Using Focused Ultrasound and Microbubbles
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BLOOD-BRAIN BARRIER PERMEABILITY IN AGING AND ALZHEIMER’S DISEASE
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The role of endothelial lipase in lipid metabolism, inflammation, and cancer.
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Glutamate Induces Blood–Brain Barrier Permeability through Activation ofN-Methyl-D-Aspartate Receptors
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Galantamine in Alzheimer’s disease
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Development of neuropeptide drugs that cross the blood-brain barrier
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A review on Parkinson’s disease treatment
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ATP-binding cassette transporters at the zebrafish blood-brain barrier and the potential utility of the zebrafish as an in vivo model
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inferred← citeshttps://doi.org/10.1080/15685551.2025.2464132openalex-snapshot
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inferred← citeshttps://doi.org/10.1080/17425247.2024.2369765openalex-snapshot
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inferred← citeshttps://doi.org/10.1080/17435889.2024.2435242openalex-snapshot
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inferred← citeshttps://doi.org/10.1080/17590914.2025.2495632openalex-snapshot
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inferred← citeshttps://doi.org/10.1080/21655979.2024.2401269openalex-snapshot
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inferred← citeshttps://doi.org/10.1080/21688370.2025.2607157openalex-snapshot
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inferred← citeshttps://doi.org/10.1111/ejn.70142openalex-snapshot
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inferred← citeshttps://doi.org/10.1124/jpet.123.001689openalex-snapshot
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inferred← citeshttps://doi.org/10.11648/j.ajbio.20231102.12openalex-snapshot
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inferred← citeshttps://doi.org/10.1177/25424823251343789openalex-snapshot
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inferred← citeshttps://doi.org/10.1186/s12302-026-01369-wopenalex-snapshot
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inferred← citeshttps://doi.org/10.1186/s12967-023-04192-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1186/s12967-026-08052-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1186/s13064-026-00298-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1186/s13064-026-00316-yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1186/s40001-024-01915-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1208/s12249-024-02946-zopenalex-snapshot
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inferred← citeshttps://doi.org/10.1208/s12249-026-03398-3openalex-snapshot
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inferred← citeshttps://doi.org/10.12677/acm.2024.1472143openalex-snapshot
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inferred← citeshttps://doi.org/10.12923/cipms-2025-0002openalex-snapshot
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inferred← citeshttps://doi.org/10.13040/ijpsr.0975-8232.14(1).80-89openalex-snapshot
inferred← citeshttps://doi.org/10.13040/ijpsr.0975-8232.15(7).2222-29openalex-snapshot
inferred← citeshttps://doi.org/10.1371/journal.pone.0340202openalex-snapshot
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inferred← citeshttps://doi.org/10.1515/nipt-2026-0010openalex-snapshot
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inferred← citeshttps://doi.org/10.1515/tnsci-2022-0258openalex-snapshot
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inferred← citeshttps://doi.org/10.17816/phf120109openalex-snapshot
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inferred← citeshttps://doi.org/10.2147/ijn.s442520openalex-snapshot
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inferred← citeshttps://doi.org/10.2147/ijn.s443498openalex-snapshot
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inferred← citeshttps://doi.org/10.2147/ijn.s457393openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/0113816128348877241202053633openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/0115672050386924250930184405openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/0115680096355101250120114819openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/0115680266347890250409153450openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/0118753183367402241216115139openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/0122103031375761250801075431openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/1381612829666230803114513openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/1389200223666220817115003openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/1566523222666221004100858openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/9789815324846125010005openalex-snapshot
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inferred← citeshttps://doi.org/10.22159/ijap.2025v17i2.52932openalex-snapshot
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inferred← citeshttps://doi.org/10.3233/jad-230603openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fcell.2025.1674333openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fmed.2025.1522223openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fnagi.2024.1329357openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fneur.2023.1324216openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fonc.2026.1717432openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/biom14091104openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/biom16010027openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/biomedicines13102476openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/cells12010192openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms232213954openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms24119218openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms241411780openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms251910632openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms252111494openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms252211888openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms26125843openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms26199478openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms262311541openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms27052370openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/jcm11195846openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/molecules30071555openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ph17030366openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ph18050751openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ph18060871openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/pharmaceutics14081737openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/pharmaceutics14081748openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/pharmaceutics14091950openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/pharmaceutics14112370openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/pharmaceutics17010128openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/pharmaceutics17030280openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/pharmaceutics17050661openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/polym15193969openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/toxins15080506openalex-snapshot
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inferred← citeshttps://doi.org/10.34172/apb.025.44026openalex-snapshot
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inferred← citeshttps://doi.org/10.3762/bjnano.15.113openalex-snapshot
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inferred← citeshttps://doi.org/10.4018/979-8-3373-1365-8.ch012openalex-snapshot
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inferred← citeshttps://doi.org/10.4018/979-8-3373-1365-8.ch016openalex-snapshot
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inferred← citeshttps://doi.org/10.4018/979-8-3373-2695-5.ch008openalex-snapshot
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inferred← citeshttps://doi.org/10.4103/1673-5374.358619openalex-snapshot
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inferred← citeshttps://doi.org/10.4103/nrr.nrr-d-24-00539openalex-snapshot
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inferred← citeshttps://doi.org/10.54878/wys7ea23openalex-snapshot
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inferred← citeshttps://doi.org/10.5599/admet.2043openalex-snapshot
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inferred← citeshttps://doi.org/10.5599/admet.2988openalex-snapshot
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inferred← citeshttps://doi.org/10.56083/rcv3n7-086openalex-snapshot
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inferred← citeshttps://doi.org/10.59717/j.xinn-med.2025.100121openalex-snapshot
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inferred← citeshttps://doi.org/10.6084/m9.figshare.26590631openalex-snapshot
Additional file 1 of Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.