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Predicting Oral Drug Absorption: Mini Review on Physiologically-Based Pharmacokinetic Models

https://doi.org/10.3390/pharmaceutics9040041

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What this work says

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inferred← citeshttps://doi.org/10.1155/2020/6307457openalex-snapshot

Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study

inferred← citeshttps://doi.org/10.1186/s13321-025-00947-zopenalex-snapshot

ADMET evaluation in drug discovery: 21. Application and industrial validation of machine learning algorithms for Caco-2 permeability prediction

inferred← citeshttps://doi.org/10.1186/s40168-024-01953-3openalex-snapshot

The role of pharmacomicrobiomics in HIV prevention, treatment, and women’s health

inferred← citeshttps://doi.org/10.1186/s43094-020-00051-zopenalex-snapshot

Zotepine loaded lipid nanoparticles for oral delivery: development, characterization, and in vivo pharmacokinetic studies

inferred← citeshttps://doi.org/10.1208/s12248-019-0364-4openalex-snapshot

Reconciling Human-Canine Differences in Oral Bioavailability: Looking beyond the Biopharmaceutics Classification System

inferred← citeshttps://doi.org/10.1208/s12248-024-00985-9openalex-snapshot

Erectile Dysfunction Therapy of Bariatric Patients: Tadalafil Biopharmaceutics and Pharmacokinetics Before vs. After Gastric Sleeve/Bypass

inferred← citeshttps://doi.org/10.1208/s12248-026-01220-3openalex-snapshot

Physiologically Based Pharmacokinetic (PBPK) Modeling of Oral Drug Absorption for Integrating Nonclinical Data into Human Pharmacokinetic Predictions

inferred← citeshttps://doi.org/10.1208/s12249-019-1598-2openalex-snapshot

Application and Impact of Human Dose Projection from Discovery to Early Drug Development

inferred← citeshttps://doi.org/10.1208/s12249-026-03348-zopenalex-snapshot

Delivery Strategies and Clinical Significance of Oral Colon-targeted Drug Delivery Systems

inferred← citeshttps://doi.org/10.1371/journal.pone.0299501openalex-snapshot

Mathematical modeling of transdermal delivery of topical drug formulations in a dynamic microfluidic diffusion chamber in health and disease

inferred← citeshttps://doi.org/10.1371/journal.pone.0319032openalex-snapshot

Exploring cotton plant compounds for novel treatments against brain-eating Naegleria fowleri: An In-silico approach

inferred← citeshttps://doi.org/10.15381/rivep.v33i6.22433openalex-snapshot

Modelo farmacocinético de florfenicol en tilapias (Oreochromis niloticus) sometidas a diferentes temperaturas de crianza

inferred← citeshttps://doi.org/10.15416/pcpr.v2i1.16213openalex-snapshot

Consumption Time of Captopril Influenced the Outcomes of Patients with Stage 1 Hypertension

inferred← citeshttps://doi.org/10.21037/aoe-20-90openalex-snapshot

In vitro modelling of the mucosa of the oesophagus and upper digestive tract: narrative review

inferred← citeshttps://doi.org/10.21037/aoe-2020-ebmg-06openalex-snapshot

In vitro modelling of the mucosa of the oesophagus and upper digestive tract

inferred← citeshttps://doi.org/10.21123/bsj.2023.8395openalex-snapshot

Pharmacokinetic Consideration to Formulate Sustained Release Drugs: Understanding the Controlled Drug Diffusion through the Body Compartment of the Systemic Circulation and Tissue Medium-A Caputo Model

inferred← citeshttps://doi.org/10.21203/rs.3.rs-687537/v1openalex-snapshot

A New Approach for In Silico Prediction of Oral Drug Concentration Profiles in Human for Drug Candidates Lack Experimental Pharmacokinetic Data

inferred← citeshttps://doi.org/10.21248/gups.61326openalex-snapshot

A physiologically based biopharmaceutical analysis of zolpidem

inferred← citeshttps://doi.org/10.2174/0115680266316570240926081647openalex-snapshot

The Anti-leukemic Activities of Campesterol and Α-Tocopherol Against BCL-2 Target through Computational Drug Design Approaches

inferred← citeshttps://doi.org/10.2174/0929867330666230408201849openalex-snapshot

PBPK Modeling as an Alternative Method of Interspecies Extrapolation that Reduces the Use of Animals: A Systematic Review

inferred← citeshttps://doi.org/10.2174/1381612825666190903155935openalex-snapshot

In-Silico Modeling in Drug Metabolism and Interaction: Current Strategies of Lead Discovery

inferred← citeshttps://doi.org/10.2174/1389200221666200312104837openalex-snapshot

Further Considerations Towards an Effective and Efficient Oncology Drug Discovery DMPK Strategy

inferred← citeshttps://doi.org/10.2174/1567201819666220411115108openalex-snapshot

A Comprehensive Review on Recent Advances and Considerations for the Selection of Cell-based In-vitro Techniques for the Assessment of Permeability of Drug Molecules

inferred← citeshttps://doi.org/10.2174/1568026619666181130140350openalex-snapshot

In Silico Assessment of ADME Properties: Advances in Caco-2 Cell Monolayer Permeability Modeling

inferred← citeshttps://doi.org/10.2174/2211556009666200413085800openalex-snapshot

Thymoquinone Glucuronide Conjugated Magnetic Nanoparticle for Bimodal Imaging and Treatment of Cancer as a Novel Theranostic Platform

inferred← citeshttps://doi.org/10.2174/9789815080056123020006openalex-snapshot

Basics of the Drug Development Process

inferred← citeshttps://doi.org/10.22159/ijap.2023v15i1.46553openalex-snapshot

IMPORTANCE OF SUFFICIENT TIME POINTS FOR EFFICIENT PHARMACOKINETIC (PK) COMPARTMENTAL MODELING

inferred← citeshttps://doi.org/10.22270/ujpr.v4i6.340openalex-snapshot

BUCCAL DRUG DELIVERY SYSTEM: AN OVERVIEW ABOUT DOSAGE FORMS AND RECENT STUDIES

inferred← citeshttps://doi.org/10.22541/au.159110373.38917551openalex-snapshot

A Promising New Approach for In Silico Prediction of Drug Concentration Profiles for Drug Candidates Lack of Experimental Pharmacokinetic Data

inferred← citeshttps://doi.org/10.2298/hemind210104002copenalex-snapshot

Integrated biopharmaceutical approach in pharmaceutical development and drug characterization: General concept and application

inferred← citeshttps://doi.org/10.23893/1307-2080.aps.05923openalex-snapshot

Design, development and in vivo pharmacokinetic evaluation of zotepine loaded solid lipid nanoparticles for enhanced oral bioavailability

inferred← citeshttps://doi.org/10.2478/cipms-2020-0017openalex-snapshot

Role of stable hydrogen isotope variations in water for drug dissolution managing

inferred← citeshttps://doi.org/10.25082/jpbr.2022.01.003openalex-snapshot

Transdermal drug delivery systems: Analysis of adhesion failure

inferred← citeshttps://doi.org/10.31024/ajpp.2019.5.4.1openalex-snapshot

Strategies in overcoming the challenges of cytotoxic agents using smart colloidal solid lipid nanoparticles and nanostructured lipid carriers - A review

inferred← citeshttps://doi.org/10.31080/asps.2021.05.0800openalex-snapshot

Bioavailability, Bioequivalence, and Pharmacokinetics: Clinical Effectiveness in Drug Development

inferred← citeshttps://doi.org/10.3389/fcvm.2022.987104openalex-snapshot

Emerging computational paradigms to address the complex role of gut microbial metabolism in cardiovascular diseases

inferred← citeshttps://doi.org/10.3389/fphar.2019.01692openalex-snapshot

Physiologically Based Pharmacokinetic Modeling to Understand the Absorption of Risperidone Orodispersible Film

inferred← citeshttps://doi.org/10.3389/fphar.2022.1087988openalex-snapshot

Editorial: Pharmacokinetic evaluation and modeling of clinically significant drug metabolites, Volume II

inferred← citeshttps://doi.org/10.3389/fphar.2024.1404619openalex-snapshot

A Bayesian framework for virtual comparative trials and bioequivalence assessments

inferred← citeshttps://doi.org/10.3389/fvets.2020.573159openalex-snapshot

Phytogenic Products and Phytochemicals as a Candidate Strategy to Improve Tolerance to Coronavirus

inferred← citeshttps://doi.org/10.33899/iphr.2023.138155.01023openalex-snapshot

Cell Line Culture in Pharmaceutical Development and Application: A Review

inferred← citeshttps://doi.org/10.3390/bioengineering11080813openalex-snapshot

Mathematical Modeling of the Gastrointestinal System for Preliminary Drug Absorption Assessment

inferred← citeshttps://doi.org/10.3390/biom15070975openalex-snapshot

Physiologically Based Pharmacokinetic Modeling for Predicting Drug Levels After Bariatric Surgery: Vardenafil Exposure Before vs. After Gastric Sleeve/Bypass

inferred← citeshttps://doi.org/10.3390/cimb48010063openalex-snapshot

Recent Advances in Oral Drug Delivery Systems for BCS III Drugs

inferred← citeshttps://doi.org/10.3390/foods10112761openalex-snapshot

A Physiological-Based Model for Simulating the Bioavailability and Kinetics of Sulforaphane from Broccoli Products

inferred← citeshttps://doi.org/10.3390/ijms23147597openalex-snapshot

Toxicologic Concerns with Current Medical Nanoparticles

inferred← citeshttps://doi.org/10.3390/ijms24010069openalex-snapshot

Prediction of Drug Synergism between Peptides and Antineoplastic Drugs Paclitaxel, 5-Fluorouracil, and Doxorubicin Using In Silico Approaches

inferred← citeshttps://doi.org/10.3390/ijms252313121openalex-snapshot

Overcoming Challenges in Small-Molecule Drug Bioavailability: A Review of Key Factors and Approaches

inferred← citeshttps://doi.org/10.3390/ijpb13020016openalex-snapshot

Theoretical Prediction of Gastrointestinal Absorption of Phytochemicals

inferred← citeshttps://doi.org/10.3390/md17120667openalex-snapshot

Toxicity, Pharmacokinetics, and Gut Microbiome of Oral Administration of Sesterterpene MHO7 Derived from a Marine Fungus

inferred← citeshttps://doi.org/10.3390/molecules28248038openalex-snapshot

The Bioavailability of Drugs—The Current State of Knowledge

inferred← citeshttps://doi.org/10.3390/ph17020177openalex-snapshot

Model-Informed Drug Development: In Silico Assessment of Drug Bioperformance following Oral and Percutaneous Administration

inferred← citeshttps://doi.org/10.3390/pharmaceutics10010013openalex-snapshot

Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape—A Summary of This Indispensable Special Issue

inferred← citeshttps://doi.org/10.3390/pharmaceutics12070672openalex-snapshot

Food Effects on Oral Drug Absorption: Application of Physiologically-Based Pharmacokinetic Modeling as a Predictive Tool

inferred← citeshttps://doi.org/10.3390/pharmaceutics12121175openalex-snapshot

BCS Class IV Oral Drugs and Absorption Windows: Regional-Dependent Intestinal Permeability of Furosemide

inferred← citeshttps://doi.org/10.3390/pharmaceutics14020364openalex-snapshot

Adaptation of the Kirkstall QV600 LLI Microfluidics System for the Study of Gastrointestinal Absorption by Mass Spectrometry Imaging and LC-MS/MS

inferred← citeshttps://doi.org/10.3390/pharmaceutics14071360openalex-snapshot

The Role of Paracellular Transport in the Intestinal Absorption and Biopharmaceutical Characterization of Minoxidil

inferred← citeshttps://doi.org/10.3390/pharmaceutics14101998openalex-snapshot

Reliable Prediction of Caco-2 Permeability by Supervised Recursive Machine Learning Approaches

inferred← citeshttps://doi.org/10.3390/pharmaceutics15010107openalex-snapshot

In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools

inferred← citeshttps://doi.org/10.3390/pharmaceutics15122795openalex-snapshot

The Complexity of Bariatric Patient’s Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass

inferred← citeshttps://doi.org/10.3390/pharmaceutics16080978openalex-snapshot

Advances in Modeling Approaches for Oral Drug Delivery: Artificial Intelligence, Physiologically-Based Pharmacokinetics, and First-Principles Models

inferred← citeshttps://doi.org/10.3390/pharmaceutics16111414openalex-snapshot

Advancements in Virtual Bioequivalence: A Systematic Review of Computational Methods and Regulatory Perspectives in the Pharmaceutical Industry

inferred← citeshttps://doi.org/10.3390/pharmaceutics17070914openalex-snapshot

Physiologically Based Pharmacokinetic Simulation of Tofacitinib in Humans Using Extrapolation from Single-Species Renal Failure Model

inferred← citeshttps://doi.org/10.3390/pharmaceutics17081002openalex-snapshot

In Silico ADME Methods Used in the Evaluation of Natural Products

inferred← citeshttps://doi.org/10.3390/s19183882openalex-snapshot

A Smartphone-Based Whole-Cell Array Sensor for Detection of Antibiotics in Milk

inferred← citeshttps://doi.org/10.35516/jjps.v17i3.1970openalex-snapshot

Preparation and Evaluation of Nanolipid Carriers of Bedaquiline- In vitro Evaluation and in silico Prediction

inferred← citeshttps://doi.org/10.4155/fmc-2021-0194openalex-snapshot

Diaminomaleonitrile Derivatives as new Potential Antichagasic Compounds: A Study of Structure–Activity Relationships

inferred← citeshttps://doi.org/10.47749/t/unicamp.2020.1162299openalex-snapshot

Desenvolvimento de partículas a partir da blenda de sericina e alginato para incorporação e liberação modificada de anti-inflamatórios cetoprofeno e naproxeno

inferred← citeshttps://doi.org/10.47750/pnr.2022.13.03.044openalex-snapshot

Preparation and in-vivo Evaluation of Ticagrelor Oral Liquid Self nano-emulsion

inferred← citeshttps://doi.org/10.51847/lx1ewvcmkuopenalex-snapshot

Drug-Likeness Beyond Lipinski: Rethinking Natural Product Developability Through Bioavailability, Structural Complexity, Formulation Feasibility, and Safety Logic

inferred← citeshttps://doi.org/10.52816/jdvat.2021.1403openalex-snapshot

Formulation and In Vitro Evaluation of Tropisetron Loaded Microspheres

inferred← citeshttps://doi.org/10.5599/admet.1513openalex-snapshot

Role of in vitro two-dimensional (2D) and three-dimensional (3D) cell culture systems for ADME-Tox screening in drug discovery and development: a comprehensive review

inferred← citeshttps://doi.org/10.59277/rjb.2025.1.01openalex-snapshot

PHARMACOKINETICS AND PHARMACODYNAMICS PREDICTED PROFILES OF STRIGOLACTONES-BIOINFORMATICS APPROACHES

inferred← citeshttps://doi.org/10.5937/arhfarm71-32479openalex-snapshot

The emerging role of physiologically-based pharmacokinetic/biopharmaceutics modeling in formulation development

inferred← citeshttps://doi.org/10.70675/7bcf6d06za15fz452fz9b70z8697a902c896openalex-snapshot

PBPK modeling of doxorubicin-loaded polymeric nanoparticles : potential for clinical translation

inferred← citeshttps://doi.org/10.70675/b19076c0z6aefz46b4z8339zf08171e4d8bfopenalex-snapshot

A quantitative approach to fetal lead exposure : development of a pregnancy physiologically based pharmacokinetic model (p-PBPK) and its application to human biomonitoring data

inferred← citeshttps://doi.org/10.7324/japs.2020.10503openalex-snapshot

Exploration of bioflavonoids targeting dengue virus NS5 RNA- dependent RNA polymerase: In silico molecular docking approach

inferred← citeshttps://doi.org/10.9734/jpri/2021/v33i47a33000openalex-snapshot

Anti Ulceration Efficacy of Boiled Aqueous Leaf Extract of Morinda lucida on Ethanol Induced Gastric Ulceration Rats

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.