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Albumin-induced premature senescence in human renal proximal tubular cells and its relationship with intercellular fibrosis

https://doi.org/10.3724/abbs.2022055
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2017.0686openalex-snapshot
Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood
inferredcites →https://doi.org/10.1002/jcp.25838openalex-snapshot
Metformin attenuates albumin‐induced alterations in renal tubular cells in vitro
inferredcites →https://doi.org/10.1007/s12079-017-0434-2openalex-snapshot
Cellular senescence in the aging and diseased kidney
inferredcites →https://doi.org/10.1016/j.cell.2019.10.005openalex-snapshot
Cellular Senescence: Defining a Path Forward
inferredcites →https://doi.org/10.1016/j.cellsig.2010.01.013openalex-snapshot
Examination of the expanding pathways for the regulation of p21 expression and activity
inferredcites →https://doi.org/10.1016/j.cub.2017.07.033openalex-snapshot
Unmasking Transcriptional Heterogeneity in Senescent Cells
inferredcites →https://doi.org/10.1016/j.dnarep.2016.04.008openalex-snapshot
Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage
inferredcites →https://doi.org/10.1016/j.jdiacomp.2014.05.010openalex-snapshot
Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy
inferredcites →https://doi.org/10.1016/j.kint.2017.09.033openalex-snapshot
Renal tubule injury: a driving force toward chronic kidney disease
inferredcites →https://doi.org/10.1016/j.lfs.2018.05.003openalex-snapshot
Dexmedetomidine attenuates renal fibrosis via α2-adrenergic receptor-dependent inhibition of cellular senescence after renal ischemia/reperfusion
inferredcites →https://doi.org/10.1016/j.matbio.2018.02.006openalex-snapshot
Renal fibrosis: Primacy of the proximal tubule
inferredcites →https://doi.org/10.1016/j.mrrev.2015.07.001openalex-snapshot
Persistent γH2AX: A promising molecular marker of DNA damage and aging
inferredcites →https://doi.org/10.1016/j.tcb.2018.02.001openalex-snapshot
Hallmarks of Cellular Senescence
inferredcites →https://doi.org/10.1016/s0140-6736(19)30772-xopenalex-snapshot
Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
inferredcites →https://doi.org/10.1038/35048096openalex-snapshot
Mitotic kinases as regulators of cell division and its checkpoints
inferredcites →https://doi.org/10.1038/cddis.2015.1openalex-snapshot
Albumin-induced apoptosis of tubular cells is modulated by BASP1
inferredcites →https://doi.org/10.1038/ki.1995.218openalex-snapshot
Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria
inferredcites →https://doi.org/10.1038/ki.2008.405openalex-snapshot
Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria
inferredcites →https://doi.org/10.1038/ki.2012.475openalex-snapshot
Selective estrogen receptor modulation attenuates proteinuria-induced renal tubular damage by modulating mitochondrial oxidative status
inferredcites →https://doi.org/10.1038/ki.2013.243openalex-snapshot
Comments on ‘KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease’
inferredcites →https://doi.org/10.1038/kisup.2014.8openalex-snapshot
Primary proximal tubule injury leads to epithelial cell cycle arrest, fibrosis, vascular rarefaction, and glomerulosclerosis
inferredcites →https://doi.org/10.1038/nm.2144openalex-snapshot
Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
inferredcites →https://doi.org/10.1038/nm.3902openalex-snapshot
Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
inferredcites →https://doi.org/10.1038/nrm3823openalex-snapshot
Cellular senescence: from physiology to pathology
inferredcites →https://doi.org/10.1038/nrneph.2011.149openalex-snapshot
Cellular and molecular mechanisms of renal fibrosis
inferredcites →https://doi.org/10.1038/nrneph.2014.116openalex-snapshot
Diabetic nephropathy—emerging epigenetic mechanisms
inferredcites →https://doi.org/10.1038/nrneph.2015.3openalex-snapshot
Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD
inferredcites →https://doi.org/10.1038/s41598-017-15972-8openalex-snapshot
Hypoxia inducible factor-1α mediates the profibrotic effect of albumin in renal tubular cells
inferredcites →https://doi.org/10.1046/j.1523-1755.2000.00208.xopenalex-snapshot
Interstitial fibrosis in mice with overload proteinuria: Deficiency of TIMP-1 is not protective
inferredcites →https://doi.org/10.1053/j.ackd.2005.01.008openalex-snapshot
Tubular changes in early diabetic nephropathy
inferredcites →https://doi.org/10.1074/jbc.m005437200openalex-snapshot
p21 Inhibits Thr161 Phosphorylation of Cdc2 to Enforce the G2 DNA Damage Checkpoint
inferredcites →https://doi.org/10.1074/jbc.m115.662064openalex-snapshot
Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation
inferredcites →https://doi.org/10.1080/15384101.2014.1000134openalex-snapshot
Senescence from G2 arrest, revisited
inferredcites →https://doi.org/10.1080/15384101.2017.1415679openalex-snapshot
Tetrandrine enhances radiosensitivity through the CDC25C/CDK1/cyclin B1 pathway in nasopharyngeal carcinoma cells
inferredcites →https://doi.org/10.1089/omi.2009.0073openalex-snapshot
Albumin Overload Induces Apoptosis in Renal Tubular Epithelial Cells through a CHOP-Dependent Pathway
inferredcites →https://doi.org/10.1093/nar/gkv927openalex-snapshot
The p53-p21-DREAM-CDE/CHR pathway regulates G 2 /M cell cycle genes
inferredcites →https://doi.org/10.1093/ndt/gfu230openalex-snapshot
Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury
inferredcites →https://doi.org/10.1093/ndt/gfx376openalex-snapshot
Albumin downregulates Klotho in tubular cells
inferredcites →https://doi.org/10.1093/qjmed/hcu170openalex-snapshot
End-stage renal disease and survival in people with diabetes: a national database linkage study
inferredcites →https://doi.org/10.1096/fj.202000949ropenalex-snapshot
Aristolochic acid induces renal fibrosis by arresting proximal tubular cells in G2/M phase mediated by HIF‐1α
inferredcites →https://doi.org/10.1097/00041552-199703000-00005openalex-snapshot
Proteinuria and progression of renal disease
inferredcites →https://doi.org/10.1101/gad.217281.113openalex-snapshot
Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence
inferredcites →https://doi.org/10.1152/ajpcell.00096.2010openalex-snapshot
Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes
inferredcites →https://doi.org/10.1152/ajprenal.00125.2016openalex-snapshot
Proteinuria causes dysfunctional autophagy in the proximal tubule
inferredcites →https://doi.org/10.1152/ajprenal.90302.2008openalex-snapshot
Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy
inferredcites →https://doi.org/10.1155/2019/7495629openalex-snapshot
The Signaling of Cellular Senescence in Diabetic Nephropathy
inferredcites →https://doi.org/10.1172/jci117214openalex-snapshot
Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.
inferredcites →https://doi.org/10.1172/jci22593openalex-snapshot
Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells
inferredcites →https://doi.org/10.1177/0963689717743512openalex-snapshot
Acute Kidney Injury as a Condition of Renal Senescence
inferredcites →https://doi.org/10.1242/dmm.019398openalex-snapshot
Albumin stimulates renal tubular inflammation through a HSP70-TLR4 axis in early diabetic nephropathy
inferredcites →https://doi.org/10.1242/jcs.106351openalex-snapshot
Phosphorylation network dynamics in the control of cell cycle transitions
inferredcites →https://doi.org/10.15252/embj.201695553openalex-snapshot
p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling
inferredcites →https://doi.org/10.2215/cjn.00580111openalex-snapshot
Albuminuria and Estimated Glomerular Filtration Rate as Predictors of Diabetic End-Stage Renal Disease and Death
inferredcites →https://doi.org/10.2337/diacare.28.1.164openalex-snapshot
Diabetic Nephropathy: Diagnosis, Prevention, and Treatment
inferredcites →https://doi.org/10.3390/ijms21228504openalex-snapshot
The Role of Cell Cycle Regulators in Cell Survival—Dual Functions of Cyclin-Dependent Kinase 20 and p21Cip1/Waf1
inferredcites →https://doi.org/10.4161/cc.5.12.2863openalex-snapshot
The Intricacies of p21 Phosphorylation: Protein/Protein Interactions, Subcellular Localization and Stability

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Role of Curcumin in Mediating BSA Fibrillation in a Cu 2 System: A Mechanistic Insight
inferred← citeshttps://doi.org/10.1016/j.clinbiochem.2023.110682openalex-snapshot
Association of elevated extracellular HSP72 in albuminuria with systemic inflammation and disease progression in type 2 diabetic kidney disease
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.178441openalex-snapshot
Azathioprine ameliorates cellular senescence in rhabdomyolysis-induced acute kidney injury by inhibiting the Vav1/Rac2/NF-κB pathway in macrophages
inferred← citeshttps://doi.org/10.1016/j.kint.2022.10.030openalex-snapshot
Targeting inflammation to treat diabetic kidney disease: the road to 2030
inferred← citeshttps://doi.org/10.1016/j.saa.2025.127093openalex-snapshot
Dual binding modes of Quercetin to BSA: Insights from spectroscopy and molecular simulations in amyloid suppression
inferred← citeshttps://doi.org/10.1093/joneph/aajaf003openalex-snapshot
Predicting the risk of lupus nephritis based on a nomogram in patients with childhood-onset systemic lupus erythematosus
inferred← citeshttps://doi.org/10.1186/s11658-026-00917-9openalex-snapshot
DYRK2 drives renal fibrosis through CDK1-dependent G2/M phase dysregulation in tubular epithelial cells
inferred← citeshttps://doi.org/10.33540/1996openalex-snapshot
Insights into protein-bound uremic toxins in proximal tubule cell senescence and kidney fibrosis
inferred← citeshttps://doi.org/10.3390/ijms24119640openalex-snapshot
Routes of Albumin Overload Toxicity in Renal Tubular Epithelial Cells
inferred← citeshttps://doi.org/10.3390/toxins15040242openalex-snapshot
The Uremic Toxin Indoxyl Sulfate Accelerates Senescence in Kidney Proximal Tubule Cells
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