On the public citation graph

Dihydropyrimidinase Protects from DNA Replication Stress Caused by Cytotoxic Metabolites

https://doi.org/10.37247/imcac.1.2021.13

0 signed · 77 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/bf00711685openalex-snapshot

Dihydropyrimidinase deficiency presenting in infancy with severe developmental delay

inferredcites →https://doi.org/10.1007/bf01799851openalex-snapshot

Dihydropyrimidinuria without clinical symptoms

inferredcites →https://doi.org/10.1007/s13277-015-3063-5openalex-snapshot

MDC1 promotes ovarian cancer metastasis by inducing epithelial-mesenchymal transition

inferredcites →https://doi.org/10.1016/0006-3002(58)90328-7openalex-snapshot

Incorporation of hydropyrimidine derivatives in ribonucleic acid with liver preparations

inferredcites →https://doi.org/10.1016/0006-3002(60)90178-5openalex-snapshot

Some enzymic actions on hydrouracil derivatives

inferredcites →https://doi.org/10.1016/0092-8674(82)90015-0openalex-snapshot

DNA synthesis in a cell-free system from Xenopus eggs: Priming and elongation on single-stranded DNA in vitro

inferredcites →https://doi.org/10.1016/j.bbadis.2010.03.013openalex-snapshot

Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients

inferredcites →https://doi.org/10.1016/j.cbi.2013.07.010openalex-snapshot

Evidence for endogenous formation of the hepatocarcinogen N-nitrosodihydrouracil in rats treated with dihydrouracil and sodium nitrite: A potential source of human hepatic DNA carboxyethylation

inferredcites →https://doi.org/10.1016/j.cell.2005.06.008openalex-snapshot

Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability

inferredcites →https://doi.org/10.1016/j.cell.2009.02.024openalex-snapshot

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

inferredcites →https://doi.org/10.1016/j.cell.2009.08.006openalex-snapshot

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

inferredcites →https://doi.org/10.1016/j.cell.2011.02.013openalex-snapshot

Hallmarks of Cancer: The Next Generation

inferredcites →https://doi.org/10.1016/j.cell.2011.03.044openalex-snapshot

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

inferredcites →https://doi.org/10.1016/j.cell.2014.07.032openalex-snapshot

Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

inferredcites →https://doi.org/10.1016/j.cell.2014.09.024openalex-snapshot

Repair of a DNA-Protein Crosslink by Replication-Coupled Proteolysis

inferredcites →https://doi.org/10.1016/j.cell.2016.12.039openalex-snapshot

Understanding the Intersections between Metabolism and Cancer Biology

inferredcites →https://doi.org/10.1016/j.cell.2018.10.053openalex-snapshot

The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

inferredcites →https://doi.org/10.1016/j.celrep.2015.12.093openalex-snapshot

Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage

inferredcites →https://doi.org/10.1016/j.devcel.2015.06.002openalex-snapshot

RAD18 Is a Maternal Limiting Factor Silencing the UV-Dependent DNA Damage Checkpoint in Xenopus Embryos

inferredcites →https://doi.org/10.1016/j.molcel.2008.07.001openalex-snapshot

MCM9 Binds Cdt1 and Is Required for the Assembly of Prereplication Complexes

inferredcites →https://doi.org/10.1016/j.molcel.2008.10.014openalex-snapshot

FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex

inferredcites →https://doi.org/10.1016/j.molcel.2010.09.019openalex-snapshot

The DNA Damage Response: Making It Safe to Play with Knives

inferredcites →https://doi.org/10.1016/j.molcel.2011.12.019openalex-snapshot

RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

inferredcites →https://doi.org/10.1016/j.molcel.2013.10.006openalex-snapshot

R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation

inferredcites →https://doi.org/10.1016/j.molcel.2015.08.020openalex-snapshot

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

inferredcites →https://doi.org/10.1016/j.molcel.2016.09.031openalex-snapshot

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN

inferredcites →https://doi.org/10.1016/j.molcel.2016.09.032openalex-snapshot

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

inferredcites →https://doi.org/10.1016/j.molcel.2018.11.024openalex-snapshot

Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts

inferredcites →https://doi.org/10.1016/j.ymeth.2012.03.029openalex-snapshot

Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins

inferredcites →https://doi.org/10.1016/j.ymgme.2007.02.008openalex-snapshot

Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency

inferredcites →https://doi.org/10.1016/s0960-9822(00)00855-1openalex-snapshot

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

inferredcites →https://doi.org/10.1021/acs.accounts.5b00056openalex-snapshot

DNA–Protein Cross-Links: Formation, Structural Identities, and Biological Outcomes

inferredcites →https://doi.org/10.1021/ja505407popenalex-snapshot

Reactivity of Damaged Pyrimidines: DNA Cleavage via Hemiaminal Formation at the C4 Positions of the Saturated Thymine of Spore Photoproduct and Dihydrouridine

inferredcites →https://doi.org/10.1038/362709a0openalex-snapshot

Instability and decay of the primary structure of DNA

inferredcites →https://doi.org/10.1038/emboj.2009.371openalex-snapshot

FANCM regulates DNA chain elongation and is stabilized by S‐phase checkpoint signalling

inferredcites →https://doi.org/10.1038/gim.2017.123openalex-snapshot

Individuals with FANCM biallelic mutations do not develop Fanconi anemia, but show risk for breast cancer, chemotherapy toxicity and may display chromosome fragility

inferredcites →https://doi.org/10.1038/nature10192openalex-snapshot

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

inferredcites →https://doi.org/10.1038/nature25507openalex-snapshot

Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress

inferredcites →https://doi.org/10.1038/nbt.1511openalex-snapshot

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

inferredcites →https://doi.org/10.1038/ncb1984openalex-snapshot

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

inferredcites →https://doi.org/10.1038/ncb2426openalex-snapshot

A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response

inferredcites →https://doi.org/10.1038/ncb2897openalex-snapshot

Causes and consequences of replication stress

inferredcites →https://doi.org/10.1038/ncb3013openalex-snapshot

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

inferredcites →https://doi.org/10.1038/nrm3289openalex-snapshot

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

inferredcites →https://doi.org/10.1038/nsmb.1927openalex-snapshot

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

inferredcites →https://doi.org/10.1038/sj.emboj.7601045openalex-snapshot

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

inferredcites →https://doi.org/10.1038/srep04628openalex-snapshot

Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism

inferredcites →https://doi.org/10.1042/bst20160073openalex-snapshot

‘Nothing of chemistry disappears in biology’: the Top 30 damage-prone endogenous metabolites

inferredcites →https://doi.org/10.1055/s-2007-973681openalex-snapshot

Dihydropyrimidinase Deficiency, a Progressive Neurological Disorder?

inferredcites →https://doi.org/10.1073/pnas.0901451106openalex-snapshot

Identification of genes conferring resistance to 5-fluorouracil

inferredcites →https://doi.org/10.1073/pnas.96.5.1921openalex-snapshot

Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage

inferredcites →https://doi.org/10.1074/jbc.m408573200openalex-snapshot

Macrophage Tropism of HIV-1 Depends on Efficient Cellular dNTP Utilization by Reverse Transcriptase

inferredcites →https://doi.org/10.1080/10409238.2019.1568963openalex-snapshot

A tumor suppressive DNA translocase named FANCM

inferredcites →https://doi.org/10.1080/15257770600894576openalex-snapshot

Activity of Pyrimidine Degradation Enzymes in Normal Tissues

inferredcites →https://doi.org/10.1083/jcb.140.6.1285openalex-snapshot

Replicon Clusters Are Stable Units of Chromosome Structure: Evidence That Nuclear Organization Contributes to the Efficient Activation and Propagation of S Phase in Human Cells

inferredcites →https://doi.org/10.1083/jcb.201406099openalex-snapshot

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

inferredcites →https://doi.org/10.1086/302022openalex-snapshot

Dihydropyrimidinase Deficiency: Structural Organization, Chromosomal Localization, and Mutation Analysis of the Human Dihydropyrimidinase Gene

inferredcites →https://doi.org/10.1093/nar/gkq128openalex-snapshot

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

inferredcites →https://doi.org/10.1093/nar/gkr1241openalex-snapshot

Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts

inferredcites →https://doi.org/10.1093/nar/gkv047openalex-snapshot

Regulation of mammalian nucleotide metabolism and biosynthesis

inferredcites →https://doi.org/10.1111/cas.12877openalex-snapshot

RAP80 regulates epithelial–mesenchymal transition related with metastasis and malignancy of cancer

inferredcites →https://doi.org/10.1126/science.1074023openalex-snapshot

Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

inferredcites →https://doi.org/10.1128/mcb.21.11.3820-3829.2001openalex-snapshot

Loss of HCF-1–Chromatin Association Precedes Temperature-Induced Growth Arrest of tsBN67 Cells

inferredcites →https://doi.org/10.1128/mcb.21.13.4129-4139.2001openalex-snapshot

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

inferredcites →https://doi.org/10.1146/annurev-pathol-012414-040424openalex-snapshot

DNA Replication Stress as a Hallmark of Cancer

inferredcites →https://doi.org/10.1155/2017/1053617openalex-snapshot

The Versatile Effects of Dihydromyricetin in Health

inferredcites →https://doi.org/10.1371/journal.pone.0038802openalex-snapshot

Flavonoid Ampelopsin Inhibits the Growth and Metastasis of Prostate Cancer In Vitro and in Mice

inferredcites →https://doi.org/10.1371/journal.pone.0127634openalex-snapshot

Inhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases

inferredcites →https://doi.org/10.15252/embj.201592426openalex-snapshot

Topoisomerase I‐mediated cleavage at unrepaired ribonucleotides generates DNA double‐strand breaks

inferredcites →https://doi.org/10.26508/lsa.201800096openalex-snapshot

Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling

inferredcites →https://doi.org/10.3324/haematol.2010.033456openalex-snapshot

A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines

inferredcites →https://doi.org/10.3892/or.2013.2705openalex-snapshot

Dihydromyricetin suppresses the proliferation of hepatocellular carcinoma cells by inducing G2/M arrest through the Chk1/Chk2/Cdc25C pathway

inferredcites →https://doi.org/10.3892/or.2014.3160openalex-snapshot

Dihydromyricetin induces cell cycle arrest and apoptosis in melanoma SK-MEL-28 cells

inferredcites →https://doi.org/10.4238/2015.december.1.7openalex-snapshot

Dihydromyricetin induces cell apoptosis via a p53-related pathway in AGS human gastric cancer cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4678160openalex-extracted

Bio Processes Generating Micp and Identification of the Functional Bio Processes During Soil Modification

inferred← citeshttps://doi.org/10.3390/diagnostics11101786openalex-snapshot

Metabolomic Profiles of Men and Women Ischemic Stroke Patients

inferred← citeshttps://doi.org/10.64898/2026.06.14.731825openalex-snapshot

Dihydropyrimidines sustain aggressive cancer states by stabilizing DPYSL2

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.