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The impact of tumour pH on cancer progression: strategies for clinical intervention

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Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan-1
inferredcites →https://doi.org/10.1002/0470868716.ch13openalex-snapshot
pH i , Aerobic Glycolysis and Vascular Endothelial Growth Factor in Tumour Growth
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Intracellular pH modulation of ADF/cofilin proteins
inferredcites →https://doi.org/10.1002/ijc.20959openalex-snapshot
Na+/H+ exchanger activity is increased in doxorubicin‐resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin
inferredcites →https://doi.org/10.1002/ijc.25009openalex-snapshot
pH‐dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity
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inferredcites →https://doi.org/10.1002/ijc.26410openalex-snapshot
Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c‐Jun activation
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Vacuolar H+ ATPase expression and activity is required for Rab27B‐dependent invasive growth and metastasis of breast cancer
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The monocarboxylate transporter family—Role and regulation
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Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down‐regulating the V‐ATPases/mTOR/HIF‐1α/P‐gp and MRP1 signaling pathway in vitro and in vivo
inferredcites →https://doi.org/10.1002/jez.1402670302openalex-snapshot
Amiloride inhibition of angiogenesis in vitro
inferredcites →https://doi.org/10.1007/s00232-005-0778-zopenalex-snapshot
Ca2+ Signaling, Intracellular pH and Cell Volume in Cell Proliferation
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Generation and characterization of the first inhibitory antibody targeting tumour-associated carbonic anhydrase XII
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The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma
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Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas
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Do proton pump inhibitors protect against cancer progression in GERD?
inferredcites →https://doi.org/10.1007/s10147-018-1289-0openalex-snapshot
In vivo detection of acute intracellular acidification in glioblastoma multiforme following a single dose of cariporide
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Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor
inferredcites →https://doi.org/10.1007/s10495-006-9789-1openalex-snapshot
Does the tumor microenvironment influence radiation-induced apoptosis?
inferredcites →https://doi.org/10.1007/s10495-013-0894-7openalex-snapshot
Targeting monocarboxylate transporter by α-cyano-4-hydroxycinnamate modulates apoptosis and cisplatin resistance of Colo205 cells: implication of altered cell survival regulation
inferredcites →https://doi.org/10.1007/s10585-010-9345-9openalex-snapshot
Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression
inferredcites →https://doi.org/10.1007/s11060-014-1433-2openalex-snapshot
Vorinostat as a radiosensitizer for brain metastasis: a phase I clinical trial
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A Biodegradable pH-sensitive Micelle System for Targeting Acidic Solid Tumors
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Omeprazole and bafilomycin, two proton pump inhibitors: Differentiation of their effects on gastric, kidney and bone H+-translocating ATPases
inferredcites →https://doi.org/10.1016/j.bbrc.2004.11.109openalex-snapshot
Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation
inferredcites →https://doi.org/10.1016/j.bbrc.2009.03.051openalex-snapshot
Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells
inferredcites →https://doi.org/10.1016/j.bbrc.2014.04.127openalex-snapshot
Lansoprazole induces apoptosis of breast cancer cells through inhibition of intracellular proton extrusion
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Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome
inferredcites →https://doi.org/10.1016/j.bbrc.2017.03.007openalex-snapshot
Elevated Na + /H + exchanger-1 expression enhances the metastatic collective migration of head and neck squamous cell carcinoma cells
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Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg’s sweet tooth and blocking acid export as an anticancer strategy
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pH-Sensitive nano-systems for drug delivery in cancer therapy
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Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines
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Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells
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Inhibition of tumor cell migration and metastasis by the proton-sensing GPR4 receptor
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The Na+/H+ exchanger NHE1, but not the Na+, HCO3- cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2
inferredcites →https://doi.org/10.1016/j.cellsig.2007.03.009openalex-snapshot
Previously postulated “ligand-independent” signaling of GPR4 is mediated through proton-sensing mechanisms
inferredcites →https://doi.org/10.1016/j.cgh.2012.11.014openalex-snapshot
Proton Pump Inhibitors Reduce the Risk of Neoplastic Progression in Patients With Barrett's Esophagus
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Targeting Na+/H+ exchanger regulation for cardiac protection: a RSKy approach?
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New strategies for targeting the hypoxic tumour microenvironment in breast cancer
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Epigenetic therapy and chemosensitization in solid malignancy
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Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression
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Selective inhibition of ion transport mechanisms regulating intracellular pH reduces proliferation and induces apoptosis in cholangiocarcinoma cells
inferredcites →https://doi.org/10.1016/j.ejca.2005.09.011openalex-snapshot
The role of carbonic anhydrase IX overexpression in kidney cancer
inferredcites →https://doi.org/10.1016/j.ejphar.2011.01.063openalex-snapshot
Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX
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Phase 2 Study of Lutetium 177–Labeled Anti–Carbonic Anhydrase IX Monoclonal Antibody Girentuximab in Patients with Advanced Renal Cell Carcinoma
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Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH
inferredcites →https://doi.org/10.1016/j.jcmgh.2016.06.003openalex-snapshot
Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)
inferredcites →https://doi.org/10.1016/j.leukres.2006.06.015openalex-snapshot
Reduction of intracellular pH inhibits the expression of VEGF in K562 cells after targeted inhibition of the Na+/H+ exchanger
inferredcites →https://doi.org/10.1016/j.molcel.2012.10.025openalex-snapshot
Histone Acetylation Regulates Intracellular pH
inferredcites →https://doi.org/10.1016/j.molmed.2015.06.005openalex-snapshot
Cell-penetrating peptides: strategies for anticancer treatment
inferredcites →https://doi.org/10.1016/j.molonc.2013.08.011openalex-snapshot
V‐ATPase inhibition overcomes trastuzumab resistance in breast cancer
inferredcites →https://doi.org/10.1016/j.mvr.2010.12.004openalex-snapshot
Suppression of NHE1 by small interfering RNA inhibits HIF-1α-induced angiogenesis in vitro via modulation of calpain activity
inferredcites →https://doi.org/10.1016/j.neo.2014.12.003openalex-snapshot
A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy
inferredcites →https://doi.org/10.1016/j.phrs.2010.02.013openalex-snapshot
Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways
inferredcites →https://doi.org/10.1016/j.radonc.2009.11.007openalex-snapshot
Glycolytic metabolism and tumour response to fractionated irradiation
inferredcites →https://doi.org/10.1016/j.radonc.2011.05.045openalex-snapshot
Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation
inferredcites →https://doi.org/10.1016/j.radonc.2013.06.018openalex-snapshot
Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs
inferredcites →https://doi.org/10.1016/j.semcancer.2008.11.009openalex-snapshot
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
inferredcites →https://doi.org/10.1016/j.semcancer.2014.08.002openalex-snapshot
Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use
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Lactate: A Metabolic Driver in the Tumour Landscape
inferredcites →https://doi.org/10.1016/j.yexcr.2010.06.005openalex-snapshot
NBCn1 and NHE1 expression and activity in ΔNErbB2 receptor-expressing MCF-7 breast cancer cells: Contributions to pHi regulation and chemotherapy resistance
inferredcites →https://doi.org/10.1016/j.yexcr.2011.05.026openalex-snapshot
NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP
inferredcites →https://doi.org/10.1016/j.yexcr.2011.11.014openalex-snapshot
Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment
inferredcites →https://doi.org/10.1016/s0014-4827(03)00351-3openalex-snapshot
Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with β-catenin
inferredcites →https://doi.org/10.1016/s0735-1097(01)01608-4openalex-snapshot
The Na+/H+exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction11This manuscript is dedicated to the memory of Karl-Ludwig Neuhaus (1944–2000).
inferredcites →https://doi.org/10.1016/s0898-6568(02)00016-5openalex-snapshot
Involvement of cytochrome c and caspases in apoptotic cell death of human submandibular gland ductal cells induced by concanamycin A
inferredcites →https://doi.org/10.1016/s1359-6349(04)80428-2openalex-snapshot
420 The combination of Indisulam (E7070) with cisplatin, oxaliplatin and 5-fluorouracil are synergistic in vitro and in vivo
inferredcites →https://doi.org/10.1016/s1569-9056(15)60015-xopenalex-snapshot
12 Phase II study of lutetium-177-labeled anti carbonic anhydrase IX monoclonal antibody girentuximab in patients with advanced renal cell carcinoma
inferredcites →https://doi.org/10.1021/bm0503571openalex-snapshot
pH-Responsive Sulfonamide/PEI System for Tumor Specific Gene Delivery: An in Vitro Study
inferredcites →https://doi.org/10.1021/jm300529uopenalex-snapshot
Antimetastatic Effect of Sulfamate Carbonic Anhydrase IX Inhibitors in Breast Carcinoma Xenografts
inferredcites →https://doi.org/10.1021/mp5002526openalex-snapshot
Targeting Breast Tumors with pH (Low) Insertion Peptides
inferredcites →https://doi.org/10.1038/35014006openalex-snapshot
Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis
inferredcites →https://doi.org/10.1038/bjc.1993.56openalex-snapshot
Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy
inferredcites →https://doi.org/10.1038/bjc.2011.156openalex-snapshot
A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer
inferredcites →https://doi.org/10.1038/bjc.2013.21openalex-snapshot
Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair
inferredcites →https://doi.org/10.1038/bjc.2013.74openalex-snapshot
A first-in-class, first-in-human, phase I trial of p28, a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with advanced solid tumours
inferredcites →https://doi.org/10.1038/bjc.2013.809openalex-snapshot
CD44 targets Na+/H+ exchanger 1 to mediate MDA-MB-231 cells’ metastasis via the regulation of ERK1/2
inferredcites →https://doi.org/10.1038/bjc.2016.278openalex-snapshot
Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
inferredcites →https://doi.org/10.1038/cdd.2010.150openalex-snapshot
Acidic stress promotes a glioma stem cell phenotype
inferredcites →https://doi.org/10.1038/nature01905openalex-snapshot
Proton-sensing G-protein-coupled receptors
inferredcites →https://doi.org/10.1038/nature11706openalex-snapshot
How cancer metabolism is tuned for proliferation and vulnerable to disruption
inferredcites →https://doi.org/10.1038/nrc2344openalex-snapshot
Hypoxia, DNA repair and genetic instability
inferredcites →https://doi.org/10.1038/nrc3110openalex-snapshot
Dysregulated pH: a perfect storm for cancer progression
inferredcites →https://doi.org/10.1038/nrc3579openalex-snapshot
Disrupting proton dynamics and energy metabolism for cancer therapy
inferredcites →https://doi.org/10.1038/nrd.2016.256openalex-snapshot
Marked for death: targeting epigenetic changes in cancer
inferredcites →https://doi.org/10.1038/nrd2467openalex-snapshot
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
inferredcites →https://doi.org/10.1038/nrm729openalex-snapshot
The vacuolar (H+)-ATPases — nature's most versatile proton pumps
inferredcites →https://doi.org/10.1038/onc.2010.455openalex-snapshot
New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
inferredcites →https://doi.org/10.1038/onc.2013.454openalex-snapshot
Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration
inferredcites →https://doi.org/10.1038/onc.2017.188openalex-snapshot
Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells
inferredcites →https://doi.org/10.1038/onc.2017.219openalex-snapshot
The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion
inferredcites →https://doi.org/10.1038/sj.bjc.6603922openalex-snapshot
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
inferredcites →https://doi.org/10.1038/sj.cdd.4401775openalex-snapshot
Reactive oxygen species-mediated regulation of the Na+–H+ exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers
inferredcites →https://doi.org/10.1038/sj.cdd.4402176openalex-snapshot
Oxidative repression of NHE1 gene expression involves iron-mediated caspase activity
inferredcites →https://doi.org/10.1038/sj.onc.1203731openalex-snapshot
G2A is an oncogenic G protein-coupled receptor
inferredcites →https://doi.org/10.1038/sj.onc.1207838openalex-snapshot
G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers
inferredcites →https://doi.org/10.1038/srep03560openalex-snapshot
pH dependent transfer of nano-pores into membrane of cancer cells to induce apoptosis
inferredcites →https://doi.org/10.1039/c2ib20153dopenalex-snapshot
Comparative study of 3D morphology and functions on genetically engineered mouse melanoma cells
inferredcites →https://doi.org/10.1039/c4cc05008hopenalex-snapshot
A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy
inferredcites →https://doi.org/10.1039/c5nr00297dopenalex-snapshot
Glutathione- and pH-responsive nonporous silica prodrug nanoparticles for controlled release and cancer therapy
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A Review of the GUARDIAN Trial Results: Clinical Implications and the Significance of Elevated Perioperative CK-MB on 6-Month Survival
inferredcites →https://doi.org/10.1049/iet-nbt:20080001openalex-snapshot
Implementation of wireless power transfer and communications for an implantable ocular drug delivery system
inferredcites →https://doi.org/10.1053/gast.2002.37052openalex-snapshot
Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9
inferredcites →https://doi.org/10.1073/pnas.040554897openalex-snapshot
Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro
inferredcites →https://doi.org/10.1073/pnas.0409415102openalex-snapshot
Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells
inferredcites →https://doi.org/10.1073/pnas.0702439104openalex-snapshot
Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo
inferredcites →https://doi.org/10.1073/pnas.0805163105openalex-snapshot
Structural model and functional significance of pH-dependent talin–actin binding for focal adhesion remodeling
inferredcites →https://doi.org/10.1073/pnas.1001165107openalex-snapshot
The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor
inferredcites →https://doi.org/10.1073/pnas.1106123108openalex-snapshot
CD147 subunit of lactate/H + symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
inferredcites →https://doi.org/10.1073/pnas.1509488112openalex-snapshot
The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions
inferredcites →https://doi.org/10.1073/pnas.1614035114openalex-snapshot
Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis
inferredcites →https://doi.org/10.1073/pnas.91.3.1128openalex-snapshot
Intracellular pH and the control of multidrug resistance.
inferredcites →https://doi.org/10.1073/pnas.92.12.5510openalex-snapshot
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
inferredcites →https://doi.org/10.1073/pnas.95.21.12334openalex-snapshot
A DNA damage and stress inducible G protein-coupled receptor blocks cells in G 2 /M
inferredcites →https://doi.org/10.1074/jbc.272.1.271openalex-snapshot
The p42/p44 Mitogen-activated Protein Kinase Cascade Is Determinant in Mediating Activation of the Na+/H+ Exchanger (NHE1 Isoform) in Response to Growth Factors
inferredcites →https://doi.org/10.1074/jbc.274.29.20206openalex-snapshot
p90RSK Is a Serum-stimulated Na+/H+ Exchanger Isoform-1 Kinase
inferredcites →https://doi.org/10.1074/jbc.275.8.5361openalex-snapshot
Phosphoinositide 3-Kinase Is Involved in the Tumor-specific Activation of Human Breast Cancer Cell Na+/H+Exchange, Motility, and Invasion Induced by Serum Deprivation
inferredcites →https://doi.org/10.1074/jbc.m108347200openalex-snapshot
Acidic Extracellular pH Induces Vascular Endothelial Growth Factor (VEGF) in Human Glioblastoma Cells via ERK1/2 MAPK Signaling Pathway
inferredcites →https://doi.org/10.1074/jbc.m110.165134openalex-snapshot
B-Raf Associates with and Activates the NHE1 Isoform of the Na+/H+ Exchanger
inferredcites →https://doi.org/10.1074/jbc.m112.384685openalex-snapshot
Acidosis Promotes Bcl-2 Family-mediated Evasion of Apoptosis
inferredcites →https://doi.org/10.1074/jbc.m112.412007openalex-snapshot
Mode of Cell Death Induction by Pharmacological Vacuolar H+-ATPase (V-ATPase) Inhibition
inferredcites →https://doi.org/10.1074/jbc.m113.503771openalex-snapshot
The Function of Vacuolar ATPase (V-ATPase) a Subunit Isoforms in Invasiveness of MCF10a and MCF10CA1a Human Breast Cancer Cells
inferredcites →https://doi.org/10.1074/jbc.m211584200openalex-snapshot
RhoA and ROCK Promote Migration by Limiting Membrane Protrusions
inferredcites →https://doi.org/10.1074/jbc.m311838200openalex-snapshot
CD44 Interaction with Na+-H+ Exchanger (NHE1) Creates Acidic Microenvironments Leading to Hyaluronidase-2 and Cathepsin B Activation and Breast Tumor Cell Invasion
inferredcites →https://doi.org/10.1074/jbc.m400814200openalex-snapshot
The NHE1 Na+/H+ Exchanger Recruits Ezrin/Radixin/Moesin Proteins to Regulate Akt-dependent Cell Survival
inferredcites →https://doi.org/10.1074/jbc.m406561200openalex-snapshot
G2A Is a Proton-sensing G-protein-coupled Receptor Antagonized by Lysophosphatidylcholine
inferredcites →https://doi.org/10.1074/jbc.m406966200openalex-snapshot
TDAG8 Is a Proton-sensing and Psychosine-sensitive G-protein-coupled Receptor
inferredcites →https://doi.org/10.1074/jbc.m407832200openalex-snapshot
Identification of T Cell Death-associated Gene 8 (TDAG8) as a Novel Acid Sensing G-protein-coupled Receptor
inferredcites →https://doi.org/10.1074/jbc.m511397200openalex-snapshot
The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism
inferredcites →https://doi.org/10.1074/jbc.m611073200openalex-snapshot
Mitogen-activated Protein Kinase-dependent Activation of the Na+/H+ Exchanger Is Mediated through Phosphorylation of Amino Acids Ser770 and Ser771
inferredcites →https://doi.org/10.1074/jbc.m800938200openalex-snapshot
Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes
inferredcites →https://doi.org/10.1074/jbc.m901201200openalex-snapshot
Function of a Subunit Isoforms of the V-ATPase in pH Homeostasis and in Vitro Invasion of MDA-MB231 Human Breast Cancer Cells
inferredcites →https://doi.org/10.1074/mcp.m400207-mcp200openalex-snapshot
Metabolic Activation-related CD147-CD98 Complex
inferredcites →https://doi.org/10.1083/jcb.200704169openalex-snapshot
Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells
inferredcites →https://doi.org/10.1083/jcb.200806019openalex-snapshot
The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-α in the primary cilium
inferredcites →https://doi.org/10.1083/jcb.201312046openalex-snapshot
Talin regulates moesin–NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis
inferredcites →https://doi.org/10.1089/108497804323071922openalex-snapshot
PET Radioimmunoscintigraphy of Renal Cell Cancer Using 89 Zr-Labeled cG250 Monoclonal Antibody in Nude Rats
inferredcites →https://doi.org/10.1089/dna.1998.17.493openalex-snapshot
Cloning, Characterization, and Mapping of Human Homolog of Mouse T-Cell Death-Associated Gene
inferredcites →https://doi.org/10.1091/mbc.9.8.2287openalex-snapshot
Na–H Exchange Acts Downstream of RhoA to Regulate Integrin-induced Cell Adhesion and Spreading
inferredcites →https://doi.org/10.1091/mbc.e04-10-0945openalex-snapshot
Protein Kinase A Gating of a Pseudopodial-located RhoA/ROCK/p38/NHE1 Signal Module Regulates Invasion in Breast Cancer Cell Lines
inferredcites →https://doi.org/10.1093/carcin/bgs196openalex-snapshot
Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors
inferredcites →https://doi.org/10.1093/carcin/bgu089openalex-snapshot
Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+extrusion, cell migration and survival
inferredcites →https://doi.org/10.1093/jb/mvg153openalex-snapshot
Vacuolar H+-ATPase Inhibitor Induces Apoptosis via Lysosomal Dysfunction in the Human Gastric Cancer Cell Line MKN-1
inferredcites →https://doi.org/10.1093/jnci/djh305openalex-snapshot
Effect of Proton Pump Inhibitor Pretreatment on Resistance of Solid Tumors to Cytotoxic Drugs
inferredcites →https://doi.org/10.1093/jnci/djm107openalex-snapshot
Ovarian Cancer G Protein Coupled Receptor 1, a New Metastasis Suppressor Gene in Prostate Cancer
inferredcites →https://doi.org/10.1096/fj.00-0029comopenalex-snapshot
Na + /H + exchanger‐dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation‐associated phenotypes
inferredcites →https://doi.org/10.1096/fj.201700834ropenalex-snapshot
GPR68, a proton‐sensing GPCR, mediates interaction of cancer‐associated fibroblasts and cancer cells
inferredcites →https://doi.org/10.1097/00001610-200309000-00003openalex-snapshot
An Overview of Proton Pump Inhibitors
inferredcites →https://doi.org/10.1097/cad.0b013e3283586743openalex-snapshot
α-Cyano-4-hydroxycinnamate induces apoptosis in Dalton’s lymphoma cells
inferredcites →https://doi.org/10.1111/cbdd.12035openalex-snapshot
Inside Out: Targeting NHE1 as an Intracellular and Extracellular Regulator of Cancer Progression
inferredcites →https://doi.org/10.1111/j.1349-7006.2011.01908.xopenalex-snapshot
Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells
inferredcites →https://doi.org/10.1111/j.1365-2567.2007.02587.xopenalex-snapshot
Cancer immunoediting from immune surveillance to immune escape
inferredcites →https://doi.org/10.1111/j.1743-6109.2006.00127.xopenalex-snapshot
Lactate stimulates endothelial cell migration
inferredcites →https://doi.org/10.1111/j.1749-6632.2009.04705.xopenalex-snapshot
Biological Effects of a New Vacuolar‐H,+‐ATPase Inhibitor in Colon Carcinoma Cell Lines
inferredcites →https://doi.org/10.1113/jphysiol.2007.145185openalex-snapshot
pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution
inferredcites →https://doi.org/10.1124/mol.106.028076openalex-snapshot
Bafilomycin Induces the p21-Mediated Growth Inhibition of Cancer Cells under Hypoxic Conditions by Expressing Hypoxia-Inducible Factor-1α
inferredcites →https://doi.org/10.1126/science.124.3215.269openalex-snapshot
On Respiratory Impairment in Cancer Cells
inferredcites →https://doi.org/10.1126/scitranslmed.3010564openalex-snapshot
An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors
inferredcites →https://doi.org/10.1128/mcb.01909-06openalex-snapshot
Vascular Abnormalities in Mice Deficient for the G Protein-Coupled Receptor GPR4 That Functions as a pH Sensor
inferredcites →https://doi.org/10.1128/mcb.22.20.7004-7014.2002openalex-snapshot
Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
inferredcites →https://doi.org/10.1128/mcb.26.2.668-677.2006openalex-snapshot
Normal Immune Development and Glucocorticoid-Induced Thymocyte Apoptosis in Mice Deficient for the T-Cell Death-Associated Gene 8 Receptor
inferredcites →https://doi.org/10.1136/gut.2009.181412openalex-snapshot
CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models
inferredcites →https://doi.org/10.1146/annurev.pharmtox.42.092001.143801openalex-snapshot
The Changing Face of the Na+/H+ Exchanger, NHE1: Structure, Regulation, and Cellular Actions
inferredcites →https://doi.org/10.1152/ajpcell.00094.2004openalex-snapshot
Na+/H+ exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes
inferredcites →https://doi.org/10.1152/ajpcell.00407.2003openalex-snapshot
Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity
inferredcites →https://doi.org/10.1152/ajpgi.90428.2008openalex-snapshot
Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-κB
inferredcites →https://doi.org/10.1152/ajprenal.00314.2002openalex-snapshot
Renal tubular epithelial cell apoptosis is associated with caspase cleavage of the NHE1 Na+/H+exchanger
inferredcites →https://doi.org/10.1152/ajprenal.90212.2008openalex-snapshot
Regulation of cell survival by Na+/H+exchanger-1
inferredcites →https://doi.org/10.1152/jappl.2000.89.1.169openalex-snapshot
Free radical scavenging and antioxidant effects of lactate ion: an in vitro study
inferredcites →https://doi.org/10.1155/2019/3702783openalex-snapshot
Upregulated Na+/H+-Exchange Protects Human Colon Cancer Tissue against Intracellular Acidification
inferredcites →https://doi.org/10.1158/0008-5472.can-03-2224openalex-snapshot
Role of Carbonic Anhydrase IX in Human Tumor Cell Growth, Survival, and Invasion
inferredcites →https://doi.org/10.1158/0008-5472.can-04-3822openalex-snapshot
The Growth and Metastasis of Human Hepatocellular Carcinoma Xenografts Are Inhibited by Small Interfering RNA Targeting to the Subunit ATP6L of Proton Pump
inferredcites →https://doi.org/10.1158/0008-5472.can-05-3260openalex-snapshot
Comparison of Metabolic Pathways between Cancer Cells and Stromal Cells in Colorectal Carcinomas: a Metabolic Survival Role for Tumor-Associated Stroma
inferredcites →https://doi.org/10.1158/0008-5472.can-05-4193openalex-snapshot
Acid-Mediated Tumor Invasion: a Multidisciplinary Study
inferredcites →https://doi.org/10.1158/0008-5472.can-06-0983openalex-snapshot
Acidic Extracellular pH Promotes Experimental Metastasis of Human Melanoma Cells in Athymic Nude Mice
inferredcites →https://doi.org/10.1158/0008-5472.can-06-1464openalex-snapshot
Heparanase, Hyaluronan, and CD44 in Cancers: A Breast Carcinoma Perspective
inferredcites →https://doi.org/10.1158/0008-5472.can-06-4095openalex-snapshot
Proton Pump Inhibitors Induce Apoptosis of Human B-Cell Tumors through a Caspase-Independent Mechanism Involving Reactive Oxygen Species
inferredcites →https://doi.org/10.1158/0008-5472.can-07-1805openalex-snapshot
Targeting Vacuolar H+-ATPases as a New Strategy against Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-08-2470openalex-snapshot
Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH
inferredcites →https://doi.org/10.1158/0008-5472.can-08-3021openalex-snapshot
Suppression of Human Solid Tumor Growth in Mice by Intratumor and Systemic Inoculation of Histidine-Rich and pH-Dependent Host Defense–like Lytic Peptides
inferredcites →https://doi.org/10.1158/0008-5472.can-08-3781openalex-snapshot
A Novel Technology for the Imaging of Acidic Prostate Tumors by Positron Emission Tomography
inferredcites →https://doi.org/10.1158/0008-5472.can-08-3907openalex-snapshot
Global Histone Modifications in Breast Cancer Correlate with Tumor Phenotypes, Prognostic Factors, and Patient Outcome
inferredcites →https://doi.org/10.1158/0008-5472.can-09-0219openalex-snapshot
Repression of NHE1 Expression by PPARγ Activation Is a Potential New Approach for Specific Inhibition of the Growth of Tumor Cells In vitro and In vivo
inferredcites →https://doi.org/10.1158/0008-5472.can-10-2828openalex-snapshot
Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis
inferredcites →https://doi.org/10.1158/0008-5472.can-10-4261openalex-snapshot
Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors
inferredcites →https://doi.org/10.1158/0008-5472.can-11-1272openalex-snapshot
Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes
inferredcites →https://doi.org/10.1158/0008-5472.can-11-1316openalex-snapshot
Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates
inferredcites →https://doi.org/10.1158/0008-5472.can-11-1627openalex-snapshot
Correction: Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors
inferredcites →https://doi.org/10.1158/0008-5472.can-11-2371openalex-snapshot
Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-11-2520openalex-snapshot
Phosphorylation of Carbonic Anhydrase IX Controls Its Ability to Mediate Extracellular Acidification in Hypoxic Tumors
inferredcites →https://doi.org/10.1158/0008-5472.can-12-2796openalex-snapshot
Acidity Generated by the Tumor Microenvironment Drives Local Invasion
inferredcites →https://doi.org/10.1158/0008-5472.can-12-2969openalex-snapshot
Real-time In Vivo Molecular Detection of Primary Tumors and Metastases with Ratiometric Activatable Cell-Penetrating Peptides
inferredcites →https://doi.org/10.1158/0008-5472.can-12-3696openalex-snapshot
The Emerging “Hallmarks” of Metabolic Reprogramming and Immune Evasion: Distinct or Linked?
inferredcites →https://doi.org/10.1158/0008-5472.can-12-4031openalex-snapshot
Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis
inferredcites →https://doi.org/10.1158/0008-5472.can-13-2034openalex-snapshot
Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
inferredcites →https://doi.org/10.1158/0008-5472.can-14-0319openalex-snapshot
Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival
inferredcites →https://doi.org/10.1158/0008-5472.can-14-0705openalex-snapshot
The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
showing the first 200 of 277 · page through all 277

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Metabolic Dialogue Shapes Immune Response in the Tumor Microenvironment
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Reversible Nucleolar Stress and Cell Growth Arrest Triggered by Acidic pH
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Measuring cerebral enzymatic activity, brain pH and extracranial muscle metabolism with hyperpolarized 13 C‐pyruvate
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Tumor Microenvironment-Responsive Nanoplatforms for Triggering Drug Delivery
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Homeodynamic Laws and Life Principles
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Preclinical Experimentation in Oncology
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Nanotheranostics in Hormone Therapy for Breast Cancer
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Mechanisms of Cancer Resistance to Various Therapies
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Proton wave propagation along collagen fibers
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Therapeutic approach for digestive system cancers and potential implications of exercise under hypoxia condition: what little is known? a narrative review
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Characteristics of the Antitumor Effect of Doxorubicin and Pegylated Hyaluronidase on Models of Rat Brain Tumors
inferred← citeshttps://doi.org/10.1007/s11010-026-05511-3openalex-snapshot
Targeting pH regulation in cancer: combined mild alkaline treatment and NHE1 inhibition as a potential therapy for clear cell renal cell carcinoma
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Exosomes and cancer: from molecular mechanisms to clinical applications
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Synthesis, Characterization, and In Vitro Evaluation of Anticancer Activity of Bevacizumab Encapsulated PLGA Nanoparticles on Ovarian Carcinoma Cells
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Plant flavonol quercetin engenders cytotoxic effect in different pre-clinical cancer models through modulation of diverse epigenetic regulators
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Contribution of mechanical homeostasis to epithelial-mesenchymal transition
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Smart pH-responsive nanomedicines for disease therapy
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Guardian of tissue, accomplice of cancer: the two faces of a proton sensor-G protein-coupled receptor 68
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CLIC1 regulation of cancer stem cells in glioblastoma
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Lipid nanoparticle-mediated CRISPR/Cas9 gene editing and metabolic engineering for anticancer immunotherapy
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An update on regulation and function of G protein-coupled receptors in cancer: A promising strategy for cancer therapy
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pH-neutralization strategy to suppress GPCR68 spatiotemporally activates T cells and enhances anti-tumor immunity
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pH modulation in adhesive cells with a protonic biotransducer
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Drug release from docetaxel-entrapped core-crosslinked polymeric micelles: A population pharmacokinetic modelling approach based on clinical data
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Engineering calcium-based nanoparticles for cancer treatment
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Liver microenvironment and therapy resistance in hepatocellular carcinoma
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The evolving role of alternative splicing in cancer stem cell plasticity: From mechanisms to clinical opportunities
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The effect of acute acid exposure on immunomodulatory protein secretion, cell survival, and cell cycle progression in tumour cell lines
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GPR65 in cancer: expression heterogeneity, invasion and metastasis, the tumor immune microenvironment, and translational implications
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Potent therapeutic efficacy of intranasally deliverable paclitaxel modified with pH-sensitive and PEGylated polymeric micelle against glioblastoma
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Complex formulation strategies to overcome the delivery hurdles of lapatinib in metastatic breast cancer
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Synthesis of 1-oxa-9-azaspiro[5.5]undecane-9-sulfonamides bearing a diverse molecular periphery and a rare zinc-binding group for carbonic anhydrase interrogation
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Livecyte kinetic cytometer combined with RpHluorin2 reporter system for real-time single-cell resolution monitoring of JTC-801-induced alkaliptosis
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Exploiting novel placental homing peptides for targeted drug delivery in breast cancer
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LDH-driven lactic acidosis in hypoxic solid tumors: Mechanisms of metastatic transformation and therapeutic opportunities
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Prognostic role of the immunohistochemical expression of proteins related to the renin–angiotensin system pathway in nonmetastatic clear cell renal cell carcinoma
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Advances in framework nucleic acid nanoprobes for tumor imaging
inferred← citeshttps://doi.org/10.1016/j.yexcr.2025.114481openalex-snapshot
Low extracellular pH enhances TRAIL-induced apoptosis by downregulating Mcl-1 expression
inferred← citeshttps://doi.org/10.1016/j.zemedi.2023.10.004openalex-snapshot
Quo Vadis Hyperpolarized 13C MRI?
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Unveiling Cellular Secrets: Illuminating Carbon Dot Lighthouses for Improved Mitochondrial Exploration
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Conditional Transmembrane Peptides as Allosteric Modulators: Thermodynamic and Functional Perspectives in Membrane Protein Regulation
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Modeling pH-Dependent Protein Dynamics by Integrating Coarse-Grained Molecular Simulation and the Deep Neural Network Model
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c01678openalex-snapshot
pH-Activatable Ruthenium(II) Fluorescein Salphen Schiff Base Photosensitizers for Theranostic Applications
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.0c01243openalex-snapshot
Evaluation of the Anticancer Activity of pH-Sensitive Polyketal Nanoparticles for Acute Myeloid Leukemia
inferred← citeshttps://doi.org/10.1021/acsabm.2c00464openalex-snapshot
Well-Defined pH-Responsive Self-Assembled Block Copolymers for the Effective Codelivery of Doxorubicin and Antisense Oligonucleotide to Breast Cancer Cells
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.5c00992openalex-snapshot
Biomedical Applications of Calcium Carbonate Nanoparticles: A Review of Recent Advances
inferred← citeshttps://doi.org/10.1021/acsnano.4c02165openalex-snapshot
Smart Accumulating Dual-Targeting Lipid Envelopes Equipping Oncolytic Adenovirus for Enhancing Cancer Gene Therapeutic Efficacy
inferred← citeshttps://doi.org/10.1021/acsomega.4c07880openalex-snapshot
Off–On Photo- and Redox-Triggered Anion Transport Using an Indole-Based Hydrogen Bond Switch
inferred← citeshttps://doi.org/10.1021/acssensors.6c02375openalex-snapshot
19F Activity-Based Barcoding Enables Simultaneous Measurement of pH and Analyte Reactivity
inferred← citeshttps://doi.org/10.1021/bk-2022-1428.ch010openalex-snapshot
Bergman Cyclization of Maleimide-Based Enediynes
inferred← citeshttps://doi.org/10.1021/cbmi.5c00034openalex-snapshot
pH-Responsive Liposomes for Targeted Detection of Pancreatic Adenocarcinoma Using MSOT
inferred← citeshttps://doi.org/10.1038/s41392-023-01652-9openalex-snapshot
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
inferred← citeshttps://doi.org/10.1038/s41568-025-00879-8openalex-snapshot
Exploiting metabolic cell death for cancer therapy
inferred← citeshttps://doi.org/10.1038/s41598-021-96531-0openalex-snapshot
Real-time cancer diagnosis of breast cancer using fluorescence lifetime endoscopy based on the pH
inferred← citeshttps://doi.org/10.1038/s41598-025-86401-4openalex-snapshot
Calcium hydroxide nanoparticles induce cell death, genomic instability, oxidative stress and apoptotic gene dysregulation on human HepG2 cells
inferred← citeshttps://doi.org/10.1038/s42003-026-11151-6openalex-snapshot
Cancer-derived lactic acid as a potential upstream contributor to tumor hypoxia
inferred← citeshttps://doi.org/10.1039/d3ra01615copenalex-snapshot
pH-dependent structural characteristics of lonidamine: 1 H and 13 C NMR study
inferred← citeshttps://doi.org/10.1039/d6ra02770aopenalex-snapshot
Biodegradable cross-linked flavone networks featuring either ester or carbamate linkages for controlled delivery of anti-cancer agents
inferred← citeshttps://doi.org/10.1039/d6tb00469eopenalex-snapshot
Ethanol-responsive fluorene-based fluorescent nanoprobes for photodynamic cancer therapy
inferred← citeshttps://doi.org/10.1039/d6tb00805dopenalex-snapshot
The development of multifunctional polysuccinimide with programmable thermoresponsiveness by modulating the hydrophobic graft architecture for advanced drug delivery applications
inferred← citeshttps://doi.org/10.1042/ebc20230077openalex-snapshot
Roles of the oncometabolite enantiomers of 2-hydroxyglutarate and their metabolism by diverse dehydrogenases
inferred← citeshttps://doi.org/10.1063/5.0300853openalex-snapshot
Advances in fluorescence lifetime imaging microscopy: Techniques and biomedical applications
inferred← citeshttps://doi.org/10.1080/14756366.2022.2051023openalex-snapshot
Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile
inferred← citeshttps://doi.org/10.1080/14756366.2026.2706109openalex-snapshot
Recent progress in small molecules targeting the acidic tumor microenvironment
inferred← citeshttps://doi.org/10.1080/15287394.2025.2511139openalex-snapshot
Dual synergetic approach for targeting dysfunctional cells based on rare-earth-doped forsterite nanoparticles
inferred← citeshttps://doi.org/10.1093/braincomms/fcae400openalex-snapshot
Alternatively activated macrophages are associated with faster growth rate in vestibular schwannoma
inferred← citeshttps://doi.org/10.1101/2023.03.23.23287579openalex-snapshot
Measuring extracellular human brain pH and amino acid metabolism with hyperpolarized [1- 13 C]pyruvate
inferred← citeshttps://doi.org/10.1101/2025.06.29.662144openalex-snapshot
Cell Settling, Migration, and Stochastic Cancer Expression Suggest Potassium Flux Per H + - Sensitive KCN Members Associated with Oncogenes and Histone/DNA Modulators Potentially Initiates pH-Reversal
inferred← citeshttps://doi.org/10.1109/jsen.2025.3579155openalex-snapshot
Sensing by Seeing: In Vivo Detection and External Transmission of Blood Viscosity Through the Internet of Bio-Nano Things
inferred← citeshttps://doi.org/10.1111/cas.15722openalex-snapshot
Metabolic adaptations of cancer in extreme tumor microenvironments
inferred← citeshttps://doi.org/10.1134/s0006297924140086openalex-snapshot
Tumor Organoids: The Era of Personalized Medicine
inferred← citeshttps://doi.org/10.1134/s0040577925070086openalex-snapshot
Modular-type nonlinearity in the modeling of tumor spheroid growth
inferred← citeshttps://doi.org/10.1186/s12645-026-00384-zopenalex-snapshot
Precision oncology with nanozymes: multifunctional platforms for targeted tumor treatment
inferred← citeshttps://doi.org/10.1186/s13550-026-01383-2openalex-snapshot
Non-invasive visualization of pH changes within the tumor-micro-environment by positron emission tomography
inferred← citeshttps://doi.org/10.12794/metadc2443168openalex-snapshot
Advancements in Micromachining Techniques for RF and Biomedical Applications: From Diffraction UV Lithography to Smart Stent Development and Beyond
inferred← citeshttps://doi.org/10.1371/journal.pone.0270599openalex-snapshot
Inducing apoptosis using chemical treatment and acidic pH, and detecting it using the Annexin V flow cytometric assay
inferred← citeshttps://doi.org/10.1515/9783112216620-007openalex-snapshot
75Three-dimensional spatiotemporal dynamics of tumor growth
inferred← citeshttps://doi.org/10.18016/ksutarimdoga.vi.1322613openalex-snapshot
Tetrazolato Ligandı ve Pt(II) Kompleksinin DNA Etkileşiminin Moleküler Doking Yöntemi ile Belirlenmesi
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2500498/v1openalex-snapshot
Intracellular Acidification in a Rat C6 Glioma Model Following Cariporide Injection Monitored by Chemical Exchange Saturation Transfer Magnetic Resonance Imaging
inferred← citeshttps://doi.org/10.2139/ssrn.4872083openalex-snapshot
Dual Synergetic Approach for Targeting Dysfunctional Cells Based on Rare-Earth-Doped Forsterite Nanoparticles
inferred← citeshttps://doi.org/10.2147/ijn.s416046openalex-snapshot
Combined Dextran-Graft-Polyacrylamide/Zinc Oxide Nanocarrier for Effective Anticancer Therapy in vitro
inferred← citeshttps://doi.org/10.2147/ijn.s569702openalex-snapshot
CD44 Receptor-Mediated Delivery of ROS/pH Dual-Sensitive Nanoparticles Based on Poly(Ethylene Glycol)-b-Poly(Doxorubicin)-b-Hyaluronic Acid Copolymer
inferred← citeshttps://doi.org/10.2174/0118741045346445250111104531openalex-snapshot
PLGA Polymers and Doxorubicin for the Treatment of Malignant Gliomas in Adults: An Overview
inferred← citeshttps://doi.org/10.2174/012212697x375313250623163944openalex-snapshot
Repositioning Proton Pump Inhibitors: Expanding Applications from Acid Suppression to Cancer Therapeutics
inferred← citeshttps://doi.org/10.2174/1573406418666220831112049openalex-snapshot
A Series of Trifluoromethylisoxazolyl- and Trifluoromethylpyrazolyl- Substituted (Hetero)aromatic Sulfonamide Carbonic Anhydrase Inhibitors: Synthesis, and Convenient Prioritization Workflow for Further In Vivo Studies
inferred← citeshttps://doi.org/10.22452/jummec.sp2023no1.12openalex-snapshot
IONIC DISSOLUTION PROFILES OF COMBINED GONIOTHALAMIN AND BIOACTIVE GLASS 45S5 IN CULTURE MEDIUM OF HUMAN OSTEOSARCOMA SAOS-2 CELLS
inferred← citeshttps://doi.org/10.31917/2203193openalex-snapshot
Acid-base balance in the regulation of tumor growth: value for the clinicians
inferred← citeshttps://doi.org/10.32388/4ellu7openalex-snapshot
A Step Beyond pH: Electrochemical Network Deregulation in Cancer, Mechanisms, Consequences, and Therapeutic Implications: A Narrative Review
inferred← citeshttps://doi.org/10.32388/vp8lqfopenalex-snapshot
The role of pH in cancer biology and its impact on cellular repair, tumor markers, tumor stages, isoenzymes, and therapeutics
inferred← citeshttps://doi.org/10.3389/fcell.2021.736910openalex-snapshot
Repurposing Combination Therapy of Voacamine With Vincristine for Downregulation of Hypoxia-Inducible Factor-1α/Fatty Acid Synthase Co-axis and Prolyl Hydroxylase-2 Activation in ER+ Mammary Neoplasia
inferred← citeshttps://doi.org/10.3389/fcell.2023.1213995openalex-snapshot
Mechanisms of alkaliptosis
inferred← citeshttps://doi.org/10.3389/fcell.2025.1727740openalex-snapshot
Establishment of RpHluorin2-expressing cell and its application in monitoring JTC-801-induced alkaliptosis via multi-dimensional fluorescence detection approaches
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1686071openalex-snapshot
Organotropic metastasis in colorectal cancer: integrating molecular pathways with therapeutic opportunities
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1690068openalex-snapshot
Lactylation and antitumor immunity
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1731784openalex-snapshot
The interplay of dietary sugar, chronic inflammation, and bladder cancer: mechanistic insights, evidence, and prevention strategies
inferred← citeshttps://doi.org/10.3389/fonc.2022.1040034openalex-snapshot
The underexplored links between cancer and the internal body climate: Implications for cancer prevention and treatment
inferred← citeshttps://doi.org/10.3389/fonc.2022.979154openalex-snapshot
Tumor acidity: From hallmark of cancer to target of treatment
inferred← citeshttps://doi.org/10.3389/fonc.2026.1791517openalex-snapshot
2-Hydroxyglutarate in onco-pathway: a metabolic driver of proto-oncogene activation
inferred← citeshttps://doi.org/10.3390/biom15081177openalex-snapshot
Cell Settling, Migration, and Stochastic Cancer Gene Expression Suggest Potassium Membrane Flux May Initiate pH Reversal
inferred← citeshttps://doi.org/10.3390/biom16020315openalex-snapshot
Exploring the Potential of Receptor Silencing in the Tumor Microenvironment by RNA Interference
inferred← citeshttps://doi.org/10.3390/biom16071038openalex-snapshot
Intercalated Motifs Contribute to Transcription Regulation in an Acidosis Model
inferred← citeshttps://doi.org/10.3390/cancers12082005openalex-snapshot
Clinical and Pre-Clinical Evidence of Carbonic Anhydrase IX in Pancreatic Cancer and Its High Expression in Pre-Cancerous Lesions
inferred← citeshttps://doi.org/10.3390/cancers13194746openalex-snapshot
Defining the Role of GLI/Hedgehog Signaling in Chemoresistance: Implications in Therapeutic Approaches
inferred← citeshttps://doi.org/10.3390/cancers17233883openalex-snapshot
Low pH, High Stakes: A Narrative Review Exploring the Acid-Sensing GPR65 Pathway as a Novel Approach in Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.3390/cells10123311openalex-snapshot
Acidic and Hypoxic Microenvironment in Melanoma: Impact of Tumour Exosomes on Disease Progression
inferred← citeshttps://doi.org/10.3390/cells13221924openalex-snapshot
Emerging Role of Extracellular pH in Tumor Microenvironment as a Therapeutic Target for Cancer Immunotherapy
inferred← citeshttps://doi.org/10.3390/cells15181663openalex-snapshot
Tumor Acidosis Boosts Antibody-Driven Cytotoxic Potential of Neutrophils
inferred← citeshttps://doi.org/10.3390/diagnostics16010076openalex-snapshot
The Role of Tumor pH in Breast Cancer Imaging: Biology, Diagnostic Applications, and Emerging Techniques
inferred← citeshttps://doi.org/10.3390/gels10070478openalex-snapshot
Stimuli-Responsive Nanocomposite Hydrogels for Oral Diseases
inferred← citeshttps://doi.org/10.3390/gels10110689openalex-snapshot
Smart Nanocomposite Hydrogels as Next-Generation Therapeutic and Diagnostic Solutions
inferred← citeshttps://doi.org/10.3390/gels10110699openalex-snapshot
Double Encapsulation of Resveratrol and Doxorubicin in Composite Nanogel—An Opportunity to Reduce Cardio- and Neurotoxicity of Doxorubicin
inferred← citeshttps://doi.org/10.3390/ijms21207475openalex-snapshot
Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era
inferred← citeshttps://doi.org/10.3390/ijms23020789openalex-snapshot
Fabrication of CaCO3-Coated Vesicles by Biomineralization and Their Application as Carriers of Drug Delivery Systems
inferred← citeshttps://doi.org/10.3390/ijms23137377openalex-snapshot
Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression
inferred← citeshttps://doi.org/10.3390/ijms23158322openalex-snapshot
A Second Life for MAP, a Model Amphipathic Peptide
inferred← citeshttps://doi.org/10.3390/ijms242015474openalex-snapshot
The OSR9 Regimen: A New Augmentation Strategy for Osteosarcoma Treatment Using Nine Older Drugs from General Medicine to Inhibit Growth Drive
inferred← citeshttps://doi.org/10.3390/ijms26146869openalex-snapshot
Metabolic Profiling of Distinct TP53-Mutant Esophageal Adenocarcinoma Models Reveals Different Bioenergetic Dependencies.
inferred← citeshttps://doi.org/10.3390/ijms26199386openalex-snapshot
Investigation of Host-Guest Inclusion Complexes Between Carmustine and α-Cyclodextrin: Synthesis, Characterization, and Evaluation
inferred← citeshttps://doi.org/10.3390/ijtm5030040openalex-snapshot
Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma (HNSCC)
inferred← citeshttps://doi.org/10.3390/jcm14082673openalex-snapshot
Repurposing Antiepileptic Drugs for Cancer: A Promising Therapeutic Strategy
inferred← citeshttps://doi.org/10.3390/jmp5040029openalex-snapshot
Oncomatrix: Molecular Composition and Biomechanical Properties of the Extracellular Matrix in Human Tumors
inferred← citeshttps://doi.org/10.3390/jnt4030014openalex-snapshot
Recent Advancement of Bio-Inspired Nanoparticles in Cancer Theragnostic
inferred← citeshttps://doi.org/10.3390/md23010006openalex-snapshot
Exploring the Pharmacological Potential of Carrageenan Disaccharides as Antitumor Agents: An In Silico Approach
inferred← citeshttps://doi.org/10.3390/metabo13070823openalex-snapshot
Intracellular Acidification in a Rat C6 Glioma Model following Cariporide Injection Investigated by CEST-MRI
inferred← citeshttps://doi.org/10.3390/molecules25235597openalex-snapshot
Neuroprotective Effects of Quercetin in Pediatric Neurological Diseases
inferred← citeshttps://doi.org/10.3390/molecules27061775openalex-snapshot
Recent Advances in Glycyrrhetinic Acid-Functionalized Biomaterials for Liver Cancer-Targeting Therapy
inferred← citeshttps://doi.org/10.3390/molecules30153081openalex-snapshot
A pH-Sensitive Glutathione Responsive Small-Molecule Probe TZ2 Sensitizes Lung Cancer Cells to Chemotherapy by Targeting Tumor Microenvironment
inferred← citeshttps://doi.org/10.3390/mps9020038openalex-snapshot
Improving Laboratory-Based Cancer Drug Discovery Study Designs for Better Research Translations
inferred← citeshttps://doi.org/10.3390/nu15234963openalex-snapshot
A Scoping Review to Explore the Potential Benefits of Nutrition Interventions for Latino/a Adult Cancer Survivors in the US
inferred← citeshttps://doi.org/10.3390/ph15070796openalex-snapshot
Physiologically Based Pharmacokinetic (PBPK) Modeling to Predict PET Image Quality of Three Generations EGFR TKI in Advanced-Stage NSCLC Patients
inferred← citeshttps://doi.org/10.3390/pharmaceutics16060787openalex-snapshot
Exploring the Potential Use of Natural Products Together with Alkalization in Cancer Therapy
inferred← citeshttps://doi.org/10.3390/pharmaceutics17080980openalex-snapshot
Leveraging the Tumor Microenvironment as a Target for Cancer Therapeutics: A Review of Emerging Opportunities
inferred← citeshttps://doi.org/10.3390/pharmaceutics18091121openalex-snapshot
Multifunctional CMC–Nanographene Oxide Hydrogels Couple Fluorophore-Free Cancer Cell Imaging with Antioxidant and Antimicrobial Activity
inferred← citeshttps://doi.org/10.3390/plants14040585openalex-snapshot
Mechanisms of Cell Death Induced by Cannabidiol Against Tumor Cells: A Review of Preclinical Studies
inferred← citeshttps://doi.org/10.3892/ijo.2021.5262openalex-snapshot
Regulation of gliomagenesis and stemness through acid sensor ASIC1a
inferred← citeshttps://doi.org/10.3892/wasj.2024.278openalex-snapshot
Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors
inferred← citeshttps://doi.org/10.4014/jmb.2504.04007openalex-snapshot
Acidic pH Reduces Fluconazole Susceptibility in Cryptococcus neoformans by Altering Iron Uptake and Enhancing Ergosterol Biosynthesis
inferred← citeshttps://doi.org/10.4213/tmf10880openalex-snapshot
Нелинейность модульного типа в моделировании роста опухолевого сфероида
inferred← citeshttps://doi.org/10.46879/ukroj.2.2023.230-242openalex-snapshot
New approaches to radio- and chemosensitization using proton pump inhibitors through the lens of tumor cell microenvironment patterns
inferred← citeshttps://doi.org/10.52214/cusj.v16i.12940openalex-snapshot
Exploring the “Cascade Effect” of AEBSF on Reduced Glioblastoma Proliferation
inferred← citeshttps://doi.org/10.5463/thesis.168openalex-snapshot
EGFR TKI PET/CT in advanced stage non-small cell lung cancer patients
inferred← citeshttps://doi.org/10.70675/076075b7z825bz48cbz82d2z47b9e8a6846dopenalex-snapshot
Characterization of the intracellular acidity regulation capacity of brain tumor cells in fluorescence imaging-Consequences for therapeutic optimization oftemozolomide
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