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Histone acetyltransferase p300/CBP inhibitor C646 blocks the survival and invasion pathways of gastric cancer cell lines
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1097-4652(199911)181:2<218::aid-jcp4>3.0.co;2-5openalex-snapshot
p300 and CBP: Partners for life and death
inferredcites →https://doi.org/10.1002/jso.22024openalex-snapshot
Mesothelin expression correlates with prolonged patient survival in gastric cancer
inferredcites →https://doi.org/10.1007/s10120-015-0471-6openalex-snapshot
Prognostic impact of HER2, EGFR, and c-MET status on overall survival of advanced gastric cancer patients
inferredcites →https://doi.org/10.1007/s13277-015-3358-6openalex-snapshot
MicroRNA-1 (miR-1) inhibits gastric cancer cell proliferation and migration by targeting MET
inferredcites →https://doi.org/10.1007/s13277-016-5390-6openalex-snapshot
Direct targeting of HGF by miR-16 regulates proliferation and migration in gastric cancer
inferredcites →https://doi.org/10.1016/j.canlet.2015.05.028openalex-snapshot
c-Met targeting in advanced gastric cancer: An open challenge
inferredcites →https://doi.org/10.1016/j.yexcr.2015.03.027openalex-snapshot
MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications
inferredcites →https://doi.org/10.1016/s0168-9525(98)01438-3openalex-snapshot
Conjunction dysfunction: CBP/p300 in human disease
inferredcites →https://doi.org/10.1016/s0962-8924(97)01048-9openalex-snapshot
The p300/CBP family: integrating signals with transcription factors and chromatin
inferredcites →https://doi.org/10.1038/bjc.2012.235openalex-snapshot
Luminal membrane expression of mesothelin is a prominent poor prognostic factor for gastric cancer
inferredcites →https://doi.org/10.1038/nature03664openalex-snapshot
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
inferredcites →https://doi.org/10.1038/sj.onc.1201298openalex-snapshot
CBP/p300 as a co-factor for the Microphthalmia transcription factor
inferredcites →https://doi.org/10.1053/j.gastro.2015.05.059openalex-snapshot
Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma
inferredcites →https://doi.org/10.1073/pnas.0401002101openalex-snapshot
p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels
inferredcites →https://doi.org/10.1074/jbc.274.42.30169openalex-snapshot
Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor
inferredcites →https://doi.org/10.1093/jjco/hyq240openalex-snapshot
Present and Future Status of Gastric Cancer Surgery
inferredcites →https://doi.org/10.1111/febs.12373openalex-snapshot
Structure and mechanism of non‐histone protein acetyltransferase enzymes
inferredcites →https://doi.org/10.1111/j.1349-7006.2008.00865.xopenalex-snapshot
Roles of the histone acetyltransferase monocytic leukemia zinc finger protein in normal and malignant hematopoiesis
inferredcites →https://doi.org/10.1126/science.1201662openalex-snapshot
The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation
inferredcites →https://doi.org/10.1128/jvi.01897-15openalex-snapshot
Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G 1 -S Cell Cycle Progression via Deregulation of the cyclin D1 Gene
inferredcites →https://doi.org/10.1146/annurev.biochem.70.1.81openalex-snapshot
Histone Acetyltransferases
inferredcites →https://doi.org/10.1155/2011/730170openalex-snapshot
Molecular Network Associated with MITF in Skin Melanoma Development and Progression
inferredcites →https://doi.org/10.1158/0008-5472.can-07-2615openalex-snapshot
Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma
inferredcites →https://doi.org/10.1158/1078-0432.ccr-0990-3openalex-snapshot
Expression of Androgen Receptor Coregulators in Prostate Cancer
inferredcites →https://doi.org/10.1158/1535-7163.mct-11-0182openalex-snapshot
Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines
inferredcites →https://doi.org/10.1186/s12943-017-0633-8openalex-snapshot
Mesothelin promotes epithelial-to-mesenchymal transition and tumorigenicity of human lung cancer and mesothelioma cells
inferredcites →https://doi.org/10.1242/jcs.114.13.2363openalex-snapshot
p300/CBP proteins: HATs for transcriptional bridges and scaffolds
inferredcites →https://doi.org/10.1371/journal.pone.0055481openalex-snapshot
A Histone Acetyltransferase p300 Inhibitor C646 Induces Cell Cycle Arrest and Apoptosis Selectively in AML1-ETO-Positive AML Cells
inferredcites →https://doi.org/10.1371/journal.pone.0102798openalex-snapshot
Integrating Genomics and Proteomics Data to Predict Drug Effects Using Binary Linear Programming
inferredcites →https://doi.org/10.18632/oncotarget.6635openalex-snapshot
A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer
inferredcites →https://doi.org/10.18632/oncotarget.9074openalex-snapshot
PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells
inferredcites →https://doi.org/10.18632/oncotarget.9238openalex-snapshot
Homeobox protein VentX induces p53-independent apoptosis in cancer cells
inferredcites →https://doi.org/10.3238/arztebl.2011.0698openalex-snapshot
Treatment Strategies in Gastric Cancer
inferredcites →https://doi.org/10.3892/mmr.2015.4110openalex-snapshot
MicroRNA-34a attenuates the proliferation, invasion and metastasis of gastric cancer cells via downregulation of MET
inferredcites →https://doi.org/10.3892/or.2013.2803openalex-snapshot
ERC/mesothelin is expressed in human gastric cancer tissues and cell lines
inferredcites →https://doi.org/10.3892/or.2014.3281openalex-snapshot
Altered expression of ETV1 and its contribution to tumorigenic phenotypes in gastrointestinal stromal tumors
inferredcites →https://doi.org/10.3892/or.2016.5080openalex-snapshot
An inhibitor of the acetyltransferases CBP/p300 exerts antineoplastic effects on gastrointestinal stromal tumor cells
inferredcites →https://doi.org/10.7314/apjcp.2014.15.10.4271openalex-snapshot
An Epigenetic Mechanism Underlying Doxorubicin Induced EMT in the Human BGC-823 Gastric Cancer Cell
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Benzimidazoles in Drug Discovery: A Patent Review
inferred← citeshttps://doi.org/10.1002/cmdc.202400792openalex-snapshot
Development of C646‐Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300
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inferred← citeshttps://doi.org/10.1016/j.bbadis.2026.168281openalex-snapshot
Targeted inhibition of the H3K27ac/OGT/O-GlcNAcylation axis to overcome gemcitabine-induced chemotherapy resistance in bladder cancer
inferred← citeshttps://doi.org/10.1016/j.biocel.2019.05.020openalex-snapshot
Resveratrol up-regulates ATP2A3 gene expression in breast cancer cell lines through epigenetic mechanisms
inferred← citeshttps://doi.org/10.1016/j.bmc.2018.07.048openalex-snapshot
Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2024.129742openalex-snapshot
Discovery of novel nucleoside derivatives as selective lysine acetyltransferase p300 inhibitors for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.canlet.2026.218754openalex-snapshot
N6-methyladenosine reader YTHDF2 facilitates malignant progression of gallbladder cancer by suppressing NME1 expression
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2022.103752openalex-snapshot
Inhibition of acetylation, is it enough to fight cancer?
inferred← citeshttps://doi.org/10.1016/j.ejphar.2018.08.021openalex-snapshot
Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy
inferred← citeshttps://doi.org/10.1016/j.genrep.2019.100405openalex-snapshot
The role of HIF-1α, CBP and p300 in the regulation of Nav1.5 expression in breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.intimp.2019.105736openalex-snapshot
C646 modulates inflammatory response and antibacterial activity of macrophage
inferred← citeshttps://doi.org/10.1016/j.jbc.2025.110715openalex-snapshot
The complex network of p300/CBP regulation: Interactions, posttranslational modifications, and therapeutic implications
inferred← citeshttps://doi.org/10.1016/j.jncc.2022.09.002openalex-snapshot
The roles of histone modifications in tumorigenesis and associated inhibitors in cancer therapy
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Genetic dysregulation of EP300 in cancers in light of cancer epigenome control – targeting of p300-proficient and -deficient cancers
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2024.108636openalex-snapshot
Characteristics of anticancer activity of CBP/p300 inhibitors – Features of their classes, intracellular targets and future perspectives of their application in cancer treatment
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105702openalex-snapshot
Targeting cancer epigenetic pathways with small-molecule compounds: Therapeutic efficacy and combination therapies
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inferred← citeshttps://doi.org/10.1016/j.tice.2024.102386openalex-snapshot
P300 reduces TUBB4B expression to facilitate the biological process of migration and invasion of non-small cell lung cancer cells
inferred← citeshttps://doi.org/10.1016/j.yexcr.2024.114068openalex-snapshot
Acetylation of ELMO1 correlates with Rac1 activity and colorectal cancer progress
inferred← citeshttps://doi.org/10.1021/acs.analchem.4c00334openalex-snapshot
Furin-Catalyzed Enhanced Magnetic Resonance Imaging Probe for Differential Diagnosis of Malignant Breast Cancers
inferred← citeshttps://doi.org/10.1038/s12276-023-00926-0openalex-snapshot
Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis
inferred← citeshttps://doi.org/10.1038/s41392-019-0095-0openalex-snapshot
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
inferred← citeshttps://doi.org/10.1038/s41392-022-01245-yopenalex-snapshot
Protein acylation: mechanisms, biological functions and therapeutic targets
inferred← citeshttps://doi.org/10.1038/s41419-021-03579-xopenalex-snapshot
The role of PKM2 nuclear translocation in the constant activation of the NF-κB signaling pathway in cancer-associated fibroblasts
inferred← citeshttps://doi.org/10.1038/s41598-020-66329-7openalex-snapshot
In silico analysis reveals EP300 as a panCancer inhibitor of anti-tumor immune response via metabolic modulation
inferred← citeshttps://doi.org/10.1038/s41598-021-89530-8openalex-snapshot
C646 inhibits G2/M cell cycle-related proteins and potentiates anti-tumor effects in pancreatic cancer
inferred← citeshttps://doi.org/10.1049/syb2.12065openalex-snapshot
Hub genes and pathways in gastric cancer: A comparison between studies that used normal tissues adjacent to the tumour and studies that used healthy tissues as calibrator
inferred← citeshttps://doi.org/10.1063/5.0239035openalex-snapshot
Epigenetic dynamics in meniscus cell migration and its zonal dependency in response to inflammatory conditions
inferred← citeshttps://doi.org/10.1080/15384101.2021.1876389openalex-snapshot
Effects of the histone acetylase inhibitor C646 on growth and differentiation of adipose-derived stem cells
inferred← citeshttps://doi.org/10.1101/2024.07.22.604178openalex-snapshot
Epigenetic Dynamics in Meniscus Cell Migration and its Zonal Dependency in Response to Inflammatory Conditions: Implications for Regeneration Strategies
inferred← citeshttps://doi.org/10.1177/15353702231165707openalex-snapshot
The deacetylation of Akt by SIRT1 inhibits inflammation in macrophages and protects against sepsis
inferred← citeshttps://doi.org/10.1186/s12864-021-08196-8openalex-snapshot
Histone acetylation regulates the expression of genes involved in worker reproduction in the ant Temnothorax rugatulus
inferred← citeshttps://doi.org/10.1186/s12957-026-04407-2openalex-snapshot
Clinical value and regulatory role of lncRNA HOXB-AS3 in gastric cancer
inferred← citeshttps://doi.org/10.1186/s13148-024-01709-8openalex-snapshot
H3K27ac acts as a molecular switch for doxorubicin-induced activation of cardiotoxic genes
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Characterization of molecular mechanisms driving Merkel cell polyomavirus oncogene transcription and tumorigenic potential
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The role of VRK1 in chromatin remodeling: regulation of histone post-translational modifications and epigenetic enzymes
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EP300 through upregulating the expression of vimentin to promote the progression of chordoma
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Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs
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P300-mediated H3K18 acetylation triggers necroptosis via modulation of KRT18 transcription in diabetic nephropathy
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CBP mediated DOT1L acetylation confers DOT1L stability and promotes cancer metastasis
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Advances in Epigenetic Cancer Therapeutics
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