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A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

https://doi.org/10.4049/jimmunol.1100412

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/meth.1999.0837openalex-snapshot

Interleukin-18

inferredcites →https://doi.org/10.1016/j.ccr.2009.01.001openalex-snapshot

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

inferredcites →https://doi.org/10.1016/j.cell.2004.07.002openalex-snapshot

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

inferredcites →https://doi.org/10.1016/j.cell.2004.07.013openalex-snapshot

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

inferredcites →https://doi.org/10.1016/j.immuni.2010.02.012openalex-snapshot

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

inferredcites →https://doi.org/10.1016/j.immuni.2010.03.003openalex-snapshot

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

inferredcites →https://doi.org/10.1016/j.immuni.2010.03.010openalex-snapshot

Interleukin-18 in Intestinal Inflammation: Friend and Foe?

inferredcites →https://doi.org/10.1016/j.it.2011.01.003openalex-snapshot

Inflammasome activation and IL-1β and IL-18 processing during infection

inferredcites →https://doi.org/10.1016/j.yexcr.2010.11.013openalex-snapshot

Chemokines in cancer related inflammation

inferredcites →https://doi.org/10.1016/s0014-5793(02)03416-6openalex-snapshot

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF‐κB and caspase‐1

inferredcites →https://doi.org/10.1016/s0952-7915(98)80227-6openalex-snapshot

How do cytotoxic lymphocytes kill their targets?

inferredcites →https://doi.org/10.1016/s1074-7613(00)80543-9openalex-snapshot

Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

inferredcites →https://doi.org/10.1016/s1097-2765(02)00599-3openalex-snapshot

The Inflammasome

inferredcites →https://doi.org/10.1038/378088a0openalex-snapshot

Cloning of a new cytokine that induces IFN-γ production by T cells

inferredcites →https://doi.org/10.1038/nature01322openalex-snapshot

Inflammation and cancer

inferredcites →https://doi.org/10.1038/nature04515openalex-snapshot

Cryopyrin activates the inflammasome in response to toxins and ATP

inferredcites →https://doi.org/10.1038/nature07450openalex-snapshot

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

inferredcites →https://doi.org/10.1038/ng1724openalex-snapshot

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

inferredcites →https://doi.org/10.1046/j.1440-1746.2003.03097.xopenalex-snapshot

Interleukin‐18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin‐18 transgenic mice

inferredcites →https://doi.org/10.1073/pnas.0405979102openalex-snapshot

Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury

inferredcites →https://doi.org/10.1073/pnas.1016814108openalex-snapshot

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

inferredcites →https://doi.org/10.1084/jem.20100050openalex-snapshot

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

inferredcites →https://doi.org/10.1084/jem.20100199openalex-snapshot

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

inferredcites →https://doi.org/10.1146/annurev-immunol-031210-101405openalex-snapshot

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

inferredcites →https://doi.org/10.1146/annurev.pathol.4.110807.092239openalex-snapshot

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

inferredcites →https://doi.org/10.1158/0008-5472.can-08-2061openalex-snapshot

The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis

inferredcites →https://doi.org/10.1159/000320276openalex-snapshot

Inflammatory Bowel Disease as a Risk Factor for Colorectal Cancer

inferredcites →https://doi.org/10.1172/jci29159openalex-snapshot

Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury

inferredcites →https://doi.org/10.1172/jci32453openalex-snapshot

Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis

inferredcites →https://doi.org/10.1172/jci33145openalex-snapshot

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis

inferredcites →https://doi.org/10.1245/aso.2006.03.096openalex-snapshot

Macrophage Inflammatory Protein-2 Promotes Angiogenesis, Cell Migration, and Tumor Growth in Hepatic Metastasis

inferredcites →https://doi.org/10.1385/ir:32:1-3:231openalex-snapshot

Interferon-γ and Cancer Immunoediting

inferredcites →https://doi.org/10.2174/156652410791316968openalex-snapshot

Molecular Pathways Linking Inflammation and Cancer

inferredcites →https://doi.org/10.4049/jimmunol.1002046openalex-snapshot

IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation

inferredcites →https://doi.org/10.4049/jimmunol.1002094openalex-snapshot

NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections

inferredcites →https://doi.org/10.4049/jimmunol.1003111openalex-snapshot

Cutting Edge: NLRC5-Dependent Activation of the Inflammasome

inferredcites →https://doi.org/10.4049/jimmunol.158.4.1818openalex-snapshot

Response to local inflammation of IL-1 beta-converting enzyme- deficient mice

inferredcites →https://doi.org/10.5840/method20011916openalex-snapshot

Translator's Introduction

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Staphylococcal nasal carriage of health care workers.

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NOD ‐Like Receptors

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Inflammasomes and Inflammation

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Inflammasome activation: from molecular mechanisms to autoinflammation

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Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis

inferred← citeshttps://doi.org/10.1002/jcp.31347openalex-snapshot

Loss of NLRP6 increases the severity of kidney fibrosis

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Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development

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The function of NOD‐like receptors in central nervous system diseases

inferred← citeshttps://doi.org/10.1002/path.4357openalex-snapshot

NLRPs , microbiota, and gut homeostasis: unravelling the connection

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Inflammasomes and Obesity

inferred← citeshttps://doi.org/10.1007/978-1-4939-3566-6_2openalex-snapshot

Atypical Inflammasomes

inferred← citeshttps://doi.org/10.1007/978-1-4939-3566-6_3openalex-snapshot

Assessment of Inflammasome Activation by Cytokine and Danger Signal Detection

inferred← citeshttps://doi.org/10.1007/978-3-030-04155-7_14openalex-snapshot

Innate Immune Pattern Recognition and the Development of Intestinal Cancer

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An Insight into the Therapeutic Potential of Phytochemicals for Colorectal Cancer: Latest Perspective

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The Gut Microbiome and Colorectal Cancer

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Supramolecular Assemblies Drive Activation of Inflammasomes

inferred← citeshttps://doi.org/10.1007/978-3-319-41171-2_7openalex-snapshot

Listeria monocytogenes and the Inflammasome: From Cytosolic Bacteriolysis to Tumor Immunotherapy

inferred← citeshttps://doi.org/10.1007/978-3-319-89390-7_10openalex-snapshot

Role of Inflammasomes in the Development of Gastrointestinal Diseases

inferred← citeshttps://doi.org/10.1007/978-3-319-89390-7_12openalex-snapshot

Inflammasome and Cancer

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Inflammasomes and Autoinflammation

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Pattern Recognition Receptors and Aging

inferred← citeshttps://doi.org/10.1007/978-4-431-54442-5_4openalex-snapshot

IL-18

inferred← citeshttps://doi.org/10.1007/978-4-431-55327-4_7openalex-snapshot

Innate Immune Receptor Signaling and IRF Family of Transcription Factors: Good Deeds and Misdeeds in Oncogenesis

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Unfolding the Mechanism of Proteases in Pathophysiology of Gastrointestinal Diseases

inferred← citeshttps://doi.org/10.1007/978-981-15-2017-4_7openalex-snapshot

Understanding Colorectal Cancer: The Basics

inferred← citeshttps://doi.org/10.1007/s00018-015-2123-8openalex-snapshot

NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions

inferred← citeshttps://doi.org/10.1007/s00018-017-2509-xopenalex-snapshot

Mechanisms and consequences of intestinal dysbiosis

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The intervention of NLRP3 inflammasome inhibitor: oridonin against azoxymethane and dextran sulfate sodium–induced colitis-associated colorectal cancer in male BALB/c mice

inferred← citeshttps://doi.org/10.1007/s00281-014-0434-8openalex-snapshot

Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease

inferred← citeshttps://doi.org/10.1007/s00281-014-0451-7openalex-snapshot

Inflammasomes and the microbiota—partners in the preservation of mucosal homeostasis

inferred← citeshttps://doi.org/10.1007/s00335-018-9783-2openalex-snapshot

NLRP3 inflammasome in colitis and colitis-associated colorectal cancer

inferred← citeshttps://doi.org/10.1007/s10565-024-09922-0openalex-snapshot

Three bioactive compounds from Huangqin decoction ameliorate Irinotecan-induced diarrhea via dual-targeting of Escherichia coli and bacterial β-glucuronidase

inferred← citeshttps://doi.org/10.1007/s10753-020-01284-zopenalex-snapshot

The Influence of Bifidobacterium bifidum and Bacteroides fragilis on Enteric Glial Cell–Derived Neurotrophic Factors and Inflammasome

inferred← citeshttps://doi.org/10.1007/s11033-024-09293-zopenalex-snapshot

The role of NLRP6 in the development and progression of neurological diseases

inferred← citeshttps://doi.org/10.1007/s11695-019-04152-4openalex-snapshot

Upregulation of Intestinal NLRP6 Inflammasomes After Roux-en-Y Gastric Bypass Promotes Gut Immune Homeostasis

inferred← citeshttps://doi.org/10.1007/s11888-013-0196-zopenalex-snapshot

The Microbiota: A New Player in the Etiology of Colorectal Cancer

inferred← citeshttps://doi.org/10.1007/s12026-012-8272-zopenalex-snapshot

The rhapsody of NLRPs: master players of inflammation … and a lot more

inferred← citeshttps://doi.org/10.1007/s12026-012-8317-3openalex-snapshot

Effector functions of NLRs in the intestine: innate sensing, cell death, and disease

inferred← citeshttps://doi.org/10.1007/s12031-019-01370-4openalex-snapshot

Effects of NLRP6 in Cerebral Ischemia/Reperfusion (I/R) Injury in Rats

inferred← citeshttps://doi.org/10.1007/s12272-025-01532-6openalex-snapshot

Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation

inferred← citeshttps://doi.org/10.1007/s13238-012-2028-3openalex-snapshot

Sensing bacterial infections by NAIP receptors in NLRC4 inflammasome activation

inferred← citeshttps://doi.org/10.1007/s13238-013-0001-4openalex-snapshot

Inflammasomes in cancer: a double-edged sword

inferred← citeshttps://doi.org/10.1007/s13238-013-3051-8openalex-snapshot

Inflammasomes in cancer: a double-edged sword

inferred← citeshttps://doi.org/10.1016/b978-0-12-809633-8.90775-1openalex-snapshot

Pathogen Sensing: Toll-Like Receptors and NODs (Innate Immunity)

inferred← citeshttps://doi.org/10.1016/b978-0-12-814649-1.00006-5openalex-snapshot

Intestinal-Based Diseases and Peripheral Infection Risk Associated with Gut Dysbiosis: Therapeutic use of Pre- and Probiotics and Fecal Microbiota Transplantation

inferred← citeshttps://doi.org/10.1016/b978-0-12-818006-8.00007-4openalex-snapshot

Infection and Immunity

inferred← citeshttps://doi.org/10.1016/b978-0-12-822368-0.00005-0openalex-snapshot

Molecular signaling of inflammatory responses in macrophages

inferred← citeshttps://doi.org/10.1016/b978-0-323-31696-5.00028-0openalex-snapshot

Immunologic Repercussions of Cell Death

inferred← citeshttps://doi.org/10.1016/b978-0-323-91802-2.00009-8openalex-snapshot

Inflammasomes and cancer

inferred← citeshttps://doi.org/10.1016/b978-0-323-91802-2.00023-2openalex-snapshot

Cellular signaling, molecular activation, and regulation of the NLRP6 inflammasome

inferred← citeshttps://doi.org/10.1016/b978-0-443-26635-5.00023-7openalex-snapshot

Caspase response of inflammasomes in breast cancer

inferred← citeshttps://doi.org/10.1016/bs.ampbs.2018.01.004openalex-snapshot

The Inflammasome: Regulation of Nitric Oxide and Antimicrobial Host Defence

inferred← citeshttps://doi.org/10.1016/j.abb.2019.02.008openalex-snapshot

NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways

inferred← citeshttps://doi.org/10.1016/j.apsb.2025.09.007openalex-snapshot

Targeting pattern recognition receptors for cancer therapy: Mechanisms and strategies

inferred← citeshttps://doi.org/10.1016/j.archoralbio.2020.104794openalex-snapshot

Expression of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 in human dental pulp tissues and cells

inferred← citeshttps://doi.org/10.1016/j.bbmt.2018.07.026openalex-snapshot

Loss of NLRP3 Function Alleviates Murine Hepatic Graft-versus-Host Disease

inferred← citeshttps://doi.org/10.1016/j.bbrc.2020.05.171openalex-snapshot

NLRP6 exerts a protective role via NF-kB with involvement of CCL20 in a mouse model of alcoholic hepatitis

inferred← citeshttps://doi.org/10.1016/j.canlet.2016.06.004openalex-snapshot

The innate immune signaling in cancer and cardiometabolic diseases: Friends or foes?

inferred← citeshttps://doi.org/10.1016/j.ccr.2025.216938openalex-snapshot

Bacteria-assisted metal antitumor immunotherapy

inferred← citeshttps://doi.org/10.1016/j.cell.2014.01.026openalex-snapshot

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

inferred← citeshttps://doi.org/10.1016/j.cell.2014.03.006openalex-snapshot

The Fire Within: Microbes Inflame Tumors

inferred← citeshttps://doi.org/10.1016/j.cell.2015.10.048openalex-snapshot

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

inferred← citeshttps://doi.org/10.1016/j.cell.2016.05.049openalex-snapshot

Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism

inferred← citeshttps://doi.org/10.1016/j.cell.2018.09.047openalex-snapshot

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection

inferred← citeshttps://doi.org/10.1016/j.cell.2020.05.048openalex-snapshot

The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis

inferred← citeshttps://doi.org/10.1016/j.cell.2023.04.025openalex-snapshot

A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases

inferred← citeshttps://doi.org/10.1016/j.cell.2023.05.005openalex-snapshot

NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

inferred← citeshttps://doi.org/10.1016/j.celrep.2016.02.064openalex-snapshot

The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals

inferred← citeshttps://doi.org/10.1016/j.celrep.2017.03.080openalex-snapshot

NLRP6 Protects Il10 Mice from Colitis by Limiting Colonization of Akkermansia muciniphila

inferred← citeshttps://doi.org/10.1016/j.celrep.2017.05.084openalex-snapshot

NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways

inferred← citeshttps://doi.org/10.1016/j.celrep.2017.12.026openalex-snapshot

The NLR Protein NLRP6 Does Not Impact Gut Microbiota Composition

inferred← citeshttps://doi.org/10.1016/j.celrep.2020.107667openalex-snapshot

hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis

inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109043openalex-snapshot

NLRP6 in host defense and intestinal inflammation

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111454openalex-snapshot

Estrogen receptor β activation inhibits colitis by promoting NLRP6-mediated autophagy

inferred← citeshttps://doi.org/10.1016/j.chom.2013.10.013openalex-snapshot

Inflammasome-Microbiota Interplay in Host Physiologies

inferred← citeshttps://doi.org/10.1016/j.chom.2025.02.008openalex-snapshot

Cross-kingdom-mediated detection of intestinal protozoa through NLRP6

inferred← citeshttps://doi.org/10.1016/j.clim.2012.12.006openalex-snapshot

Specific inflammasomes in complex diseases

inferred← citeshttps://doi.org/10.1016/j.coi.2012.04.010openalex-snapshot

Nod-like receptors in the control of intestinal inflammation

inferred← citeshttps://doi.org/10.1016/j.coi.2017.12.003openalex-snapshot

Disease tolerance: concept and mechanisms

inferred← citeshttps://doi.org/10.1016/j.compbiomed.2023.107343openalex-snapshot

Exploration of pyroptosis-associated prognostic gene signature and lncRNA regulatory network in ovarian cancer

inferred← citeshttps://doi.org/10.1016/j.cyto.2012.03.016openalex-snapshot

Aggregatibacter actinomycetemcomitans targets NLRP3 and NLRP6 inflammasome expression in human mononuclear leukocytes

inferred← citeshttps://doi.org/10.1016/j.cyto.2013.02.007openalex-snapshot

IL-1 and EGF regulate expression of genes important in inflammation and cancer

inferred← citeshttps://doi.org/10.1016/j.cytogfr.2011.09.003openalex-snapshot

NOD-like receptors and the innate immune system: Coping with danger, damage and death

inferred← citeshttps://doi.org/10.1016/j.cytogfr.2012.09.003openalex-snapshot

Pattern recognition receptors—Molecular orchestrators of inflammation in inflammatory bowel disease

inferred← citeshttps://doi.org/10.1016/j.cytogfr.2014.04.003openalex-snapshot

The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases – Lessons learned from experimental models

inferred← citeshttps://doi.org/10.1016/j.cytogfr.2014.07.020openalex-snapshot

Inflammasome activation and metabolic disease progression

inferred← citeshttps://doi.org/10.1016/j.dci.2020.103874openalex-snapshot

The neutrophil inflammasome

inferred← citeshttps://doi.org/10.1016/j.ddmec.2011.11.003openalex-snapshot

Inflammasomes and intestinal tumorigenesis

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2019.109687openalex-snapshot

Is NLRP3 or NLRP6 inflammasome activation associated with inflammation-related lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide?

inferred← citeshttps://doi.org/10.1016/j.fct.2019.110597openalex-snapshot

A single or short time repeated arsenic oral exposure in mice impacts mRNA expression for signaling and immunity related genes in the gut

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2016.11.011openalex-snapshot

Regulation of the gut microbiome by inflammasomes

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2021.04.008openalex-snapshot

Hepatocyte-specific deletion of Nlrp6 in mice exacerbates the development of non-alcoholic steatohepatitis

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2026.02.061openalex-snapshot

NLRP6 is essential for TREM2-alleviated cardiac ischemia/reperfusion injury via affecting PANoptosis

inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e28432openalex-snapshot

REV-ERBα negatively regulates NLRP6 transcription and reduces the severity of Salmonella infection in mice

inferred← citeshttps://doi.org/10.1016/j.hoc.2018.12.002openalex-snapshot

Innate Immune Stimulation in Cancer Therapy

inferred← citeshttps://doi.org/10.1016/j.humimm.2013.11.010openalex-snapshot

Trichothecene mycotoxins activate NLRP3 inflammasome through a P2X7 receptor and Src tyrosine kinase dependent pathway

inferred← citeshttps://doi.org/10.1016/j.immuni.2012.02.001openalex-snapshot

An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages

inferred← citeshttps://doi.org/10.1016/j.immuni.2013.08.037openalex-snapshot

Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

inferred← citeshttps://doi.org/10.1016/j.immuni.2013.12.007openalex-snapshot

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

inferred← citeshttps://doi.org/10.1016/j.immuni.2014.01.010openalex-snapshot

NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING

inferred← citeshttps://doi.org/10.1016/j.immuni.2015.03.006openalex-snapshot

The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells

inferred← citeshttps://doi.org/10.1016/j.immuni.2015.10.009openalex-snapshot

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

inferred← citeshttps://doi.org/10.1016/j.immuni.2018.08.024openalex-snapshot

SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer

inferred← citeshttps://doi.org/10.1016/j.immuni.2020.04.010openalex-snapshot

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

inferred← citeshttps://doi.org/10.1016/j.immuni.2024.03.012openalex-snapshot

The NLR family of innate immune and cell death sensors

inferred← citeshttps://doi.org/10.1016/j.intimp.2019.105740openalex-snapshot

NLRP6 deficiency aggravates liver injury after allogeneic hematopoietic stem cell transplantation

inferred← citeshttps://doi.org/10.1016/j.intimp.2019.106183openalex-snapshot

NLRP6 expressed in astrocytes aggravates neurons injury after OGD/R through activating the inflammasome and inducing pyroptosis

inferred← citeshttps://doi.org/10.1016/j.intimp.2020.107287openalex-snapshot

Natterin an aerolysin-like fish toxin drives IL-1β-dependent neutrophilic inflammation mediated by caspase-1 and caspase-11 activated by the inflammasome sensor NLRP6

inferred← citeshttps://doi.org/10.1016/j.intimp.2021.108091openalex-snapshot

Matrine protects against DSS-induced murine colitis by improving gut barrier integrity, inhibiting the PPAR-α signaling pathway, and modulating gut microbiota

inferred← citeshttps://doi.org/10.1016/j.intimp.2026.116814openalex-snapshot

Polysaccharide from Armillariella tabescens mycelia alleviates lipopolysaccharide-induced neuroinflammation via regulating the microbiota-gut-brain axis

inferred← citeshttps://doi.org/10.1016/j.it.2013.07.001openalex-snapshot

Impact of the gut microbiome on mucosal inflammation

inferred← citeshttps://doi.org/10.1016/j.it.2015.06.002openalex-snapshot

Inflammasomes of the intestinal epithelium

inferred← citeshttps://doi.org/10.1016/j.it.2017.01.001openalex-snapshot

NLRP6: A Multifaceted Innate Immune Sensor

inferred← citeshttps://doi.org/10.1016/j.it.2019.09.005openalex-snapshot

Emerging Activators and Regulators of Inflammasomes and Pyroptosis

inferred← citeshttps://doi.org/10.1016/j.jaci.2017.04.018openalex-snapshot

Desiccating stress worsens alkali burn injury by magnifying caspase-8-induced imbalance of NLRP3 and NLRP6

inferred← citeshttps://doi.org/10.1016/j.jcmgh.2014.11.006openalex-snapshot

Mechanisms of Immune Signaling in Colitis-Associated Cancer

inferred← citeshttps://doi.org/10.1016/j.jcmgh.2015.01.006openalex-snapshot

Experimental Models of Inflammatory Bowel Diseases

inferred← citeshttps://doi.org/10.1016/j.jds.2022.09.009openalex-snapshot

Role of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 in activation of inflammation in human umbilical vein endothelial cells stimulated by Porphyromonas gingivalis-an in vitro study

inferred← citeshttps://doi.org/10.1016/j.jep.2022.115152openalex-snapshot

Traditional Mongolian medicine (HHQG) attenuates CCl4-induced acute liver injury through inhibiting monocyte/macrophage infiltration via the p-P38/p-JNK pathway

inferred← citeshttps://doi.org/10.1016/j.jhazmat.2026.142151openalex-snapshot

Coexposure to heat stress and polystyrene nanoplastics induces neuroinflammation and cognitive impairment via oxidative stress-NLRP6-pyroptosis axis

inferred← citeshttps://doi.org/10.1016/j.jmb.2017.07.012openalex-snapshot

Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice

inferred← citeshttps://doi.org/10.1016/j.jmb.2017.09.019openalex-snapshot

How Inflammasomes Inform Adaptive Immunity

inferred← citeshttps://doi.org/10.1016/j.lfs.2026.124388openalex-snapshot

NLRP6 drives cutaneous wound healing during Staphylococcus aureus infection in mice

inferred← citeshttps://doi.org/10.1016/j.mam.2020.100859openalex-snapshot

NLRP6 inflammasome

inferred← citeshttps://doi.org/10.1016/j.mam.2020.100887openalex-snapshot

NLRP12 in innate immunity and inflammation

inferred← citeshttps://doi.org/10.1016/j.mib.2012.11.008openalex-snapshot

Inflammasomes and host defenses against bacterial infections

inferred← citeshttps://doi.org/10.1016/j.micinf.2013.06.009openalex-snapshot

NLRP6 in infection and inflammation

inferred← citeshttps://doi.org/10.1016/j.molcel.2014.03.039openalex-snapshot

The Multifaceted Role of the Intestinal Microbiota in Colon Cancer

inferred← citeshttps://doi.org/10.1016/j.molimm.2016.09.023openalex-snapshot

Transcriptional regulation of inflammasome-associated pattern recognition receptors, and the relevance to disease pathogenesis

inferred← citeshttps://doi.org/10.1016/j.mucimm.2024.10.004openalex-snapshot

TRIM29 controls enteric RNA virus-induced intestinal inflammation by targeting NLRP6 and NLRP9b signaling pathways

inferred← citeshttps://doi.org/10.1016/j.neulet.2021.135954openalex-snapshot

BRCC3 promotes activation of the NLRP6 inflammasome following cerebral ischemia/reperfusion (I/R) injury in rats

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2014.02.002openalex-snapshot

Inflammasome: Cancer's friend or foe?

inferred← citeshttps://doi.org/10.1016/j.phrs.2020.105017openalex-snapshot

Promising targets based on pattern recognition receptors for cancer immunotherapy

inferred← citeshttps://doi.org/10.1016/j.phymed.2026.157903openalex-snapshot

Mulberroside A inhibits NLRP6 to prevent alveolar macrophage efferocytosis and lung-derived SAA3-platelet transport in high fructose-induced hippocampal inflammation

inferred← citeshttps://doi.org/10.1016/j.prp.2022.153881openalex-snapshot

P38α deficiency in macrophages ameliorates murine experimental colitis by regulating inflammation and immune process

inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.09.013openalex-snapshot

Inflammasomes in cancer: Effect of epigenetic and autophagic modulations

inferred← citeshttps://doi.org/10.1016/j.smim.2011.11.002openalex-snapshot

The mammalian intestinal epithelium as integral player in the establishment and maintenance of host–microbial homeostasis

inferred← citeshttps://doi.org/10.1016/j.smim.2012.01.001openalex-snapshot

Examining host–microbial interactions through the lens of NOD: From plants to mammals

inferred← citeshttps://doi.org/10.1016/j.smim.2013.09.007openalex-snapshot

An epithelial armamentarium to sense the microbiota

inferred← citeshttps://doi.org/10.1016/j.smim.2023.101815openalex-snapshot

Inflammasomes as regulators of non-infectious disease

inferred← citeshttps://doi.org/10.1016/j.tcb.2014.12.009openalex-snapshot

Mechanisms of inflammasome activation: recent advances and novel insights

inferred← citeshttps://doi.org/10.1016/j.tibs.2013.01.001openalex-snapshot

NLR activation takes a direct route

inferred← citeshttps://doi.org/10.1016/j.tranon.2021.101233openalex-snapshot

Novel prognostic model established for patients with head and neck squamous cell carcinoma based on pyroptosis-related genes

inferred← citeshttps://doi.org/10.1016/j.trsl.2022.09.002openalex-snapshot

Inflammasome signaling in colorectal cancer

inferred← citeshttps://doi.org/10.1016/j.vetmic.2024.110166openalex-snapshot

The suppressive role of NLRP6 in host defense against Streptococcus suis infection

inferred← citeshttps://doi.org/10.1016/j.yexcr.2020.112177openalex-snapshot

NLRP6 suppresses gastric cancer growth via GRP78 ubiquitination

inferred← citeshttps://doi.org/10.1016/j.yexcr.2024.114393openalex-snapshot

The effect of cancer cell-derived exosomal proteins on macrophage polarization: An in-depth review

inferred← citeshttps://doi.org/10.1021/acsami.3c04206openalex-snapshot

Encapsulation of MCC950 in Liposomes Decorated with Anti-Frizzled 1 Improves Drug Bioavailability and Effectiveness in Fatty Liver Disease

inferred← citeshttps://doi.org/10.1038/cdd.2014.56openalex-snapshot

Gut microbiome and anticancer immune response: really hot Sh*t!

inferred← citeshttps://doi.org/10.1038/cmi.2016.35openalex-snapshot

The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway

inferred← citeshttps://doi.org/10.1038/cr.2012.55openalex-snapshot

The inflammasome: A remote control for metabolic syndrome

inferred← citeshttps://doi.org/10.1038/embor.2012.96openalex-snapshot

Innate immune signalling at the intestinal epithelium in homeostasis and disease

inferred← citeshttps://doi.org/10.1038/mi.2012.115openalex-snapshot

Integrative inflammasome activity in the regulation of intestinal mucosal immune responses

inferred← citeshttps://doi.org/10.1038/mi.2013.13openalex-snapshot

The role of pattern recognition receptors in intestinal inflammation

inferred← citeshttps://doi.org/10.1038/mi.2015.32openalex-snapshot

New developments in goblet cell mucus secretion and function

inferred← citeshttps://doi.org/10.1038/mi.2016.55openalex-snapshot

NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury

inferred← citeshttps://doi.org/10.1038/mi.2017.19openalex-snapshot

Inflammasomes and intestinal inflammation

inferred← citeshttps://doi.org/10.1038/mi.2017.87openalex-snapshot

A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation

inferred← citeshttps://doi.org/10.1038/nature10759openalex-snapshot

Inflammasomes in health and disease

inferred← citeshttps://doi.org/10.1038/nature11250openalex-snapshot

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

inferred← citeshttps://doi.org/10.1038/nature18847openalex-snapshot

The microbiome and innate immunity

inferred← citeshttps://doi.org/10.1038/ni.2224openalex-snapshot

Inflammasomes in carcinogenesis and anticancer immune responses

inferred← citeshttps://doi.org/10.1038/nm.3908openalex-snapshot

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

inferred← citeshttps://doi.org/10.1038/nrc3611openalex-snapshot

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

inferred← citeshttps://doi.org/10.1038/nrgastro.2015.94openalex-snapshot

Inflammasome activation and function in liver disease

inferred← citeshttps://doi.org/10.1038/nri3261openalex-snapshot

Lighting the fires within: the cell biology of autoinflammatory diseases

inferred← citeshttps://doi.org/10.1038/nri3452openalex-snapshot

Activation and regulation of the inflammasomes

inferred← citeshttps://doi.org/10.1038/nri3479openalex-snapshot

Newly described pattern recognition receptors team up against intracellular pathogens

inferred← citeshttps://doi.org/10.1038/s41385-020-00357-4openalex-snapshot

NLRP6 modulates neutrophil homeostasis in bacterial pneumonia-derived sepsis

inferred← citeshttps://doi.org/10.1038/s41385-020-0256-zopenalex-snapshot

The NLRP6 inflammasome in health and disease

inferred← citeshttps://doi.org/10.1038/s41385-021-00426-2openalex-snapshot

PRKAR2A deficiency protects mice from experimental colitis by increasing IFN-stimulated gene expression and modulating the intestinal microbiota

inferred← citeshttps://doi.org/10.1038/s41388-018-0613-5openalex-snapshot

Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis

inferred← citeshttps://doi.org/10.1038/s41388-025-03642-3openalex-snapshot

NLRPs and tumor: research progress from molecular mechanisms to clinical applications

inferred← citeshttps://doi.org/10.1038/s41396-023-01483-0openalex-snapshot

Potential effects of gut microbiota on host cancers: focus on immunity, DNA damage, cellular pathways, and anticancer therapy

inferred← citeshttps://doi.org/10.1038/s41419-021-03558-2openalex-snapshot

N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway

inferred← citeshttps://doi.org/10.1038/s41419-021-04420-1openalex-snapshot

Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases

inferred← citeshttps://doi.org/10.1038/s41421-020-0167-xopenalex-snapshot

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

inferred← citeshttps://doi.org/10.1038/s41435-021-00124-wopenalex-snapshot

Epithelial sensing of microbiota-derived signals

inferred← citeshttps://doi.org/10.1038/s41467-019-11811-8openalex-snapshot

VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

inferred← citeshttps://doi.org/10.1038/s41467-023-41739-zopenalex-snapshot

NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis

inferred← citeshttps://doi.org/10.1038/s41467-024-45466-xopenalex-snapshot

NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress

inferred← citeshttps://doi.org/10.1038/s41467-026-73760-3openalex-snapshot

Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity

inferred← citeshttps://doi.org/10.1038/s41564-019-0373-1openalex-snapshot

Host NLRP6 exacerbates graft-versus-host disease independent of gut microbial composition

inferred← citeshttps://doi.org/10.1038/s41568-019-0123-yopenalex-snapshot

Diverging inflammasome signals in tumorigenesis and potential targeting

inferred← citeshttps://doi.org/10.1038/s41568-022-00462-5openalex-snapshot

Context-dependent functions of pattern recognition receptors in cancer

inferred← citeshttps://doi.org/10.1038/s41571-024-00908-9openalex-snapshot

Exploiting bacteria for cancer immunotherapy

inferred← citeshttps://doi.org/10.1038/s41575-018-0054-1openalex-snapshot

Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis

inferred← citeshttps://doi.org/10.1038/s41577-023-00849-xopenalex-snapshot

The NLR gene family: from discovery to present day

inferred← citeshttps://doi.org/10.1038/s41586-021-03875-8openalex-snapshot

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

inferred← citeshttps://doi.org/10.1038/s41590-020-0681-xopenalex-snapshot

Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation

inferred← citeshttps://doi.org/10.1038/s41598-019-57043-0openalex-snapshot

NLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation

inferred← citeshttps://doi.org/10.1038/s41598-022-05599-9openalex-snapshot

Construction and validation of a pyroptosis-related gene signature associated with the tumor microenvironment in uveal melanoma

inferred← citeshttps://doi.org/10.1038/s41698-021-00154-7openalex-snapshot

Dynamic roles of inflammasomes in inflammatory tumor microenvironment

inferred← citeshttps://doi.org/10.1038/s42003-022-03491-wopenalex-snapshot

Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles

inferred← citeshttps://doi.org/10.1038/srep36107openalex-snapshot

Targeting inflammasome/IL-1 pathways for cancer immunotherapy

inferred← citeshttps://doi.org/10.1053/j.gastro.2011.10.002openalex-snapshot

Inflammasomes in Intestinal Inflammation and Cancer

inferred← citeshttps://doi.org/10.1053/j.gastro.2013.02.038openalex-snapshot

Stress-Induced Corticotropin-Releasing Hormone-Mediated NLRP6 Inflammasome Inhibition and Transmissible Enteritis in Mice

inferred← citeshttps://doi.org/10.1053/j.gastro.2017.11.276openalex-snapshot

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis

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