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Cytokine Signaling: Birth of a Pathway

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/j.1460-2075.1994.tb06422.xopenalex-snapshot
Ligand‐induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).
inferredcites →https://doi.org/10.1016/0092-8674(84)90270-8openalex-snapshot
Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells
inferredcites →https://doi.org/10.1016/0092-8674(92)90105-lopenalex-snapshot
A protein tyrosine kinase in the interferon αβ signaling pathway
inferredcites →https://doi.org/10.1016/0092-8674(93)90414-lopenalex-snapshot
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
inferredcites →https://doi.org/10.1016/0092-8674(93)90415-mopenalex-snapshot
Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase
inferredcites →https://doi.org/10.1016/j.immuni.2010.06.003openalex-snapshot
Discrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during T Helper Cell Differentiation
inferredcites →https://doi.org/10.1016/j.semcdb.2008.06.001openalex-snapshot
Identification of JAK/STAT pathway regulators—Insights from RNAi screens
inferredcites →https://doi.org/10.1016/s0021-9258(17)42492-6openalex-snapshot
Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction.
inferredcites →https://doi.org/10.1016/s0021-9258(18)42011-xopenalex-snapshot
Mammary gland-specific nuclear factor is present in lactating rodent and bovine mammary tissue and composed of a single polypeptide of 89 kDa.
inferredcites →https://doi.org/10.1016/s0092-8674(00)81288-xopenalex-snapshot
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
inferredcites →https://doi.org/10.1016/s0092-8674(00)81289-1openalex-snapshot
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
inferredcites →https://doi.org/10.1016/s1074-7613(03)00211-5openalex-snapshot
Molecular Phylogeny within Type I Cytokines and Their Cognate Receptors
inferredcites →https://doi.org/10.1038/366129a0openalex-snapshot
The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction
inferredcites →https://doi.org/10.1038/366166a0openalex-snapshot
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway
inferredcites →https://doi.org/10.1038/366580a0openalex-snapshot
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins
inferredcites →https://doi.org/10.1038/366583a0openalex-snapshot
Interferon-induced nuclear signalling by Jak protein tyrosine kinases
inferredcites →https://doi.org/10.1038/377065a0openalex-snapshot
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
inferredcites →https://doi.org/10.1038/gene.2008.1openalex-snapshot
Variant form of STAT4 is associated with primary Sjögren's syndrome
inferredcites →https://doi.org/10.1038/nature06096openalex-snapshot
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
inferredcites →https://doi.org/10.1038/nature08448openalex-snapshot
JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin
inferredcites →https://doi.org/10.1038/ng1097openalex-snapshot
Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency
inferredcites →https://doi.org/10.1038/nri2958openalex-snapshot
Genomic views of STAT function in CD4+ T helper cell differentiation
inferredcites →https://doi.org/10.1056/nejmoa051113openalex-snapshot
A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders
inferredcites →https://doi.org/10.1056/nejmoa073003openalex-snapshot
STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.1056/nejmoa073687openalex-snapshot
STAT3 Mutations in the Hyper-IgE Syndrome
inferredcites →https://doi.org/10.1056/nejmoa1002028openalex-snapshot
Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis
inferredcites →https://doi.org/10.1073/pnas.81.21.6733openalex-snapshot
Transcriptional induction of two genes in human cells by beta interferon.
inferredcites →https://doi.org/10.1073/pnas.85.22.8521openalex-snapshot
Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.
inferredcites →https://doi.org/10.1073/pnas.87.21.8555openalex-snapshot
ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains.
inferredcites →https://doi.org/10.1073/pnas.88.24.11455openalex-snapshot
High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.
inferredcites →https://doi.org/10.1073/pnas.89.16.7836openalex-snapshot
Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.
inferredcites →https://doi.org/10.1073/pnas.89.16.7840openalex-snapshot
The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.
inferredcites →https://doi.org/10.1084/jem.20110958openalex-snapshot
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
inferredcites →https://doi.org/10.1086/428480openalex-snapshot
Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.1101/gad.4.10.1753openalex-snapshot
Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.
inferredcites →https://doi.org/10.1111/j.1600-065x.2008.00754.xopenalex-snapshot
Janus kinases in immune cell signaling
inferredcites →https://doi.org/10.1126/science.1061154openalex-snapshot
Impairment of Mycobacterial But Not Viral Immunity by a Germline Human STAT1 Mutation
inferredcites →https://doi.org/10.1126/science.1164551openalex-snapshot
Function of Mitochondrial Stat3 in Cellular Respiration
inferredcites →https://doi.org/10.1126/science.1171721openalex-snapshot
Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation
inferredcites →https://doi.org/10.1126/science.1496401openalex-snapshot
Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor
inferredcites →https://doi.org/10.1126/science.270.5237.794openalex-snapshot
Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3
inferredcites →https://doi.org/10.1126/science.270.5237.797openalex-snapshot
Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development
inferredcites →https://doi.org/10.1126/science.270.5237.800openalex-snapshot
Defective Lymphoid Development in Mice Lacking Jak3
inferredcites →https://doi.org/10.1126/science.8197455openalex-snapshot
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
inferredcites →https://doi.org/10.1128/mcb.11.4.2057openalex-snapshot
Two Novel Protein-Tyrosine Kinases, Each with a Second Phosphotransferase-Related Catalytic Domain, Define a New Class of Protein Kinase
inferredcites →https://doi.org/10.1128/mcb.12.8.3315openalex-snapshot
Subunit of an Alpha-Interferon-Responsive Transcription Factor Is Related to Interferon Regulatory Factor and Myb Families of DNA-Binding Proteins
inferredcites →https://doi.org/10.1128/mcb.13.1.276openalex-snapshot
Acute-Phase Response Factor, a Nuclear Factor Binding to Acute-Phase Response Elements, is Rapidly Activated by Interleukin-6 at the Posttranslational Level
inferredcites →https://doi.org/10.1146/annurev.bi.64.070195.003201openalex-snapshot
TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway
inferredcites →https://doi.org/10.1146/annurev.immunol.16.1.293openalex-snapshot
JAKS AND STATS: Biological Implications
inferredcites →https://doi.org/10.1371/journal.pone.0010373openalex-snapshot
Evidence for STAT4 as a Common Autoimmune Gene: rs7574865 Is Associated with Colonic Crohn's Disease and Early Disease Onset
inferredcites →https://doi.org/10.4049/jimmunol.157.11.4781openalex-snapshot
Activation of STAT4 by IL-12 and IFN-α: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation
inferredcites →https://doi.org/10.4049/jimmunol.177.5.2770openalex-snapshot
Cutting Edge: Decreased Accumulation and Regulatory Function of CD4+CD25high T Cells in Human STAT5b Deficiency

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4657450openalex-extracted
Fabrication of Uniform Bifunctional Pamam@Dextran Barcodes Based on Microfluidic Technology for High-Sensitivity Multiplex Detection of Cytokines
inferred← citeshttps://doi.org/10.1002/adom.202400608openalex-snapshot
Recent Developments on Optical Aptasensors for the Detection of Pro‐Inflammatory Cytokines with Advanced Nanostructures
inferred← citeshttps://doi.org/10.1002/cyto.a.23103openalex-snapshot
A rapid method for quantifying cytoplasmic versus nuclear localization in endogenous peripheral blood leukocytes by conventional flow cytometry
inferred← citeshttps://doi.org/10.1002/ddr.21546openalex-snapshot
Efficacy of a phenol derivative, isopropyl vanillate, as an anti‐inflammatory agent: A new small molecule inhibitor of COX and neutrophil migration
inferred← citeshttps://doi.org/10.1002/ptr.6686openalex-snapshot
Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin‐induced rat model of sporadic Alzheimer's disease: The role of JAK2 / STAT3 and Nrf2/ HO ‐1 signalling pathway modulation
inferred← citeshttps://doi.org/10.1007/978-3-319-63001-4_13openalex-snapshot
Cytokines and Aging
inferred← citeshttps://doi.org/10.1007/978-3-319-89354-9_3openalex-snapshot
Case Studies
inferred← citeshttps://doi.org/10.1007/s13361-015-1189-8openalex-snapshot
EPOR-Based Purification and Analysis of Erythropoietin Mimetic Peptides from Human Urine by Cys-Specific Cleavage and LC/MS/MS
inferred← citeshttps://doi.org/10.1007/s40259-013-0040-7openalex-snapshot
The Arrival of JAK Inhibitors: Advancing the Treatment of Immune and Hematologic Disorders
inferred← citeshttps://doi.org/10.1016/b978-0-12-385157-4.00175-5openalex-snapshot
Cytokines
inferred← citeshttps://doi.org/10.1016/b978-0-12-800254-4.00012-xopenalex-snapshot
Dual Effect of Interferon (IFNγ)-Induced Nitric Oxide on Tumorigenesis and Intracellular Bacteria
inferred← citeshttps://doi.org/10.1016/b978-0-12-801577-3.00001-0openalex-snapshot
Systems Immunology
inferred← citeshttps://doi.org/10.1016/b978-0-323-90052-2.00017-2openalex-snapshot
Antineuroinflammatory potentials of Clinacanthus nutans leaf
inferred← citeshttps://doi.org/10.1016/j.acthis.2022.151908openalex-snapshot
Molecular signaling pathways, pathophysiological features in various organs, and treatment strategies in SARS-CoV2 infection
inferred← citeshttps://doi.org/10.1016/j.bios.2016.01.020openalex-snapshot
Recent advances in cytokine detection by immunosensing
inferred← citeshttps://doi.org/10.1016/j.cels.2023.12.006openalex-snapshot
Predicting gene-level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework
inferred← citeshttps://doi.org/10.1016/j.clim.2016.09.014openalex-snapshot
Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases
inferred← citeshttps://doi.org/10.1016/j.coph.2012.06.008openalex-snapshot
Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease
inferred← citeshttps://doi.org/10.1016/j.envpol.2017.06.041openalex-snapshot
Identification of novel cytokine biomarkers of hexanal exposure associated with pulmonary toxicity
inferred← citeshttps://doi.org/10.1016/j.immuni.2012.03.016openalex-snapshot
Inborn Errors of Human JAKs and STATs
inferred← citeshttps://doi.org/10.1016/j.jaci.2013.06.035openalex-snapshot
IL-4 confers resistance to IL-27–mediated suppression on CD4+ T cells by impairing signal transducer and activator of transcription 1 signaling
inferred← citeshttps://doi.org/10.1016/j.snb.2020.128096openalex-snapshot
Electrochemical immunoplatform to improve the reliability of breast cancer diagnosis through the simultaneous determination of RANKL and TNF in serum
inferred← citeshttps://doi.org/10.1016/j.trac.2018.03.002openalex-snapshot
Advances in structure-switching aptasensing towards real time detection of cytokines
inferred← citeshttps://doi.org/10.1016/j.virol.2013.12.015openalex-snapshot
The differential interferon responses of two strains of Stat1-deficient mice do not alter susceptibility to HSV-1 and VSV in vivo
inferred← citeshttps://doi.org/10.1021/acsbiomedchemau.2c00052openalex-snapshot
Activity-Based Sensing for Chemistry-Enabled Biology: Illuminating Principles, Probes, and Prospects for Boronate Reagents for Studying Hydrogen Peroxide
inferred← citeshttps://doi.org/10.1021/acssensors.9b01211openalex-snapshot
Sensitive and Multiplexed SERS Nanotags for the Detection of Cytokines Secreted by Lymphoma
inferred← citeshttps://doi.org/10.1038/jidsymp.2013.29openalex-snapshot
Janus Kinases: An Ideal Target for the Treatment of Autoimmune Diseases
inferred← citeshttps://doi.org/10.1038/s44318-024-00200-7openalex-snapshot
The fitness cost of spurious phosphorylation
inferred← citeshttps://doi.org/10.1039/c6ra01906dopenalex-snapshot
Nano-cuprous oxide catalyzed one-pot synthesis of a carbazole-based STAT3 inhibitor: a facile approach via intramolecular C–N bond formation reactions
inferred← citeshttps://doi.org/10.1111/bcpt.12164openalex-snapshot
Therapeutic Targeting of the JAK / STAT Pathway
inferred← citeshttps://doi.org/10.1111/ejh.13912openalex-snapshot
In chronic lymphocytic leukemia, activation of the thrombopoietin receptor promotes T‐cell inhibitory properties, contributing to immunosuppression
inferred← citeshttps://doi.org/10.1111/imm.12336openalex-snapshot
Conjugated bilirubin affects cytokine profiles in hepatitis A virus infection by modulating function of signal transducer and activator of transcription factors
inferred← citeshttps://doi.org/10.1111/imm.12521openalex-snapshot
STAT3 promotes CD1d‐mediated lipid antigen presentation by regulating a critical gene in glycosphingolipid biosynthesis
inferred← citeshttps://doi.org/10.1155/2016/9564814openalex-snapshot
Noncanonical IFN Signaling: Mechanistic Linkage of Genetic and Epigenetic Events
inferred← citeshttps://doi.org/10.1189/jlb.1ri0614-293ropenalex-snapshot
The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiation
inferred← citeshttps://doi.org/10.1371/journal.pone.0178232openalex-snapshot
Interleukin-6 stimulates Akt and p38 MAPK phosphorylation and fibroblast migration in non-diabetic but not diabetic mice
inferred← citeshttps://doi.org/10.1371/journal.pone.0238503openalex-snapshot
The anti-neuroinflammatory effects of Clinacanthus nutans leaf extract on metabolism elucidated through 1H NMR in correlation with cytokines microarray
inferred← citeshttps://doi.org/10.14232/phd.2974openalex-snapshot
Abnormalities in the psoriatic non-lesional skin
inferred← citeshttps://doi.org/10.1515/jcim-2022-0114openalex-snapshot
The roles of HDAC with IMPDH and mTOR with JAK as future targets in the treatment of rheumatoid arthritis with combination therapy
inferred← citeshttps://doi.org/10.18154/rwth-2017-01944openalex-snapshot
Die Rolle der STAT3 N-terminale Domäne und GAS-Sequenzerkennung bei der Signaltransduktion und der Wechselwirkung mit STAT1 und NF-κB
inferred← citeshttps://doi.org/10.3389/fimmu.2019.00771openalex-snapshot
Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1669688openalex-snapshot
JAK/STAT in human diseases: a common axis in immunodeficiencies and hematological disorders
inferred← citeshttps://doi.org/10.5772/intechopen.102442openalex-snapshot
Signaling Pathways Regulating Axogenesis and Dendritogenesis in Sympathetic Neurons
inferred← citeshttps://doi.org/10.5772/intechopen.80480openalex-snapshot
Regulation of Dendritogenesis in Sympathetic Neurons
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