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Ultrasensitive Sub-Pg/Ml Determination of Tiotropium Bromide in Human Plasma by 2D-UHPLC–MS/MS: Challenges and Solutions

https://doi.org/10.4155/bio.15.256
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bdd.280openalex-snapshot
Pharmacokinetics and tissue distribution of the anticholinergics tiotropium and ipratropium in the rat and dog
inferredcites →https://doi.org/10.1002/elps.200800121openalex-snapshot
Microfluidics: Applications for analytical purposes in chemistry and biochemistry
inferredcites →https://doi.org/10.1002/rcm.3021openalex-snapshot
Highly sensitive assay for tiotropium, a quaternary ammonium, in human plasma by high‐performance liquid chromatography/tandem mass spectrometry
inferredcites →https://doi.org/10.1002/rcm.4670openalex-snapshot
Liquid chromatography/tandem mass spectrometry sensitivity enhancement via online sample dilution and trapping: applications in microdosing and dried blood spot (DBS) bioanalysis
inferredcites →https://doi.org/10.1007/s00216-004-2516-2openalex-snapshot
Multidimensional LC-LC and LC-CE for high-resolution separations of biological molecules
inferredcites →https://doi.org/10.1016/j.clinthera.2005.04.006openalex-snapshot
Tiotropium bromide: A new long-acting bronchodilator for the treatment of chronic obstructive pulmonary disease
inferredcites →https://doi.org/10.1016/j.jchromb.2005.05.037openalex-snapshot
Improving LC–MS sensitivity through increases in chromatographic performance: Comparisons of UPLC–ES/MS/MS to HPLC–ES/MS/MS
inferredcites →https://doi.org/10.1016/j.jchromb.2006.12.030openalex-snapshot
Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses
inferredcites →https://doi.org/10.1016/s0024-3205(98)00588-8openalex-snapshot
Tiotropium (SPIRIVA™): Mechanistical considerations and clinical profile in obstructive lung disease
inferredcites →https://doi.org/10.1021/ac050871xopenalex-snapshot
Two-Dimensional Gas-Phase Separations Coupled to Mass Spectrometry for Analysis of Complex Mixtures
inferredcites →https://doi.org/10.1081/jlc-200053046openalex-snapshot
UPLC ™ : An Introduction and Review
inferredcites →https://doi.org/10.1136/thorax.55.4.289openalex-snapshot
A randomised controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease
inferredcites →https://doi.org/10.1164/ajrccm.161.4.9903044openalex-snapshot
Long-Acting Bronchodilation with Once-Daily Dosing of Tiotropium (Spiriva) in Stable Chronic Obstructive Pulmonary Disease
inferredcites →https://doi.org/10.1177/0091270003261315openalex-snapshot
Pharmacokinetics of Intravenous, Single‐Dose Tiotropium in Subjects with Different Degrees of Renal Impairment
inferredcites →https://doi.org/10.1183/09031936.02.00269802openalex-snapshot
A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease
inferredcites →https://doi.org/10.1208/s12248-009-9100-9openalex-snapshot
Workshop Report and Follow-Up—AAPS Workshop on Current Topics in GLP Bioanalysis: Assay Reproducibility for Incurred Samples—Implications of Crystal City Recommendations
inferredcites →https://doi.org/10.1253/circj.70.1658openalex-snapshot
Tiotropium, a Novel Muscarinic M3 Receptor Antagonist, Improved Symptoms of Chronic Obstructive Pulmonary Disease Complicated by Chronic Heart Failure
inferredcites →https://doi.org/10.1373/clinchem.2013.216515openalex-snapshot
Quantification of Tau in Cerebrospinal Fluid by Immunoaffinity Enrichment and Tandem Mass Spectrometry
inferredcites →https://doi.org/10.4155/bio.11.119openalex-snapshot
LC–MS/MS Sensitivity Enhancement Using 2D-SCX/RPLC and its Application in the Assessment of Pharmacokinetics of Clonidine in Dried Blood Spots
inferredcites →https://doi.org/10.4155/bio.13.201openalex-snapshot
Case Studies: The Impact of Nonanalyte Components on LC–MS/MS-Based Bioanalysis: Strategies for Identifying and Overcoming Matrix Effects
inferredcites →https://doi.org/10.4155/bio.13.215openalex-snapshot
High-Throughput Bioanalysis of Bile Acids and Their Conjugates Using UHPLC Coupled to HRMS
inferredcites →https://doi.org/10.4155/bio.13.81openalex-snapshot
High-Resolution MS in Regulated Bioanalysis: Where are We Now and Where Do We Go from Here?

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4608356openalex-extracted
Comparative Characterization of Tiotropium and Formoterol Drug Combination in Metered Dose Inhaler and Dry Powder Inhaler for the Treatment of Chronic Obstructive Pulmonary Diseases
inferred← citeshttps://doi.org/10.1002/9781119274315.ch1openalex-snapshot
Basic Sample Preparation Techniques in LC‐MS Bioanalysis
inferred← citeshttps://doi.org/10.1002/9781119413073.ch10openalex-snapshot
Strategies for Improving Sensitivity for Targeted Quantitation by LC–MS
inferred← citeshttps://doi.org/10.1007/s00216-022-04335-6openalex-snapshot
A semi-covalent molecularly imprinted electrochemical sensor for rapid and selective detection of tiotropium bromide
inferred← citeshttps://doi.org/10.1007/s10337-017-3413-0openalex-snapshot
Development and Validation of RP-HPLC Method for Simultaneous Estimation of Tiotropium Bromide, Formoterol Fumarate, and Olodaterol HCl in Bulk and Metered Dose Aerosols: Application to Olodaterol HCl Forced Degradation Study and Degradation Kinetics
inferred← citeshttps://doi.org/10.1007/s11094-022-02591-5openalex-snapshot
Method Development and Validation for Determining Formoterol Fumarate and Tiotropium in Tiomate Transcaps Dry Powder Inhaler
inferred← citeshttps://doi.org/10.1007/s11094-022-02700-4openalex-snapshot
Comparative Evaluation of Fine Particle Fraction and T2 Fraction by Using Next Generation Impactor (NGI) and Glass Twin Impinger (GTI) on Formoterol Fumarate and Tiotropium Dry Powder Inhaler (DPI) Marketed Products
inferred← citeshttps://doi.org/10.1007/s40261-016-0441-8openalex-snapshot
Pharmacokinetic Bioequivalence of Two Inhaled Tiotropium Bromide Formulations in Healthy Volunteers
inferred← citeshttps://doi.org/10.1016/j.jchromb.2017.04.001openalex-snapshot
Quantitation of levodopa and carbidopa in rat plasma by LC–MS/MS: The key role of ion-pairing reversed-phase chromatography
inferred← citeshttps://doi.org/10.1016/j.jpba.2020.113530openalex-snapshot
Liquid chromatography–mass spectrometry method for the quantification of corticosteroids, β2-adrenoreceptor agonists and anticholinergics in human hair
inferred← citeshttps://doi.org/10.1080/03639045.2019.1680993openalex-snapshot
An evaluation of the pharmacokinetics of tiotropium following a single-dose inhalation in healthy subjects using an ultra-sensitive bioanalytical method
inferred← citeshttps://doi.org/10.1177/14690667231217879openalex-snapshot
Simultaneous quantification of tiotropium bromide impurities G + H in capsule formulation by LC-MS/MS
inferred← citeshttps://doi.org/10.4274/tjps.galenos.2021.77177openalex-snapshot
Quantitative Determination of Related Substances in Formoterol Fumarate and Tiotropium in Tiomate Transcaps® Dry Powder Inhaler
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