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mTOR Kinase and the Regulatory Subunit of Protein Kinase A (PRKAR1A) Spatially and Functionally Interact during Autophagosome Maturation

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/0006-291x(71)90086-6openalex-snapshot
Separation of regulatory and catalytic subunits of the cyclic 3′, 5′-adenosine monophosphate-dependent protein kinase(s) of rabbit skeletal muscle
inferredcites →https://doi.org/10.1016/s0891-5849(02)00959-0openalex-snapshot
Lipofuscin: mechanisms of age-related accumulation and influence on cell function12 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.
inferredcites →https://doi.org/10.1038/79238openalex-snapshot
Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex
inferredcites →https://doi.org/10.1078/0171-9335-00433openalex-snapshot
Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material
inferredcites →https://doi.org/10.1091/mbc.11.2.467openalex-snapshot
Rab7: A Key to Lysosome Biogenesis
inferredcites →https://doi.org/10.1093/emboj/19.21.5720openalex-snapshot
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
inferredcites →https://doi.org/10.1093/hmg/ddl239openalex-snapshot
Depletion of type IA regulatory subunit (RIα) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency
inferredcites →https://doi.org/10.1111/j.1749-6632.2002.tb04323.xopenalex-snapshot
Mutations of the Gene Encoding the Protein Kinase A Type I‐α Regulatory Subunit (PRKAR1A) in Patients with the “Complex of Spotty Skin Pigmentation, Myxomas, Endocrine Overactivity, and Schwannomas” (Carney Complex)
inferredcites →https://doi.org/10.1126/science.277.5322.99openalex-snapshot
Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin
inferredcites →https://doi.org/10.1242/jcs.01114openalex-snapshot
Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
inferredcites →https://doi.org/10.1242/jcs.01370openalex-snapshot
Role for Rab7 in maturation of late autophagic vacuoles
inferredcites →https://doi.org/10.1242/jcs.01620openalex-snapshot
The molecular machinery of autophagy: unanswered questions
inferredcites →https://doi.org/10.4161/auto.1.1.1270openalex-snapshot
Maturation of Autophagic Vacuoles in Mammalian Cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4795887openalex-extracted
Cinnamic Acid Improves Skeletal Muscle Hypertrophy and Metabolism Through Activation of Gpr109a/Pka Pathway
inferred← citeshttps://doi.org/10.1002/bies.20705openalex-snapshot
cAMP‐dependent protein kinase A and the dynamics of epithelial cell surface domains: Moving membranes to keep in shape
inferred← citeshttps://doi.org/10.1007/978-1-4419-6382-6_7openalex-snapshot
Protein Kinase A: The Enzyme and Cyclic AMP Signaling
inferred← citeshttps://doi.org/10.1007/s00018-009-0080-9openalex-snapshot
A small GTPase, human Rab32, is required for the formation of autophagic vacuoles under basal conditions
inferred← citeshttps://doi.org/10.1007/s12031-009-9218-3openalex-snapshot
Integrin-Linked Kinase Is Involved in Cocaine Sensitization by Regulating PSD-95 and Synapsin I Expression and GluR1 Ser845 Phosphorylation
inferred← citeshttps://doi.org/10.1007/s12035-017-0630-3openalex-snapshot
Endogenous Expression of ODN-Related Peptides in Astrocytes Contributes to Cell Protection Against Oxidative Stress: Astrocyte-Neuron Crosstalk Relevance for Neuronal Survival
inferred← citeshttps://doi.org/10.1007/s13105-019-00708-1openalex-snapshot
The role of autophagy in brown and beige adipose tissue plasticity
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2025.10.006openalex-snapshot
Autophagy in adipose tissue thermogenic function
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2018.10.020openalex-snapshot
The protein interaction networks of mucolipins and two-pore channels
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.06.108openalex-snapshot
Cordycepin alleviates hepatic lipid accumulation by inducing protective autophagy via PKA/mTOR pathway
inferred← citeshttps://doi.org/10.1016/j.mce.2011.10.006openalex-snapshot
The cAMP pathway and the control of adrenocortical development and growth
inferred← citeshttps://doi.org/10.1016/j.microc.2025.115245openalex-snapshot
A dual-targeted fluorescent probe reveals the changes in the polarity of endosomes and mitochondria during ferroptosis
inferred← citeshttps://doi.org/10.1016/j.molcel.2026.07.027openalex-snapshot
ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology
inferred← citeshttps://doi.org/10.1016/j.phymed.2025.156851openalex-snapshot
Cinnamic acid-GPR109A pathway improves skeletal muscle hypertrophy and metabolism
inferred← citeshttps://doi.org/10.1038/cdd.2016.59openalex-snapshot
A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress
inferred← citeshttps://doi.org/10.1038/cddis.2013.39openalex-snapshot
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis
inferred← citeshttps://doi.org/10.1074/jbc.m113.455782openalex-snapshot
Transforming Growth Factor β Integrates Smad 3 to Mechanistic Target of Rapamycin Complexes to Arrest Deptor Abundance for Glomerular Mesangial Cell Hypertrophy
inferred← citeshttps://doi.org/10.1080/10408360903044068openalex-snapshot
Autophagy: Regulation and role in disease
inferred← citeshttps://doi.org/10.1089/ars.2010.3491openalex-snapshot
Retinoic Acid Induces Autophagosome Maturation Through Redistribution of the Cation-Independent Mannose-6-Phosphate Receptor
inferred← citeshttps://doi.org/10.1093/hmg/ddu265openalex-snapshot
mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD)
inferred← citeshttps://doi.org/10.1111/j.1365-2958.2011.07950.xopenalex-snapshot
Identification of a protein kinase A regulatory subunit from Leishmania having importance in metacyclogenesis through induction of autophagy
inferred← citeshttps://doi.org/10.1124/molpharm.121.000302openalex-snapshot
G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation
inferred← citeshttps://doi.org/10.1126/science.1157535openalex-snapshot
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
inferred← citeshttps://doi.org/10.1128/ec.00088-08openalex-snapshot
TOR1 and TOR2 Have Distinct Locations in Live Cells
inferred← citeshttps://doi.org/10.1128/iai.00101-12openalex-snapshot
Coxiella burnetii Alters Cyclic AMP-Dependent Protein Kinase Signaling during Growth in Macrophages
inferred← citeshttps://doi.org/10.1155/2018/6141902openalex-snapshot
Emerging Role of mTOR Signaling‐Related miRNAs in Cardiovascular Diseases
inferred← citeshttps://doi.org/10.1158/0008-5472.can-08-0064openalex-snapshot
Protein Kinase A Effects of an Expressed PRKAR1A Mutation Associated with Aggressive Tumors
inferred← citeshttps://doi.org/10.1164/rccm.201911-2137ocopenalex-snapshot
Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension Via mTORC1 Signaling
inferred← citeshttps://doi.org/10.1210/jc.2013-3101openalex-snapshot
Follicular Thyroid Cancers Demonstrate Dual Activation of PKA and mTOR as Modeled by Thyroid-Specific Deletion of Prkar1a and Pten in Mice
inferred← citeshttps://doi.org/10.1371/journal.pgen.1000980openalex-snapshot
Cushing's Syndrome and Fetal Features Resurgence in Adrenal Cortex–Specific Prkar1a Knockout Mice
inferred← citeshttps://doi.org/10.1371/journal.pone.0039438openalex-snapshot
Viral FLICE Inhibitory Protein of Rhesus Monkey Rhadinovirus Inhibits Apoptosis by Enhancing Autophagosome Formation
inferred← citeshttps://doi.org/10.14310/horm.2002.1111037openalex-snapshot
Autophagy in aging and in neurodegenerative disorders
inferred← citeshttps://doi.org/10.1517/14728220802555554openalex-snapshot
Autophagy: a target for therapeutic interventions in myocardial pathophysiology
inferred← citeshttps://doi.org/10.21203/rs.3.rs-472876/v1openalex-snapshot
Neuroendocrine Control of Brown Adipocytes: Functions, Beiging, Whitening and Autophagy
inferred← citeshttps://doi.org/10.3390/cancers13153834openalex-snapshot
PRKAR1A and Thyroid Tumors
inferred← citeshttps://doi.org/10.4061/2011/782971openalex-snapshot
Role of cAMP Signaling in the Survival and Infectivity of the Protozoan Parasite,Leishmania donovani
inferred← citeshttps://doi.org/10.70675/7076b966z729fz4200z82dcz22235060a8bdopenalex-snapshot
Rôle de la signalisation PKA dans la zonation de la glande surrénale : modèles génétiques murins et mécanismes post-traductionnels
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