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Ivermectin and COVID-19: Keeping Rigor in Times of Urgency

https://doi.org/10.4269/ajtmh.20-0271
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1 of the 25 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1016/j.ijantimicag.2020.105949 (notice 2024-12-16).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics
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Metabolism and Tissue Residues
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Ivermectin inhibits porcine reproductive and respiratory syndrome virus in cultured porcine alveolar macrophages
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Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin
inferredcites →https://doi.org/10.1016/j.antiviral.2015.12.012openalex-snapshot
Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses
inferredcites →https://doi.org/10.1016/j.antiviral.2020.104760openalex-snapshot
The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer
inferredcites →https://doi.org/10.1016/j.antiviral.2020.104787openalex-snapshot
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
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The blood-brain barrier in systemic inflammation
inferredcites →https://doi.org/10.1016/j.chom.2016.07.004openalex-snapshot
A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection
inferredcites →https://doi.org/10.1016/j.ijantimicag.2020.105949openalex-snapshot
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
inferredcites →https://doi.org/10.1016/j.medmal.2020.03.006openalex-snapshot
No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection
inferredcites →https://doi.org/10.1016/j.pt.2014.07.005openalex-snapshot
Ivermectin: panacea for resource-poor communities?
inferredcites →https://doi.org/10.1016/j.vetpar.2004.11.028openalex-snapshot
Influence of the route of administration on efficacy and tissue distribution of ivermectin in goat
inferredcites →https://doi.org/10.1016/s0006-2952(99)00026-xopenalex-snapshot
HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833
inferredcites →https://doi.org/10.1042/bj20120150openalex-snapshot
Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus
inferredcites →https://doi.org/10.1093/jac/dks147openalex-snapshot
Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug
inferredcites →https://doi.org/10.1128/aac.01089-12openalex-snapshot
Cobicistat Boosts the Intestinal Absorption of Transport Substrates, Including HIV Protease Inhibitors and GS-7340, In Vitro
inferredcites →https://doi.org/10.1148/radiol.2020201187openalex-snapshot
COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features
inferredcites →https://doi.org/10.1177/009127002237994openalex-snapshot
Safety, Tolerability, and Pharmacokinetics of Escalating High Doses of Ivermectin in Healthy Adult Subjects
inferredcites →https://doi.org/10.1186/s12936-017-1801-4openalex-snapshot
Ivermectin to reduce malaria transmission I. Pharmacokinetic and pharmacodynamic considerations regarding efficacy and safety
inferredcites →https://doi.org/10.1371/journal.pntd.0001883openalex-snapshot
Relative Neurotoxicity of Ivermectin and Moxidectin in Mdr1ab (−/−) Mice and Effects on Mammalian GABA(A) Channel Activity
inferredcites →https://doi.org/10.1371/journal.pntd.0003996openalex-snapshot
Selamectin Is the Avermectin with the Best Potential for Buruli Ulcer Treatment
inferredcites →https://doi.org/10.3785/j.issn.1008-9292.2020.03.03openalex-snapshot
[A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19].
inferredcites →https://doi.org/10.4269/ajtmh.17-0042openalex-snapshot
Serious Neurological Adverse Events after Ivermectin—Do They Occur beyond the Indication of Onchocerciasis?
inferredcites →https://doi.org/10.4269/ajtmh.19-0620openalex-snapshot
A Roadmap for the Development of Ivermectin as a Complementary Malaria Vector Control Tool

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Ivermectin as a Repurposed Drug for COVID‐19
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Quantitative proteomics reveals a broad‐spectrum antiviral property of ivermectin, benefiting for COVID‐19 treatment
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An Update on Pharmacological Relevance and Chemical Synthesis of Natural Products and Derivatives with Anti SARS‐CoV‐2 Activity
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Antiviral Drug Ivermectin at Nanomolar Concentrations Inhibits Glycine-Induced Chloride Current in Rat Hippocampal Neurons
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Ivermectin modulated cerebral γ-aminobutyric acid (GABA) and reduced the number of chronic Toxoplasma gondii cysts significantly in the brains of immunocompromised mice
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Current and Emerging Therapies for COVID-19 in Lung Transplantation
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Ivermectin-Induced Clinical Improvement and Alleviation of Significant Symptoms of COVID-19 Outpatients: A Cross-Sectional Study
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Ivermectin: An Anthelmintic, an Insecticide, and Much More
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Continuous high-dose ivermectin appears to be safe in patients with acute myelogenous leukemia and could inform clinical repurposing for COVID-19 infection
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Erythromycin, Retapamulin, Pyridoxine, Folic acid and Ivermectin dose dependently inhibit cytopathic effect, Papain-like Protease and M PRO of SARS-CoV-2
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Research Into Potential Therapies Against COVID-19, With Focus On Ivermectin
inferred← citeshttps://doi.org/10.31219/osf.io/gkeadopenalex-snapshot
Research Into Potential Therapies Against COVID-19, With Focus On Ivermectin
inferred← citeshttps://doi.org/10.31222/osf.io/3whptopenalex-snapshot
Research Into Potential Therapies Against COVID-19, With Focus On Ivermectin
inferred← citeshttps://doi.org/10.3329/imcjms.v14i2.52826openalex-snapshot
Outcome of ivermectin treated mild to moderate COVID-19 cases: a single-centre, open-label, randomised controlled study
inferred← citeshttps://doi.org/10.33320/maced.pharm.bull.2023.69.03.035openalex-snapshot
Development and characterization of ivermectin loaded liposomes prepared by lipid film hydration and ethanol injection method
inferred← citeshttps://doi.org/10.33448/rsd-v10i12.20486openalex-snapshot
Conhecimento sobre o tratamento precoce e as medidas de prevenção da Covid-19 em moradores do Estado do Pará-Brasil
inferred← citeshttps://doi.org/10.33448/rsd-v9i8.6234openalex-snapshot
Ivermectina como possível aliado no tratamento da COVID-19: perspectivas acerca de sua ação antiviral
inferred← citeshttps://doi.org/10.3389/fcimb.2023.1273982openalex-snapshot
Erythromycin, retapamulin, pyridoxine, folic acid, and ivermectin inhibit cytopathic effect, papain-like protease, and MPRO enzymes of SARS-CoV-2
inferred← citeshttps://doi.org/10.3389/fimmu.2021.683694openalex-snapshot
Will Auranofin Become a Golden New Treatment Against COVID-19?
inferred← citeshttps://doi.org/10.3389/fimmu.2021.752227openalex-snapshot
Beyond Vaccines: Clinical Status of Prospective COVID-19 Therapeutics
inferred← citeshttps://doi.org/10.3389/fphar.2021.666348openalex-snapshot
A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients
inferred← citeshttps://doi.org/10.3389/fpubh.2022.788972openalex-snapshot
Ivermectin and the Integrity of Healthcare Evidence During COVID-19
inferred← citeshttps://doi.org/10.3390/antibiotics10040381openalex-snapshot
Repurposing Avermectins and Milbemycins against Mycobacteroides abscessus and Other Nontuberculous Mycobacteria
inferred← citeshttps://doi.org/10.3390/antibiotics14050459openalex-snapshot
Repurposing Anthelmintic Drugs for COVID-19 Treatment: A Comprehensive Meta-Analysis of Randomized Clinical Trials on Ivermectin and Mebendazole
inferred← citeshttps://doi.org/10.3390/biology10101064openalex-snapshot
Human Drug Pollution in the Aquatic System: The Biochemical Responses of Danio rerio Adults
inferred← citeshttps://doi.org/10.3390/chemistry4020019openalex-snapshot
Recent Advances in Influenza, HIV and SARS-CoV-2 Infection Prevention and Drug Treatment—The Need for Precision Medicine
inferred← citeshttps://doi.org/10.3390/covid2010005openalex-snapshot
Low Selectivity Indices of Ivermectin and Macrocyclic Lactones on SARS-CoV-2 Replication In Vitro
inferred← citeshttps://doi.org/10.3390/ijms22041737openalex-snapshot
Understanding Viral Infection Mechanisms and Patient Symptoms for the Development of COVID-19 Therapeutics
inferred← citeshttps://doi.org/10.3390/ijms241612782openalex-snapshot
The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases
inferred← citeshttps://doi.org/10.3390/microorganisms10030633openalex-snapshot
Ivermectin Does Not Protect against SARS-CoV-2 Infection in the Syrian Hamster Model
inferred← citeshttps://doi.org/10.3390/pathogens10060636openalex-snapshot
Fundamental and Advanced Therapies, Vaccine Development against SARS-CoV-2
inferred← citeshttps://doi.org/10.3390/ph13080196openalex-snapshot
Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects
inferred← citeshttps://doi.org/10.3390/pharmaceutics13010081openalex-snapshot
Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters
inferred← citeshttps://doi.org/10.3390/pr8080937openalex-snapshot
The Significance of Natural Product Derivatives and Traditional Medicine for COVID-19
inferred← citeshttps://doi.org/10.34119/bjhrv4n3-053openalex-snapshot
Drogas off label na COVID-19: Mecanismo de ação e atualizações The use of off label drugs for COVID-19: Mechanisms of action and updates
inferred← citeshttps://doi.org/10.34172/ps.2020.82openalex-snapshot
A Summary of Coronavirus Disease 2019: What We Should Know?
inferred← citeshttps://doi.org/10.35366/99417openalex-snapshot
Actualización del manejo clínico de COVID-19 en pediatría: a un año de pandemia
inferred← citeshttps://doi.org/10.35381/s.v.v5i1.1595openalex-snapshot
Ivermectina como alternativa de tratamiento para pacientes COVID-19
inferred← citeshttps://doi.org/10.35587/brj.ed.0001334openalex-snapshot
PROMOÇÃO DE HÁBITOS SAUDÁVEIS DE VIDA PARA HIPERTENSOS USANDO GRUPOS OPERATIVOS, NA ATENÇÃO PRIMÁRIA EM SAÚDE
inferred← citeshttps://doi.org/10.35587/brj.ed.0001336openalex-snapshot
ACOMPANHAMENTO FARMACOTERAPÊUTICO NOS CUIDADOS PALIATIVOS: ASSISTÊNCIA AO PACIENTE PEDIÁTRICO?
inferred← citeshttps://doi.org/10.35839/repis.4.3.747openalex-snapshot
COVID-19 y la “locura” por la ivermectina
inferred← citeshttps://doi.org/10.36829/63cts.v7i3.1002openalex-snapshot
La acelerada búsqueda de candidatos terapéuticos contra SARS-CoV-2, métodos in silico: Revisión
inferred← citeshttps://doi.org/10.36829/63cts.v7i3.976openalex-snapshot
Evidencia disponible sobre el abordaje terapéutico de pacientes con COVID-19: una revisión narrativa
inferred← citeshttps://doi.org/10.36959/577/493openalex-snapshot
Natural Experiments that Allow to Study Potential Drugs in Coronavirus Disease 2019 (COVID-19) from the General Practice Level
inferred← citeshttps://doi.org/10.38137/vetfarmatoksbulten.769889openalex-snapshot
COVID-19 FARMAKOTERAPİSİ
inferred← citeshttps://doi.org/10.4103/ecdt.ecdt_30_21openalex-snapshot
Efficacy of ivermectin in patients with coronavirus disease 2019 pneumonia with severe and critically ill status
inferred← citeshttps://doi.org/10.4103/ijoem.ijoem_460_20openalex-snapshot
COVID-19—Practicing prevention in the workplace
inferred← citeshttps://doi.org/10.4103/mamcjms.mamcjms_77_21openalex-snapshot
Efficacy of Single-Dose Ivermectin on Virologic and Clinical Recovery in COVID-19
inferred← citeshttps://doi.org/10.4103/mjmsr.mjmsr_19_21openalex-snapshot
Drug interactions of ivermectin with a focus on COVID-19 treatment
inferred← citeshttps://doi.org/10.46295/2:1.covrevopenalex-snapshot
The five axes of COVID-19 treatment: attacking the disease from several angles.
inferred← citeshttps://doi.org/10.46912/wjmbs.2openalex-snapshot
As Drugs Assemble to Treat SARS-COV-2, Which Drug will Prove Efficacious : A Search for Suitable Drug or Vaccine to Manage COVID-19 Pandemic
inferred← citeshttps://doi.org/10.47992/ijhsp.2581.6411.0060openalex-snapshot
An Overview of Drugs Used in COVID-19: A Pharmacotherapeutic Approach
inferred← citeshttps://doi.org/10.48550/arxiv.2005.05954openalex-snapshot
COVID-19Base: A knowledgebase to explore biomedical entities related to COVID-19
inferred← citeshttps://doi.org/10.51699/ijbea.v3i1.3296openalex-snapshot
Role of Ivermectin and Colchicine in Treatment of COVID-19: A Randomized Controlled Clinical Trial
inferred← citeshttps://doi.org/10.51723/ccs.v31isuppl1.693openalex-snapshot
Abordagem profilática da nitazoxanida e ivermectina na COVID-19: Sumário de Evidências
inferred← citeshttps://doi.org/10.51891/rease.v7i5.1208openalex-snapshot
TRATAMENTO FARMACOLÓGICO DA COVID-19 À LUZ DAS EVIDÊNCIAS: OS PRINCIPAIS FÁRMACOS, SUAS INDICAÇÕES E SEU MANEJO TERAPÊUTICO, UMA REVISÃO INTEGRATIVA
inferred← citeshttps://doi.org/10.51952/9781447363972.ch012openalex-snapshot
Conducting ethical research in crisis situations: COVID-19
inferred← citeshttps://doi.org/10.52225/narra.v2i3.92openalex-snapshot
A comprehensive review on pharmacologic agents, immunotherapies and supportive therapeutics for COVID-19
inferred← citeshttps://doi.org/10.5377/rmh.v89i1.11577openalex-snapshot
COVID-19 y protocolo MAÍZ como tratamiento profiláctico en Honduras, 2020: Artículo de revisión
inferred← citeshttps://doi.org/10.53854/liim-2903-2openalex-snapshot
Current status of therapeutic alternatives for COVID-19: A narrative review
inferred← citeshttps://doi.org/10.54139/salus.v25i3.125openalex-snapshot
Uso de compuestos potencialmente tóxicos en el contexto de la pandemia por COVID-2019.
inferred← citeshttps://doi.org/10.5530/jppcm.2020.4.19openalex-snapshot
Unapproved Combination Therapy of Doxycycline and Ivermectin in Covid-19 Pandemic, an Opportunistic Chance of Self-medication: A Case Report
inferred← citeshttps://doi.org/10.56687/9781447363972-010openalex-snapshot
Ethical research in public policy
inferred← citeshttps://doi.org/10.61186/jcbior.3.3.172openalex-snapshot
A comprehensive review of novel coronavirus disease 2019 (nCOVID-19) characteristics, diagnosis, treatment, and prevention
inferred← citeshttps://doi.org/10.63845/3gw6kd57openalex-snapshot
COVID-19, ASPECTOS GERAIS E A TRAJETÓRIA DO VÍRUS NO ESTADO DE SANTA CATARINA
inferred← citeshttps://doi.org/10.64461/hjps.v01i01y23.02openalex-snapshot
Comparative clinical management, treatment pattern and medications of COVID-19 practiced at Dhaka city in Bangladesh: a randomized cross-sectional study
inferred← citeshttps://doi.org/10.70675/cf058269z5911z4582z94fezcb6761f74dddopenalex-snapshot
Impact of Listeria monocytogenes on microglia and cerebral homeostasis
inferred← citeshttps://doi.org/10.7322/abcshs.2021069.2004openalex-snapshot
Main aspects and prophylatic measures of COVID-19 in Brazil
inferred← citeshttps://doi.org/10.7759/cureus.26141openalex-snapshot
Ivermectin-Induced Acute Psychosis in Patients Infected With COVID-19 Pneumonia
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