On the public citation graph

A Hypothesis to Explain How the DNA of Elderly People Is Prone to Damage: Genome-Wide Hypomethylation Drives Genomic Instability in the Elderly by Reducing Youth-Associated Gnome-Stabilizing DNA Gaps

https://doi.org/10.5772/intechopen.83372

0 signed · 92 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/anie.201103899openalex-snapshot

The Discovery of 5‐Formylcytosine in Embryonic Stem Cell DNA

inferredcites →https://doi.org/10.1007/s13148-010-0017-zopenalex-snapshot

Epigenetic mechanisms and genome stability

inferredcites →https://doi.org/10.1016/0959-437x(93)90036-oopenalex-snapshot

Regulating the HO endonuclease in yeast

inferredcites →https://doi.org/10.1016/j.bbadis.2015.08.017openalex-snapshot

Sirtuin regulation in aging and injury

inferredcites →https://doi.org/10.1016/j.bbagrm.2009.09.008openalex-snapshot

HMGB proteins: Interactions with DNA and chromatin

inferredcites →https://doi.org/10.1016/j.cell.2011.02.013openalex-snapshot

Hallmarks of Cancer: The Next Generation

inferredcites →https://doi.org/10.1016/j.cell.2011.03.022openalex-snapshot

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

inferredcites →https://doi.org/10.1016/j.cell.2013.05.039openalex-snapshot

The Hallmarks of Aging

inferredcites →https://doi.org/10.1016/j.cell.2015.10.055openalex-snapshot

Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures

inferredcites →https://doi.org/10.1016/j.cub.2004.12.065openalex-snapshot

Yeast Nhp6A/B and Mammalian Hmgb1 Facilitate the Maintenance of Genome Stability

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2007.06.027openalex-snapshot

An epigenetic perspective on the free radical theory of development

inferredcites →https://doi.org/10.1016/j.molcel.2007.06.029openalex-snapshot

HMGB1 Is a Cofactor in Mammalian Base Excision Repair

inferredcites →https://doi.org/10.1016/j.molcel.2007.11.015openalex-snapshot

The DNA Damage Response: Ten Years After

inferredcites →https://doi.org/10.1016/j.molcel.2010.09.019openalex-snapshot

The DNA Damage Response: Making It Safe to Play with Knives

inferredcites →https://doi.org/10.1016/j.mrfmmm.2014.11.009openalex-snapshot

DNA damage in non-communicable diseases: A clinical and epidemiological perspective

inferredcites →https://doi.org/10.1016/j.mrfmmm.2016.02.009openalex-snapshot

Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart

inferredcites →https://doi.org/10.1016/j.mrrev.2015.07.001openalex-snapshot

Persistent γH2AX: A promising molecular marker of DNA damage and aging

inferredcites →https://doi.org/10.1016/j.tig.2007.11.004openalex-snapshot

Age to survive: DNA damage and aging

inferredcites →https://doi.org/10.1016/s0165-4608(98)00143-5openalex-snapshot

Frequent Hypomethylation in Wilms Tumors of Pericentromeric DNA in Chromosomes 1 and 16

inferredcites →https://doi.org/10.1016/s1476-5586(03)80039-8openalex-snapshot

Exceptionally High Protection of Photocarcinogenesis by Topical Application of (-)-Epi gal locatechin-3-Gal late in Hydrophilic Cream in SKH-1 Hairless Mouse Model: Relationship to Inhibition of UVB-Induced Global DNA Hypomethylation

inferredcites →https://doi.org/10.1038/25779openalex-snapshot

DNA hypomethylation leads to elevated mutation rates

inferredcites →https://doi.org/10.1038/46052openalex-snapshot

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

inferredcites →https://doi.org/10.1038/nature03001openalex-snapshot

Finishing the euchromatic sequence of the human genome

inferredcites →https://doi.org/10.1038/nature05456openalex-snapshot

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

inferredcites →https://doi.org/10.1038/sj.onc.1208137openalex-snapshot

Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis

inferredcites →https://doi.org/10.1038/srep15971openalex-snapshot

Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia

inferredcites →https://doi.org/10.1042/bj2980415openalex-snapshot

Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism

inferredcites →https://doi.org/10.1073/pnas.011506198openalex-snapshot

The Sir2 protein family: A novel deacetylase for gene silencing and more

inferredcites →https://doi.org/10.1073/pnas.94.6.2545openalex-snapshot

DNA methylation and genetic instability in colorectal cancer cells

inferredcites →https://doi.org/10.1080/10715760600953859openalex-snapshot

Clinical oxidation parameters of aging

inferredcites →https://doi.org/10.1093/emboj/16.10.2656openalex-snapshot

Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double‐strand breaks

inferredcites →https://doi.org/10.1093/mutage/geh025openalex-snapshot

Endogenous DNA damage in humans: a review of quantitative data

inferredcites →https://doi.org/10.1093/nar/gkm756openalex-snapshot

Changes in DNA repair during aging

inferredcites →https://doi.org/10.1093/nar/gkn261openalex-snapshot

LINE-1 methylation status of endogenous DNA double-strand breaks

inferredcites →https://doi.org/10.1093/nar/gkn571openalex-snapshot

LINE-1 methylation patterns of different loci in normal and cancerous cells

inferredcites →https://doi.org/10.1093/nar/gkw059openalex-snapshot

An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation

inferredcites →https://doi.org/10.1093/nar/gkw925openalex-snapshot

L1Base 2: more retrotransposition-active LINE-1s, more mammalian genomes

inferredcites →https://doi.org/10.1093/nar/gkx587openalex-snapshot

Prediction of genome-wide DNA methylation in repetitive elements

inferredcites →https://doi.org/10.1096/fj.201800218rropenalex-snapshot

Reduction in replication‐independent endogenous DNA double‐strand breaks promotes genomic instability during chronological aging in yeast

inferredcites →https://doi.org/10.1101/cshperspect.a012716openalex-snapshot

DNA Damage Sensing by the ATM and ATR Kinases

inferredcites →https://doi.org/10.1111/1567-1364.12115openalex-snapshot

Yeast sirtuins and the regulation of aging

inferredcites →https://doi.org/10.1111/bpa.12216openalex-snapshot

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain

inferredcites →https://doi.org/10.1111/j.1753-4887.2008.00070.xopenalex-snapshot

Folate, DNA methylation, and mouse models of breast tumorigenesis

inferredcites →https://doi.org/10.1111/nyas.13533openalex-snapshot

Revisiting the genomic hypomethylation hypothesis of aging

inferredcites →https://doi.org/10.1126/science.1083557openalex-snapshot

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

inferredcites →https://doi.org/10.1126/science.1210597openalex-snapshot

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

inferredcites →https://doi.org/10.1126/science.1210944openalex-snapshot

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

inferredcites →https://doi.org/10.1128/mcb.06147-11openalex-snapshot

SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities

inferredcites →https://doi.org/10.1128/mcb.18.4.2029openalex-snapshot

Structure of Nonhairpin Coding-End DNA Breaks in Cells Undergoing V(D)J Recombination

inferredcites →https://doi.org/10.1152/physiolgenomics.00146.2009openalex-snapshot

Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences

inferredcites →https://doi.org/10.1155/2012/135206openalex-snapshot

Free Radicals and Extrinsic Skin Aging

inferredcites →https://doi.org/10.1158/0008-5472.can-06-2995openalex-snapshot

Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene

inferredcites →https://doi.org/10.1159/000334368openalex-snapshot

Measuring Genome Instability in Aging – A Mini-Review

inferredcites →https://doi.org/10.1186/1471-2164-15-750openalex-snapshot

Characteristics of replication-independent endogenous double-strand breaks in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1186/1476-4598-9-70openalex-snapshot

Replication independent DNA double-strand break retention may prevent genomic instability

inferredcites →https://doi.org/10.1186/s12881-016-0335-xopenalex-snapshot

Association between global leukocyte DNA methylation and cardiovascular risk in postmenopausal women

inferredcites →https://doi.org/10.1186/s12977-018-0442-1openalex-snapshot

Nomenclature for endogenous retrovirus (ERV) loci

inferredcites →https://doi.org/10.1186/s13148-017-0395-6openalex-snapshot

The association between Alu hypomethylation and severity of type 2 diabetes mellitus

inferredcites →https://doi.org/10.1200/jco.2013.51.1055openalex-snapshot

Aging and Risk of Severe, Disabling, Life-Threatening, and Fatal Events in the Childhood Cancer Survivor Study

inferredcites →https://doi.org/10.1371/journal.pone.0015367openalex-snapshot

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

inferredcites →https://doi.org/10.1371/journal.pone.0017934openalex-snapshot

Hypomethylation of Intragenic LINE-1 Represses Transcription in Cancer Cells through AGO2

inferredcites →https://doi.org/10.1371/journal.pone.0037009openalex-snapshot

Long Interspersed Nuclear Element-1 Hypomethylation and Oxidative Stress: Correlation and Bladder Cancer Diagnostic Potential

inferredcites →https://doi.org/10.1371/journal.pone.0045292openalex-snapshot

Patterns and Possible Roles of LINE-1 Methylation Changes in Smoke-Exposed Epithelia

inferredcites →https://doi.org/10.1371/journal.pone.0070386openalex-snapshot

Hypomethylation of Alu Elements in Post-Menopausal Women with Osteoporosis

inferredcites →https://doi.org/10.1371/journal.pone.0072706openalex-snapshot

Replication-Independent Endogenous DNA Double-Strand Breaks in Saccharomyces cerevisiae Model

inferredcites →https://doi.org/10.1371/journal.pone.0120032openalex-snapshot

Higher Alu Methylation Levels in Catch-Up Growth in Twenty-Year-Old Offsprings

inferredcites →https://doi.org/10.1371/journal.pone.0177119openalex-snapshot

EnHERV: Enrichment analysis of specific human endogenous retrovirus patterns and their neighboring genes

inferredcites →https://doi.org/10.18632/oncotarget.13562openalex-snapshot

Whole genome DNA methylation: beyond genes silencing

inferredcites →https://doi.org/10.18632/oncotarget.5899openalex-snapshot

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging

inferredcites →https://doi.org/10.2217/epi-2017-0096openalex-snapshot

Alu siRNA to Increase Alu Element Methylation and Prevent DNA Damage

inferredcites →https://doi.org/10.2217/epi.13.72openalex-snapshot

Epigenetics: The Language of the Cell?

inferredcites →https://doi.org/10.3389/fgene.2018.00501openalex-snapshot

Pathologic Replication-Independent Endogenous DNA Double-Strand Breaks Repair Defect in Chronological Aging Yeast

inferredcites →https://doi.org/10.3389/fonc.2018.00015openalex-snapshot

DNA Damage, Repair, and Cancer Metabolism

inferredcites →https://doi.org/10.3945/an.111.000992openalex-snapshot

Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate's Role

inferredcites →https://doi.org/10.4161/epi.7.2.18764openalex-snapshot

Basic concepts of epigenetics

inferredcites →https://doi.org/10.7150/ijbs.11218openalex-snapshot

DNA Methylation, Its Mediators and Genome Integrity

inferredcites →https://doi.org/10.7314/apjcp.2013.14.9.5495openalex-snapshot

Alu Hypomethylation in Smoke-Exposed Epithelia and Oral Squamous Carcinoma

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4628537openalex-extracted

Changes in Immune Cell Subtypes During Ageingchanges in Immune Cell Subtypes During Ageing

inferred← citeshttps://doi.org/10.1016/j.archger.2024.105376openalex-snapshot

Changes in immune cell subtypes during ageing

inferred← citeshttps://doi.org/10.1016/j.burns.2021.10.002openalex-snapshot

Alu repetitive sequence CpG methylation changes in burn scars

inferred← citeshttps://doi.org/10.1016/j.imbio.2026.153220openalex-snapshot

Changes of systemic immune cells subtypes in colorectal carcinoma patients

inferred← citeshttps://doi.org/10.1101/2024.08.26.609793openalex-snapshot

Immunophenotypic changes in peripheral blood of colorectal cancer patients: a potential diagnostic marker for CD4+ monocytes

inferred← citeshttps://doi.org/10.1186/s13148-020-00972-9openalex-snapshot

Altered immune phenotype and DNA methylation in panic disorder

inferred← citeshttps://doi.org/10.2217/epi-2019-0064openalex-snapshot

Is Global Hypomethylation a Nidus for Molecular Pathogenesis of Age-Related Noncommunicable Diseases?

inferred← citeshttps://doi.org/10.31557/apjcp.2022.23.11.3753openalex-snapshot

Upregulation of p16INK4A in Peripheral White Blood Cells as a Novel Screening Marker for Colorectal Carcinoma

inferred← citeshttps://doi.org/10.3389/fcell.2021.802024openalex-snapshot

B1 siRNA Increases de novo DNA Methylation of B1 Elements and Promotes Wound Healing in Diabetic Rats

inferred← citeshttps://doi.org/10.3389/fgene.2019.00580openalex-snapshot

Transposable Elements and Their Epigenetic Regulation in Mental Disorders: Current Evidence in the Field

inferred← citeshttps://doi.org/10.3389/fgene.2019.00645openalex-snapshot

Argonaute 4 as an Effector Protein in RNA-Directed DNA Methylation in Human Cells

inferred← citeshttps://doi.org/10.58837/chula.the.2019.29openalex-snapshot

Argonaute 4 promotes genomic methylation

inferred← citeshttps://doi.org/10.58837/chula.the.2021.21openalex-snapshot

Deprogramming senescence by genomic stabilizing molecules in vivo

inferred← citeshttps://doi.org/10.58837/chula.the.2022.24openalex-snapshot

The role of b1 methylation, physiologic replication independent endogenous dna double strand breaks (phy-rind-edsb) and laminin 511 e8 proteins in rat second degree burn wound healing

inferred← citeshttps://doi.org/10.58837/chula.the.2022.25openalex-snapshot

Senescent white blood cells in colorectal carcinoma patients

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.