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Metabolic pathway competition sensitizes thioredoxin reductase-depleted Candida albicans to cell wall stress and antifungals

https://doi.org/10.64898/2025.12.02.691982

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Mismatch Binding Protein-Based Mutation Detection Systems

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[11] Diamide: An oxidant probe for thiols

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Changes in glutathione-dependent redox status and mitochondrial energetic strategies are part of the adaptive response during the filamentation process in Candida albicans

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Structure, mechanism, and substrate specificity of kynureninase

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2005.11.019openalex-snapshot

Cap1p is involved in multiple pathways of oxidative stress response in Candida albicans

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Redox-based regulation of signal transduction: Principles, pitfalls, and promises

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2014.10.736openalex-snapshot

Changes in glutathione-dependent redox status and mitochondrial energetic strategies are part of the adaptive response during the filamentation process in Candida albicans

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Thoughts on the evolution of Core Environmental Responses in yeasts

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Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement

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Scalar nanostructure of the Candida albicans cell wall; a molecular, cellular and ultrastructural analysis and interpretation

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Anticipatory Stress Responses and Immune Evasion in Fungal Pathogens

inferredcites →https://doi.org/10.1016/s0014-5793(03)01363-2openalex-snapshot

Disruption of γ‐glutamylcysteine synthetase results in absolute glutathione auxotrophy and apoptosis in Candida albicans

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UDP-glucose pyrophosphorylase. Stereochemical course of the reaction of glucose 1-phosphate with uridine-5'[1-thiotriphosphate].

inferredcites →https://doi.org/10.1016/s0021-9258(18)47038-xopenalex-snapshot

Thioredoxin-dependent peroxide reductase from yeast.

inferredcites →https://doi.org/10.1016/s0092-8674(00)80358-xopenalex-snapshot

Nonfilamentous C. albicans Mutants Are Avirulent

inferredcites →https://doi.org/10.1021/acs.jproteome.5c00137openalex-snapshot

Integrative Phosphoproteomic and Proteomic Analysis of Candida albicans Exposed to Oxidative Stress

inferredcites →https://doi.org/10.1021/acsinfecdis.8b00026openalex-snapshot

Chemical Warfare at the Microorganismal Level: A Closer Look at the Superoxide Dismutase Enzymes of Pathogens

inferredcites →https://doi.org/10.1038/nbt0709-604openalex-snapshot

Metabolic reconfiguration precedes transcriptional regulation in the antioxidant response

inferredcites →https://doi.org/10.1038/nprot.2012.024openalex-snapshot

A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

inferredcites →https://doi.org/10.1038/s41467-025-61678-1openalex-snapshot

Distinct echinocandin responses of Candida albicans and Candida auris cell walls revealed by solid-state NMR

inferredcites →https://doi.org/10.1038/s42255-023-00863-2openalex-snapshot

The pentose phosphate pathway in health and disease

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Redox-dependent Regulation of Gluconeogenesis by a Novel Mechanism Mediated by a Peroxidatic Cysteine of Peroxiredoxin

inferredcites →https://doi.org/10.1042/bj1380425openalex-snapshot

Regulation of the pentose phosphate cycle

inferredcites →https://doi.org/10.1042/bj20030414openalex-snapshot

Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1073/pnas.0407097102openalex-snapshot

A contact-activated kinase signals Candida albicans invasive growth and biofilm development

inferredcites →https://doi.org/10.1073/pnas.0809147105openalex-snapshot

The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferation

inferredcites →https://doi.org/10.1073/pnas.1504022112openalex-snapshot

Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis

inferredcites →https://doi.org/10.1073/pnas.2020484118openalex-snapshot

Immune cells fold and damage fungal hyphae

inferredcites →https://doi.org/10.1073/pnas.2023328119openalex-snapshot

Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome

inferredcites →https://doi.org/10.1073/pnas.94.8.3621openalex-snapshot

The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

inferredcites →https://doi.org/10.1074/jbc.274.12.7695openalex-snapshot

New Thioredoxins and Glutaredoxins as Electron Donors of 3′-Phosphoadenylylsulfate Reductase

inferredcites →https://doi.org/10.1091/mbc.e04-03-0181openalex-snapshot

A Conserved Stress-activated Protein Kinase Regulates a Core Stress Response in the Human Pathogen Candida albicans

inferredcites →https://doi.org/10.1093/cid/civ1194openalex-snapshot

Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America

inferredcites →https://doi.org/10.1093/emboj/20.17.4742openalex-snapshot

NRG1 represses yeast–hypha morphogenesis and hypha‐specific gene expression in Candida albicans

inferredcites →https://doi.org/10.1093/emboj/20.17.4753openalex-snapshot

NRG1, a repressor of filamentous growth in C.albicans, is down‐regulated during filament induction

inferredcites →https://doi.org/10.1093/infdis/154.1.76openalex-snapshot

Amphotericin B-Induced Oxidative Damage and Killing of Candida albicans

inferredcites →https://doi.org/10.1093/jac/dkp407openalex-snapshot

Fluconazole at subinhibitory concentrations induces the oxidative- and nitrosative-responsive genes TRR1, GRE2 and YHB1, and enhances the resistance of Candida albicans to phagocytes

inferredcites →https://doi.org/10.1099/00221287-144-2-411openalex-snapshot

A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicans

inferredcites →https://doi.org/10.1099/mic.0.045054-0openalex-snapshot

Glutathione biosynthesis in the yeast pathogens Candida glabrata and Candida albicans: essential in C. glabrata, and essential for virulence in C. albicans

inferredcites →https://doi.org/10.1099/mic.0.28038-0openalex-snapshot

The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans

inferredcites →https://doi.org/10.1099/mic.0.28616-0openalex-snapshot

The MAP kinase signal transduction network in Candida albicans

inferredcites →https://doi.org/10.1111/j.1365-2958.2005.04771.xopenalex-snapshot

The moonlighting protein Tsa1p is implicated in oxidative stress response and in cell wall biogenesis in Candida albicans

inferredcites →https://doi.org/10.1111/j.1432-1033.1995.520_2.xopenalex-snapshot

Genetic and Biochemical Characterization of the UGP1 Gene Encoding the UDP‐Glucose Pyrophosphorylase from Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1111/j.1462-5822.2012.01813.xopenalex-snapshot

Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen

inferredcites →https://doi.org/10.1111/j.1742-4658.2009.06985.xopenalex-snapshot

Typical 2‐Cys peroxiredoxins – structures, mechanisms and functions

inferredcites →https://doi.org/10.1126/science.6322306openalex-snapshot

Entamoeba histolytica : a Eukaryote Without Glutathione Metabolism

inferredcites →https://doi.org/10.1128/aac.03570-14openalex-snapshot

The Production of Reactive Oxygen Species Is a Universal Action Mechanism of Amphotericin B against Pathogenic Yeasts and Contributes to the Fungicidal Effect of This Drug

inferredcites →https://doi.org/10.1128/ec.00171-12openalex-snapshot

Physiologic Expression of the Candida albicans Pescadillo Homolog Is Required for Virulence in a Murine Model of Hematogenously Disseminated Candidiasis

inferredcites →https://doi.org/10.1128/ec.00278-12openalex-snapshot

Surface Stress Induces a Conserved Cell Wall Stress Response in the Pathogenic Fungus Candida albicans

inferredcites →https://doi.org/10.1128/ec.4.2.487-489.2005openalex-snapshot

Thioredoxin Reductase Is Essential for Viability in the Fungal Pathogen Cryptococcus neoformans

inferredcites →https://doi.org/10.1128/mbio.00414-23openalex-snapshot

CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from Aspergillus nidulans reveals key conformations for activity regulation and function

inferredcites →https://doi.org/10.1128/mbio.00986-15openalex-snapshot

Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance

inferredcites →https://doi.org/10.1128/mbio.03225-19openalex-snapshot

Phosphoric Metabolites Link Phosphate Import and Polysaccharide Biosynthesis for Candida albicans Cell Wall Maintenance

inferredcites →https://doi.org/10.1128/mcb.00313-10openalex-snapshot

Thioredoxin Regulates Multiple Hydrogen Peroxide-Induced Signaling Pathways in Candida albicans

inferredcites →https://doi.org/10.1186/jbiol61openalex-snapshot

Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

inferredcites →https://doi.org/10.1371/journal.pgen.1011455openalex-snapshot

Candida albicans pathways that protect against organic peroxides and lipid peroxidation

inferredcites →https://doi.org/10.1371/journal.pone.0001092openalex-snapshot

Biosynthesis of Vitamin C by Yeast Leads to Increased Stress Resistance

inferredcites →https://doi.org/10.1371/journal.pone.0097774openalex-snapshot

Genetic and Metabolomic Dissection of the Ergothioneine and Selenoneine Biosynthetic Pathway in the Fission Yeast, S. pombe, and Construction of an Overproduction System

inferredcites →https://doi.org/10.1371/journal.pone.0126940openalex-snapshot

Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicans

inferredcites →https://doi.org/10.1371/journal.ppat.1000040openalex-snapshot

Stimulation of Chitin Synthesis Rescues Candida albicans from Echinocandins

inferredcites →https://doi.org/10.1371/journal.ppat.1005295openalex-snapshot

SOD Enzymes and Microbial Pathogens: Surviving the Oxidative Storm of Infection

inferredcites →https://doi.org/10.1371/journal.ppat.1010089openalex-snapshot

Stress- and metabolic responses of Candida albicans require Tor1 kinase N-terminal HEAT repeats

inferredcites →https://doi.org/10.1371/journal.ppat.1012314openalex-snapshot

Stress contingent changes in Hog1 pathway architecture and regulation in Candida albicans

inferredcites →https://doi.org/10.3389/fcimb.2019.00261openalex-snapshot

Stress-Activated Protein Kinases in Human Fungal Pathogens

inferredcites →https://doi.org/10.3389/fmicb.2020.01383openalex-snapshot

The Essential Thioredoxin Reductase of the Human Pathogenic Mold Aspergillus fumigatus Is a Promising Antifungal Target

inferredcites →https://doi.org/10.3389/fmicb.2021.663481openalex-snapshot

Thioredoxin Reductase Is a Valid Target for Antimicrobial Therapeutic Development Against Gram-Positive Bacteria

inferredcites →https://doi.org/10.3389/frabi.2023.1179354openalex-snapshot

Gold complex compounds that inhibit drug-resistant Staphylococcus aureus by targeting thioredoxin reductase

inferredcites →https://doi.org/10.3390/biom5010142openalex-snapshot

Oxidative Stress Responses in the Human Fungal Pathogen, Candida albicans

inferredcites →https://doi.org/10.5897/ajmr11.1295openalex-snapshot

Candida albicans TRR1 heterozygotes show increased sensitivity to oxidative stress and decreased pathogenicity

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.64898/2025.12.23.696271openalex-snapshot

Oxidative Stress-Responsive Cell Wall Remodeling Depends on Phosphate in Candida albicans

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