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The sequence context of RG/RGG motifs determines condensate formation, transportin-1 binding and chaperoning

https://doi.org/10.64898/2026.01.26.701751
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Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
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Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites
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Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation
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FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions
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The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors
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Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II
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ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function
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TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics
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RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43
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RNA modulates physiological and neuropathological protein phase transitions
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The Role of Proline and Glycine in Determining the Backbone Flexibility of a Channel-Forming Peptide
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Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases
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Arginine methylation next to the PY‐NLS modulates Transportin binding and nuclear import of FUS
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FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion
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Phase transitions in the assembly of multivalent signalling proteins
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Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
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Integrated molecular analysis of clear-cell renal cell carcinoma
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Intrinsically disordered proteins in cellular signalling and regulation
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Structure-based design of a pathway-specific nuclear import inhibitor
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Liquid–liquid phase separation in human health and diseases
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Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains
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Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
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Molecular basis of C9orf72 poly-PR interference with the β-karyopherin family of nuclear transport receptors
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Conformational Entropy of Intrinsically Disordered Proteins from Amino Acid Triads
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Arginine side chain interactions and the role of arginine as a gating charge carrier in voltage sensitive ion channels
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Revisiting sulfur H-bonds in proteins: The example of peroxiredoxin AhpE
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FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription
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Structural and energetic basis of ALS-causing mutations in the atypical proline–tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS)
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Self-assembled FUS binds active chromatin and regulates gene transcription
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FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP
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Nonclassical nuclear localization signals mediate nuclear import of CIRBP
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Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior
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Prediction of phase-separation propensities of disordered proteins from sequence
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Reconstitution of HIV-1 Rev nuclear export: Independent requirements for nuclear import and export
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Cation-π interactions in structural biology
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Phase separation drives decision making in cell division
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The molecular language of membraneless organelles
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The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization
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Improving protein disorder prediction by deep bidirectional long short-term memory recurrent neural networks
inferredcites →https://doi.org/10.1093/hmg/ddr448openalex-snapshot
Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations
inferredcites →https://doi.org/10.1093/nar/gkx460openalex-snapshot
Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding
inferredcites →https://doi.org/10.1110/ps.073002307openalex-snapshot
Models of S/π interactions in protein structures: Comparison of the H2S–benzene complex with PDB data
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CHAINS OF ALTERNATING SULFUR AND π‐BONDED ATOMS IN EIGHT SMALL PROTEINS
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Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
inferredcites →https://doi.org/10.1146/annurev-genet-112618-043527openalex-snapshot
Liquid–Liquid Phase Separation in Disease
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The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response
inferredcites →https://doi.org/10.1186/s12964-015-0125-7openalex-snapshot
Phase separation in biology; functional organization of a higher order
inferredcites →https://doi.org/10.1371/journal.pgen.1003895openalex-snapshot
ALS-Associated FUS Mutations Result in Compromised FUS Alternative Splicing and Autoregulation
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Landscape of nuclear transport receptor cargo specificity
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A Quantitative Assay to Measure Stress Granule Association of Proteins and Peptides in Semi-permeabilized Human Cells
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Dysregulation of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis
inferredcites →https://doi.org/10.3390/e21070662openalex-snapshot
Entropy and Information within Intrinsically Disordered Protein Regions
inferredcites →https://doi.org/10.3390/molecules24081622openalex-snapshot
Fused in Sarcoma: Properties, Self-Assembly and Correlation with Neurodegenerative Diseases
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RGG motif proteins: Modulators of mRNA functional states
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Extensive cargo identification reveals distinct biological roles of the 12 importin pathways
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Pi-Pi contacts are an overlooked protein feature relevant to phase separation
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