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An Inositol Receptor Orchestrates Carbon Utilization and Fungal Virulence

https://doi.org/10.64898/2026.03.02.708983

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Cryptococcal meningitis in HIV-infected patients

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The Human Fungal Pathogen Cryptococcus Can Complete Its Sexual Cycle during a Pathogenic Association with Plants

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Expulsion of Live Pathogenic Yeast by Macrophages

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Phagosome Extrusion and Host-Cell Survival after Cryptococcus neoformans Phagocytosis by Macrophages

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Concurrent knock‐out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae

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Dual control of inositol transport in Saccharomyces cerevisiae by irreversible inactivation of permease and regulation of permease synthesis by INO2, INO4, and OPI1.

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Glucose repression in yeast

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Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis

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Structural basis for Mep2 ammonium transceptor activation by phosphorylation

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Single nucleotide polymorphisms are associated with strain-specific virulence differences among clinical isolates of Cryptococcus neoformans

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Highly accurate protein structure prediction with AlphaFold

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Treatment of Cryptococcal Meningitis Associated with the Acquired Immunodeficiency Syndrome

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Timing of Antiretroviral Therapy after Diagnosis of Cryptococcal Meningitis

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Glucose sensing and signaling in Saccharomyces cerevisiae through the Rgt2 glucose sensor and casein kinase I

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Capsule of Cryptococcus neoformans grows by enlargement of polysaccharide molecules

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Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages

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Does amoeboid reasoning explain the evolution and maintenance of virulence factors in Cryptococcus neoformans ?

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Regulation of Inositol Transport in Saccharomyces cerevisiae Involves Inositol-induced Changes in Permease Stability and Endocytic Degradation in the Vacuole

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Cryptococcus neoformans Activates RhoGTPase Proteins Followed by Protein Kinase C, Focal Adhesion Kinase, and Ezrin to Promote Traversal across the Blood-Brain Barrier

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Inositol transport in Saccharomyces cerevisiae is regulated by transcriptional and degradative endocytic mechanisms during the growth cycle that are distinct from inositol-induced regulation.

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Specialization of the HOG Pathway and Its Impact on Differentiation and Virulence ofCryptococcus neoformans

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G Protein-coupled Receptor Gpr4 Senses Amino Acids and Activates the cAMP-PKA Pathway in Cryptococcus neoformans

inferredcites →https://doi.org/10.1091/mbc.e08-01-0033openalex-snapshot

A Mep2-dependent Transcriptional Profile Links Permease Function to Gene Expression during Pseudohyphal Growth inSaccharomyces cerevisiae

inferredcites →https://doi.org/10.1091/mbc.e15-07-0487openalex-snapshot

Phosphatidylserine translocation at the yeasttrans-Golgi network regulates protein sorting into exocytic vesicles

inferredcites →https://doi.org/10.1093/emboj/17.5.1236openalex-snapshot

The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1093/femsyr/fov068openalex-snapshot

Glucose repression in Saccharomyces cerevisiae

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INOSITOL MUTANTS OF SACCHAROMYCES CEREVISIAE: MAPPING THE ino1 LOCUS AND CHARACTERIZING ALLELES OF THE ino1, ino2 AND ino4 LOCI

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A PCR-based strategy to generate integrative targeting alleles with large regions of homology

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Strategies for acquiring the phospholipid metabolite inositol in pathogenic bacteria, fungi and protozoa: making it and taking it

inferredcites →https://doi.org/10.1099/mic.0.26644-0openalex-snapshot

High-affinity myo-inositol transport in Candida albicans: substrate specificity and pharmacology

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Cryptococcus neoformans mating and virulence are regulated by the G-protein α subunit GPA1 and cAMP

inferredcites →https://doi.org/10.1111/j.1365-2958.2010.07511.xopenalex-snapshot

Evidence for branching in cryptococcal capsular polysaccharides and consequences on its biological activity

inferredcites →https://doi.org/10.1111/j.1462-5822.2008.01172.xopenalex-snapshot

Invasion ofCryptococcus neoformansinto human brain microvascular endothelial cells requires protein kinase C-α activation

inferredcites →https://doi.org/10.1128/aem.01018-16openalex-snapshot

Metabolism of myo -Inositol by Legionella pneumophila Promotes Infection of Amoebae and Macrophages

inferredcites →https://doi.org/10.1128/ec.00004-11openalex-snapshot

The F-Box Protein Fbp1 Regulates Sexual Reproduction and Virulence in Cryptococcus neoformans

inferredcites →https://doi.org/10.1128/ec.00327-10openalex-snapshot

Two Major Inositol Transporters and Their Role in Cryptococcal Virulence

inferredcites →https://doi.org/10.1128/ec.00378-07openalex-snapshot

Cryptococcus neoformans Capsular Polysaccharide and Exopolysaccharide Fractions Manifest Physical, Chemical, and Antigenic Differences

inferredcites →https://doi.org/10.1128/ec.3.1.221-231.2004openalex-snapshot

Regulatory Network Connecting Two Glucose Signal Transduction Pathways in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1128/iai.00585-24openalex-snapshot

The hypervirulent Type-1/Type-17 phenotype of Cryptococcus neoformans clinical isolates is specific to A/J mice

inferredcites →https://doi.org/10.1128/iai.00994-13openalex-snapshot

Fbp1-Mediated Ubiquitin-Proteasome Pathway Controls Cryptococcus neoformans Virulence by Regulating Fungal Intracellular Growth in Macrophages

inferredcites →https://doi.org/10.1128/iai.01514-07openalex-snapshot

Candida albicans Uses Multiple Mechanisms To Acquire the Essential Metabolite Inositol during Infection

inferredcites →https://doi.org/10.1128/iai.68.2.443-448.2000openalex-snapshot

Urease as a Virulence Factor in Experimental Cryptococcosis

inferredcites →https://doi.org/10.1128/iai.71.9.4862-4872.2003openalex-snapshot

Cryptococcus neoformansVirulence Is Enhanced after Growth in the Genetically Malleable HostDictyostelium discoideum

inferredcites →https://doi.org/10.1128/mbio.00084-10openalex-snapshot

Role of an Expanded Inositol Transporter Repertoire in Cryptococcus neoformans Sexual Reproduction and Virulence

inferredcites →https://doi.org/10.1128/mbio.00567-21openalex-snapshot

Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence

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Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans Infection

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The F-Box Protein Fbp1 Shapes the Immunogenic Potential of Cryptococcus neoformans

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A Heat-Killed Cryptococcus Mutant Strain Induces Host Protection against Multiple Invasive Mycoses in a Murine Vaccine Model

inferredcites →https://doi.org/10.1128/mbio.02313-21openalex-snapshot

Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System

inferredcites →https://doi.org/10.1128/mbio.02790-21openalex-snapshot

Inositol Metabolism Regulates Capsule Structure and Virulence in the Human Pathogen Cryptococcus neoformans

inferredcites →https://doi.org/10.1128/mcb.18.11.6273openalex-snapshot

Snf1 Protein Kinase Regulates Phosphorylation of the Mig1 Repressor in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1128/mmbr.62.2.334-361.1998openalex-snapshot

Yeast Carbon Catabolite Repression

inferredcites →https://doi.org/10.1128/mmbr.70.1.253-282.2006openalex-snapshot

Glucose Signaling in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1128/msphere.00080-15openalex-snapshot

The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans

inferredcites →https://doi.org/10.1146/annurev.micro.62.081307.162753openalex-snapshot

How Sweet it is! Cell Wall Biogenesis and Polysaccharide Capsule Formation in Cryptococcus neoformans

inferredcites →https://doi.org/10.1172/jci112000openalex-snapshot

Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide.

inferredcites →https://doi.org/10.1186/gb-2010-11-10-r106openalex-snapshot

Differential expression analysis for sequence count data

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The Glucose Sensor-Like Protein Hxs1 Is a High-Affinity Glucose Transporter and Required for Virulence in Cryptococcus neoformans

inferredcites →https://doi.org/10.1371/journal.pone.0085533openalex-snapshot

Analysis of Dictyostelium discoideum Inositol Pyrophosphate Metabolism by Gel Electrophoresis

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Cryptococcus and Beyond—Inositol Utilization and Its Implications for the Emergence of Fungal Virulence

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Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier

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Cocaine Hijacks σ1 Receptor to Initiate Induction of Activated Leukocyte Cell Adhesion Molecule: Implication for Increased Monocyte Adhesion and Migration in the CNS

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SNF1/AMPK pathways in yeast

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