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An in silico analysis reveals eutherian NLRP3 is distinguished by conserved regulatory features absent in non-eutherian NLRP3-like proteins

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Outgoing claims: the papers this work cites, builds on, or argues with.

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UCSF ChimeraX : Tools for structure building and analysis
inferredcites →https://doi.org/10.1007/s00239-014-9614-3openalex-snapshot
The Evolution of Reproduction-Related NLRP Genes
inferredcites →https://doi.org/10.1016/j.cell.2021.11.011openalex-snapshot
NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation
inferredcites →https://doi.org/10.1016/j.cell.2021.12.016openalex-snapshot
Adipose-tissue plasticity in health and disease
inferredcites →https://doi.org/10.1016/j.cell.2023.04.025openalex-snapshot
A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases
inferredcites →https://doi.org/10.1016/j.celrep.2024.114070openalex-snapshot
NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation
inferredcites →https://doi.org/10.1016/j.celrep.2024.114609openalex-snapshot
FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation
inferredcites →https://doi.org/10.1016/j.immuni.2012.06.013openalex-snapshot
Cell Volume Regulation Modulates NLRP3 Inflammasome Activation
inferredcites →https://doi.org/10.1016/j.immuni.2013.02.006openalex-snapshot
Cell Swelling and the NLRP3 Inflammasome
inferredcites →https://doi.org/10.1016/j.immuni.2013.05.016openalex-snapshot
K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
inferredcites →https://doi.org/10.1016/j.immuni.2016.01.012openalex-snapshot
Human Monocytes Engage an Alternative Inflammasome Pathway
inferredcites →https://doi.org/10.1016/j.immuni.2016.08.010openalex-snapshot
K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria
inferredcites →https://doi.org/10.1016/j.jbc.2024.107386openalex-snapshot
Post-translational control of NLRP3 inflammasome signaling
inferredcites →https://doi.org/10.1016/j.molcel.2024.08.001openalex-snapshot
Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation
inferredcites →https://doi.org/10.1016/s0021-9258(17)36591-2openalex-snapshot
Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.
inferredcites →https://doi.org/10.1038/nature08938openalex-snapshot
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
inferredcites →https://doi.org/10.1038/nature10291openalex-snapshot
A Jurassic eutherian mammal and divergence of marsupials and placentals
inferredcites →https://doi.org/10.1038/nature11729openalex-snapshot
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
inferredcites →https://doi.org/10.1038/nature16959openalex-snapshot
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
inferredcites →https://doi.org/10.1038/ni.1935openalex-snapshot
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
inferredcites →https://doi.org/10.1038/nm.2279openalex-snapshot
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
inferredcites →https://doi.org/10.1038/nri.2016.58openalex-snapshot
Inflammasomes: mechanism of assembly, regulation and signalling
inferredcites →https://doi.org/10.1038/s41422-025-01096-6openalex-snapshot
Signal-induced NLRP3 phase separation initiates inflammasome activation
inferredcites →https://doi.org/10.1038/s41423-022-00922-wopenalex-snapshot
How location and cellular signaling combine to activate the NLRP3 inflammasome
inferredcites →https://doi.org/10.1038/s41423-025-01358-8openalex-snapshot
IL-1 family cytokines in inflammation and immunity
inferredcites →https://doi.org/10.1038/s41467-024-45396-8openalex-snapshot
Structural basis for the oligomerization-facilitated NLRP3 activation
inferredcites →https://doi.org/10.1038/s41586-018-0761-3openalex-snapshot
PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
inferredcites →https://doi.org/10.1038/s41586-019-1295-zopenalex-snapshot
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
inferredcites →https://doi.org/10.1038/s41586-022-04467-wopenalex-snapshot
Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
inferredcites →https://doi.org/10.1038/s41586-022-05570-8openalex-snapshot
Cryo-EM structures of the active NLRP3 inflammasome disc
inferredcites →https://doi.org/10.1042/bcj20190472openalex-snapshot
The NLRP3 inflammasome regulates adipose tissue metabolism
inferredcites →https://doi.org/10.1042/bst20241738openalex-snapshot
Greasing the wheels of inflammasome formation: regulation of NLRP3 function by S-linked fatty acids
inferredcites →https://doi.org/10.1073/pnas.1701129114openalex-snapshot
Embryo implantation evolved from an ancestral inflammatory attachment reaction
inferredcites →https://doi.org/10.1073/pnas.1809046116openalex-snapshot
Nutrition, the visceral immune system, and the evolutionary origins of pathogenic obesity
inferredcites →https://doi.org/10.1073/pnas.2121353119openalex-snapshot
Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation
inferredcites →https://doi.org/10.1093/bioinformatics/btp033openalex-snapshot
Jalview Version 2—a multiple sequence alignment editor and analysis workbench
inferredcites →https://doi.org/10.1093/gbe/evae138openalex-snapshot
Unanticipated Loss of Inflammasomes in Birds
inferredcites →https://doi.org/10.1093/molbev/mst010openalex-snapshot
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
inferredcites →https://doi.org/10.1093/oso/9780199535033.003.0071openalex-snapshot
Placental mammals (Eutheria)
inferredcites →https://doi.org/10.1101/2023.07.07.548075openalex-snapshot
Non-decameric NLRP3 forms an MTOC-independent inflammasome
inferredcites →https://doi.org/10.1101/gr.5918807openalex-snapshot
Using genomic data to unravel the root of the placental mammal phylogeny
inferredcites →https://doi.org/10.1126/sciadv.abf4468openalex-snapshot
Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation
inferredcites →https://doi.org/10.1126/science.adg1947openalex-snapshot
Two-stage evolution of mammalian adipose tissue thermogenesis
inferredcites →https://doi.org/10.1146/annurev-immunol-081022-021207openalex-snapshot
Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation
inferredcites →https://doi.org/10.1242/jcs.248344openalex-snapshot
Recent insights into the regulatory networks of NLRP3 inflammasome activation
inferredcites →https://doi.org/10.21203/rs.3.rs-9449872/v1openalex-snapshot
Structure of zebrafish NLRP3 reveals a novel mode of inflammasome activation
inferredcites →https://doi.org/10.24272/j.issn.2095-8137.2024.409openalex-snapshot
Palmitoylation-mediated NLRP3 inflammasome activation in teleosts highlights evolutionary divergence in immune regulation
inferredcites →https://doi.org/10.4049/jimmunol.1502060openalex-snapshot
Reassessing the Evolutionary Importance of Inflammasomes
inferredcites →https://doi.org/10.64898/2026.03.12.707678openalex-snapshot
NLRP3 acts as a direct sensor of intracellular potassium ions
inferredcites →https://doi.org/10.7554/elife.94302openalex-snapshot
S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi
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