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Cholesterol and p53 promote senescence and systemic fibrosis in metabolic dysfunction-associated steatohepatitis

https://doi.org/10.64898/2026.09.02.748892

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Outgoing claims: the papers this work cites, builds on, or argues with.

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p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver

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Cholesterol Crystals in Hepatocyte Lipid Droplets Are Strongly Associated With Human Nonalcoholic Steatohepatitis

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Tissue‐specific and age‐dependent effects of global Mdm2 loss

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose

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Hepatic steatosis and respiratory diseases: a new panorama

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Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo

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Senescence of Activated Stellate Cells Limits Liver Fibrosis

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Putting p53 in Context

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GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

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Mechanisms and disease consequences of nonalcoholic fatty liver disease

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Plasma signals of lung tumor promotion for molecular cancer prevention

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Dietary Cholesterol Intake Is Associated With Progression of Liver Disease in Patients With Chronic Hepatitis C: Analysis of the Hepatitis C Antiviral Long-term Treatment Against Cirrhosis Trial

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Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

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Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

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GDF15 suppresses liver inflammation independently of weight loss through neuroendocrine glucocorticoid signaling

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Circulating tumor necrosis factor-related biomarkers predict kidney function decline in Japanese patients with diabetes: An observational cohort study

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Alterations of TP53 are associated with a poor outcome for patients with hepatocellular carcinoma: Evidence from a systematic review and meta-analysis

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Protective role of p53 in acetaminophen hepatotoxicity

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Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma

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p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice

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Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease

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The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis

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EASL–EASD–EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)

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Integrative metabolism in MASLD and MASH: Pathophysiology and emerging mechanisms

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Cellular senescence in liver diseases: From molecular drivers to therapeutic targeting

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EASL position paper on preclinical models of steatotic liver disease

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p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis

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Evidence of sex differences in cellular senescence

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Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities

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Non-alcoholic fatty liver disease

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The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

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Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1)

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Non-alcoholic fatty liver disease and risk of fatal and non-fatal cardiovascular events: an updated systematic review and meta-analysis

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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Regulation of p53 stability by Mdm2

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Hepatic progenitor cells of biliary origin with liver repopulation capacity

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p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl4

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Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network

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Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH

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Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction

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Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ

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NASH limits anti-tumour surveillance in immunotherapy-treated HCC

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Impact of Non-alcoholic Fatty Liver Disease on long-term cardiovascular events and death in Chronic Obstructive Pulmonary Disease

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Gene Expression Predicts Histological Severity and Reveals Distinct Molecular Profiles of Nonalcoholic Fatty Liver Disease

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Urinary growth differentiation factor 15 predicts renal function decline in diabetic kidney disease

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Cholesterol-rich diet exacerbates steatohepatitis in the STAM mouse model

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A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures

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Obesity and hepatocellular carcinoma

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A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis

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Correction for Sakuma et al., Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis

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PTGF-β , a type β transforming growth factor (TGF-β) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-β signaling pathway

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The impact of metabolic dysfunction-associated steatotic liver disease (MASH) on the high risk of cardiovascular disease in CKD: interconnections and management

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Induction of medulloblastomas in p53 -null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum

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Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice

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c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity

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The guardian's choice: how p53 enables context‐specific decision‐making in individual cells

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Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis

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Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological Lesions

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Novel Roles of GDF15 in Alleviating Renal Fibrosis: Promoting Autophagy and Lysosome Biogenesis via Inhibition of the PI3K /Akt/ mTOR Pathway

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Association among circulating erythropoietin‐producing hepatoma A2 , progranulin, and kidney function in individuals with diabetes

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Impact of Metabolic Syndrome Traits on Kidney Disease Risk in Individuals with MASLD : A UK Biobank Study

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Association of metabolic syndrome and chronic kidney disease

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A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo

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Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

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Semaglutide: FDA approves weight loss jab to treat severe liver disease

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Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification

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CXCR2 inhibition enables NASH-HCC immunotherapy

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GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis

inferredcites →https://doi.org/10.1152/ajprenal.00020.2006openalex-snapshot

Upregulation of EphA2 during in vivo and in vitro renal ischemia-reperfusion injury: role of Src kinases

inferredcites →https://doi.org/10.1158/0008-5472.can-14-1446openalex-snapshot

MDM2–p53 Pathway in Hepatocellular Carcinoma

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Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease

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Proteomic profiling of cellular steatosis with concomitant oxidative stress in vitro

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Differing rates of cholesterol absorption among inbred mouse strains yield differing levels of HDL-cholesterol

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Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH

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Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice

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A comprehensive definition for metabolic syndrome

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p53 protects against alcoholic fatty liver disease via ALDH2 inhibition

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GDF15 Promotes Cardiac Fibrosis and Proliferation of Cardiac Fibroblasts via the MAPK/ERK1/2 Pathway after Irradiation in Rats

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Circulating TNF Receptors 1 and 2 Predict ESRD in Type 2 Diabetes

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