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A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/1097-0142(19890301)63:5<901::aid-cncr2820630518>3.0.co;2-gopenalex-snapshot
Effects of sodium ascorbate (vitamin C) and 2-methyl-1,4-naphthoquinone (vitamin K3) treatment on human tumor cell growth in vitro. I. Synergism of combined vitamin C and K3 action
inferredcites →https://doi.org/10.1002/1097-0142(19931101)72:9<2638::aid-cncr2820720919>3.0.co;2-nopenalex-snapshot
Linear regressive analysis using prostate-specific antigen doubling time for predicting tumor biology and clinical outcome in prostate cancer
inferredcites →https://doi.org/10.1002/chin.200616260openalex-snapshot
The in vitro and in vivo Antitumor Activity of Vitamin C: K3 Combinations Against Prostate Cancer
inferredcites →https://doi.org/10.1016/j.juro.2006.06.042openalex-snapshot
Vitamins C and K3 Sensitize Human Urothelial Tumors to Gemcitabine
inferredcites →https://doi.org/10.1016/j.urology.2003.11.016openalex-snapshot
Prostate-specific antigen doubling time predicts response to deferred antiandrogen therapy in men with androgen-independent prostate cancer
inferredcites →https://doi.org/10.1016/j.urology.2004.07.019openalex-snapshot
Bone mineral density in patients with prostate cancer without bone metastases treated with intermittent androgen suppression
inferredcites →https://doi.org/10.1016/s0022-5347(01)62625-9openalex-snapshot
Watchful Waiting or Watchful Progression? Prostate Specific Antigen Doubling Times and Clinical Behavior in Patients With Early Untreated Prostate Carcinoma
inferredcites →https://doi.org/10.1016/s0022-5347(17)34863-2openalex-snapshot
Megadose Vitamins in Bladder Cancer: A Double-Blind Clinical Trial
inferredcites →https://doi.org/10.1016/s0090-4295(01)01242-0openalex-snapshot
Early versus late androgen deprivation therapy in metastatic disease
inferredcites →https://doi.org/10.1016/s1569-9056(03)90528-8openalex-snapshot
Prostate specific antigen doubling time predicts response to deferred antiandrogen therapy in men with androgen independent prostate cancer
inferredcites →https://doi.org/10.1038/sj.pcan.4500679openalex-snapshot
Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study
inferredcites →https://doi.org/10.1056/nejmoa041318openalex-snapshot
Docetaxel and Estramustine Compared with Mitoxantrone and Prednisone for Advanced Refractory Prostate Cancer
inferredcites →https://doi.org/10.1080/01913120590951239openalex-snapshot
Cell Death by Autoschizis in TRAMP Prostate Carcinoma Cells as a Result of Treatment by Ascorbate: Menadione Combination
inferredcites →https://doi.org/10.1097/00005392-199810000-00127openalex-snapshot
Watchful Waiting or Watchful Progression? Prostate Specific Antigen Doubling Times and Clinical Behavior in Patients With Early Untreated Prostate Carcinoma
inferredcites →https://doi.org/10.1097/01.ju.0000141845.99899.12openalex-snapshot
PROSTATE SPECIFIC ANTIGEN DOUBLING TIME AS A SURROGATE END POINT FOR PROSTATE CANCER SPECIFIC MORTALITY FOLLOWING RADICAL PROSTATECTOMY OR RADIATION THERAPY
inferredcites →https://doi.org/10.1177/1534735404273861openalex-snapshot
Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years Later
inferredcites →https://doi.org/10.1385/mo:20:1:45openalex-snapshot
Serum Markers Variation Consistent with Autoschizis Induced by Ascorbic Acid-Menadione in Patients with Prostate Cancer
inferredcites →https://doi.org/10.7326/0003-4819-140-7-200404060-00010openalex-snapshot
Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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In Vitro Investigation of Vitamin K3 and Doxorubicin Administration Regimens for Anticancer Activity in Free and Liposomal Forms
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Vitamin K: A novel cancer chemosensitizer
inferred← citeshttps://doi.org/10.1007/s00432-021-03759-4openalex-snapshot
Clinical efficacy and safety of oral and intravenous vitamin C use in patients with malignant diseases
inferred← citeshttps://doi.org/10.1007/s10973-015-4575-3openalex-snapshot
Thermal and spectral properties of alkali metal complexes of vitamin K3 analogue phthiocol
inferred← citeshttps://doi.org/10.1007/s11010-015-2485-0openalex-snapshot
Differential behaviors of trastuzumab-sensitive and -resistant SKBR3 cells treated with menadione reveal the involvement of Notch1/Akt/FOXO1 signaling elements
inferred← citeshttps://doi.org/10.1007/s11626-015-9961-4openalex-snapshot
Augmentation of oxidative stress-induced apoptosis in MCF7 cells by ascorbate–tamoxifen and/or ascorbate–juglone treatments
inferred← citeshttps://doi.org/10.1007/s12094-024-03553-xopenalex-snapshot
High-dose vitamin C as a metabolic treatment of cancer: a new dimension in the era of adjuvant and intensive therapy
inferred← citeshttps://doi.org/10.1007/s12156-010-0068-6openalex-snapshot
Signal transduction of vitamin K3 for pancreas cancer therapy
inferred← citeshttps://doi.org/10.1016/b978-0-12-811907-5.00027-0openalex-snapshot
Prostate cancer and applications of vitamin K
inferred← citeshttps://doi.org/10.1016/j.bbadis.2020.166016openalex-snapshot
Cancer cell metabolism: Rewiring the mitochondrial hub
inferred← citeshttps://doi.org/10.1016/j.bcp.2008.10.019openalex-snapshot
Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death
inferred← citeshttps://doi.org/10.1016/j.bcp.2011.07.102openalex-snapshot
Intracellular ATP levels determine cell death fate of cancer cells exposed to both standard and redox chemotherapeutic agents
inferred← citeshttps://doi.org/10.1016/j.canlet.2017.09.023openalex-snapshot
Accumulation of cytoplasmic CDC25A in cutaneous squamous cell carcinoma leads to a dependency on CDC25A for cancer cell survival and tumor growth
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2019.01.037openalex-snapshot
The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2025.03.049openalex-snapshot
Selenium supplementation protects cancer cells from the oxidative stress and cytotoxicity induced by the combination of ascorbate and menadione sodium bisulfite
inferred← citeshttps://doi.org/10.1016/j.leukres.2014.04.010openalex-snapshot
Novel insights into the antiproliferative effects and synergism of quercetin and menadione in human leukemia Jurkat T cells
inferred← citeshttps://doi.org/10.1016/j.mam.2010.02.008openalex-snapshot
The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.phrs.2015.12.013openalex-snapshot
Cellular determinants involving mitochondrial dysfunction, oxidative stress and apoptosis correlate with the synergic cytotoxicity of epigallocatechin-3-gallate and menadione in human leukemia Jurkat T cells
inferred← citeshttps://doi.org/10.1016/j.plaphy.2014.08.024openalex-snapshot
The induction of menadione stress tolerance in the marine microalga, Dunaliella viridis , through cold pretreatment and modulation of the ascorbate and glutathione pools
inferred← citeshttps://doi.org/10.1016/j.redox.2026.104274openalex-snapshot
Ascorbate-driven quinone redox cycling as a pro-oxidant anticancer strategy
inferred← citeshttps://doi.org/10.1038/sj.bjc.6605617openalex-snapshot
α-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate
inferred← citeshttps://doi.org/10.1039/c4tb00069bopenalex-snapshot
Preparation and characterization of novel water-based biodegradable polyurethane nanoparticles encapsulating superparamagnetic iron oxide and hydrophobic drugs
inferred← citeshttps://doi.org/10.1080/10428194.2019.1620940openalex-snapshot
Anti-leukemia effect of vitamin K3 is mediated through mitochondrial complexes I and II
inferred← citeshttps://doi.org/10.1080/13102818.2021.1996268openalex-snapshot
Inhibition of ATP-synthase potentiates cytotoxicity of combination drug menadione/ascorbate in leukaemia lymphocytes
inferred← citeshttps://doi.org/10.1080/13510002.2023.2220531openalex-snapshot
Tolerable treatment of glioblastoma with redox-cycling ‘mitocans': a comparative study in vivo
inferred← citeshttps://doi.org/10.1089/ars.2012.5147openalex-snapshot
SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways
inferred← citeshttps://doi.org/10.1097/coc.0000000000001353openalex-snapshot
Vitamin C as an Adjunctive Therapy in Cancer
inferred← citeshttps://doi.org/10.1101/2024.08.29.610353openalex-snapshot
Design, Synthesis, and Efficacy of Novel Trojan Horse Compounds Targeting Metabolic Vulnerabilities in Prostate Cancer
inferred← citeshttps://doi.org/10.1111/1574-6968.12544openalex-snapshot
Inactivation of bacteria via photosensitization of vitamin K3 by UV-A light
inferred← citeshttps://doi.org/10.1155/2020/6212935openalex-snapshot
Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant
inferred← citeshttps://doi.org/10.1155/2022/2998132openalex-snapshot
Combination of Ascorbic Acid and Menadione Induces Cytotoxic Autophagy in Human Glioblastoma Cells
inferred← citeshttps://doi.org/10.1159/000341715openalex-snapshot
Design, Mechanism of Action, Bioavailability and Therapeutic Effects of Mn Porphyrin-Based Redox Modulators
inferred← citeshttps://doi.org/10.1177/1091581809333139openalex-snapshot
Menadione Reduction by Pharmacological Doses of Ascorbate Induces an Oxidative Stress That Kills Breast Cancer Cells
inferred← citeshttps://doi.org/10.1186/1479-5876-12-208openalex-snapshot
Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?
inferred← citeshttps://doi.org/10.1186/s12894-021-00856-xopenalex-snapshot
Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer
inferred← citeshttps://doi.org/10.1186/s13046-015-0270-2openalex-snapshot
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug
inferred← citeshttps://doi.org/10.1371/journal.pone.0052263openalex-snapshot
Alpha-Tocopheryl Succinate Inhibits Autophagic Survival of Prostate Cancer Cells Induced by Vitamin K3 and Ascorbate to Trigger Cell Death
inferred← citeshttps://doi.org/10.1371/journal.pone.0144033openalex-snapshot
The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process
inferred← citeshttps://doi.org/10.1515/acph-2017-0013openalex-snapshot
Comparing monolithic and fused core HPLC columns for fast chromatographic analysis of fat-soluble vitamins
inferred← citeshttps://doi.org/10.1515/pac-2016-1219openalex-snapshot
Anti-cancer agents and reactive oxygen species modulators that target cancer cell metabolism
inferred← citeshttps://doi.org/10.1517/13543776.2013.798303openalex-snapshot
Recent development on naphthoquinone derivatives and their therapeutic applications as anticancer agents
inferred← citeshttps://doi.org/10.1590/s0100-879x2012007500078openalex-snapshot
2-Bromo-1,4-naphthoquinone: a potentially improved substitute of menadione in Apatone™ therapy
inferred← citeshttps://doi.org/10.17352/ahr.000017openalex-snapshot
Vitamin K: A potential Liver Cancer treatment way
inferred← citeshttps://doi.org/10.21037/jgo-21-81openalex-snapshot
Identification of gene signatures and potential therapeutic targets for acquired chemotherapy resistance in gastric cancer patients
inferred← citeshttps://doi.org/10.2139/ssrn.5137710openalex-snapshot
Selenium Supplementation Protects Cancer Cells from the Oxidative Stress and Cytotoxicity Induced by the Combination of Ascorbate and Menadione
inferred← citeshttps://doi.org/10.2174/092986711796011256openalex-snapshot
Molecular Chaperone Hsp90 as a Target for Oxidant-Based Anticancer Therapies
inferred← citeshttps://doi.org/10.2174/0929867321666140915142219openalex-snapshot
Redox-active and Redox-silent Compounds: Synergistic Therapeutics in Cancer
inferred← citeshttps://doi.org/10.2174/1568009621999210120182834openalex-snapshot
The Efficacy of Vitamin K, A Member Of Naphthoquinones in the Treatment of Cancer: A Systematic Review and Meta-Analysis
inferred← citeshttps://doi.org/10.2174/187152011795255902openalex-snapshot
Redox-Active Quinones and Ascorbate: An Innovative Cancer Therapy That Exploits the Vulnerability of Cancer Cells to Oxidative Stress
inferred← citeshttps://doi.org/10.21873/anticanres.14151openalex-snapshot
Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin
inferred← citeshttps://doi.org/10.2478/ahem-2021-0031openalex-snapshot
Vitamin C and cancer risk and treatment
inferred← citeshttps://doi.org/10.3109/01913121003662304openalex-snapshot
Cell Damage and Death by Autoschizis in Human Bladder (RT4) Carcinoma Cells Resulting from Treatment with Ascorbate and Menadione
inferred← citeshttps://doi.org/10.3109/01913123.2013.852645openalex-snapshot
Synergistic Antitumor Cytotoxic Actions of Ascorbate and Menadione on Human Prostate (DU145) Cancer Cells In Vitro: Nucleus and Other Injuries Preceding Cell Death by Autoschizis
inferred← citeshttps://doi.org/10.3109/01913123.2014.927404openalex-snapshot
Pro-oxidant Treatment of Human Prostate Carcinoma (DU145) Induces Autoschizis Cell Death: Autophagosomes Build up out of Injured Endomembranes and Mitochondria
inferred← citeshttps://doi.org/10.3109/10715762.2011.616199openalex-snapshot
Cytotoxic effects of Mn(III)N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate
inferred← citeshttps://doi.org/10.3390/antiox9040320openalex-snapshot
Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells
inferred← citeshttps://doi.org/10.3390/biomedicines11102652openalex-snapshot
Pharmacological Akt and JNK Kinase Inhibitors 10-DEBC and SP600125 Potentiate Anti-Glioblastoma Effect of Menadione and Ascorbic Acid Combination in Human U251 Glioblastoma Cells
inferred← citeshttps://doi.org/10.3390/ijms24098435openalex-snapshot
Redox-Cycling “Mitocans” as Effective New Developments in Anticancer Therapy
inferred← citeshttps://doi.org/10.3390/insects12121109openalex-snapshot
Effects of Menadione on Survival, Feeding, and Tunneling Activity of the Formosan Subterranean Termite
inferred← citeshttps://doi.org/10.4172/1948-5956.1000223openalex-snapshot
Vitamin C and K3 Combination Causes Enhanced Anticancer Activity against RT-4 Bladder Cancer Cells
inferred← citeshttps://doi.org/10.4236/jct.2013.46a3002openalex-snapshot
Synergistic Antitumor Activity of Vitamins C and K3 on Human Bladder Cancer Cell Lines
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