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SFI Enhances Therapeutic Efficiency of Gefitinib: An Insight into Reversal of Resistance to Targeted Therapy in Non-small Cell Lung Cancer Cells

https://doi.org/10.7150/jca.32989
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2014.3741openalex-snapshot
Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs
inferredcites →https://doi.org/10.1002/cam4.1419openalex-snapshot
Traditional Chinese Medicine CFF ‐1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR ‐related pathways in prostate cancer
inferredcites →https://doi.org/10.1002/ijc.29210openalex-snapshot
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
inferredcites →https://doi.org/10.1002/jcp.26351openalex-snapshot
High cholesterol in lipid rafts reduces the sensitivity to EGFR‐TKI therapy in non‐small cell lung cancer
inferredcites →https://doi.org/10.1002/pmic.201400243openalex-snapshot
Phospholipids of tumor extracellular vesicles stratify gefitinib‐resistant nonsmall cell lung cancer cells from gefitinib‐sensitive cells
inferredcites →https://doi.org/10.1016/0065-2571(84)90007-4openalex-snapshot
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
inferredcites →https://doi.org/10.1016/j.bbrc.2017.07.052openalex-snapshot
RETRACTED: Astragaloside IV inhibits progression of glioma via blocking MAPK/ERK signaling pathway
inferredcites →https://doi.org/10.1016/j.cell.2012.12.030openalex-snapshot
Architecture and Membrane Interactions of the EGF Receptor
inferredcites →https://doi.org/10.1016/j.cmet.2010.12.004openalex-snapshot
Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques
inferredcites →https://doi.org/10.1016/j.cmet.2020.11.013openalex-snapshot
Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques
inferredcites →https://doi.org/10.1016/j.intimp.2016.10.001openalex-snapshot
Astragaloside IV inhibits breast cancer cell invasion by suppressing Vav3 mediated Rac1/MAPK signaling
inferredcites →https://doi.org/10.1016/j.jtho.2017.07.032openalex-snapshot
Potential Resistance Mechanisms Revealed by Targeted Sequencing from Lung Adenocarcinoma Patients with Primary Resistance to Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors (TKIs)
inferredcites →https://doi.org/10.1016/j.omtn.2018.07.016openalex-snapshot
BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells
inferredcites →https://doi.org/10.1016/s0022-2275(20)32079-4openalex-snapshot
Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade
inferredcites →https://doi.org/10.1016/s0092-8674(00)80213-5openalex-snapshot
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
inferredcites →https://doi.org/10.1038/aps.2016.175openalex-snapshot
Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation
inferredcites →https://doi.org/10.1038/nature17960openalex-snapshot
Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors
inferredcites →https://doi.org/10.1038/nature25183openalex-snapshot
The biology and management of non-small cell lung cancer
inferredcites →https://doi.org/10.1038/nrc.2017.84openalex-snapshot
Understanding and targeting resistance mechanisms in NSCLC
inferredcites →https://doi.org/10.1038/nrendo.2017.91openalex-snapshot
SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology
inferredcites →https://doi.org/10.1038/onc.2008.245openalex-snapshot
PI3K pathway alterations in cancer: variations on a theme
inferredcites →https://doi.org/10.1038/s41419-018-0330-6openalex-snapshot
Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer
inferredcites →https://doi.org/10.1038/s41467-018-04664-0openalex-snapshot
Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy
inferredcites →https://doi.org/10.1038/s41588-017-0027-2openalex-snapshot
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer
inferredcites →https://doi.org/10.1053/j.gastro.2010.12.006openalex-snapshot
Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1056/nejmoa0904554openalex-snapshot
Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer
inferredcites →https://doi.org/10.1073/pnas.0709662105openalex-snapshot
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
inferredcites →https://doi.org/10.1074/jbc.273.29.18623openalex-snapshot
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
inferredcites →https://doi.org/10.1126/scisignal.2004652openalex-snapshot
Bypass Mechanisms of Resistance to Receptor Tyrosine Kinase Inhibition in Lung Cancer
inferredcites →https://doi.org/10.1155/2018/8258246openalex-snapshot
Shenqi Fuzheng Injection Reverses Cisplatin Resistance through Mitofusin‐2‐Mediated Cell Cycle Arrest and Apoptosis in A549/DDP Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-15-0620openalex-snapshot
Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Naïve EGFR L858R-Induced Lung Adenocarcinoma
inferredcites →https://doi.org/10.1186/1471-213x-8-42openalex-snapshot
The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish
inferredcites →https://doi.org/10.1186/1756-9966-29-137openalex-snapshot
Shenqi fuzheng, an injection concocted from chinese medicinal herbs, combined with platinum-based chemotherapy for advanced non-small cell lung cancer: a systematic review
inferredcites →https://doi.org/10.1186/s12906-018-2347-xopenalex-snapshot
Investigate the mechanisms of Chinese medicine Fuzhengkangai towards EGFR mutation-positive lung adenocarcinomas by network pharmacology
inferredcites →https://doi.org/10.1186/s12943-018-0778-0openalex-snapshot
Third generation EGFR TKIs: current data and future directions
inferredcites →https://doi.org/10.1371/journal.pone.0152270openalex-snapshot
The Effect of ShenQi FuZheng Injection in Combination with Chemotherapy versus Chemotherapy Alone on the Improvement of Efficacy and Immune Function in Patients with Advanced Non-Small Cell Lung Cancer: A Meta-Analysis
inferredcites →https://doi.org/10.1371/journal.pone.0185254openalex-snapshot
ShenQi FuZheng Injection combined with chemotherapy in the treatment of colorectal cancer: A meta-analysis
inferredcites →https://doi.org/10.14343/jcscr.2016.4e1003openalex-snapshot
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012
inferredcites →https://doi.org/10.2174/13816128113196660763openalex-snapshot
Signaling Intermediates (MAPK and PI3K) as Therapeutic Targets in NSCLC
inferredcites →https://doi.org/10.2741/a782openalex-snapshot
Roles of Erbb family receptor tyrosine kinases and downstream signaling pathways in the control of cell growth and survival
inferredcites →https://doi.org/10.2741/grantopenalex-snapshot
Roles of Erbb family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival
inferredcites →https://doi.org/10.3322/caac.21492openalex-snapshot
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
inferredcites →https://doi.org/10.3389/fphar.2018.00345openalex-snapshot
Astragaloside IV Inhibits Triglyceride Accumulation in Insulin-Resistant HepG2 Cells via AMPK-Induced SREBP-1c Phosphorylation
inferredcites →https://doi.org/10.3892/ol.2018.8058openalex-snapshot
Sterol regulatory element-binding protein 1 cooperates with c-Myc to promote epithelial-mesenchymal transition in colorectal cancer
inferredcites →https://doi.org/10.4065/83.5.584openalex-snapshot
Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship
inferredcites →https://doi.org/10.4268/cjcmm20152036openalex-snapshot
Systematic review and Meta-analysis of Shenqi Fuzheng injection combined with first-line chemotherapy for non-small cell lung cancer

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4673085openalex-extracted
A Dft Study on the Excited States and Active Sites of Gefitinib
inferred← citeshttps://doi.org/10.1002/ptr.8130openalex-snapshot
Tanshinone IIA reverses gefitinib resistance in EGFR ‐mutant lung cancer via inhibition of SREBP1 ‐mediated lipogenesis
inferred← citeshttps://doi.org/10.1007/s00432-022-04297-3openalex-snapshot
Efficacy and safety of EGFR‑TKIs plus Shenqi Fuzheng injection for non-small cell lung cancer patients with EGFR-sensitive mutations
inferred← citeshttps://doi.org/10.1007/s12672-024-01029-6openalex-snapshot
Shenqi Fuzheng injection hinders non-small cell lung cancer cell growth by regulating the Bax/Bcl-2 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.bbcan.2023.188997openalex-snapshot
Tumor microenvironment diversity and plasticity in cancer multidrug resistance
inferred← citeshttps://doi.org/10.1016/j.metabol.2026.156593openalex-snapshot
PDAP1 reprograms fatty acid metabolism and drives malignant transformation via HSPA8-Mediated ERK/MAPK activation in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155171openalex-snapshot
Shenqi Fuzheng injection modulates tumor fatty acid metabolism to downregulate MDSCs infiltration, enhancing PD-L1 antibody inhibition of intracranial growth in Melanoma
inferred← citeshttps://doi.org/10.1080/13880209.2023.2292266openalex-snapshot
Shenqi Fuzheng injection restores the sensitivity to gefitinib in non-small cell lung cancer by inhibiting the IL-22/STAT3/AKT pathway
inferred← citeshttps://doi.org/10.1360/tb-2020-0455openalex-snapshot
Combination of Chinese and western medicine to prevent and reverse resistance of cancer cells to anticancer drugs
inferred← citeshttps://doi.org/10.17352/aprc.000040openalex-snapshot
Correlation of clinical, radiologic and pathologic manifestations with prognosis in lung cancer patients
inferred← citeshttps://doi.org/10.2147/dddt.s522445openalex-snapshot
Traditional Chinese Medicines as Anticancer Agents for Non-Small Cell Lung Cancer with EGFR Mutations: A Review
inferred← citeshttps://doi.org/10.2147/ott.s254464openalex-snapshot
JuBei Oral Liquid Induces Mitochondria-Mediated Apoptosis in NSCLC Cells
inferred← citeshttps://doi.org/10.3389/fendo.2023.1292011openalex-snapshot
Circadian clock and lipid metabolism disorders: a potential therapeutic strategy for cancer
inferred← citeshttps://doi.org/10.3389/fonc.2021.727130openalex-snapshot
Proteome Analysis of Camellia nitidissima Chi Revealed Its Role in Colon Cancer Through the Apoptosis and Ferroptosis Pathway
inferred← citeshttps://doi.org/10.5582/bst.2021.01140openalex-snapshot
Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents
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