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Asparagus Polysaccharide inhibits the Hypoxia-induced migration, invasion and angiogenesis of Hepatocellular Carcinoma Cells partly through regulating HIF1α/VEGF expression via MAPK and PI3K signaling pathway
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ptr.6058openalex-snapshot
An Asparagus polysaccharide fraction inhibits MDSCs by inducing apoptosis through toll‐like receptor 4
inferredcites →https://doi.org/10.1007/s13277-013-1464-xopenalex-snapshot
Anticancer effects of deproteinized asparagus polysaccharide on hepatocellular carcinoma in vitro and in vivo
inferredcites →https://doi.org/10.1016/j.ejca.2008.11.038openalex-snapshot
Resistance to EGF-R (erbB-1) and VEGF-R modulating agents
inferredcites →https://doi.org/10.1016/j.gde.2009.10.009openalex-snapshot
HIF-1: upstream and downstream of cancer metabolism
inferredcites →https://doi.org/10.1016/j.semcancer.2008.11.009openalex-snapshot
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
inferredcites →https://doi.org/10.1016/s1535-6108(03)00085-0openalex-snapshot
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
inferredcites →https://doi.org/10.1038/nrc2468openalex-snapshot
Hypoxia, HIF1 and glucose metabolism in the solid tumour
inferredcites →https://doi.org/10.1038/sj.bjc.6600331openalex-snapshot
Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells
inferredcites →https://doi.org/10.1074/jbc.270.3.1230openalex-snapshot
Purification and Characterization of Hypoxia-inducible Factor 1
inferredcites →https://doi.org/10.1074/jbc.m411858200openalex-snapshot
Hypoxia-inducible Factor-1-dependent Overexpression of Myeloid Cell Factor-1 Protects Hypoxic Cells against tert-Butyl Hydroperoxide-induced Apoptosis
inferredcites →https://doi.org/10.1128/mcb.12.12.5447openalex-snapshot
A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation
inferredcites →https://doi.org/10.1155/2013/685308openalex-snapshot
Microenvironment and Radiation Therapy
inferredcites →https://doi.org/10.1158/1078-0432.ccr-12-0858openalex-snapshot
Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy
inferredcites →https://doi.org/10.1158/1541-7786.mcr-10-0139openalex-snapshot
Mechanisms of Motility in Metastasizing Cells
inferredcites →https://doi.org/10.1158/1541-7786.mcr-10-0469openalex-snapshot
HIF-1–Dependent Stromal Adaptation to Ischemia Mediates In Vivo Tumor Radiation Resistance
inferredcites →https://doi.org/10.1186/cc7685openalex-snapshot
Excess circulating angiopoietin-2 levels in sepsis: harbinger of death in the intensive care unit?
inferredcites →https://doi.org/10.1200/jco.2005.06.081openalex-snapshot
Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
inferredcites →https://doi.org/10.1245/s10434-010-1444-yopenalex-snapshot
Normoxically Overexpressed Hypoxia Inducible Factor 1-Alpha is Involved in Arsenic Trioxide Resistance Acquisition in Hepatocellular Carcinoma
inferredcites →https://doi.org/10.17615/1726-2j32openalex-snapshot
Tumor Cells Upregulate Normoxic HIF-1 in Response to Doxorubicin
inferredcites →https://doi.org/10.2174/1568009611313030003openalex-snapshot
Oxygen-independent Regulation of HIF-1: Novel Involvement of PI3K/ AKT/mTOR Pathway in Cancer
inferredcites →https://doi.org/10.3322/caac.21492openalex-snapshot
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
inferredcites →https://doi.org/10.3892/or.2019.7397openalex-snapshot
Hypoxia‑inducible factors in hepatocellular carcinoma (Review)
inferredcites →https://doi.org/10.4174/astr.2015.89.1.1openalex-snapshot
Pivotal role of vascular endothelial growth factor pathway in tumor angiogenesis
inferredcites →https://doi.org/10.7314/apjcp.2014.15.24.10949openalex-snapshot
Asparagus Polysaccharide and Gum with Hepatic Artery Embolization Induces Tumor Growth and Inhibits Angiogenesis in an Orthotopic Hepatocellular Carcinoma Model
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4761735openalex-extracted
Sulfated Modification, Structural Features, and Anti-Tumor Effects of Polysaccharides from Medicago Sativa L. Stems
inferred← citeshttps://doi.org/10.1002/adhm.202503562openalex-snapshot
Multifunctional Copper Ion‐Mediated Carrier‐Free Scutellarin Hydrogel for Diabetic Wound Healing
inferred← citeshttps://doi.org/10.1002/cam4.70701openalex-snapshot
The Role of Chemokine (C‐C Motif) Ligand 7 ( CCL7 ) in Hepatocellular Carcinoma: Expression, Function, and Mechanisms
inferred← citeshttps://doi.org/10.1002/fft2.466openalex-snapshot
Natural products‐based antiangiogenic agents: New frontiers in cancer therapy
inferred← citeshttps://doi.org/10.1002/jbt.70097openalex-snapshot
TFAP2A Activates ADAM8 to Promote Lung Adenocarcinoma Angiogenesis Through the JAK/STAT Signaling Pathway
inferred← citeshttps://doi.org/10.1007/s00018-023-04767-yopenalex-snapshot
HIF-1α-activated TMEM237 promotes hepatocellular carcinoma progression via the NPHP1/Pyk2/ERK pathway
inferred← citeshttps://doi.org/10.1007/s12013-026-02136-7openalex-snapshot
Asparagus Polysaccharide Ameliorates TNF-α-Mediated MH7A Cell Dysfunction and Collagen-Induced Arthritis in Mice
inferred← citeshttps://doi.org/10.1016/j.carbpol.2026.125093openalex-snapshot
Structure–function paradigms of natural polysaccharides in hepatocellular carcinoma therapy
inferred← citeshttps://doi.org/10.1016/j.carpta.2025.100957openalex-snapshot
Preparation, structural analysis, antitumor mechanism and research in drug delivery systems of natural plant polysaccharides: a review
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117612openalex-snapshot
Histone lactylation-driven intratumoral IGFBP2+ NK cells promote tumor immune evasion
inferred← citeshttps://doi.org/10.1016/j.fsi.2022.08.007openalex-snapshot
Acute hypoxia promotes the liver angiogenesis of largemouth bass (Micropterus salmoides) by HIF - Dependent pathway
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.126766openalex-snapshot
Recent advances in natural polysaccharides against hepatocellular carcinoma: A review
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.148198openalex-snapshot
Structural characteristics of a fructan-type polysaccharide from Asparagus cochinchinensis rhizome and its anti-osteosarcoma activity mediated via macrophage polarization
inferred← citeshttps://doi.org/10.1016/j.jff.2026.107153openalex-snapshot
Extraction, purification, structural characterization, and bioactivities of Asparagus polysaccharides
inferred← citeshttps://doi.org/10.1016/j.phrs.2022.106553openalex-snapshot
Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154568openalex-snapshot
Salidroside intensifies mitochondrial function of CoCl2-damaged HT22 cells by stimulating PI3K-AKT-MAPK signaling pathway
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155294openalex-snapshot
Polysaccharide of Asparagus cochinchinensis (Lour.) Merr regulates macrophage immune response and epigenetic memory through TLR4-JNK/p38/ERK signaling pathway and histone modification
inferred← citeshttps://doi.org/10.1021/acs.jafc.2c06780openalex-snapshot
Targeting mTOR Signaling by Dietary Polysaccharides in Cancer Prevention: Advances and Challenges
inferred← citeshttps://doi.org/10.1080/10286020.2025.2521824openalex-snapshot
Study on the synthesis, structural characterization, and anti-hepatoma cell proliferation effects of sulfated alfalfa polysaccharides
inferred← citeshttps://doi.org/10.1111/bph.16232openalex-snapshot
Natural products targeting tumour angiogenesis
inferred← citeshttps://doi.org/10.1111/jgh.70017openalex-snapshot
Mechanosensitive Ion Channel Piezo Therapy in Digestive Diseases
inferred← citeshttps://doi.org/10.1155/omcl/9816894openalex-snapshot
RETRACTION: Downregulation of the Proton‐Activated Cl‐ Channel TMEM206 Inhibits Malignant Properties of Human Osteosarcoma Cells
inferred← citeshttps://doi.org/10.20892/j.issn.2095-3941.2022.0449openalex-snapshot
Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies
inferred← citeshttps://doi.org/10.2147/jir.s501270openalex-snapshot
Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products
inferred← citeshttps://doi.org/10.2147/ott.s444214openalex-snapshot
Traditional Chinese Medicine in Regulating Tumor Microenvironment
inferred← citeshttps://doi.org/10.2174/1574892819666230915103434openalex-snapshot
Research Progress on the Anticancer Activity of Plant Polysaccharides
inferred← citeshttps://doi.org/10.32604/biocell.2025.059970openalex-snapshot
Evaluating Oncogenic Drivers and Therapeutic Potential of the PI3K/AKT/mTOR Pathway in Hepatocellular Carcinoma: An Overview of Clinical Trials
inferred← citeshttps://doi.org/10.3389/fonc.2021.756334openalex-snapshot
A New Antitumor Direction: Tumor-Specific Endothelial Cells
inferred← citeshttps://doi.org/10.3389/fonc.2025.1595195openalex-snapshot
Aberrant angiogenic signaling in HCC: therapeutic targeting and drug resistance
inferred← citeshttps://doi.org/10.3389/fonc.2026.1937787openalex-snapshot
Combination therapy with Nifuroxazide and Lenvatinib exerts superior anti-hepatocellular carcinoma effect by enhancing the anti-tumor immune response
inferred← citeshttps://doi.org/10.3389/fphar.2022.862966openalex-snapshot
Combining Network Pharmacology and Experimental Validation to Study the Action and Mechanism of Water extract of Asparagus Against Colorectal Cancer
inferred← citeshttps://doi.org/10.3389/fphar.2023.1076815openalex-snapshot
RETRACTED: Mechanism of action of Asparagus officinalis extract against multiple myeloma using bioinformatics tools, in silico and in vitro study
inferred← citeshttps://doi.org/10.3390/nu14112303openalex-snapshot
The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases
inferred← citeshttps://doi.org/10.3390/nu16111642openalex-snapshot
Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms
inferred← citeshttps://doi.org/10.37349/edd.2025.100588openalex-snapshot
The role of medicinal plants in the management of hepatocellular carcinoma and its metastasis
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