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Histone deacetylase (HDAC) 11 inhibits matrix metalloproteinase (MMP) 3 expression to suppress colorectal cancer metastasis

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/glia.20729openalex-snapshot
Histone deacetylase 11 regulates oligodendrocyte‐specific gene expression and cell development in OL‐1 oligodendroglia cells
inferredcites →https://doi.org/10.1002/ijc.20395openalex-snapshot
Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients
inferredcites →https://doi.org/10.1002/jcb.20179openalex-snapshot
Regulation of histone deacetylase activities
inferredcites →https://doi.org/10.1007/s10549-005-6001-1openalex-snapshot
Quantitation of HDAC1 mRNA Expression in Invasive Carcinoma of the Breast*
inferredcites →https://doi.org/10.1007/s10620-008-0601-7openalex-snapshot
Global Histone H4 Acetylation and HDAC2 Expression in Colon Adenoma and Carcinoma
inferredcites →https://doi.org/10.1007/s10620-009-0926-xopenalex-snapshot
Elevated Serum Matrix Metalloproteinase-3 and -7 in H. pylori-Related Gastric Cancer Can Be Biomarkers Correlating with a Poor Survival
inferredcites →https://doi.org/10.1007/s13277-014-2358-2openalex-snapshot
Down-regulation of HDAC5 inhibits growth of human hepatocellular carcinoma by induction of apoptosis and cell cycle arrest
inferredcites →https://doi.org/10.1007/s13277-014-2434-7openalex-snapshot
Molecular regulation of ovarian cancer cell invasion
inferredcites →https://doi.org/10.1016/j.biopha.2020.110607openalex-snapshot
HDAC11: a rising star in epigenetics
inferredcites →https://doi.org/10.1016/j.canlet.2008.10.047openalex-snapshot
HDAC expression and clinical prognosis in human malignancies
inferredcites →https://doi.org/10.1016/j.cell.2012.06.013openalex-snapshot
Cancer Epigenetics: From Mechanism to Therapy
inferredcites →https://doi.org/10.1016/j.cub.2004.07.007openalex-snapshot
Histones and histone modifications
inferredcites →https://doi.org/10.1016/j.molimm.2014.08.002openalex-snapshot
Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function
inferredcites →https://doi.org/10.1016/s0959-8049(00)00156-8openalex-snapshot
Matrix metalloproteinases
inferredcites →https://doi.org/10.1038/cddis.2014.433openalex-snapshot
HDAC1 and Klf4 interplay critically regulates human myeloid leukemia cell proliferation
inferredcites →https://doi.org/10.1038/ng.3146openalex-snapshot
Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes
inferredcites →https://doi.org/10.1038/ni.1673openalex-snapshot
The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance
inferredcites →https://doi.org/10.1053/j.gastro.2020.02.068openalex-snapshot
Global Burden of 5 Major Types of Gastrointestinal Cancer
inferredcites →https://doi.org/10.1074/jbc.m111871200openalex-snapshot
Cloning and Functional Characterization of HDAC11, a Novel Member of the Human Histone Deacetylase Family
inferredcites →https://doi.org/10.1074/jbc.m113.498758openalex-snapshot
Histone Deacetylase (HDAC) 10 Suppresses Cervical Cancer Metastasis through Inhibition of Matrix Metalloproteinase (MMP) 2 and 9 Expression
inferredcites →https://doi.org/10.1093/carcin/bgs183openalex-snapshot
Dynamic activation of the key pathways: linking colitis to colorectal cancer in a mouse model
inferredcites →https://doi.org/10.1111/acer.12465openalex-snapshot
Acute Ethanol Alters Multiple Histone Modifications at Model Gene Promoters in the Cerebral Cortex
inferredcites →https://doi.org/10.1111/cpr.12815openalex-snapshot
The function and mechanism of circular RNAs in gastrointestinal tumours
inferredcites →https://doi.org/10.1136/gutjnl-2014-307094openalex-snapshot
Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study
inferredcites →https://doi.org/10.1152/ajprenal.00015.2013openalex-snapshot
Gender-specific role of HDAC11 in kidney ischemia- and reperfusion-induced PAI-1 expression and injury
inferredcites →https://doi.org/10.1158/0008-5472.can-17-0072openalex-snapshot
HDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-20-3044openalex-snapshot
HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness
inferredcites →https://doi.org/10.1158/1055-9965.epi-10-0437openalex-snapshot
Global Patterns of Cancer Incidence and Mortality Rates and Trends
inferredcites →https://doi.org/10.1158/1078-0432.ccr-10-0395openalex-snapshot
HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth
inferredcites →https://doi.org/10.1158/1078-0432.ccr-14-0968openalex-snapshot
A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study
inferredcites →https://doi.org/10.1158/1541-7786.mcr-13-0557-topenalex-snapshot
Tumor Cell–Derived MMP3 Orchestrates Rac1b and Tissue Alterations That Promote Pancreatic Adenocarcinoma
inferredcites →https://doi.org/10.1182/blood-2010-08-303701openalex-snapshot
HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma
inferredcites →https://doi.org/10.1186/1465-9921-7-21openalex-snapshot
Epigenetics and airways disease
inferredcites →https://doi.org/10.1186/s12929-014-0072-4openalex-snapshot
The biochemical value of urinary metalloproteinases 3 and 9 in diagnosis and prognosis of bladder cancer in Egypt
inferredcites →https://doi.org/10.1371/journal.pone.0108520openalex-snapshot
Further Characterization of HDAC and SIRT Gene Expression Patterns in Pancreatic Cancer and Their Relation to Disease Outcome
inferredcites →https://doi.org/10.3322/caac.21387openalex-snapshot
Cancer statistics, 2017
inferredcites →https://doi.org/10.3389/fmolb.2021.720020openalex-snapshot
Comprehensive Analysis of HDAC Family Identifies HDAC1 as a Prognostic and Immune Infiltration Indicator and HDAC1-Related Signature for Prognosis in Glioma
inferredcites →https://doi.org/10.3390/cells4020135openalex-snapshot
HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities
inferredcites →https://doi.org/10.7150/thno.49168openalex-snapshot
The emerging role of super enhancer-derived noncoding RNAs in human cancer

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4749929openalex-extracted
Anti-Tumor Metastasis of Water-Soluble Sulfated Β-Glucan Derivatives from Saccharomyces Cerevisiae
inferred← citeshttps://doi.org/10.1002/mco2.495openalex-snapshot
Epigenetic regulation in cancer
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Molecular Targets of Epigenetic Regulators
inferred← citeshttps://doi.org/10.1007/s00210-026-05591-4openalex-snapshot
Integrated network toxicology and experimental validation to investigate potential mechanisms associated with aspartame-induced malignant phenotypic changes in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s00262-023-03624-yopenalex-snapshot
HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block PD-L1 for colorectal cancer immunotherapy
inferred← citeshttps://doi.org/10.1007/s11010-025-05402-zopenalex-snapshot
Epigenetic modulation of CTCs as a novel therapeutic target in oncology
inferred← citeshttps://doi.org/10.1007/s12672-025-02024-1openalex-snapshot
ZNF385A was identified as a novel colorectal cancer-related functional gene by analysis of the interaction and immune characteristics of oxidative stress and the inflammatory response
inferred← citeshttps://doi.org/10.1016/bs.mie.2026.05.045openalex-snapshot
Critical structural features of HDAC11 inhibitors
inferred← citeshttps://doi.org/10.1016/j.aspen.2026.102539openalex-snapshot
Identification and functional analysis of the HDAC11 gene in Helicoverpa armigera
inferred← citeshttps://doi.org/10.1016/j.bbrep.2026.102814openalex-snapshot
Membrane-associated HDAC11: A potential new therapeutic targeting compartment in cancer cells
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115418openalex-snapshot
HDAC11: A novel target for improved cancer therapy
inferred← citeshttps://doi.org/10.1016/j.carbpol.2024.122466openalex-snapshot
Anti-tumor and anti-metastasis of water-soluble sulfated β-glucan derivatives from Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2025.104920openalex-snapshot
Unlocking the therapeutic potential of HDAC inhibitors in colorectal cancer: Mechanisms, efficacy, and future perspectives
inferred← citeshttps://doi.org/10.1016/j.gene.2025.149594openalex-snapshot
Transcriptomic profiling and bioinformatics-driven statistical prioritization of CRC biomarkers: A step toward precision oncology
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.152323openalex-snapshot
Butyrate-loaded gelatin methacryloyl microneedle accelerates diabetic wound healing through enhanced lipid metabolism and M2 macrophage polarization
inferred← citeshttps://doi.org/10.1016/j.prp.2024.155129openalex-snapshot
Comparative transcriptomic analyses reveal activation of the epithelial-mesenchymal transition program in non-metastasizing low grade pseudomyxoma peritonei
inferred← citeshttps://doi.org/10.1016/j.yexmp.2025.104954openalex-snapshot
Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer
inferred← citeshttps://doi.org/10.1038/s41392-024-01938-6openalex-snapshot
Circulating tumor cells: from new biological insights to clinical practice
inferred← citeshttps://doi.org/10.1038/s41417-023-00616-zopenalex-snapshot
Identification of HDAC4 as a potential therapeutic target and prognostic biomarker for ZFTA-fused ependymomas
inferred← citeshttps://doi.org/10.1080/1354750x.2026.2674791openalex-snapshot
Prognostic model for colorectal cancer based on folic acid metabolism-related genes reveals immune landscape
inferred← citeshttps://doi.org/10.1093/pcmedi/pbad028openalex-snapshot
Emerging roles of activating transcription factor 2 in the development of breast cancer: a comprehensive review
inferred← citeshttps://doi.org/10.1101/2024.08.07.606975openalex-snapshot
Research on the Mechanism of Lphn1 Knockout in Inhibiting Colorectal Cancer
inferred← citeshttps://doi.org/10.1186/s12864-023-09879-0openalex-snapshot
Prognostic value of oxidative stress-related genes in colorectal cancer and its correlation with tumor immunity
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1529239openalex-snapshot
Mechanisms of HDACs in cancer development
inferred← citeshttps://doi.org/10.3389/fphar.2023.1111912openalex-snapshot
Uncovering the effects and molecular mechanism of Astragalus membranaceus (Fisch.) Bunge and its bioactive ingredients formononetin and calycosin against colon cancer: An integrated approach based on network pharmacology analysis coupled with experimental validation and molecular docking
inferred← citeshttps://doi.org/10.3390/biomedinformatics2030030openalex-snapshot
Analysis of Differentially Expressed Genes, MMP3 and TESC, and Their Potential Value in Molecular Pathways in Colon Adenocarcinoma: A Bioinformatics Approach
inferred← citeshttps://doi.org/10.3390/cancers16193359openalex-snapshot
Histone Deacetylase Inhibitors for Peripheral T-Cell Lymphomas
inferred← citeshttps://doi.org/10.3390/ijms241411579openalex-snapshot
Expression of Immune-Related and Inflammatory Markers and Their Prognostic Impact in Colorectal Cancer Patients
inferred← citeshttps://doi.org/10.3390/ph18040563openalex-snapshot
Histone Deacetylase Inhibitors Promote the Anticancer Activity of Cisplatin: Mechanisms and Potential
inferred← citeshttps://doi.org/10.34172/ps.2023.19openalex-snapshot
Effects of 5-Fluorouracil on the Expression of Epigenetic Enzymes and Promoter Methylation of Selected Genes in Monolayer and Spheroid Cultures of Colorectal Cancer Cells
inferred← citeshttps://doi.org/10.6084/m9.figshare.24934177openalex-snapshot
Additional file 1 of Prognostic value of oxidative stress-related genes in colorectal cancer and its correlation with tumor immunity
inferred← citeshttps://doi.org/10.6084/m9.figshare.24934532openalex-snapshot
Additional file 2 of Prognostic value of oxidative stress-related genes in colorectal cancer and its correlation with tumor immunity
inferred← citeshttps://doi.org/10.7150/jca.91277openalex-snapshot
Development and validation of matrix metalloproteinase for predicting prognosis and tumour microenvironment immune profiles in uterine corpus endometrial carcinoma
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