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Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs

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Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization

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Exosome Biochemistry and Advanced Nanotechnology for Next‐Generation Theranostic Platforms

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Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy

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Cancer‐Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

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X‐ray‐Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery

inferredcites →https://doi.org/10.1002/anie.201107960openalex-snapshot

Stimulated Release of Size‐Selected Cargos in Succession from Mesoporous Silica Nanoparticles

inferredcites →https://doi.org/10.1002/anie.201912524openalex-snapshot

Responsive Exosome Nano‐bioconjugates for Synergistic Cancer Therapy

inferredcites →https://doi.org/10.1002/smll.200700595openalex-snapshot

Cytotoxicity of Nanoparticles

inferredcites →https://doi.org/10.1002/wnan.1452openalex-snapshot

Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles

inferredcites →https://doi.org/10.1016/j.addr.2015.10.022openalex-snapshot

Recent advances of cocktail chemotherapy by combination drug delivery systems

inferredcites →https://doi.org/10.1016/j.addr.2017.06.004openalex-snapshot

Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs

inferredcites →https://doi.org/10.1016/j.bcmd.2005.04.008openalex-snapshot

Exosome release by reticulocytes—An integral part of the red blood cell differentiation system

inferredcites →https://doi.org/10.1016/j.biomaterials.2016.10.053openalex-snapshot

Precision combination therapy for triple negative breast cancer via biomimetic polydopamine polymer core-shell nanostructures

inferredcites →https://doi.org/10.1016/j.jconrel.2013.08.014openalex-snapshot

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

inferredcites →https://doi.org/10.1016/j.molmed.2015.01.001openalex-snapshot

Cancer nanomedicine: from targeted delivery to combination therapy

inferredcites →https://doi.org/10.1016/j.tibtech.2017.03.004openalex-snapshot

Exosomes in Cancer Nanomedicine and Immunotherapy: Prospects and Challenges

inferredcites →https://doi.org/10.1021/acs.nanolett.9b01660openalex-snapshot

Stimuli-Responsive Polymer–Prodrug Hybrid Nanoplatform for Multistage siRNA Delivery and Combination Cancer Therapy

inferredcites →https://doi.org/10.1021/acsnano.5b06939openalex-snapshot

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

inferredcites →https://doi.org/10.1021/acsnano.6b00870openalex-snapshot

Stimuli-Responsive Programmed Specific Targeting in Nanomedicine

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Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics

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Stimuli-Responsive Nano-Architecture Drug-Delivery Systems to Solid Tumor Micromilieu: Past, Present, and Future Perspectives

inferredcites →https://doi.org/10.1021/acsnano.9b04651openalex-snapshot

Rapid On-Demand Extracellular Vesicle Augmentation with Versatile Oligonucleotide Tethers

inferredcites →https://doi.org/10.1021/ja809086qopenalex-snapshot

PEG Branched Polymer for Functionalization of Nanomaterials with Ultralong Blood Circulation

inferredcites →https://doi.org/10.1021/jacs.8b10047openalex-snapshot

Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity

inferredcites →https://doi.org/10.1038/labinvest.2009.126openalex-snapshot

Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status

inferredcites →https://doi.org/10.1038/nature22341openalex-snapshot

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

inferredcites →https://doi.org/10.1038/nbt.1807openalex-snapshot

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

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Principles of nanoparticle design for overcoming biological barriers to drug delivery

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Overcoming cellular barriers for RNA therapeutics

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide

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Stimuli-responsive nanocarriers for drug delivery

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Cancer nanomedicine: progress, challenges and opportunities

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Ligand-targeted therapeutics in anticancer therapy

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Extracellular vesicles: biology and emerging therapeutic opportunities

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Efficient RNA drug delivery using red blood cell extracellular vesicles

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Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

inferredcites →https://doi.org/10.1038/s41556-018-0250-9openalex-snapshot

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

inferredcites →https://doi.org/10.1038/s41565-017-0012-zopenalex-snapshot

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

inferredcites →https://doi.org/10.1038/s41565-019-0567-yopenalex-snapshot

Smart cancer nanomedicine

inferredcites →https://doi.org/10.1038/s41929-019-0333-4openalex-snapshot

Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis

inferredcites →https://doi.org/10.1039/c2cs35094gopenalex-snapshot

Cationic polymers and their therapeutic potential

inferredcites →https://doi.org/10.1126/science.2876518openalex-snapshot

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

inferredcites →https://doi.org/10.1126/scitranslmed.aav8521openalex-snapshot

Advances in therapeutic applications of extracellular vesicles

inferredcites →https://doi.org/10.1158/0008-5472.can-17-2880openalex-snapshot

Aptamer-Conjugated Extracellular Nanovesicles for Targeted Drug Delivery

inferredcites →https://doi.org/10.1186/s12951-019-0526-7openalex-snapshot

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

inferredcites →https://doi.org/10.1517/14728222.2013.819853openalex-snapshot

MicroRNA-21: a therapeutic target for reversing drug resistance in cancer

inferredcites →https://doi.org/10.3402/jev.v4.30087openalex-snapshot

Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

inferredcites →https://doi.org/10.7150/thno.13515openalex-snapshot

Triple-Layered pH-Responsive Micelleplexes Loaded with siRNA and Cisplatin Prodrug for NF-Kappa B Targeted Treatment of Metastatic Breast Cancer

inferredcites →https://doi.org/10.7150/thno.16684openalex-snapshot

Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment

inferredcites →https://doi.org/10.7150/thno.28241openalex-snapshot

In vivo Imaging-Guided Nanoplatform for Tumor Targeting Delivery and Combined Chemo-, Gene- and Photothermal Therapy

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Engineered Extracellular Vesicles for Targeted Paclitaxel Delivery in Cancer Therapy: Advances, Challenges, and Prospects

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Application of exosomes as nanocarriers in cancer therapy

inferred← citeshttps://doi.org/10.1039/d4bm00558aopenalex-snapshot

A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications

inferred← citeshttps://doi.org/10.1080/08830185.2026.2614776openalex-snapshot

Recent advances in dendritic cell-derived exosomes in cancer and cancer stem cell therapy

inferred← citeshttps://doi.org/10.1080/10408444.2023.2184325openalex-snapshot

Regulatory roles of extracellular vesicles in adverse pregnancy outcomes exposed with environmental toxicants

inferred← citeshttps://doi.org/10.1088/1748-605x/abd2c8openalex-snapshot

Membrane vesicles nanotheranostic systems: sources, engineering methods, and challenges

inferred← citeshttps://doi.org/10.1088/2516-1091/ac73c9openalex-snapshot

Advances in engineered exosomes towards cancer diagnosis and therapeutics

inferred← citeshttps://doi.org/10.1093/jmcb/mjae025openalex-snapshot

Extracellular vesicles in cancer: golden goose or Trojan horse

inferred← citeshttps://doi.org/10.1093/neuonc/noac071openalex-snapshot

Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy

inferred← citeshttps://doi.org/10.1093/neuonc/noac214openalex-snapshot

Hurdling over the blood–brain barrier with exosome technology

inferred← citeshttps://doi.org/10.1113/jp289298openalex-snapshot

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

inferred← citeshttps://doi.org/10.1134/s2079086425601541openalex-snapshot

Molecular and Cellular Mechanisms for Maintaining and Restoring Dynamic States of Tissue Homeostasis

inferred← citeshttps://doi.org/10.1136/jitc-2021-003217openalex-snapshot

Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment

inferred← citeshttps://doi.org/10.1136/jitc-2024-011148openalex-snapshot

Engineered red blood cell extracellular vesicles for delivery of Dox and siIDO1 enhance targeted chemo-immunotherapy of acute myeloid leukemia

inferred← citeshttps://doi.org/10.1155/2021/8502021openalex-snapshot

Design and Optimization of the Circulatory Cell-Driven Drug Delivery Platform

inferred← citeshttps://doi.org/10.1186/s12645-026-00367-0openalex-snapshot

Exosome-encapsulated perfluorocarbon nanoprobes for precise imaging and persistent monitoring of liver metastasis

inferred← citeshttps://doi.org/10.1186/s12890-024-02938-6openalex-snapshot

Folate-modified liposomes mediate the co-delivery of cisplatin with miR-219a-5p for the targeted treatment of cisplatin-resistant lung cancer

inferred← citeshttps://doi.org/10.1186/s12943-024-02215-4openalex-snapshot

Emerging role of exosomes in cancer therapy: progress and challenges

inferred← citeshttps://doi.org/10.1186/s12951-022-01462-1openalex-snapshot

Engineering a HEK-293T exosome-based delivery platform for efficient tumor-targeting chemotherapy/internal irradiation combination therapy

inferred← citeshttps://doi.org/10.1186/s12951-022-01472-zopenalex-snapshot

Recent advances in exosome-mediated nucleic acid delivery for cancer therapy

inferred← citeshttps://doi.org/10.1186/s12951-022-01638-9openalex-snapshot

Nanoengineering facilitating the target mission: targeted extracellular vesicles delivery systems design

inferred← citeshttps://doi.org/10.1186/s12951-023-02064-1openalex-snapshot

Engineered extracellular vesicles-like biomimetic nanoparticles as an emerging platform for targeted cancer therapy

inferred← citeshttps://doi.org/10.1186/s12951-024-02935-1openalex-snapshot

Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine

inferred← citeshttps://doi.org/10.1186/s12951-025-03523-7openalex-snapshot

Transdermal delivery of CRISPR/Cas9-mediated melanoma gene therapy via polyamines-modified thermosensitive hydrogels

inferred← citeshttps://doi.org/10.1186/s12964-025-02268-yopenalex-snapshot

Functionalized exosomes for targeted therapy in cancer and regenerative medicine: genetic, chemical, and physical modifications

inferred← citeshttps://doi.org/10.1208/s12248-021-00554-4openalex-snapshot

Extracellular Vesicles in Oncology: from Immune Suppression to Immunotherapy

inferred← citeshttps://doi.org/10.1210/endocr/bqaa250openalex-snapshot

Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer

inferred← citeshttps://doi.org/10.14218/jerp.2022.00078openalex-snapshot

Therapeutic Potential of Extracellular Vesicles as Vehicles to Deliver Druggable Molecules for Hepatocellular Carcinoma

inferred← citeshttps://doi.org/10.15212/bioi-2025-0208openalex-snapshot

Engineered Extracellular Vesicles: Advancing Cancer Therapy Through Precision Nanomedicine

inferred← citeshttps://doi.org/10.18632/oncotarget.27927openalex-snapshot

Advances in innovative exosome-technology for real time monitoring of viable drugs in clinical translation, prognosis and treatment response

inferred← citeshttps://doi.org/10.20517/microstructures.2026.03openalex-snapshot

Diagnostic and therapeutic applications of melanoma-derived exosomes in nanomedicine

inferred← citeshttps://doi.org/10.2147/jhc.s580617openalex-snapshot

Exosome-Mediated Regulation of Aerobic Glycolysis in Hepatocellular Carcinoma: Mechanisms and Therapeutic Implications

inferred← citeshttps://doi.org/10.2174/1386207326666230213141627openalex-snapshot

Effect of the Application of Exosome on Gastric Cancer

inferred← citeshttps://doi.org/10.3389/fbioe.2021.752019openalex-snapshot

Extracellular Vesicles as Natural Delivery Carriers Regulate Oxidative Stress Under Pathological Conditions

inferred← citeshttps://doi.org/10.3389/fbioe.2023.1254356openalex-snapshot

Engineered exosomes as drug and RNA co-delivery system: new hope for enhanced therapeutics?

inferred← citeshttps://doi.org/10.3389/fcell.2024.1372847openalex-snapshot

Application of exosomes in tumor immunity: recent progresses

inferred← citeshttps://doi.org/10.3389/fchem.2022.910341openalex-snapshot

Direct Modification of Extracellular Vesicles and Its Applications for Cancer Therapy: A Mini-Review

inferred← citeshttps://doi.org/10.3389/fimmu.2025.1613178openalex-snapshot

Engineered NK92 cell-derived exosomes inhibit ovarian cancer progression by degrading GPRC5A

inferred← citeshttps://doi.org/10.3389/fimmu.2025.1687953openalex-snapshot

Smart nanocarriers for cancer: harnessing exosomes and lipid systems in photodynamic and immunotherapy

inferred← citeshttps://doi.org/10.3389/fimmu.2026.1933602openalex-snapshot

Engineering extracellular vesicles for inflammatory bowel disease and colitis-associated colorectal cancer: from therapeutic innovation to clinical translation

inferred← citeshttps://doi.org/10.3389/fmed.2021.761362openalex-snapshot

Red Blood Cell Extracellular Vesicle-Based Drug Delivery: Challenges and Opportunities

inferred← citeshttps://doi.org/10.3389/fmolb.2021.764222openalex-snapshot

Exosome-Mediated Crosstalk Between Tumor and Tumor-Associated Macrophages

inferred← citeshttps://doi.org/10.3389/fmolb.2022.1036746openalex-snapshot

Research advances and challenges in tissue-derived extracellular vesicles

inferred← citeshttps://doi.org/10.3389/fnano.2022.939197openalex-snapshot

Advancement in exosome-based cancer therapeutics: A new era in cancer treatment

inferred← citeshttps://doi.org/10.3389/fonc.2022.887532openalex-snapshot

Exosome-Derived Non-Coding RNAs in the Tumor Microenvironment of Colorectal Cancer: Possible Functions, Mechanisms and Clinical Applications

inferred← citeshttps://doi.org/10.3389/fphar.2021.786700openalex-snapshot

Nanotherapeutics Overcoming the Blood-Brain Barrier for Glioblastoma Treatment

inferred← citeshttps://doi.org/10.3389/fphar.2022.878058openalex-snapshot

Exosome: The “Off-the-Shelf” Cellular Nanocomponent as a Potential Pathogenic Agent, a Disease Biomarker, and Neurotherapeutics

inferred← citeshttps://doi.org/10.3389/fphar.2025.1529375openalex-snapshot

The biology of exosomes and exosomal non-coding RNAs in cardiovascular diseases

inferred← citeshttps://doi.org/10.3390/biomedicines12122834openalex-snapshot

Extracellular Vesicles from Plasma of Patients with Glioblastoma Promote Invasion of Glioblastoma Cells Even After Tumor Resection

inferred← citeshttps://doi.org/10.3390/cancers15010080openalex-snapshot

Exosome-Derived microRNA: Implications in Melanoma Progression, Diagnosis and Treatment

inferred← citeshttps://doi.org/10.3390/cancers15102838openalex-snapshot

Surface-Engineered Extracellular Vesicles in Cancer Immunotherapy

inferred← citeshttps://doi.org/10.3390/cells12030356openalex-snapshot

The Role of Exosomes in Human Carcinogenesis and Cancer Therapy—Recent Findings from Molecular and Clinical Research

inferred← citeshttps://doi.org/10.3390/cells12101416openalex-snapshot

Current Strategies for Exosome Cargo Loading and Targeting Delivery

inferred← citeshttps://doi.org/10.3390/diagnostics16091305openalex-snapshot

Extracellular Vesicles in Myocardial Infarction: Dual Role in Ferroptosis Regulation and In Vivo Imaging

inferred← citeshttps://doi.org/10.3390/ijms23115927openalex-snapshot

Roles and Applications of Red Blood Cell-Derived Extracellular Vesicles in Health and Diseases

inferred← citeshttps://doi.org/10.3390/ijms232314775openalex-snapshot

The Roles of MiRNAs (MicroRNAs) in Melanoma Immunotherapy

inferred← citeshttps://doi.org/10.3390/ijtm4020015openalex-snapshot

Potential of Exosomes as Therapeutics and Therapy Targets in Cancer Patients

inferred← citeshttps://doi.org/10.3390/molecules26061544openalex-snapshot

Factors Affecting Extracellular Vesicles Based Drug Delivery Systems

inferred← citeshttps://doi.org/10.3390/molecules28093816openalex-snapshot

Abscopal Effect, Extracellular Vesicles and Their Immunotherapeutic Potential in Cancer Treatment

inferred← citeshttps://doi.org/10.3390/pharmaceutics13010003openalex-snapshot

Exosomes as Drug Delivery Systems: Endogenous Nanovehicles for Treatment of Systemic Lupus Erythematosus

inferred← citeshttps://doi.org/10.3390/pharmaceutics15051439openalex-snapshot

Therapeutic and Diagnostic Potential of Exosomes as Drug Delivery Systems in Brain Cancer

inferred← citeshttps://doi.org/10.3390/pharmaceutics18101215openalex-snapshot

Engineering and Precision Delivery Strategies of Functionalized Extracellular Vesicles for Antitumor Therapy

inferred← citeshttps://doi.org/10.4103/abr.abr_124_24openalex-snapshot

Effect of siRNA-mediated LGR5 Inhibition on the Expression of Stemness-related Genes in Triple-negative Breast Cancer Spheroid Model

inferred← citeshttps://doi.org/10.52768/epidemiolpublichealth/1026openalex-snapshot

Potential of Exosomes as Therapeutics and Therapy Targets in Cancer Patients

inferred← citeshttps://doi.org/10.5772/intechopen.94502openalex-snapshot

Extracellular Vesicles: “Stealth Transport Aircrafts” for Drugs

inferred← citeshttps://doi.org/10.6084/m9.figshare.19947338openalex-snapshot

Additional file 1 of Engineering a HEK-293T exosome-based delivery platform for efficient tumor-targeting chemotherapy/internal irradiation combination therapy

inferred← citeshttps://doi.org/10.6084/m9.figshare.25522692openalex-snapshot

Additional file 1 of Folate-modified liposomes mediate the co-delivery of cisplatin with miR-219a-5p for the targeted treatment of cisplatin-resistant lung cancer

inferred← citeshttps://doi.org/10.6084/m9.figshare.25522796openalex-snapshot

Additional file 2 of Folate-modified liposomes mediate the co-delivery of cisplatin with miR-219a-5p for the targeted treatment of cisplatin-resistant lung cancer

inferred← citeshttps://doi.org/10.7150/thno.102964openalex-snapshot

RNA nanotherapeutics for hepatocellular carcinoma treatment

inferred← citeshttps://doi.org/10.7150/thno.57828openalex-snapshot

Recent progress in nanomedicine for enhanced cancer chemotherapy

inferred← citeshttps://doi.org/10.7150/thno.62708openalex-snapshot

Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics

inferred← citeshttps://doi.org/10.7150/thno.92703openalex-snapshot

CRISPR-Cas9 library screening combined with an exosome-targeted delivery system addresses tumorigenesis/TMZ resistance in the mesenchymal subtype of glioblastoma

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