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Fructose-coated Angstrom silver inhibits osteosarcoma growth and metastasis via promoting ROS-dependent apoptosis through the alteration of glucose metabolism by inhibiting PDK

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Nanomaterials: Applications in Cancer Imaging and Therapy
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Controllable synthesis of monodispersed silver nanoparticles as standards for quantitative assessment of their cytotoxicity
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Reactive Oxygen Species in Cancer: A Dance with the Devil
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Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential
inferredcites →https://doi.org/10.1016/j.ccell.2017.11.004openalex-snapshot
Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis
inferredcites →https://doi.org/10.1016/j.ccr.2006.10.020openalex-snapshot
A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
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Superoxide Flashes in Single Mitochondria
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Phenyl butyrate inhibits pyruvate dehydrogenase kinase 1 and contributes to its anti-cancer effect
inferredcites →https://doi.org/10.1016/j.nano.2013.07.001openalex-snapshot
Nanomaterials in combating cancer: Therapeutic applications and developments
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Mitochondria in cancer cells: what is so special about them?
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Targeting Metabolic–Redox Circuits for Cancer Therapy
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Sequelae of osteosarcoma medical therapy: a review of rare acute toxicities and late effects
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Bioorthogonal DNA Adsorption on Polydopamine Nanoparticles Mediated by Metal Coordination for Highly Robust Sensing in Serum and Living Cells
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Elimination Pathways of Nanoparticles
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Seed-Mediated Synthesis of Ag Nanocubes with Controllable Edge Lengths in the Range of 30−200 nm and Comparison of Their Optical Properties
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Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression
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inferredcites →https://doi.org/10.1073/pnas.1704173114openalex-snapshot
BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation
inferredcites →https://doi.org/10.1080/15548627.2016.1239676openalex-snapshot
GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagy
inferredcites →https://doi.org/10.1080/21691401.2019.1584110openalex-snapshot
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inferredcites →https://doi.org/10.1111/jcmm.12966openalex-snapshot
RETRACTED: Micro RNA ‐379 suppresses osteosarcoma progression by targeting PDK 1
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The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62
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inferredcites →https://doi.org/10.1126/sciimmunol.aat2738openalex-snapshot
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Prevention of Chemotherapy-Induced Anemia and Thrombocytopenia by Constant Administration of Stem Cell Factor
inferredcites →https://doi.org/10.1172/jci78437openalex-snapshot
IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling
inferredcites →https://doi.org/10.1200/jco.2011.36.8456openalex-snapshot
First-SIGNAL: First-Line Single-Agent Iressa Versus Gemcitabine and Cisplatin Trial in Never-Smokers With Adenocarcinoma of the Lung
inferredcites →https://doi.org/10.1200/jco.2014.59.4895openalex-snapshot
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inferredcites →https://doi.org/10.15171/apb.2018.006openalex-snapshot
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inferredcites →https://doi.org/10.2147/ijn.s103695openalex-snapshot
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inferredcites →https://doi.org/10.2147/ijn.s11727openalex-snapshot
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inferredcites →https://doi.org/10.2147/ijn.s15493openalex-snapshot
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inferredcites →https://doi.org/10.2147/ijn.s191340openalex-snapshot
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inferredcites →https://doi.org/10.2217/nnm.14.1openalex-snapshot
Targeted Delivery of Silver Nanoparticles and Alisertib: In Vitro and In Vivo Synergistic Effect Against Glioblastoma
inferredcites →https://doi.org/10.3322/caac.21199openalex-snapshot
Nanooncology: The future of cancer diagnosis and therapy
inferredcites →https://doi.org/10.3389/fgene.2018.00135openalex-snapshot
TIMP3 Overexpression Improves the Sensitivity of Osteosarcoma to Cisplatin by Reducing IL-6 Production
inferredcites →https://doi.org/10.3389/fonc.2013.00038openalex-snapshot
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inferredcites →https://doi.org/10.3390/nano8090681openalex-snapshot
Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview
inferredcites →https://doi.org/10.7150/thno.22958openalex-snapshot
Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis
inferredcites →https://doi.org/10.7150/thno.27351openalex-snapshot
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inferredcites →https://doi.org/10.7150/thno.31884openalex-snapshot
Synechococcus elongatus PCC7942 secretes extracellular vesicles to accelerate cutaneous wound healing by promoting angiogenesis
inferredcites →https://doi.org/10.7150/thno.35219openalex-snapshot
Vitamin C kills thyroid cancer cells through ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways via distinct mechanisms
inferredcites →https://doi.org/10.7150/thno.39831openalex-snapshot
Cooperation of endogenous and exogenous reactive oxygen species induced by zinc peroxide nanoparticles to enhance oxidative stress-based cancer therapy

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4757503openalex-extracted
A Multifunctional 3d Printed Composite Porous Shape Memory Scaffold with Photothermal and Magnetothermal Effects for Multimodal Tumor Therapy and Bone Defect Repair
inferred← citeshttps://doi.org/10.1002/adhm.202100619openalex-snapshot
The Action‐Networks of Nanosilver: Bridging the Gap between Material and Biology
inferred← citeshttps://doi.org/10.1002/adtp.202200100openalex-snapshot
Fructose‐Coated Ångstrom Silver Particles Suppress Gastric Cancer Growth by Activating Gasdermin D‐Mediated Pyroptosis
inferred← citeshttps://doi.org/10.1002/adtp.202400363openalex-snapshot
Dimethyl Fumarate Augments Anticancer Activity of Ångstrom Silver Particles in Myeloma Cells through NRF2 Activation
inferred← citeshttps://doi.org/10.1002/cam4.3984openalex-snapshot
Signature based on metabolic‐related gene pairs can predict overall survival of osteosarcoma patients
inferred← citeshttps://doi.org/10.1007/978-3-031-28780-0_59openalex-snapshot
Use of Plant-Derived Nanoparticles in Cancer Therapy
inferred← citeshttps://doi.org/10.1007/s00011-023-01778-0openalex-snapshot
Ångstrom-scale silver particles ameliorate collagen-induced and K/BxN-transfer arthritis in mice via the suppression of inflammation and osteoclastogenesis
inferred← citeshttps://doi.org/10.1007/s00432-022-04333-2openalex-snapshot
A novel organic arsenic derivative MZ2 remodels metabolism and triggers mtROS-mediated apoptosis in acute myeloid leukemia
inferred← citeshttps://doi.org/10.1007/s13402-026-01229-yopenalex-snapshot
M6A-modified lncRNA HULC promotes osteosarcoma progression by stabilizing GLUT1 mRNA through interaction with TAF15
inferred← citeshttps://doi.org/10.1016/j.bbadis.2023.166739openalex-snapshot
Advanced nanoscale drug delivery systems for bone cancer therapy
inferred← citeshttps://doi.org/10.1016/j.bmc.2025.118162openalex-snapshot
Identification of effective anti-osteosarcoma agents via screening of an in-house NQO1-targeted compound library
inferred← citeshttps://doi.org/10.1016/j.chembiol.2026.06.009openalex-snapshot
The pyruvate dehydrogenase complex at the crossroads of cancer metabolism and cell death
inferred← citeshttps://doi.org/10.1016/j.gendis.2026.102111openalex-snapshot
Molecular mechanisms and targeted therapeutic strategies for glycolytic reprogramming in osteosarcoma
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.148083openalex-snapshot
Integrative bioinformatics and experimental validation identify pyrroline-5-carboxylate reductase 1 as a mitochondrial regulator and diagnostic biomarker in osteosarcoma
inferred← citeshttps://doi.org/10.1016/j.jare.2024.09.027openalex-snapshot
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy
inferred← citeshttps://doi.org/10.1016/j.jbo.2024.100521openalex-snapshot
Reprogramming of glucose metabolism: Metabolic alterations in the progression of osteosarcoma
inferred← citeshttps://doi.org/10.1016/j.jcis.2022.02.050openalex-snapshot
Ag nanoparticles enhance immune checkpoint blockade efficacy by promoting of immune surveillance in melanoma
inferred← citeshttps://doi.org/10.1016/j.jos.2022.07.009openalex-snapshot
MicroRNA-455-3p inhibits osteosarcoma progression via HSF1 downregulation
inferred← citeshttps://doi.org/10.1016/j.mtbio.2025.102071openalex-snapshot
Tailoring innovative silver nanoparticles for modern medicine: The importance of size and shape control and functional modifications
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.5c00136openalex-snapshot
Nrf2 Activation Mitigates Silver Nanoparticle-Induced Ferroptosis in Hepatocytes
inferred← citeshttps://doi.org/10.1038/s41388-026-03930-6openalex-snapshot
Metabolites and cancer metastasis
inferred← citeshttps://doi.org/10.1038/s41419-022-05401-8openalex-snapshot
ADCK1 is a potential therapeutic target of osteosarcoma
inferred← citeshttps://doi.org/10.1038/s41419-024-06722-6openalex-snapshot
Targeting the mitochondrial protein YME1L to inhibit osteosarcoma cell growth in vitro and in vivo
inferred← citeshttps://doi.org/10.1039/d1nr06220dopenalex-snapshot
Biomineralization-inspired synthesis of amorphous manganese phosphates for GLUT5-targeted drug-free catalytic therapy of osteosarcoma
inferred← citeshttps://doi.org/10.1039/d2tb00336hopenalex-snapshot
Ångstrom-scale silver particles potently combat SARS-CoV-2 infection by suppressing the ACE2 expression and inflammatory responses
inferred← citeshttps://doi.org/10.1088/1758-5090/adc29eopenalex-snapshot
Multifunctional 4D printed shape memory composite scaffolds with photothermal and magnetothermal effects for multimodal tumor therapy and bone repair
inferred← citeshttps://doi.org/10.1093/abbs/gmab060openalex-snapshot
7,8-Dihydroxyflavone suppresses proliferation and induces apoptosis of human osteosarcoma cells
inferred← citeshttps://doi.org/10.1111/cas.15779openalex-snapshot
MicroRNA ‐324‐3p inhibits osteosarcoma progression by suppressing PGAM1 ‐mediated aerobic glycolysis
inferred← citeshttps://doi.org/10.1111/os.13806openalex-snapshot
Research Progress of Nanomaterials in Chemotherapy of Osteosarcoma
inferred← citeshttps://doi.org/10.1126/sciadv.aba0942openalex-snapshot
Ångstrom-scale silver particle–embedded carbomer gel promotes wound healing by inhibiting bacterial colonization and inflammation
inferred← citeshttps://doi.org/10.1177/15330338221124696openalex-snapshot
Current Status and Prospects of Clinical Treatment of Osteosarcoma
inferred← citeshttps://doi.org/10.1177/20417314231170371openalex-snapshot
Multifunctional 3D-printed bioceramic scaffolds: Recent strategies for osteosarcoma treatment
inferred← citeshttps://doi.org/10.1186/s12906-024-04354-zopenalex-snapshot
Network pharmacology and experimental validation to study the potential mechanism of Tongguanteng injection in regulating apoptosis in osteosarcoma
inferred← citeshttps://doi.org/10.1186/s12935-024-03604-xopenalex-snapshot
Mir-615-3p promotes osteosarcoma progression via the SESN2/AMPK/mTOR pathway
inferred← citeshttps://doi.org/10.1186/s12951-024-02585-3openalex-snapshot
Strategic disruption of cancer’s powerhouse: precise nanomedicine targeting of mitochondrial metabolism
inferred← citeshttps://doi.org/10.1186/s12957-026-04312-8openalex-snapshot
MiR-381-3p inhibits Warburg effect and progression in osteosarcoma via targeting PFKFB3
inferred← citeshttps://doi.org/10.1186/s12967-022-03549-7openalex-snapshot
IGF2BP1-regulated expression of ERRα is involved in metabolic reprogramming of chemotherapy resistant osteosarcoma cells
inferred← citeshttps://doi.org/10.1186/s12967-022-03862-1openalex-snapshot
Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3576713/v1openalex-snapshot
Network pharmacology and experimental validation to study the potential mechanism of Tongguanteng injection against osteosarcoma
inferred← citeshttps://doi.org/10.2147/ijn.s304515openalex-snapshot
Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8+ T Cells and Macrophages
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inferred← citeshttps://doi.org/10.2147/ijn.s549587openalex-snapshot
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inferred← citeshttps://doi.org/10.2174/0115665240322280240903111159openalex-snapshot
COL12A1 Promotes Osteosarcoma Progression via the FAK/PI3K/AKT/mTOR Pathway
inferred← citeshttps://doi.org/10.22038/ijbms.2021.59424.13196openalex-snapshot
Vitexin ameliorates glycochenodeoxycholate-induced hepatocyte injury through SIRT6 and JAK2/STAT3 pathways.
inferred← citeshttps://doi.org/10.25259/ajc_1045_2025openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fendo.2022.983606openalex-snapshot
Sphingolipid metabolism is associated with osteosarcoma metastasis and prognosis: Evidence from interaction analysis
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1463078openalex-snapshot
Global research trends and hotspots in metabolomics of osteosarcoma: a decade-spanning bibliometric and visualized analysis
inferred← citeshttps://doi.org/10.3389/fmolb.2022.1105540openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fonc.2020.586580openalex-snapshot
Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy
inferred← citeshttps://doi.org/10.3389/fphar.2022.855488openalex-snapshot
Noncoding RNAs in the Glycolysis of Ovarian Cancer
inferred← citeshttps://doi.org/10.3390/genes13091524openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/jfb16060213openalex-snapshot
Material-Driven Therapeutics: Functional Nanomaterial Design Paradigms Revolutionizing Osteosarcoma Treatment
inferred← citeshttps://doi.org/10.3390/life13020466openalex-snapshot
The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?
inferred← citeshttps://doi.org/10.3390/ma15113837openalex-snapshot
Silver Nanoparticles Inhibit Metastasis of 4T1 Tumor in Mice after Intragastric but Not Intravenous Administration
inferred← citeshttps://doi.org/10.6084/m9.figshare.26559911openalex-snapshot
Additional file 1 of Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1
inferred← citeshttps://doi.org/10.7150/ijbs.100015openalex-snapshot
HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling
inferred← citeshttps://doi.org/10.7150/ijbs.68861openalex-snapshot
Identification of Gαi3 as a promising target for osteosarcoma treatment
inferred← citeshttps://doi.org/10.7150/ijms.108549openalex-snapshot
Fructose Metabolism in Cancer: Molecular Mechanisms and Therapeutic Implications
inferred← citeshttps://doi.org/10.7150/thno.55334openalex-snapshot
Fructose-coated Ångstrom silver prevents sepsis by killing bacteria and attenuating bacterial toxin-induced injuries
inferred← citeshttps://doi.org/10.7150/thno.55655openalex-snapshot
The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma
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