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Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Defective mitochondria‐lysosomal axis enhances the release of extracellular vesicles containing mitochondrial DNA and proteins in Huntington's disease
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Embryonic stem cells neural differentiation qualifies the role of Wnt/β-Catenin signals in human telencephalic specification and regionalization
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The Neuropathology of Huntington’s Disease
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Human-to-mouse prion-like propagation of mutant huntingtin protein
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Cognitive changes in patients with Huntington?s disease (HD) and asymptomatic carriers of the HD mutation
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Human Pluripotent Stem Cell Differentiation into Authentic Striatal Projection Neurons
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The effects of neurotensin on GABA and acetylcholine release in the dorsal striatum of the rat: an in vivo mirodialysis study
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Distribution of GABA in post-mortem brain tissue from control, psychotic and Huntington's chorea subjects
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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
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Structural insight into transmissive mutant huntingtin species by correlative light and electron microscopy and cryo-electron tomography
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α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
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TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning
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Integrative Characterization of the R6/2 Mouse Model of Huntington’s Disease Reveals Dysfunctional Astrocyte Metabolism
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Human Huntington’s Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation
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Neurexin1α Differentially Regulates Synaptic Efficacy within Striatal Circuits
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miRNAs in synapse development and synaptic plasticity
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ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease
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Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease
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Symptom heterogeneity in Huntington's disease correlates with neuronal degeneration in the cerebral cortex
inferredcites →https://doi.org/10.1016/j.nbd.2021.105374openalex-snapshot
Exosomes as a potential messenger unit during heterochronic parabiosis for amelioration of Huntington's disease
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Inhibition of BDNF production by MPP + through up-regulation of miR-210-3p contributes to dopaminergic neuron damage in MPTP model
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Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin
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Novel Primate miRNAs Coevolved with Ancient Target Genes in Germinal Zone-Specific Expression Patterns
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SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
inferredcites →https://doi.org/10.1016/j.neuroscience.2016.05.027openalex-snapshot
Early GABAergic transmission defects in the external globus pallidus and rest/activity rhythm alteration in a mouse model of Huntington’s disease
inferredcites →https://doi.org/10.1016/j.neuroscience.2019.02.007openalex-snapshot
Alterations in Hippocampal Inhibitory Synaptic Transmission in the R6/2 Mouse Model of Huntington’s Disease
inferredcites →https://doi.org/10.1016/j.nlm.2021.107459openalex-snapshot
High ethanol preference and dissociated memory are co-occurring phenotypes associated with hippocampal GABAAR-δ receptor levels
inferredcites →https://doi.org/10.1016/j.omtn.2018.01.007openalex-snapshot
Supplemental Treatment for Huntington’s Disease with miR-132 that Is Deficient in Huntington’s Disease Brain
inferredcites →https://doi.org/10.1016/j.phrs.2016.05.005openalex-snapshot
Circulating microRNAs in Huntington’s disease: Emerging mediators in metabolic impairment
inferredcites →https://doi.org/10.1016/j.pneurobio.2006.11.001openalex-snapshot
The corticostriatal pathway in Huntington's disease
inferredcites →https://doi.org/10.1016/j.psychres.2010.04.030openalex-snapshot
Earliest functional declines in Huntington disease
inferredcites →https://doi.org/10.1016/j.redox.2022.102424openalex-snapshot
Mitochondrial and redox modifications in early stages of Huntington's disease
inferredcites →https://doi.org/10.1016/s0072-9752(07)01256-0openalex-snapshot
Neuropathology of Huntington's Disease
inferredcites →https://doi.org/10.1016/s1474-4422(11)70263-0openalex-snapshot
Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data
inferredcites →https://doi.org/10.1016/s1474-4422(14)70238-8openalex-snapshot
Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study
inferredcites →https://doi.org/10.1038/nbt.1529openalex-snapshot
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
inferredcites →https://doi.org/10.1038/ncomms2146openalex-snapshot
Evolution of the human-specific microRNA miR-941
inferredcites →https://doi.org/10.1038/nn.3691openalex-snapshot
Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice
inferredcites →https://doi.org/10.1038/nn.4532openalex-snapshot
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
inferredcites →https://doi.org/10.1038/npp.2012.116openalex-snapshot
The Impact of MeCP2 Loss- or Gain-of-Function on Synaptic Plasticity
inferredcites →https://doi.org/10.1038/nprot.2006.37openalex-snapshot
Production and purification of lentiviral vectors
inferredcites →https://doi.org/10.1038/nprot.2015.052openalex-snapshot
NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data
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Autophagy inhibition of hsa-miR-19a-3p/19b-3p by targeting TGF-β R II during TGF-β1-induced fibrogenesis in human cardiac fibroblasts
inferredcites →https://doi.org/10.1073/pnas.1703920114openalex-snapshot
Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus
inferredcites →https://doi.org/10.1073/pnas.1715865115openalex-snapshot
Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes
inferredcites →https://doi.org/10.1073/pnas.1716871115openalex-snapshot
Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model
inferredcites →https://doi.org/10.1073/pnas.1902513116openalex-snapshot
Exosomes regulate neurogenesis and circuit assembly
inferredcites →https://doi.org/10.1074/jbc.m306230200openalex-snapshot
Cysteine String Protein (CSP) Inhibition of N-type Calcium Channels Is Blocked by Mutant Huntingtin
inferredcites →https://doi.org/10.1080/10641955.2022.2056194openalex-snapshot
Long non-coding RNA PAXIP-AS1 promotes viability, invasion, and migration of HTR-8/SVneo cells through miR-210-3p/BDNF axis
inferredcites →https://doi.org/10.1080/20013078.2018.1535750openalex-snapshot
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
inferredcites →https://doi.org/10.1080/20013078.2020.1809064openalex-snapshot
Extracellular vesicles from human iPSC‐derived neural stem cells: miRNA and protein signatures, and anti‐inflammatory and neurogenic properties
inferredcites →https://doi.org/10.1093/bioinformatics/btr026openalex-snapshot
Quality control and preprocessing of metagenomic datasets
inferredcites →https://doi.org/10.1093/bioinformatics/btu170openalex-snapshot
Trimmomatic: a flexible trimmer for Illumina sequence data
inferredcites →https://doi.org/10.1093/hmg/ddv080openalex-snapshot
HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity
inferredcites →https://doi.org/10.1093/nar/gkaa1047openalex-snapshot
Rfam 14: expanded coverage of metagenomic, viral and microRNA families
inferredcites →https://doi.org/10.1093/nar/gkq575openalex-snapshot
A myriad of miRNA variants in control and Huntington’s disease brain regions detected by massively parallel sequencing
inferredcites →https://doi.org/10.1093/nar/gkr688openalex-snapshot
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
inferredcites →https://doi.org/10.1093/nar/gkv468openalex-snapshot
ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap
inferredcites →https://doi.org/10.1093/nar/gky1141openalex-snapshot
miRBase: from microRNA sequences to function
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NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis
inferredcites →https://doi.org/10.1093/nar/gkz757openalex-snapshot
miRDB: an online database for prediction of functional microRNA targets
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Insights into GABA A ergic system alteration in Huntington's disease
inferredcites →https://doi.org/10.1111/cns.12804openalex-snapshot
Potassium channel dysfunction in neurons and astrocytes in Huntington's disease
inferredcites →https://doi.org/10.1111/cns.12826openalex-snapshot
Alteration of GABA ergic neurotransmission in Huntington's disease
inferredcites →https://doi.org/10.1111/ejn.13275openalex-snapshot
Exosomes from adipose‐derived stem cells ameliorate phenotype of Huntington's disease in vitro model
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A guided tour into subcellular colocalization analysis in light microscopy
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Cysteine string protein‐α is essential for the high calcium sensitivity of exocytosis in a vertebrate synapse
inferredcites →https://doi.org/10.1111/j.1471-4159.2005.03348.xopenalex-snapshot
Purification of neuronal inclusions of patients with Huntington's disease reveals a broad range of N‐terminal fragments of expanded huntingtin and insoluble polymers
inferredcites →https://doi.org/10.1111/j.1471-4159.2012.07925.xopenalex-snapshot
Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin
inferredcites →https://doi.org/10.1111/jnc.15001openalex-snapshot
Impact of neural stem cell‐derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level, and synaptic deficits in Alzheimer’s disease
inferredcites →https://doi.org/10.1152/jn.00601.2009openalex-snapshot
MeCP2 Is Required for Normal Development of GABAergic Circuits in the Thalamus
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Early Defects of GABAergic Synapses in the Brain Stem of a MeCP2 Mouse Model of Rett Syndrome
inferredcites →https://doi.org/10.1159/000444713openalex-snapshot
Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
inferredcites →https://doi.org/10.1172/jci.insight.88995openalex-snapshot
SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington’s disease
inferredcites →https://doi.org/10.1176/appi.neuropsych.11030057openalex-snapshot
Longitudinal Evaluation of Neuropsychiatric Symptoms in Huntington's Disease
inferredcites →https://doi.org/10.1186/gb-2009-10-1-r1openalex-snapshot
Analysis of the platypus genome suggests a transposon origin for mammalian imprinting
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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
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Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation
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Murine patellar tendon transplantation requires transosseous cerclage augmentation — development of a transplantation model for investigation of systemic and local drivers of healing
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Making (anti-) sense out of huntingtin levels in Huntington disease
inferredcites →https://doi.org/10.1186/s13046-021-02197-xopenalex-snapshot
Long noncoding RNA TINCR facilitates hepatocellular carcinoma progression and dampens chemosensitivity to oxaliplatin by regulating the miR-195-3p/ST6GAL1/NF-κB pathway
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Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages
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Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?
inferredcites →https://doi.org/10.1212/01.wnl.0000222734.56412.17openalex-snapshot
Microglial activation correlates with severity in Huntington disease
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GABA deficiency in NF1
inferredcites →https://doi.org/10.1212/wnl.0000000000004844openalex-snapshot
MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study
inferredcites →https://doi.org/10.1371/journal.pone.0148680openalex-snapshot
Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells
inferredcites →https://doi.org/10.1523/jneurosci.0530-13.2013openalex-snapshot
TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABA A Receptors
inferredcites →https://doi.org/10.1523/jneurosci.1418-17.2017openalex-snapshot
Mutant Huntingtin Inhibits αB-Crystallin Expression and Impairs Exosome Secretion from Astrocytes
inferredcites →https://doi.org/10.1523/jneurosci.2033-12.2013openalex-snapshot
Mutant Huntingtin Alters Retrograde Transport of TrkB Receptors in Striatal Dendrites
inferredcites →https://doi.org/10.1523/jneurosci.2688-06.2006openalex-snapshot
Neural Cell Adhesion Molecule L1-Transfected Embryonic Stem Cells Promote Functional Recovery after Excitotoxic Lesion of the Mouse Striatum
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Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α
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The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex
inferredcites →https://doi.org/10.3389/fcell.2020.576592openalex-snapshot
Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting
inferredcites →https://doi.org/10.3389/fcell.2021.635104openalex-snapshot
Exosomes: Innocent Bystanders or Critical Culprits in Neurodegenerative Diseases
inferredcites →https://doi.org/10.3389/fncel.2017.00205openalex-snapshot
Mesenchymal Stem Cell-Derived Extracellular Vesicles Ameliorates Hippocampal Synaptic Impairment after Transient Global Ischemia
inferredcites →https://doi.org/10.3389/fnmol.2017.00198openalex-snapshot
Differential Alteration in Expression of Striatal GABAAR Subunits in Mouse Models of Huntington’s Disease
inferredcites →https://doi.org/10.7554/elife.12748openalex-snapshot
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Additional file 1 of Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy
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Additional file 1 of Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice
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