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Stiffening Matrix Induces Age‐Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/advs.202201483openalex-snapshot
Stiffening Matrix Induces Age‐Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions
inferredcites →https://doi.org/10.1006/exnr.1993.1095openalex-snapshot
Microvascular Density of the Human Paraventricular Nucleus Decreases with Aging but Not Hypertension
inferredcites →https://doi.org/10.1007/978-981-13-2835-0_7openalex-snapshot
Extracellular Matrix and Ageing
inferredcites →https://doi.org/10.1016/0197-4580(90)90001-gopenalex-snapshot
Neuritic plaques and vessels of visual cortex in aging and Alzheimer's dementia
inferredcites →https://doi.org/10.1016/j.actbio.2019.07.030openalex-snapshot
Substrate stiffness directs diverging vascular fates
inferredcites →https://doi.org/10.1016/j.biomaterials.2019.119634openalex-snapshot
Cell-mediated matrix stiffening accompanies capillary morphogenesis in ultra-soft amorphous hydrogels
inferredcites →https://doi.org/10.1016/j.bpj.2017.06.033openalex-snapshot
Stiff Substrates Increase Inflammation-Induced Endothelial Monolayer Tension and Permeability
inferredcites →https://doi.org/10.1016/j.celrep.2012.09.018openalex-snapshot
Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening
inferredcites →https://doi.org/10.1016/j.celrep.2018.06.083openalex-snapshot
Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells
inferredcites →https://doi.org/10.1016/j.celrep.2020.108015openalex-snapshot
Cell-Based Strain Remodeling of a Nonfibrous Matrix as an Organizing Principle for Vasculogenesis
inferredcites →https://doi.org/10.1016/j.cjca.2016.02.070openalex-snapshot
Vascular Fibrosis in Aging and Hypertension: Molecular Mechanisms and Clinical Implications
inferredcites →https://doi.org/10.1016/j.cub.2013.04.049openalex-snapshot
Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1
inferredcites →https://doi.org/10.1016/j.cub.2017.06.020openalex-snapshot
VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN
inferredcites →https://doi.org/10.1016/j.cub.2017.08.064openalex-snapshot
VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN
inferredcites →https://doi.org/10.1016/j.isci.2021.102246openalex-snapshot
HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics
inferredcites →https://doi.org/10.1016/j.kint.2017.02.036openalex-snapshot
Molecular mechanisms of renal aging
inferredcites →https://doi.org/10.1016/j.stem.2020.08.005openalex-snapshot
Hydrogel Network Dynamics Regulate Vascular Morphogenesis
inferredcites →https://doi.org/10.1016/j.yjmcc.2015.01.021openalex-snapshot
Cellular and molecular biology of aging endothelial cells
inferredcites →https://doi.org/10.1016/s0272-6386(01)80019-6openalex-snapshot
Impaired angiogenesis in the aging kidney: Vascular endothelial growth factor and Thrombospondin-1 in renal disease
inferredcites →https://doi.org/10.1016/s0895-7061(02)03029-7openalex-snapshot
Influence of age, risk factors, and cardiovascular and renal disease on arterial stiffness: clinical applications
inferredcites →https://doi.org/10.1021/la034136xopenalex-snapshot
Nanoscale Mapping of the Elasticity of Microbial Cells by Atomic Force Microscopy
inferredcites →https://doi.org/10.1038/nature13716openalex-snapshot
Synaptic dysregulation in a human iPS cell model of mental disorders
inferredcites →https://doi.org/10.1038/nature24998openalex-snapshot
A non-canonical Notch complex regulates adherens junctions and vascular barrier function
inferredcites →https://doi.org/10.1038/ncomms13546openalex-snapshot
PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis
inferredcites →https://doi.org/10.1038/ncomms4984openalex-snapshot
Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells
inferredcites →https://doi.org/10.1038/ncomms7429openalex-snapshot
Integrin β1 controls VE-cadherin localization and blood vessel stability
inferredcites →https://doi.org/10.1038/nm.4126openalex-snapshot
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice
inferredcites →https://doi.org/10.1038/nmat4483openalex-snapshot
Stress-stiffening-mediated stem-cell commitment switch in soft responsive hydrogels
inferredcites →https://doi.org/10.1038/nmeth.2019openalex-snapshot
Fiji: an open-source platform for biological-image analysis
inferredcites →https://doi.org/10.1038/s41569-018-0030-zopenalex-snapshot
Endothelial dysfunction and angiogenesis impairment in the ageing vasculature
inferredcites →https://doi.org/10.1038/s41569-018-0064-2openalex-snapshot
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
inferredcites →https://doi.org/10.1038/s41598-020-69558-yopenalex-snapshot
Decrease of laminin-511 in the basement membrane due to photoaging reduces epidermal stem/progenitor cells
inferredcites →https://doi.org/10.1038/s41598-021-01735-zopenalex-snapshot
Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall
inferredcites →https://doi.org/10.1038/s41598-021-04712-8openalex-snapshot
Aging-related cerebral microvascular changes visualized using ultrasound localization microscopy in the living mouse
inferredcites →https://doi.org/10.1038/srep20989openalex-snapshot
Myosin di-phosphorylation and peripheral actin bundle formation as initial events during endothelial barrier disruption
inferredcites →https://doi.org/10.1073/pnas.1306562110openalex-snapshot
Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix
inferredcites →https://doi.org/10.1073/pnas.1613058113openalex-snapshot
Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs
inferredcites →https://doi.org/10.1073/pnas.1613855114openalex-snapshot
Matrix stiffening promotes a tumor vasculature phenotype
inferredcites →https://doi.org/10.1073/pnas.1722619115openalex-snapshot
Cell contraction induces long-ranged stress stiffening in the extracellular matrix
inferredcites →https://doi.org/10.1088/0957-4484/6/1/001openalex-snapshot
Calculation of thermal noise in atomic force microscopy
inferredcites →https://doi.org/10.1091/mbc.e19-02-0076openalex-snapshot
Myosin IIA–mediated forces regulate multicellular integrity during vascular sprouting
inferredcites →https://doi.org/10.1093/emboj/20.17.4639openalex-snapshot
Activation of integrins in endothelial cells by fluid shear stress mediates Rho‐dependent cytoskeletal alignment
inferredcites →https://doi.org/10.1093/ndt/gfaa006openalex-snapshot
Early vascular ageing in chronic kidney disease: impact of inflammation, vitamin K, senescence and genomic damage
inferredcites →https://doi.org/10.1096/fj.201800841ropenalex-snapshot
Matrix stiffness regulates vascular integrity through focal adhesion kinase activity
inferredcites →https://doi.org/10.1111/j.1365-2990.2010.01139.xopenalex-snapshot
Review: Cerebral microvascular pathology in ageing and neurodegeneration
inferredcites →https://doi.org/10.1126/sciadv.abd7819openalex-snapshot
High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging
inferredcites →https://doi.org/10.1126/scitranslmed.3002761openalex-snapshot
Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration
inferredcites →https://doi.org/10.1152/ajpendo.00411.2011openalex-snapshot
Age-dependent renal cortical microvascular loss in female mice
inferredcites →https://doi.org/10.1152/ajpheart.00495.2009openalex-snapshot
Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat
inferredcites →https://doi.org/10.1152/ajpheart.01086.2002openalex-snapshot
Effects of aging on capillary geometry and hemodynamics in rat spinotrapezius muscle
inferredcites →https://doi.org/10.1152/jappl.2000.88.4.1321openalex-snapshot
Aging of skeletal muscle: a 12-yr longitudinal study
inferredcites →https://doi.org/10.1159/000091823openalex-snapshot
Age-Related Changes of the Cutaneous Microcirculation in vivo
inferredcites →https://doi.org/10.1161/01.cir.99.1.111openalex-snapshot
Age-Dependent Impairment of Angiogenesis
inferredcites →https://doi.org/10.1161/01.hyp.0000209939.05482.61openalex-snapshot
Effects of Aging and Hypertension on the Microcirculation
inferredcites →https://doi.org/10.1161/01.res.0000269183.13937.e8openalex-snapshot
Direct Evidence of Endothelial Oxidative Stress With Aging in Humans
inferredcites →https://doi.org/10.1161/cir.0000000000000558openalex-snapshot
Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association
inferredcites →https://doi.org/10.1161/circresaha.118.311378openalex-snapshot
Mechanisms of Vascular Aging
inferredcites →https://doi.org/10.1161/hypertensionaha.114.03618openalex-snapshot
Matrix Metalloproteinases Promote Arterial Remodeling in Aging, Hypertension, and Atherosclerosis
inferredcites →https://doi.org/10.1167/iovs.17-21460openalex-snapshot
Age-Related Alterations in the Retinal Microvasculature, Microcirculation, and Microstructure
inferredcites →https://doi.org/10.1167/iovs.18-25864openalex-snapshot
Age-Related Alterations in Retinal Tissue Perfusion and Volumetric Vessel Density
inferredcites →https://doi.org/10.1172/jci.insight.131828openalex-snapshot
iPSC-derived endothelial cell response to hypoxia via SDF1a/CXCR4 axis facilitates incorporation to revascularize ischemic retina
inferredcites →https://doi.org/10.1182/blood-2010-12-327338openalex-snapshot
Controlled activation of morphogenesis to generate a functional human microvasculature in a synthetic matrix
inferredcites →https://doi.org/10.1210/en.138.8.3515openalex-snapshot
Decreases in Cerebral Microvasculature with Age Are Associated with the Decline in Growth Hormone and Insulin-Like Growth Factor 1
inferredcites →https://doi.org/10.1242/jcs.017897openalex-snapshot
The role of adherens junctions and VE-cadherin in the control of vascular permeability
inferredcites →https://doi.org/10.1369/0022155418774779openalex-snapshot
The Effects of Normal Aging on Regional Accumulation of Hyaluronan and Chondroitin Sulfate Proteoglycans in the Mouse Brain
inferredcites →https://doi.org/10.14336/ad.2017.0430openalex-snapshot
Age-related Impairment of Vascular Structure and Functions
inferredcites →https://doi.org/10.14336/ad.2019.0315openalex-snapshot
A Microcirculatory Theory of Aging
inferredcites →https://doi.org/10.15252/embj.2020105242openalex-snapshot
Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system
inferredcites →https://doi.org/10.1681/asn.v92231openalex-snapshot
Tubulointerstitial disease in aging
inferredcites →https://doi.org/10.2174/1573403x14666180801153801openalex-snapshot
Arterial Aging, Metalloproteinase Regulation, and the Potential of Resistance Exercise
inferredcites →https://doi.org/10.3389/fgene.2015.00112openalex-snapshot
Age-related vascular stiffening: causes and consequences
inferredcites →https://doi.org/10.3389/fnagi.2020.557384openalex-snapshot
Aging of the Vascular System and Neural Diseases
inferredcites →https://doi.org/10.7555/jbr.27.20130064openalex-snapshot
Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/adhm.202300458openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/adhm.202301701openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/advs.202302228openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/advs.202417778openalex-snapshot
CaMKK2 Regulates Macrophage Polarization Induced by Matrix Stiffness: Implications for Shaping the Immune Response in Stiffened Tissues
inferred← citeshttps://doi.org/10.1002/advs.76304openalex-snapshot
Matrix Stiffness Induces Endothelial Network Senescence
inferred← citeshttps://doi.org/10.1002/agm2.70043openalex-snapshot
The Mechanism and Potential Therapeutic Strategies of Vascular Aging
inferred← citeshttps://doi.org/10.1007/s10456-023-09904-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10522-025-10191-5openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10555-026-10345-yopenalex-snapshot
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Reversible shear stress-mediated mechanoregulation of endothelial cell function in thixotropic hydrogels via L-type Ca2+ channel and focal adhesion molecules for accelerated vascularization
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2026.124460openalex-snapshot
Dynamic stiffening to improve vasculogenesis of hiPSC-Derived endothelial progenitors
inferred← citeshttps://doi.org/10.1016/j.crphys.2025.100140openalex-snapshot
Microvascular endothelial cells display organ-specific responses to extracellular matrix stiffness
inferred← citeshttps://doi.org/10.1016/j.molmed.2022.10.005openalex-snapshot
Engineering of the microenvironment to accelerate vascular regeneration
inferred← citeshttps://doi.org/10.1021/accountsmr.4c00390openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acsami.4c05864openalex-snapshot
Physical Properties and Biochemical Composition of Extracellular Matrix-Derived Hydrogels Dictate Vascularization Potential in an Organ-Dependent Fashion
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.4c01170openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41419-025-08014-zopenalex-snapshot
Intracellular pH dynamics respond to extracellular matrix stiffening and mediate vasculogenic mimicry through β-catenin
inferred← citeshttps://doi.org/10.1038/s41467-023-43768-0openalex-snapshot
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