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Signal regulatory protein alpha blockade potentiates tumoricidal effects of macrophages on gastroenterological neoplastic cells in syngeneic immunocompetent mice

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1097-4652(200102)186:2<282::aid-jcp1028>3.0.co;2-2openalex-snapshot

Opposite effects on human colon cancer cell proliferation of two dietary Thomsen-Friedenreich antigen-binding lectins

inferredcites →https://doi.org/10.1002/ags3.12205openalex-snapshot

Signal regulatory protein alpha blockade potentiates tumoricidal effects of macrophages on gastroenterological neoplastic cells in syngeneic immunocompetent mice

inferredcites →https://doi.org/10.1002/hep.26391openalex-snapshot

Signal Regulatory Protein α Is Associated With Tumor-Polarized Macrophages Phenotype Switch and Plays a Pivotal Role in Tumor Progression

inferredcites →https://doi.org/10.1007/s00384-013-1791-9openalex-snapshot

Colonoscopy as a tool for evaluating colorectal tumor development in a mouse model

inferredcites →https://doi.org/10.1016/j.cell.2005.08.032openalex-snapshot

Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

inferredcites →https://doi.org/10.1016/j.cell.2009.05.045openalex-snapshot

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

inferredcites →https://doi.org/10.1016/j.cell.2009.05.046openalex-snapshot

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

inferredcites →https://doi.org/10.1016/j.cell.2010.07.044openalex-snapshot

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

inferredcites →https://doi.org/10.1016/j.it.2008.02.004openalex-snapshot

Innate immune ‘self’ recognition: a role for CD47–SIRPα interactions in hematopoietic stem cell transplantation

inferredcites →https://doi.org/10.1016/j.jhep.2010.04.023openalex-snapshot

Experimentally induced liver metastases from colorectal cancer can be prevented by mononuclear phagocyte-mediated monoclonal antibody therapy

inferredcites →https://doi.org/10.1016/j.leukres.2015.04.007openalex-snapshot

CD47 protein expression in acute myeloid leukemia: A tissue microarray-based analysis

inferredcites →https://doi.org/10.1038/mt.2013.135openalex-snapshot

Intravenous Delivery of siRNA Targeting CD47 Effectively Inhibits Melanoma Tumor Growth and Lung Metastasis

inferredcites →https://doi.org/10.1038/ni1527openalex-snapshot

Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells

inferredcites →https://doi.org/10.1038/nm.3931openalex-snapshot

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

inferredcites →https://doi.org/10.1038/sj.jid.5700176openalex-snapshot

Engagement of CD47 Inhibits the Contact Hypersensitivity Response Via the Suppression of Motility and B7 Expression by Langerhans Cells

inferredcites →https://doi.org/10.1073/pnas.0609661104openalex-snapshot

Role for CD47-SIRPα signaling in xenograft rejection by macrophages

inferredcites →https://doi.org/10.1073/pnas.1106550108openalex-snapshot

CD47–signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction

inferredcites →https://doi.org/10.1073/pnas.1121623109openalex-snapshot

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

inferredcites →https://doi.org/10.1073/pnas.1121629109openalex-snapshot

Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma

inferredcites →https://doi.org/10.1073/pnas.1305569110openalex-snapshot

Anti-CD47 antibody–mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

inferredcites →https://doi.org/10.1073/pnas.1520032112openalex-snapshot

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

inferredcites →https://doi.org/10.1073/pnas.1604268113openalex-snapshot

Durable antitumor responses to CD47 blockade require adaptive immune stimulation

inferredcites →https://doi.org/10.1074/jbc.273.15.9234openalex-snapshot

Roles of the Complex Formation of SHPS-1 with SHP-2 in Insulin-stimulated Mitogen-activated Protein Kinase Activation

inferredcites →https://doi.org/10.1074/jbc.273.21.13223openalex-snapshot

Integrin-mediated Tyrosine Phosphorylation of SHPS-1 and Its Association with SHP-2

inferredcites →https://doi.org/10.1074/jbc.m104138200openalex-snapshot

The Role of CD47 in Neutrophil Transmigration

inferredcites →https://doi.org/10.1083/jcb.200708043openalex-snapshot

Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cells

inferredcites →https://doi.org/10.1084/jem.193.7.855openalex-snapshot

Cd47-Signal Regulatory Protein α (Sirpα) Regulates Fcγ and Complement Receptor–Mediated Phagocytosis

inferredcites →https://doi.org/10.1084/jem.194.4.541openalex-snapshot

Cd47 (Integrin-Associated Protein) Engagement of Dendritic Cell and Macrophage Counterreceptors Is Required to Prevent the Clearance of Donor Lymphohematopoietic Cells

inferredcites →https://doi.org/10.1093/emboj/cdg278openalex-snapshot

Role of the CD47–SHPS‐1 system in regulation of cell migration

inferredcites →https://doi.org/10.1097/01.tp.0000161667.99145.20openalex-snapshot

Low Incidence of Acute Rejection after Living-Donor Liver Transplantation: Immunologic Analyses by Mixed Lymphocyte Reaction using a Carboxyfluorescein Diacetate Succinimidyl Ester Labeling Technique

inferredcites →https://doi.org/10.1111/j.1349-7006.2006.00245.xopenalex-snapshot

CD47 regulation of epithelial cell spreading and migration, and its signal transduction

inferredcites →https://doi.org/10.1111/j.1399-3089.2004.00195.xopenalex-snapshot

Evidence of macrophage receptors capable of direct recognition of xenogeneic epitopes without opsonization

inferredcites →https://doi.org/10.1126/science.288.5473.2051openalex-snapshot

Role of CD47 as a Marker of Self on Red Blood Cells

inferredcites →https://doi.org/10.1126/scitranslmed.3001375openalex-snapshot

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

inferredcites →https://doi.org/10.1126/scitranslmed.3009457openalex-snapshot

Endoscopic molecular imaging of human bladder cancer using a CD47 antibody

inferredcites →https://doi.org/10.1158/0008-5472.can-07-2735openalex-snapshot

Mouse Model of Colonic Adenoma-Carcinoma Progression Based on Somatic Apc Inactivation

inferredcites →https://doi.org/10.1158/0008-5472.can-10-2238openalex-snapshot

Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia

inferredcites →https://doi.org/10.1158/0008-5472.can-14-0037-topenalex-snapshot

CD47 in the Tumor Microenvironment Limits Cooperation between Antitumor T-cell Immunity and Radiotherapy

inferredcites →https://doi.org/10.1158/0008-5472.can-15-1330openalex-snapshot

Antibody-Dependent Phagocytosis of Tumor Cells by Macrophages: A Potent Effector Mechanism of Monoclonal Antibody Therapy of Cancer

inferredcites →https://doi.org/10.1172/jci66776openalex-snapshot

Macrophages eliminate circulating tumor cells after monoclonal antibody therapy

inferredcites →https://doi.org/10.1182/blood-2004-08-2980openalex-snapshot

Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia

inferredcites →https://doi.org/10.1182/blood-2008-01-134429openalex-snapshot

Endothelial CD47 interaction with SIRPγ is required for human T-cell transendothelial migration under shear flow conditions in vitro

inferredcites →https://doi.org/10.1371/journal.pone.0058359openalex-snapshot

Expression of Recipient CD47 on Rat Insulinoma Cell Xenografts Prevents Macrophage-Mediated Rejection through SIRPα Inhibitory Signaling in Mice

inferredcites →https://doi.org/10.4049/jimmunol.1101008openalex-snapshot

SIRPα/CD172a Regulates Eosinophil Homeostasis

inferredcites →https://doi.org/10.4049/jimmunol.174.4.2004openalex-snapshot

Negative Regulation of Phagocytosis in Macrophages by the CD47-SHPS-1 System

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4628680openalex-extracted

Disruption of CD47-SIRPα Signalling Restores Inflammatory Function in Tumour-Associated Myeloid Derived Suppressor Cells

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Macrophage‐Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention

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Bioconjugated Antibody‐Trojan Immune Converter Enhance Cancer Immunotherapy with Minimized Toxicity by Programmed Two‐Step Immunomodulation of Myeloid Cells

inferred← citeshttps://doi.org/10.1016/j.addr.2022.114239openalex-snapshot

Imaging and therapeutic targeting of the tumor immune microenvironment with biologics

inferred← citeshttps://doi.org/10.1016/j.intimp.2022.109569openalex-snapshot

Tumor-associated macrophages employ immunoediting mechanisms in colorectal tumor progression: Current research in Macrophage repolarization immunotherapy

inferred← citeshttps://doi.org/10.1016/j.isci.2024.109546openalex-snapshot

Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells

inferred← citeshttps://doi.org/10.1016/j.jare.2023.10.009openalex-snapshot

Deciphering the role of CD47 in cancer immunotherapy

inferred← citeshttps://doi.org/10.1016/j.jpha.2024.101099openalex-snapshot

Therapeutic strategies targeting CD47-SIRPα signaling pathway in gastrointestinal cancers treatment

inferred← citeshttps://doi.org/10.1016/j.nantod.2022.101651openalex-snapshot

Nanoparticle-enabled concurrent modulation of phagocytosis and repolarization of macrophages for enhanced cancer immunotherapy

inferred← citeshttps://doi.org/10.1016/j.phrs.2022.106264openalex-snapshot

Overcoming immunotherapeutic resistance in PDAC: SIRPα-CD47 blockade

inferred← citeshttps://doi.org/10.1038/s41392-023-01365-zopenalex-snapshot

Emerging phagocytosis checkpoints in cancer immunotherapy

inferred← citeshttps://doi.org/10.1093/postmj/qgaf072openalex-snapshot

CD47 as a biomarker for ovarian cancer: prospects and challenges

inferred← citeshttps://doi.org/10.1126/sciimmunol.abl9330openalex-snapshot

ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer

inferred← citeshttps://doi.org/10.1136/jitc-2020-001408openalex-snapshot

Phagocytic function of tumor-associated macrophages as a key determinant of tumor progression control: a review

inferred← citeshttps://doi.org/10.2147/ott.s220196openalex-snapshot

Checkpoint CD47 Function On Tumor Metastasis And Immune Therapy

inferred← citeshttps://doi.org/10.2174/0109298673383976250911101532openalex-snapshot

CD47-SIRPα: A Pivotal Signaling Pathway for Targeting Immunotherapy in Non-Small Cell Lung Cancer

inferred← citeshttps://doi.org/10.3389/fimmu.2020.00018openalex-snapshot

Advances in Anti-Tumor Treatments Targeting the CD47/SIRPα Axis

inferred← citeshttps://doi.org/10.3389/fimmu.2022.1027235openalex-snapshot

Inhibition of the CD47-SIRPα axis for cancer therapy: A systematic review and meta-analysis of emerging clinical data

inferred← citeshttps://doi.org/10.3389/fimmu.2025.1642091openalex-snapshot

Tumor-associated macrophages in colon cancer immunotherapy: mechanisms, natural product interventions, and microenvironment remodeling

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7S,15R-Dihydroxy-16S,17S-Epoxy-Docosapentaenoic Acid, a Novel DHA Epoxy Derivative, Inhibits Colorectal Cancer Stemness through Repolarization of Tumor-Associated Macrophage Functions and the ROS/STAT3 Signaling Pathway

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Anti-Leishmanial Vaccines: Assumptions, Approaches, and Annulments

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