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End‐to‐End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Flow Chemistry – A Key Enabling Technology for (Multistep) Organic Synthesis
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Multistep Continuous‐Flow Microchemical Synthesis Involving Multiple Reactions and Separations
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The Continuous‐Flow Synthesis of Ibuprofen
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Pro und kontra Strömungsreaktoren in der Synthese
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Multistep Continuous‐Flow Microchemical Synthesis Involving Multiple Reactions and Separations
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The Continuous‐Flow Synthesis of Ibuprofen
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Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis
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Microreactor Technology: A Revolution for the Fine Chemical and Pharmaceutical Industries?
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Seed loading effects on the mean crystal size of acetylsalicylic acid in a continuous‐flow crystallization device
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Production and Characterization of Carbamazepine Nanocrystals by Electrospraying for Continuous Pharmaceutical Manufacturing
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Electrospun Formulations Containing Crystalline Active Pharmaceutical Ingredients
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Improving Pharmaceutical Product Development and Manufacturing: Impact on Cost of Drug Development and Cost of Goods Sold of Pharmaceuticals
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A review on the continuous blending of powders
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Reducing the mean size of API crystals by continuous manufacturing with product classification and recycle
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Design and operation of a filter reactor for continuous production of a selected pharmaceutical intermediate
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An integrated approach for dynamic flowsheet modeling and sensitivity analysis of a continuous tablet manufacturing process
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Process design applied to optimise a directly compressible powder produced via a continuous manufacturing process
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Active pharmaceutical ingredient (API) production involving continuous processes – A process system engineering (PSE)-assisted design framework
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Continuous Flow Synthesis. A Pharma Perspective
inferredcites →https://doi.org/10.1021/ol100427vopenalex-snapshot
Total Synthesis of “Aliskiren”: The First Renin Inhibitor in Clinical Practice for Hypertension
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Amide Bond Formation via Reversible, Carboxylic Acid-Promoted Lactone Aminolysis
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Key Green Engineering Research Areas for Sustainable Manufacturing: A Perspective from Pharmaceutical and Fine Chemicals Manufacturers
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Continuous Hydrolysis and Liquid–Liquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale Hydrophobic Membrane Separator
inferredcites →https://doi.org/10.1021/op2002886openalex-snapshot
Development of Continuous Anti-Solvent/Cooling Crystallization Process using Cascaded Mixed Suspension, Mixed Product Removal Crystallizers
inferredcites →https://doi.org/10.1021/op200362hopenalex-snapshot
Development and Scale-Up of a Continuous, High-Pressure, Asymmetric Hydrogenation Reaction, Workup, and Isolation
inferredcites →https://doi.org/10.1021/op300159yopenalex-snapshot
Continuous Processing in the Manufacture of Active Pharmaceutical Ingredients and Finished Dosage Forms: An Industry Perspective
inferredcites →https://doi.org/10.1021/op8001273openalex-snapshot
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inferredcites →https://doi.org/10.1021/op900237xopenalex-snapshot
Continuous Crystallization of Pharmaceuticals Using a Continuous Oscillatory Baffled Crystallizer
inferredcites →https://doi.org/10.1039/b610888aopenalex-snapshot
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Industrial Case Study on Scale Up and System Dynamics Characterization of Pharmaceutical Continuous Production Line
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Concluding Remarks and Perspectives
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inferred← citeshttps://doi.org/10.1007/s41981-025-00343-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s43393-021-00024-0openalex-snapshot
Digital Twin in biomanufacturing: challenges and opportunities towards its implementation
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Emerging Technology for Modernizing Pharmaceutical Production
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Data Processing in Multivariate Analysis of Pharmaceutical Processes
inferred← citeshttps://doi.org/10.1016/b978-0-12-812659-2.00016-8openalex-snapshot
Future of microfluidics in research and in the market
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Scale-Up Studies in Pharmaceutical Products Development
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Challenges and Directions for Green Chemical Engineering—Role of Nanoscale Materials
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Sustainable separations in pharmaceutical manufacturing
inferred← citeshttps://doi.org/10.1016/b978-0-12-824304-6.00018-3openalex-snapshot
Chemical development: Synthetic studies and engineering including aspects of batch production and continuous processing
inferred← citeshttps://doi.org/10.1016/b978-0-323-88506-5.50188-1openalex-snapshot
Systematic model-based dynamic optimization of a combined cooling and antisolvent multistage continuous crystallization process
inferred← citeshttps://doi.org/10.1016/b978-0-323-88506-5.50211-4openalex-snapshot
Control of Batch and Continuous Crystallization Processes using Reinforcement Learning
inferred← citeshttps://doi.org/10.1016/b978-0-323-95879-0.50031-xopenalex-snapshot
Combined optimization of start-up shutdown and grade transition of a multistage continuous crystallization process
inferred← citeshttps://doi.org/10.1016/b978-0-323-95879-0.50130-2openalex-snapshot
Digital design and optimization of an integrated reaction-extraction-crystallization-filtration continuous pharmaceutical process
inferred← citeshttps://doi.org/10.1016/b978-0-443-15274-0.50265-1openalex-snapshot
Multi-Agent Reinforcement Learning and RL-Based Adaptive PID Control of Crystallization Processes
inferred← citeshttps://doi.org/10.1016/b978-0-443-32832-9.00001-1openalex-snapshot
Modeling of Pharmaceutical Processing Using ANNs
inferred← citeshttps://doi.org/10.1016/b978-0-444-63428-3.50179-xopenalex-snapshot
Multi-parametric Statistical Analysis of Economic Data for Continuous Pharmaceutical Manufacturing
inferred← citeshttps://doi.org/10.1016/b978-0-444-63576-1.50063-7openalex-snapshot
Plantwide Design and Economic Evaluation of Two Continuous Pharmaceutical Manufacturing (CPM) Cases: Ibuprofen and Artemisinin
inferred← citeshttps://doi.org/10.1016/b978-0-444-63963-9.00006-3openalex-snapshot
Applications of a plant-wide dynamic model of an integrated continuous pharmaceutical plant: Design of the recycle in the case of multiple impurities
inferred← citeshttps://doi.org/10.1016/b978-0-444-63963-9.00011-7openalex-snapshot
Process dynamics and control of API manufacturing and purification processes
inferred← citeshttps://doi.org/10.1016/b978-0-444-63963-9.00014-2openalex-snapshot
Fast stochastic model predictive control of end-to-end continuous pharmaceutical manufacturing 1 1Financial support from Novartis is acknowledged.
inferred← citeshttps://doi.org/10.1016/b978-0-444-63963-9.00016-6openalex-snapshot
Control system implementation and plant-wide control of continuous pharmaceutical manufacturing pilot plant (end-to-end manufacturing process)
inferred← citeshttps://doi.org/10.1016/b978-0-444-63965-3.50469-4openalex-snapshot
Dynamic Optimization of Continuous Manufacturing of Pharmaceuticals
inferred← citeshttps://doi.org/10.1016/b978-0-444-63977-6.00022-5openalex-snapshot
Hyperspectral imaging as a part of pharmaceutical product design
inferred← citeshttps://doi.org/10.1016/b978-0-444-64235-6.50280-1openalex-snapshot
A Global State Feedback Linearization and Decoupling MPC of a MIMO Continuous MSMPR Cooling Crystallization Process
inferred← citeshttps://doi.org/10.1016/b978-0-444-64241-7.50346-3openalex-snapshot
A shortcut approach for decision-making and operational analysis of an integrated end-to-end continuous pharmaceutical process
inferred← citeshttps://doi.org/10.1016/b978-0-444-64301-8.00003-2openalex-snapshot
Biopharmaceutical development, production, and quality
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Flow Synthesis of Heterocycles
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Recent Advances of Microfluidics Technologies in the Field of Medicinal Chemistry
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Recent developments in micro- and nanofabrication techniques for the preparation of amorphous pharmaceutical dosage forms
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Ready, steady, flow: Pd-loaded hypercrosslinked microreactors for the flow synthesis of paracetamol
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Data-driven engineering framework with AI algorithm of Ginkgo Folium tablets manufacturing
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Pharmaceutical formulation and manufacturing using particle/powder technology for personalized medicines
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Smart Pharmaceutical Manufacturing: Ensuring End-to-End Traceability and Data Integrity in Medicine Production
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The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds
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Continuous synthesis of dolutegravir sodium crystals using liquid-gas heterogeneous microreactor
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Design and optimization of coupling a continuously operated reactor with simulated moving bed chromatography
inferred← citeshttps://doi.org/10.1016/j.cej.2014.12.050openalex-snapshot
CRE for MAGIC (modular, agile, intensified & continuous) processes
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Residence time distribution of dispersed liquid and solid phase in a continuous oscillatory flow baffled crystallizer
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Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning
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Suspension flow behavior and particle residence time distribution in helical tube devices
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Screening of functional solvent system for automatic aldehyde and ketone separation in aldol reaction: A combined COSMO-RS and experimental approach
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Competing commercial catalysts: Unprecedented catalyst activity and stability of Mizoroki-Heck reaction in a continuous packed bed reactor
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Process intensification for production of dispersants via integration of reaction and separation in a horizontal thin film evaporator
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Continuous flow synthesis of fluconazole monitored by inline ultraviolet spectroscopy: 3D microfluidic platform and Bayesian optimization
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A simple AI-driven process intensification protocol for active pharmaceutical ingredients synthesis
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Evaluating the potential for the continuous processing of pharmaceutical products—a supply network perspective
inferred← citeshttps://doi.org/10.1016/j.cep.2016.02.002openalex-snapshot
Continuous crystallization using a sonicated tubular system for controlling particle size in an API manufacturing process
inferred← citeshttps://doi.org/10.1016/j.cep.2016.08.006openalex-snapshot
Evaluation of mixed suspension mixed product removal crystallization processes coupled with a continuous filtration system
inferred← citeshttps://doi.org/10.1016/j.cep.2016.09.017openalex-snapshot
Modules in process industry − A life cycle definition
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Optimal campaigns in end-to-end continuous pharmaceuticals manufacturing. Part 1: Nonsmooth dynamic modeling
inferred← citeshttps://doi.org/10.1016/j.cep.2018.01.015openalex-snapshot
Optimal campaigns in end-to-end continuous pharmaceuticals manufacturing. Part 2: Dynamic optimization
inferred← citeshttps://doi.org/10.1016/j.cep.2018.03.018openalex-snapshot
Process intensification for pharmaceutical crystallization
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Continuous synthesis of isobornyl acetate catalyzed by a strong acid cation exchange resin in an oscillatory flow reactor
inferred← citeshttps://doi.org/10.1016/j.cep.2019.107559openalex-snapshot
Microfluidic process intensification for synthesis and formulation in the pharmaceutical industry
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Process intensified anti-solvent crystallization of o-aminobenzoic acid via sonication and flow
inferred← citeshttps://doi.org/10.1016/j.cep.2023.109291openalex-snapshot
Process intensification for decentralized production
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Fluidic separation in microstructured devices – Concepts and their Integration into process flow networks
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Continuous synthesis of PVP stabilized biocompatible gold nanoparticles with a controlled size using a 3D glass capillary microfluidic device
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Kinetic model discrimination of penicillin G acylase thermal deactivation by non-isothermal continuous activity assay
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Image analysis framework with focus evaluation for in situ characterisation of particle size and shape attributes
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Model evaluation of particle breakage facilitated process intensification for Mixed-Suspension-Mixed-Product-Removal (MSMPR) crystallization
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Mathematical modeling and digital design of an intensified filtration-washing-drying unit for pharmaceutical continuous manufacturing
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Continuous crystallization of paracetamol exploiting gas–liquid flow in modular nucleation and growth stages
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Continuous-flow synthesis of the liquid crystal intermediate 1-(4-ethoxy-2,3-difluorobenzyl)-4-propylcyclohexan-1-ol in a microfluidic system: Experimental and numerical studies
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Model-based solvent selection for the synthesis and crystallisation of pharmaceutical compounds
inferred← citeshttps://doi.org/10.1016/j.ces.2023.119688openalex-snapshot
Population balance model enabled digital design and uncertainty analysis framework for continuous crystallization of pharmaceuticals using an automated platform with full recycle and minimal material use
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In-situ wet milling for particle size control in continuous crystallization: Expanding the attainable region
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Process modelling and simulation for continuous pharmaceutical manufacturing of ibuprofen
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Sustainability benefits of a continuous phase transfer catalyzed process for a model pharmaceutical intermediate
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Process modelling and simulation for continuous pharmaceutical manufacturing of artemisinin
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Development of high-performance hybrid ANN-finite volume scheme (ANN-FVS) for simulation of pharmaceutical continuous granulation
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Modeling and analysis of MSMPR cascades involving nucleation, growth and agglomeration mechanisms with slurry recycling
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Synthesis of a dipeptide by integrating a continuous flow reaction and continuous crystallization
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Automated and continuous synthesis of drug substances
inferred← citeshttps://doi.org/10.1016/j.cherd.2023.07.003openalex-snapshot
Digital process design to define and deliver pharmaceutical particle attributes
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A framework for systematic crystal shape tuning – Case of Lovastatin's needle-shaped crystals
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Continuous manufacturing based paradigm shift in pharmaceuticals production and current regulatory framework
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Design and optimization of a shared synthetic route for multiple active pharmaceutical ingredients through combined computer aided retrosynthesis and flow chemistry
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Modular and mobile facility location problems: A systematic review
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Perspectives on the flexibility analysis for continuous pharmaceutical manufacturing processes
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Pharmaceutical industry perspectives on flow chemocatalysis and biocatalysis
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Plantwide design and economic evaluation of two Continuous Pharmaceutical Manufacturing (CPM) cases: Ibuprofen and artemisinin
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2016.10.007openalex-snapshot
A superstructure-based framework for bio-separation network synthesis
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Challenges and opportunities in biopharmaceutical manufacturing control
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Process modelling, simulation and technoeconomic evaluation of crystallisation antisolvents for the continuous pharmaceutical manufacturing of rufinamide
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A framework for model reliability and estimability analysis of crystallization processes with multi-impurity multi-dimensional population balance models
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Process modelling, design and technoeconomic Liquid–Liquid Extraction (LLE) optimisation for comparative evaluation of batch vs. continuous pharmaceutical manufacturing of atropine
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