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Structure and Biocatalytic Scope of Coclaurine N‐Methyltransferase

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ange.201508287openalex-snapshot
Effects of Active‐Site Modification and Quaternary Structure on the Regioselectivity of Catechol‐O‐Methyltransferase
inferredcites →https://doi.org/10.1002/ange.201705855openalex-snapshot
Enzymatic and Chemoenzymatic Three‐Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines
inferredcites →https://doi.org/10.1002/anie.201508287openalex-snapshot
Effects of Active‐Site Modification and Quaternary Structure on the Regioselectivity of Catechol‐O‐Methyltransferase
inferredcites →https://doi.org/10.1002/anie.201705855openalex-snapshot
Enzymatic and Chemoenzymatic Three‐Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines
inferredcites →https://doi.org/10.1002/anie.201805060openalex-snapshot
Structure and Biocatalytic Scope of Coclaurine N‐Methyltransferase
inferredcites →https://doi.org/10.1002/chem.201201895openalex-snapshot
Inverting the Regioselectivity of the Berberine Bridge Enzyme by Employing Customized Fluorine‐Containing Substrates
inferredcites →https://doi.org/10.1016/0031-9422(90)85263-fopenalex-snapshot
Purification and characterization of three isoforms of S-adenosyl-l-methionine: (R,S)-Tetrahydrobenzylisoquinoline-N-methyltransferase from Berberis koetineana cell cultures
inferredcites →https://doi.org/10.1016/j.cbpa.2015.12.006openalex-snapshot
Biocatalysts from alkaloid producing plants
inferredcites →https://doi.org/10.1016/j.tetlet.2011.12.089openalex-snapshot
Biocatalytic production of tetrahydroisoquinolines
inferredcites →https://doi.org/10.1016/j.tibtech.2015.12.005openalex-snapshot
Microbial Factories for the Production of Benzylisoquinoline Alkaloids
inferredcites →https://doi.org/10.1016/s0031-9422(00)00481-7openalex-snapshot
Purification and characterization of coclaurine N-methyltransferase from cultured Coptis japonica cells
inferredcites →https://doi.org/10.1038/ncomms1327openalex-snapshot
A bacterial platform for fermentative production of plant alkaloids
inferredcites →https://doi.org/10.1038/ncomms14883openalex-snapshot
Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines
inferredcites →https://doi.org/10.1038/ncomms4283openalex-snapshot
Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1038/srep03640openalex-snapshot
Correction: Corrigendum: Promising operational stability of high-efficiency organic light-emitting diodes based on thermally activated delayed fluorescence
inferredcites →https://doi.org/10.1038/srep06695openalex-snapshot
(R,S)-Tetrahydropapaveroline production by stepwise fermentation using engineered Escherichia coli
inferredcites →https://doi.org/10.1039/c3ra42123fopenalex-snapshot
The role of biocatalysis in the asymmetric synthesis of alkaloids
inferredcites →https://doi.org/10.1039/c5sc00164aopenalex-snapshot
Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase
inferredcites →https://doi.org/10.1042/bst0351583openalex-snapshot
Cross-linked enzyme aggregates (CLEA®s): stable and recyclable biocatalysts
inferredcites →https://doi.org/10.1074/jbc.m106405200openalex-snapshot
Molecular Cloning and Characterization of CoclaurineN-Methyltransferase from Cultured Cells of Coptis japonica
inferredcites →https://doi.org/10.1074/jbc.m116.747261openalex-snapshot
Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism
inferredcites →https://doi.org/10.1074/jbc.m116.750893openalex-snapshot
Isolation and Characterization of Reticuline N-Methyltransferase Involved in Biosynthesis of the Aporphine Alkaloid Magnoflorine in Opium Poppy
inferredcites →https://doi.org/10.1093/pcp/pct020openalex-snapshot
Benzylisoquinoline Alkaloid Metabolism: A Century of Discovery and a Brave New World
inferredcites →https://doi.org/10.1111/j.1365-313x.2009.03980.xopenalex-snapshot
Targeted metabolite and transcript profiling for elucidating enzyme function: isolation of novel N‐ methyltransferases from three benzylisoquinoline alkaloid‐producing species
inferredcites →https://doi.org/10.1126/science.aac9373openalex-snapshot
Complete biosynthesis of opioids in yeast

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2019.112193zenodo-depositor-declared
A single residue determines substrate preference in benzylisoquinoline alkaloid N-methyltransferases
inferred← citeshttps://doi.org/10.1002/ange.202004963openalex-snapshot
Engineering Orthogonal Methyltransferases to Create Alternative Bioalkylation Pathways
inferred← citeshttps://doi.org/10.1002/ange.202104476openalex-snapshot
Multienzyme One‐Pot Cascades Incorporating Methyltransferases for the Strategic Diversification of Tetrahydroisoquinoline Alkaloids
inferred← citeshttps://doi.org/10.1002/anie.202004963openalex-snapshot
Engineering Orthogonal Methyltransferases to Create Alternative Bioalkylation Pathways
inferred← citeshttps://doi.org/10.1002/anie.202104476openalex-snapshot
Multienzyme One‐Pot Cascades Incorporating Methyltransferases for the Strategic Diversification of Tetrahydroisoquinoline Alkaloids
inferred← citeshttps://doi.org/10.1002/cbic.202300170openalex-snapshot
Rapid, Label‐Free Screening of Diverse Biotransformations by Flow‐Injection Mass Spectrometry
inferred← citeshttps://doi.org/10.1002/cctc.202401668openalex-snapshot
Bioalkylation Strategies to Synthesize Allylated Tetrahydroisoquinolines by Using Norcoclaurine Synthase and O‐Methyltransferases
inferred← citeshttps://doi.org/10.1007/s10295-020-02300-9openalex-snapshot
Back to the plant: overcoming roadblocks to the microbial production of pharmaceutically important plant natural products
inferred← citeshttps://doi.org/10.1007/s10529-019-02785-0openalex-snapshot
Identification and characterization of methyltransferases involved in benzylisoquinoline alkaloids biosynthesis from Stephania intermedia
inferred← citeshttps://doi.org/10.1007/s11101-019-09644-wopenalex-snapshot
Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update
inferred← citeshttps://doi.org/10.1007/s43393-026-00503-2openalex-snapshot
A designed modular chemoenzymatic platform simplifies the manufacture of bioactive components from Coptidis Rhizoma
inferred← citeshttps://doi.org/10.1007/s43630-023-00448-8openalex-snapshot
Visible-light promoted photoredox catalysis in flow: addition of biologically important α‑amino radicals to michael acceptors
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14696-7openalex-snapshot
Plant Alkaloid Engineering
inferred← citeshttps://doi.org/10.1016/bs.alkal.2018.07.001openalex-snapshot
Bisbenzylisoquinoline Alkaloids
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108238openalex-snapshot
Functional characterization and regioselectivity manipulation of two Benzylisoquinoline alkaloids O-methyltransferases from Stephania yunnanensis
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2026.108949openalex-snapshot
Programmable methylation engineering: Design principles from alkaloid biosynthesis
inferred← citeshttps://doi.org/10.1016/j.chemphys.2026.113179openalex-snapshot
Mechanistic investigation of peroxyl radical scavenging by benzylisoquinoline alkaloids: role of hydrogen transfer and acid–base speciation
inferred← citeshttps://doi.org/10.1016/j.copbio.2021.02.010openalex-snapshot
Enzyme-mediated bioorthogonal technologies: catalysts, chemoselective reactions and recent methyltransferase applications
inferred← citeshttps://doi.org/10.1016/j.plaphy.2025.110067openalex-snapshot
Coclaurine N-methyltransferase-like enzymes drive the final biosynthetic reaction of the anti-Alzheimer's drug galanthamine in Amaryllidaceae
inferred← citeshttps://doi.org/10.1016/j.xplc.2026.101786openalex-snapshot
Biosynthesis of benzylisoquinoline alkaloids and its evolution in plants
inferred← citeshttps://doi.org/10.1021/acs.jafc.4c04818openalex-snapshot
Characterization and Molecular Engineering of a N-Methyltransferase from Edible Nelumbo nucifera Leaves Involved in Nuciferine Biosynthesis
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c16426openalex-snapshot
Engineering Substrate Promiscuity and Catalytic Efficiency of Benzylisoquinoline Alkaloids N -Methyltransferases
inferred← citeshttps://doi.org/10.1021/acs.joc.0c01275openalex-snapshot
Using the Competing Enantioselective Conversion Method to Assign the Absolute Configuration of Cyclic Amines with Bode’s Acylation Reagents
inferred← citeshttps://doi.org/10.1021/acscatal.1c06012openalex-snapshot
Engineering Imine Reductase for Efficient Biosynthesis of 1-Aryl-Tetrahydro-β-Carbolines and Their N-Methylation Products
inferred← citeshttps://doi.org/10.1021/acscatal.9b05417openalex-snapshot
Structure-Guided Engineering of a Scoulerine 9- O -Methyltransferase Enables the Biosynthesis of Tetrahydropalmatrubine and Tetrahydropalmatine in Yeast
inferred← citeshttps://doi.org/10.1038/s41467-023-44420-7openalex-snapshot
Modular assembly of an artificially concise biocatalytic cascade for the manufacture of phenethylisoquinoline alkaloids
inferred← citeshttps://doi.org/10.1038/s41598-023-29415-0openalex-snapshot
Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera)
inferred← citeshttps://doi.org/10.1039/c9ob01090dopenalex-snapshot
Dehydrogenative C(sp 3 )–H bond functionalization of tetrahydroisoquinolines mediated by organic oxidants under mild conditions
inferred← citeshttps://doi.org/10.1039/c9sc03773jopenalex-snapshot
Biosynthesis of plant tetrahydroisoquinoline alkaloids through an imine reductase route
inferred← citeshttps://doi.org/10.1039/d0ob02582hopenalex-snapshot
Visible light promoted photoredox C(sp 3 )–H bond functionalization of tetrahydroisoquinolines in flow
inferred← citeshttps://doi.org/10.1039/d1cs00065aopenalex-snapshot
Biosynthesis and synthetic biology of psychoactive natural products
inferred← citeshttps://doi.org/10.1039/d1ra03692kopenalex-snapshot
Cross-linking of a polyketide synthase domain leads to a recyclable biocatalyst for chiral oxygen heterocycle synthesis
inferred← citeshttps://doi.org/10.1039/d1ra04181aopenalex-snapshot
The role of biocatalysis in the asymmetric synthesis of alkaloids – an update
inferred← citeshttps://doi.org/10.1039/d4np00029copenalex-snapshot
Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids
inferred← citeshttps://doi.org/10.1039/d6np00042hopenalex-snapshot
SAM-dependent methyltransferases: from chemoenzymatic natural product synthesis to industrial application
inferred← citeshttps://doi.org/10.1074/jbc.ra119.009214openalex-snapshot
Structure–function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition
inferred← citeshttps://doi.org/10.1111/tpj.15966openalex-snapshot
Characterization of benzylisoquinoline alkaloid methyltransferases in Liriodendron chinense provides insights into the phylogenic basis of angiosperm alkaloid diversity
inferred← citeshttps://doi.org/10.1111/tpj.70910openalex-snapshot
A Golgi‐localized N‐methyltransferase and reversible aldo–keto reductases coordinate dual terminal routes in galanthamine biosynthesis
inferred← citeshttps://doi.org/10.1126/sciadv.ads3596openalex-snapshot
Convergent evolution of berberine biosynthesis
inferred← citeshttps://doi.org/10.3389/fpls.2019.01058openalex-snapshot
Molecular Origins of Functional Diversity in Benzylisoquinoline Alkaloid Methyltransferases
inferred← citeshttps://doi.org/10.3390/catal9121030openalex-snapshot
Recent Advances in Flavin-Dependent Halogenase Biocatalysis: Sourcing, Engineering, and Application
inferred← citeshttps://doi.org/10.3390/ijms26178280openalex-snapshot
Neuroprotective Potential of Major Alkaloids from Nelumbo nucifera (Lotus): Mechanisms and Therapeutic Implications
inferred← citeshttps://doi.org/10.3390/molecules28010043openalex-snapshot
Functional Diversification and Structural Origins of Plant Natural Product Methyltransferases
inferred← citeshttps://doi.org/10.3390/plants14121885openalex-snapshot
Metabolomic Insights into Sexual Multi-Morphism of Sinomenine Accumulation in Sinomenium acutum
inferred← citeshttps://doi.org/10.64898/2025.12.20.695673openalex-snapshot
Branch-Enabling N-Methyltransferase in Golgi Reconciles Divergent Models of Galanthamine Biosynthesis
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