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A Cryptic Plant Terpene Cyclase Producing Unconventional 18‐ and 14‐Membered Macrocyclic C25 and C20 Terpenoids with Immunosuppressive Activity
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Glandular Trichomes of Leucosceptrum canum Harbor Defensive Sesterterpenoids
inferredcites →https://doi.org/10.1002/ange.201403648openalex-snapshot
Substratinduzierte Konformationsänderungen in Klasse‐I‐Terpencyclasen
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An Unusual Chimeric Diterpene Synthase from Emericella variecolor and Its Functional Conversion into a Sesterterpene Synthase by Domain Swapping
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Diverged Plant Terpene Synthases Reroute the Carbocation Cyclization Path towards the Formation of Unprecedented 6/11/5 and 6/6/7/5 Sesterterpene Scaffolds
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Zwei Diterpensynthasen für Spiroalbaten und Cembren A aus Allokutzneria albata
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inferredcites →https://doi.org/10.1002/anie.201000449openalex-snapshot
Glandular Trichomes of Leucosceptrum canum Harbor Defensive Sesterterpenoids
inferredcites →https://doi.org/10.1002/anie.201403648openalex-snapshot
Induced‐Fit Mechanism in Class I Terpene Cyclases
inferredcites →https://doi.org/10.1002/anie.201509263openalex-snapshot
An Unusual Chimeric Diterpene Synthase from Emericella variecolor and Its Functional Conversion into a Sesterterpene Synthase by Domain Swapping
inferredcites →https://doi.org/10.1002/anie.201711444openalex-snapshot
Diverged Plant Terpene Synthases Reroute the Carbocation Cyclization Path towards the Formation of Unprecedented 6/11/5 and 6/6/7/5 Sesterterpene Scaffolds
inferredcites →https://doi.org/10.1002/anie.201800385openalex-snapshot
Two Diterpene Synthases for Spiroalbatene and Cembrene A from Allokutzneria albata
inferredcites →https://doi.org/10.1002/anie.202010084openalex-snapshot
The Biosynthetic Gene Cluster for Sestermobaraenes—Discovery of a Geranylfarnesyl Diphosphate Synthase and a Multiproduct Sesterterpene Synthase from Streptomyces mobaraensis
inferredcites →https://doi.org/10.1002/anie.202109465openalex-snapshot
Functional Switch and Ethyl Group Formation in the Bacterial Polytrichastrene Synthase from Chryseobacterium polytrichastri
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Trichome specific expression of the tobacco (Nicotiana sylvestris) cembratrien-ol synthase genes is controlled by both activating and repressing cis-regions
inferredcites →https://doi.org/10.1007/s11427-019-9521-2openalex-snapshot
Recently duplicated sesterterpene (C25) gene clusters in Arabidopsis thaliana modulate root microbiota
inferredcites →https://doi.org/10.1016/0040-4020(79)85048-6openalex-snapshot
New macrocyclic sesterterpenoids from a scale insect (ceroplastes ceriferus)
inferredcites →https://doi.org/10.1016/j.bbrc.2010.01.063openalex-snapshot
Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution
inferredcites →https://doi.org/10.1016/j.fgb.2019.03.007openalex-snapshot
Rapid discovery and functional characterization of diterpene synthases from basidiomycete fungi by genome mining
inferredcites →https://doi.org/10.1016/j.jaci.2016.06.033openalex-snapshot
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases
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Characterization of a sesquiterpene cyclase from the glandular trichomes of Leucosceptrum canum for sole production of cedrol in Escherichia coli and Nicotiana benthamiana
inferredcites →https://doi.org/10.1016/j.tips.2019.12.006openalex-snapshot
Identifying Missing Biosynthesis Enzymes of Plant Natural Products
inferredcites →https://doi.org/10.1016/j.xplc.2020.100051openalex-snapshot
Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases
inferredcites →https://doi.org/10.1016/j.ymben.2017.04.006openalex-snapshot
Releasing the potential power of terpene synthases by a robust precursor supply platform
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Chemistry of ayurvedic crude drugs—II
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Structural and Chemical Biology of Terpenoid Cyclases
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Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis
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(+)-Thalianatriene and (−)-Retigeranin B Catalyzed by Sesterterpene Synthases from Arabidopsis thaliana
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Characterization of Micromonocyclol Synthase from the Marine Actinomycete Micromonospora marina
inferredcites →https://doi.org/10.1021/acscatal.1c01113openalex-snapshot
Bacterial Diterpene Synthases Prenylate Small Molecules
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Enantioselective Conversion of Oligoprenol Derivatives to Macrocycles in the Germacrene, Cembrene, and 18-Membered Cyclic Sesterterpene Series
inferredcites →https://doi.org/10.1021/np990170topenalex-snapshot
Sesterterpenoids and Diterpenoids of the Wax Excreted by a Scale Insect, Ceroplastes pseudoceriferus
inferredcites →https://doi.org/10.1021/ol4004756openalex-snapshot
Peltate Glandular Trichomes of Colquhounia coccinea var. mollis Harbor a New Class of Defensive Sesterterpenoids
inferredcites →https://doi.org/10.1038/nature04607openalex-snapshot
Designed divergent evolution of enzyme function
inferredcites →https://doi.org/10.1038/ncomms1494openalex-snapshot
Identification and microbial production of a terpene-based advanced biofuel
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Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases
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Characterisation of three terpene synthases for β-barbatene, β-araneosene and nephthenol from social amoebae
inferredcites →https://doi.org/10.1039/d0np00070aopenalex-snapshot
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The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis
inferredcites →https://doi.org/10.1073/pnas.1422108112openalex-snapshot
Terpene synthases are widely distributed in bacteria
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Unearthing a sesterterpene biosynthetic repertoire in the Brassicaceae through genome mining reveals convergent evolution
inferredcites →https://doi.org/10.1073/pnas.1705586114openalex-snapshot
Blue fluorescent amino acid for biological spectroscopy and microscopy
inferredcites →https://doi.org/10.1073/pnas.91.18.8497openalex-snapshot
Cloning of casbene synthase cDNA: evidence for conserved structural features among terpenoid cyclases in plants.
inferredcites →https://doi.org/10.1105/tpc.106.047779openalex-snapshot
Rational Conversion of Substrate and Product Specificity in a Salvia Monoterpene Synthase: Structural Insights into the Evolution of Terpene Synthase Function
inferredcites →https://doi.org/10.1105/tpc.15.00715openalex-snapshot
A Geranylfarnesyl Diphosphate Synthase Provides the Precursor for Sesterterpenoid (C25) Formation in the Glandular Trichomes of the Mint Species Leucosceptrum canum
inferredcites →https://doi.org/10.1111/j.1467-7652.2009.00434.xopenalex-snapshot
pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants
inferredcites →https://doi.org/10.1111/nph.15778openalex-snapshot
Promiscuous terpene synthases from Prunella vulgaris highlight the importance of substrate and compartment switching in terpene synthase evolution
inferredcites →https://doi.org/10.1126/science.1072682openalex-snapshot
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
inferredcites →https://doi.org/10.1126/science.277.5333.1815openalex-snapshot
Structural Basis for Cyclic Terpene Biosynthesis by Tobacco 5-Epi-Aristolochene Synthase
inferredcites →https://doi.org/10.1246/cl.1977.705openalex-snapshot
CYCLIZATION OF POLYENES XXIV. EFFECTIVE CONSTRUCTION OF ALBOCEROL SKELETON BY INTRAMOLECULAR ACYLATION OF GERANYLFARNESIC ACID CHLORIDE
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113531zenodo-depositor-declared
Labdane diterpenoids from the heartwood of Leucosceptrum canum that impact on root growth and seed germination of Arabidopsis thaliana
inferred← citeshttps://doi.org/10.1002/advs.202415370openalex-snapshot
From Monocyclization to Pentacyclization: A Versatile Plant Cyclase Produces Diverse Sesterterpenes with Anti‐Liver Fibrosis Potential
inferred← citeshttps://doi.org/10.1002/ange.202306429openalex-snapshot
Mechanistische Charakterisierung der Bakteriellen Sesterviriden‐Synthase aus Kitasatospora viridis
inferred← citeshttps://doi.org/10.1002/ange.202401539openalex-snapshot
Zwei Sesterterpen‐Syntasen aus Lentzea atacamensis demonstrieren die Rolle der Konformationsvariabilität in der Terpenbiosynthese
inferred← citeshttps://doi.org/10.1002/ange.202405140openalex-snapshot
Strukturelle Einblicke in die Terpencyclasedomänen Zweier Pilzlicher Sesterterpensyntasen und Enzymengineering zur Diversifizierung von Sesterterpenen
inferred← citeshttps://doi.org/10.1002/ange.202406246openalex-snapshot
Function Switch of a Fungal Sesterterpene Synthase through Molecular Dynamics Simulation Assisted Alteration of an Aromatic Residue Cluster in the Active Pocket of PfNS
inferred← citeshttps://doi.org/10.1002/ange.2037917openalex-snapshot
Evolutionäre, funktionelle und mechanistische Charakterisierung mikrobieller Terpensynthase‐ähnlicher Gene aus Springschwänzen
inferred← citeshttps://doi.org/10.1002/anie.202306429openalex-snapshot
Mechanistic Characterisation of the Bacterial Sesterviridene Synthase from Kitasatospora viridis
inferred← citeshttps://doi.org/10.1002/anie.202401539openalex-snapshot
Two Sesterterpene Synthases from Lentzea atacamensis Demonstrate the Role of Conformational Variability in Terpene Biosynthesis
inferred← citeshttps://doi.org/10.1002/anie.202405140openalex-snapshot
Structural Insights Into the Terpene Cyclization Domains of Two Fungal Sesterterpene Synthases and Enzymatic Engineering for Sesterterpene Diversification
inferred← citeshttps://doi.org/10.1002/anie.202406246openalex-snapshot
Function Switch of a Fungal Sesterterpene Synthase through Molecular Dynamics Simulation Assisted Alteration of an Aromatic Residue Cluster in the Active Pocket of PfNS
inferred← citeshttps://doi.org/10.1002/anie.2037917openalex-snapshot
Evolutionary, Functional and Mechanistic Characterisation of Microbial Terpene Synthase‐Like Genes From Springtails
inferred← citeshttps://doi.org/10.1016/j.apsb.2025.09.006openalex-snapshot
Undulanoids A−D: Unexpected sesterterpenoids as potent S100A8/A9 complex inhibitors for psoriasis treatment
inferred← citeshttps://doi.org/10.1016/j.cclet.2022.04.067openalex-snapshot
Characterization of two chimeric sesterterpene synthases from a fungal symbiont isolated from a sesterterpenoid-producing Lamiaceae plant Leucosceptrum canum
inferred← citeshttps://doi.org/10.1016/j.fbio.2025.107776openalex-snapshot
Enhancing the antioxidant and anti-inflammatory potential of Citrus aurantium L. var. amara Engl. Via strain-specific microbial fermentation
inferred← citeshttps://doi.org/10.1016/j.indcrop.2025.121808openalex-snapshot
Identification of OjGBS, a terpene synthase involved in germacrene B biosynthesis in Oenanthe javanica
inferred← citeshttps://doi.org/10.1016/j.phytochem.2023.113681openalex-snapshot
A new sesquiterpene synthase catalyzing the formation of (R)-β-bisabolene from medicinal plant Colquhounia coccinea var. mollis and its anti-adipogenic and antibacterial activities
inferred← citeshttps://doi.org/10.1016/j.phytochem.2024.114304openalex-snapshot
Z/E configuration controlled by a Taxus sesquiterpene synthase facilitating the biosynthesis of (3Z,6E)-α-farnesene
inferred← citeshttps://doi.org/10.1021/acs.jafc.3c07573openalex-snapshot
Identification and Characterization of a Nerol Synthase in Fungi
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c11512openalex-snapshot
Genome Mining Guided Discovery of Macrocyclic Sesterterpenoids with Anti-MRSA and Anti-Neuroinflammatory Activities
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.5c00870openalex-snapshot
Discovery and Characterization of a cis -Casbene Diterpene Synthase from Streptomyces paromomycinus
inferred← citeshttps://doi.org/10.1021/acs.joc.4c01915openalex-snapshot
Total Synthesis of an Immunosuppressive C25 Macrocyclic Terpenoid Produced by Terpene Synthase (LcTPS2)
inferred← citeshttps://doi.org/10.1021/acscatal.3c03047openalex-snapshot
Decoding Catalysis by Terpene Synthases
inferred← citeshttps://doi.org/10.1021/acscatal.3c03740openalex-snapshot
Turning a Sesquiterpene Synthase into a Di- and Sesterterpene Synthase
inferred← citeshttps://doi.org/10.1021/acscatal.5c07482openalex-snapshot
Engineering the D-Helix in Fungal Sesterterpene Synthase ZbSS Unlocks a Skeletal Rearrangement Cyclization Route toward Sesterterpene Diversification
inferred← citeshttps://doi.org/10.1021/acscatal.6c03869openalex-snapshot
α1-Loop/D-Helix Remodeling Governs Reversible GFPP vs GGPP Selectivity in Fungal Sesterterpene Synthases
inferred← citeshttps://doi.org/10.1021/jacs.5c11309openalex-snapshot
Structure-Guided Engineering of a Bacterial Sesterterpene Synthase for Sesterviridene Diversification
inferred← citeshttps://doi.org/10.1021/jacs.5c19381openalex-snapshot
Dihydroxy Terpene Synthase: Spatiotemporally Precise Manipulation of Water-Mediated Dihydroxylation via Stepwise Quenching of Carbocations
inferred← citeshttps://doi.org/10.1021/jacs.6c06677openalex-snapshot
Local Active-Site Architecture Directs Divergent Carbocation Cascades in Sesterterpene Synthases
inferred← citeshttps://doi.org/10.1038/s41467-023-39706-9openalex-snapshot
Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase
inferred← citeshttps://doi.org/10.1038/s41586-022-04773-3openalex-snapshot
Discovery of non-squalene triterpenes
inferred← citeshttps://doi.org/10.1039/d4np00041bopenalex-snapshot
Sesterterpenoids: sources, structural diversity, biological activity, and data management
inferred← citeshttps://doi.org/10.1111/jipb.13454openalex-snapshot
Heteromerization of short‐chain trans‐prenyltransferase controls precursor allocation within a plastidial terpenoid network
inferred← citeshttps://doi.org/10.1111/jipb.13836openalex-snapshot
Molecular and biochemical evolution of casbene‐type diterpene and sesquiterpene biosynthesis in rice
inferred← citeshttps://doi.org/10.3389/fpls.2026.1833733openalex-snapshot
Integrated characterization of six sesquiterpene synthases unravels diversified terpene biosynthesis in the mint species Leucosceptrum canum
inferred← citeshttps://doi.org/10.3390/ijms23031903openalex-snapshot
The Biosynthesis and Transport of Ophiobolins in Aspergillus ustus 094102
inferred← citeshttps://doi.org/10.3390/jof8101080openalex-snapshot
Research Progress on Fungal Sesterterpenoids Biosynthesis
inferred← citeshttps://doi.org/10.3390/plants15111614openalex-snapshot
Heterologous Expression and In Vivo Functional Analysis of OsTPS2 in Yeast, Tobacco, and Rice
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Enhancing structural diversity of terpenoids by multisubstrate terpene synthases
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