On the public citation graph

Designed divergent evolution of enzyme function

0 signed · 455 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/jmbi.1996.0167openalex-snapshot

An Evolutionary Trace Method Defines Binding Surfaces Common to Protein Families

inferredcites →https://doi.org/10.1006/jmbi.2000.4259openalex-snapshot

In vitro Evolution of Beta-glucuronidase into a Beta-galactosidase Proceeds Through Non-specific Intermediates

inferredcites →https://doi.org/10.1007/s00438-002-0709-yopenalex-snapshot

Genomic analysis of the terpenoid synthase (AtTPS) gene family of Arabidopsis thaliana

inferredcites →https://doi.org/10.1016/0278-6915(83)90167-9openalex-snapshot

Encyclopaedia of the Terpenoids

inferredcites →https://doi.org/10.1016/j.abb.2004.07.034openalex-snapshot

Divergent evolution in the enolase superfamily: the interplay of mechanism and specificity

inferredcites →https://doi.org/10.1016/s0003-9861(02)00068-1openalex-snapshot

Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases δ-selinene synthase and γ-humulene synthase

inferredcites →https://doi.org/10.1016/s0968-0004(03)00135-xopenalex-snapshot

Conformational diversity and protein evolution – a 60-year-old hypothesis revisited

inferredcites →https://doi.org/10.1016/s1074-5521(99)80033-7openalex-snapshot

Catalytic promiscuity and the evolution of new enzymatic activities

inferredcites →https://doi.org/10.1016/s1357-4310(95)91170-7openalex-snapshot

Comparative protein modeling by satisfaction of spatial restraints

inferredcites →https://doi.org/10.1016/s1367-5931(03)00032-2openalex-snapshot

Enzymes with extra talents: moonlighting functions and catalytic promiscuity

inferredcites →https://doi.org/10.1021/bi011960gopenalex-snapshot

X-ray Crystal Structures of D100E Trichodiene Synthase and Its Pyrophosphate Complex Reveal the Basis for Terpene Product Diversity,

inferredcites →https://doi.org/10.1021/bi048052eopenalex-snapshot

Inverse Thinking about Double Mutants of Enzymes

inferredcites →https://doi.org/10.1038/21395openalex-snapshot

Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation

inferredcites →https://doi.org/10.1038/339191a0openalex-snapshot

Structural plasticity broadens the specificity of an engineered protease

inferredcites →https://doi.org/10.1038/370389a0openalex-snapshot

Rapid evolution of a protein in vitro by DNA shuffling

inferredcites →https://doi.org/10.1038/nbt833openalex-snapshot

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

inferredcites →https://doi.org/10.1038/ng1482openalex-snapshot

The 'evolvability' of promiscuous protein functions

inferredcites →https://doi.org/10.1073/pnas.160175897openalex-snapshot

Inversion of stereospecificity of vanillyl-alcohol oxidase

inferredcites →https://doi.org/10.1073/pnas.231313098openalex-snapshot

Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade

inferredcites →https://doi.org/10.1073/pnas.2536901100openalex-snapshot

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization

inferredcites →https://doi.org/10.1073/pnas.95.8.4126openalex-snapshot

Plant terpenoid synthases: Molecular biology and phylogenetic analysis

inferredcites →https://doi.org/10.1074/jbc.273.4.2078openalex-snapshot

Sesquiterpene Synthases from Grand Fir (Abies grandis)

inferredcites →https://doi.org/10.1074/jbc.m000433200openalex-snapshot

Crystal Structure Determination of Aristolochene Synthase from the Blue Cheese Mold, Penicillium roqueforti*

inferredcites →https://doi.org/10.1104/pp.104.042028openalex-snapshot

Functional Characterization of Nine Norway Spruce TPS Genes and Evolution of Gymnosperm Terpene Synthases of the TPS-d Subfamily

inferredcites →https://doi.org/10.1126/science.1065659openalex-snapshot

Protein Structure Prediction and Structural Genomics

inferredcites →https://doi.org/10.1126/science.1079731openalex-snapshot

Antibody Multispecificity Mediated by Conformational Diversity

inferredcites →https://doi.org/10.1126/science.277.5333.1815openalex-snapshot

Structural Basis for Cyclic Terpene Biosynthesis by Tobacco 5-Epi-Aristolochene Synthase

inferredcites →https://doi.org/10.1126/science.277.5333.1820openalex-snapshot

Crystal Structure of Pentalenene Synthase: Mechanistic Insights on Terpenoid Cyclization Reactions in Biology

inferredcites →https://doi.org/10.1146/annurev.mi.30.100176.002205openalex-snapshot

ENZYME RECRUITMENT IN EVOLUTION OF NEW FUNCTION

inferredcites →https://doi.org/10.2210/pdb1e0y/pdbopenalex-snapshot

Structure of the D170S/T457E double mutant of vanillyl-alcohol oxidase

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2020.112286zenodo-depositor-declared

Site-directed mutagenesis of β sesquiphellandrene synthase enhances enzyme promiscuity

inferred← citeshttps://doi.org/10.1002/9780470048672.wecb125openalex-snapshot

Directed Evolution: Novel and Improved Enzymes

inferred← citeshttps://doi.org/10.1002/9780470048672.wecb377openalex-snapshot

Natural Products: An Overview

inferred← citeshttps://doi.org/10.1002/9780470437988.ch14openalex-snapshot

The Synthetic Approach for Regulatory and Metabolic Circuits

inferred← citeshttps://doi.org/10.1002/9780470627303.ch2openalex-snapshot

Directed Enzyme and Pathway Evolution

inferred← citeshttps://doi.org/10.1002/9781118010518.ch71openalex-snapshot

The Small‐Molecule Dimension: Mass‐Spectrometry‐Based Metabolomics, Enzyme Assays, and Imaging

inferred← citeshttps://doi.org/10.1002/9781118028308.ch1openalex-snapshot

Biotechnology Tools for Green Synthesis: Enzymes, Metabolic Pathways, and their Improvement by Engineering

inferred← citeshttps://doi.org/10.1002/9781119991311.ch8openalex-snapshot

Terpenoid Biosynthesis

inferred← citeshttps://doi.org/10.1002/9783527631827.ch14openalex-snapshot

Designing New Proteins

inferred← citeshttps://doi.org/10.1002/9783527634026.ch3openalex-snapshot

Mechanism and Catalytic Promiscuity: Emerging Mechanistic Principles for Identification and Manipulation of Catalytically Promiscuous Enzymes

inferred← citeshttps://doi.org/10.1002/9783527634026.ch34openalex-snapshot

Biosynthetic Pathway Engineering Strategies

inferred← citeshttps://doi.org/10.1002/9783527639861.ch41openalex-snapshot

Enzymatic Catalytic Promiscuity and the Design of New Enzyme Catalyzed Reactions

inferred← citeshttps://doi.org/10.1002/9783527843954.ch23openalex-snapshot

Farnesene

inferred← citeshttps://doi.org/10.1002/adbi.201700190openalex-snapshot

Metabolic Engineering of Microorganisms for the Production of Natural Compounds

inferred← citeshttps://doi.org/10.1002/ange.200604205openalex-snapshot

Minimale Umgestaltung aktiver Enzymtaschen – wie man alten Enzymen neue Kunststücke beibringt

inferred← citeshttps://doi.org/10.1002/ange.200702751openalex-snapshot

Alternate‐Site Enzyme Promiscuity

inferred← citeshttps://doi.org/10.1002/ange.201301362openalex-snapshot

High‐Throughput Screening for Terpene‐Synthase‐Cyclization Activity and Directed Evolution of a Terpene Synthase

inferred← citeshttps://doi.org/10.1002/ange.201308176openalex-snapshot

Rational Design of Modular Polyketide Synthases: Morphing the Aureothin Pathway into a Luteoreticulin Assembly Line

inferred← citeshttps://doi.org/10.1002/ange.201407883openalex-snapshot

Terpenoid‐Biosynthese abseits bekannter Wege: unkonventionelle Cyclasen und ihre Bedeutung für die biomimetische Synthese

inferred← citeshttps://doi.org/10.1002/ange.202110842openalex-snapshot

A Cryptic Plant Terpene Cyclase Producing Unconventional 18‐ and 14‐Membered Macrocyclic C25 and C20 Terpenoids with Immunosuppressive Activity

inferred← citeshttps://doi.org/10.1002/ange.202215088openalex-snapshot

Regiodivergent and Enantioselective Hydroxylation of C−H bonds by Synergistic Use of Protein Engineering and Exogenous Dual‐Functional Small Molecules

inferred← citeshttps://doi.org/10.1002/ange.202315674openalex-snapshot

Characterization and Engineering of Two Highly Paralogous Sesquiterpene Synthases Reveal a Regioselective Reprotonation Switch

inferred← citeshttps://doi.org/10.1002/anie.200604205openalex-snapshot

Minimalist Active‐Site Redesign: Teaching Old Enzymes New Tricks

inferred← citeshttps://doi.org/10.1002/anie.200702751openalex-snapshot

Alternate‐Site Enzyme Promiscuity

inferred← citeshttps://doi.org/10.1002/anie.201301362openalex-snapshot

High‐Throughput Screening for Terpene‐Synthase‐Cyclization Activity and Directed Evolution of a Terpene Synthase

inferred← citeshttps://doi.org/10.1002/anie.201308176openalex-snapshot

Rational Design of Modular Polyketide Synthases: Morphing the Aureothin Pathway into a Luteoreticulin Assembly Line

inferred← citeshttps://doi.org/10.1002/anie.201407883openalex-snapshot

Terpenoid Biosynthesis Off the Beaten Track: Unconventional Cyclases and Their Impact on Biomimetic Synthesis

inferred← citeshttps://doi.org/10.1002/anie.202110842openalex-snapshot

A Cryptic Plant Terpene Cyclase Producing Unconventional 18‐ and 14‐Membered Macrocyclic C25 and C20 Terpenoids with Immunosuppressive Activity

inferred← citeshttps://doi.org/10.1002/anie.202215088openalex-snapshot

Regiodivergent and Enantioselective Hydroxylation of C−H bonds by Synergistic Use of Protein Engineering and Exogenous Dual‐Functional Small Molecules

inferred← citeshttps://doi.org/10.1002/anie.202315674openalex-snapshot

Characterization and Engineering of Two Highly Paralogous Sesquiterpene Synthases Reveal a Regioselective Reprotonation Switch

inferred← citeshttps://doi.org/10.1002/bab.1272openalex-snapshot

Insight into yeast: A study model of lipid metabolism and terpenoid biosynthesis

inferred← citeshttps://doi.org/10.1002/biot.200600170openalex-snapshot

Better library design: data‐driven protein engineering

inferred← citeshttps://doi.org/10.1002/biot.200900220openalex-snapshot

Advanced biofuel production in microbes

inferred← citeshttps://doi.org/10.1002/biot.201200238openalex-snapshot

Protein design in systems metabolic engineering for industrial strain development

inferred← citeshttps://doi.org/10.1002/biot.201300021openalex-snapshot

Expanding the metabolic engineering toolbox with directed evolution

inferred← citeshttps://doi.org/10.1002/biot.201300028openalex-snapshot

From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1002/bit.21216openalex-snapshot

Metabolic engineering of sesquiterpene metabolism in yeast

inferred← citeshttps://doi.org/10.1002/bit.21455openalex-snapshot

Directed evolution of novel protein functions

inferred← citeshttps://doi.org/10.1002/bit.22077openalex-snapshot

Engineered enzymes for chemical production

inferred← citeshttps://doi.org/10.1002/bit.25468openalex-snapshot

Natural and engineered production of taxadiene with taxadiene synthase

inferred← citeshttps://doi.org/10.1002/cbic.200800573openalex-snapshot

From Kinase to Cyclase: An Unusual Example of Catalytic Promiscuity Modulated by Metal Switching

inferred← citeshttps://doi.org/10.1002/cbic.201000662openalex-snapshot

A Site‐Saturated Mutagenesis Study of Pentaerythritol Tetranitrate Reductase Reveals that Residues 181 and 184 Influence Ligand Binding, Stereochemistry and Reactivity

inferred← citeshttps://doi.org/10.1002/cbic.201402620openalex-snapshot

Directed Divergent Evolution of a Thermostable D ‐Tagatose Epimerase towards Improved Activity for Two Hexose Substrates

inferred← citeshttps://doi.org/10.1002/cbic.201500308openalex-snapshot

Moonlighting Metals: Insights into Regulation of Cyclization Pathways in Fungal Δ6‐Protoilludene Sesquiterpene Synthases

inferred← citeshttps://doi.org/10.1002/cbic.201600149openalex-snapshot

Mutations Closer to the Active Site Improve the Promiscuous Aldolase Activity of 4‐Oxalocrotonate Tautomerase More Effectively than Distant Mutations

inferred← citeshttps://doi.org/10.1002/cbic.201800218openalex-snapshot

Sesquiterpene Synthase‐Catalysed Formation of a New Medium‐Sized Cyclic Terpenoid Ether from Farnesyl Diphosphate Analogues

inferred← citeshttps://doi.org/10.1002/cbic.202100484openalex-snapshot

Predictive Engineering of Class I Terpene Synthases Using Experimental and Computational Approaches

inferred← citeshttps://doi.org/10.1002/cctc.201300733openalex-snapshot

Production of Macrocyclic Sesqui‐ and Diterpenes in Heterologous Microbial Hosts: A Systems Approach to Harness Nature’s Molecular Diversity

inferred← citeshttps://doi.org/10.1002/cctc.201500602openalex-snapshot

Advances in Pathway Engineering for Natural Product Biosynthesis

inferred← citeshttps://doi.org/10.1002/chem.201201895openalex-snapshot

Inverting the Regioselectivity of the Berberine Bridge Enzyme by Employing Customized Fluorine‐Containing Substrates

inferred← citeshttps://doi.org/10.1002/cssc.201300853openalex-snapshot

Biological Production of 2‐Butanone in Escherichia coli

inferred← citeshttps://doi.org/10.1002/ffj.1938openalex-snapshot

Volatiles from leaves of field‐grown plants and shoot cultures of Gynura bicolor DC

inferred← citeshttps://doi.org/10.1002/ffj.1981openalex-snapshot

Biotechnology in plant essential oil production: progress and perspective in metabolic engineering of the terpene pathway

inferred← citeshttps://doi.org/10.1002/minf.201100087openalex-snapshot

A Mechanism for Evolving Novel Plant Sesquiterpene Synthase Function

inferred← citeshttps://doi.org/10.1002/pro.691openalex-snapshot

Computational design and selections for an engineered, thermostable terpene synthase

inferred← citeshttps://doi.org/10.1002/prot.22678openalex-snapshot

Circular permuted proteins in the universe of protein folds

inferred← citeshttps://doi.org/10.1002/slct.201600572openalex-snapshot

Substrate Pre‐Folding and Water Molecule Organization Matters for Terpene Cyclase Catalyzed Conversion of Unnatural Substrates

inferred← citeshttps://doi.org/10.1007/10_2009_52openalex-snapshot

De Novo Metabolic Engineering and the Promise of Synthetic DNA

inferred← citeshttps://doi.org/10.1007/978-1-4020-6031-1_1openalex-snapshot

Biosynthesis of Plant Natural Products and Characterization of Plant Biosynthetic Pathways in Recombinant Microorganisms

inferred← citeshttps://doi.org/10.1007/978-1-4614-4063-5_12openalex-snapshot

Strategies for the Manipulation of Carbocations by Aristolochene Synthase

inferred← citeshttps://doi.org/10.1007/978-1-4939-7366-8_11openalex-snapshot

Practical Considerations Regarding the Choice of the Best High-Throughput Assay

inferred← citeshttps://doi.org/10.1007/978-3-319-04045-5_5openalex-snapshot

Bioproducts, Biofuels, and Perfumes: Conifer Terpene Synthases and their Potential for Metabolic Engineering

inferred← citeshttps://doi.org/10.1007/978-3-319-31421-1_219-1openalex-snapshot

Microbial Production of Isoprenoids

inferred← citeshttps://doi.org/10.1007/978-3-319-31421-1_219-2openalex-snapshot

Microbial Production of Isoprenoids

inferred← citeshttps://doi.org/10.1007/978-3-319-50436-0_219openalex-snapshot

Microbial Production of Isoprenoids

inferred← citeshttps://doi.org/10.1007/978-3-540-77587-4_179openalex-snapshot

Exploiting Microbial Diversity: The Challenges and the Means

inferred← citeshttps://doi.org/10.1007/978-3-540-77587-4_219openalex-snapshot

Microbial Production of Isoprenoids

inferred← citeshttps://doi.org/10.1007/978-3-540-77587-4_97openalex-snapshot

Emerging Systems and Synthetic Biology Approaches to Hydrocarbon Biotechnology

inferred← citeshttps://doi.org/10.1007/978-3-7091-0140-7_3openalex-snapshot

Combinatorial and Synthetic Biosynthesis in Actinomycetes

inferred← citeshttps://doi.org/10.1007/978-4-431-54607-8openalex-snapshot

Microbial Production

inferred← citeshttps://doi.org/10.1007/978-81-322-2595-9_12openalex-snapshot

Synthetic Biology in Aid of Bioactive Molecules

inferred← citeshttps://doi.org/10.1007/978-90-481-2752-8_2openalex-snapshot

Autocatalytic Processes and the Role of Essential Elements in Plant Growth

inferred← citeshttps://doi.org/10.1007/978-90-481-2752-8_4openalex-snapshot

The Evolution of Essentiality

inferred← citeshttps://doi.org/10.1007/978-94-007-6606-8_5openalex-snapshot

Molecular and Pathway Controls on Biogenic Volatile Organic Compound Emissions

inferred← citeshttps://doi.org/10.1007/978-981-10-4284-3_6openalex-snapshot

Enzyme Engineering

inferred← citeshttps://doi.org/10.1007/978-981-13-0785-0_39openalex-snapshot

Future of Enzymology: An Appraisal

inferred← citeshttps://doi.org/10.1007/978-981-97-8179-9_40openalex-snapshot

Future of Enzymology—An Appraisal

inferred← citeshttps://doi.org/10.1007/s00018-008-8285-xopenalex-snapshot

The chemical versatility of the β–α–β fold: Catalytic promiscuity and divergent evolution in the tautomerase superfamily

inferred← citeshttps://doi.org/10.1007/s00018-009-0066-7openalex-snapshot

Diversity, regulation, and genetic manipulation of plant mono- and sesquiterpenoid biosynthesis

inferred← citeshttps://doi.org/10.1007/s00216-017-0570-9openalex-snapshot

Direct analysis of terpenes from biological buffer systems using SESI and IR-MALDESI

inferred← citeshttps://doi.org/10.1007/s00253-006-0593-1openalex-snapshot

Biosynthesis and engineering of isoprenoid small molecules

inferred← citeshttps://doi.org/10.1007/s00253-007-0964-2openalex-snapshot

Protein engineering: opportunities and challenges

inferred← citeshttps://doi.org/10.1007/s00253-010-2578-3openalex-snapshot

Synthetic biology approaches in drug discovery and pharmaceutical biotechnology

inferred← citeshttps://doi.org/10.1007/s00253-015-6503-7openalex-snapshot

Identification and regulation of the catalytic promiscuity of (−)-γ-lactamase from Microbacterium hydrocarbonoxydans

inferred← citeshttps://doi.org/10.1007/s00425-010-1137-6openalex-snapshot

Cloning and characterization of a novel gene that encodes (S)-β-bisabolene synthase from ginger, Zingiber officinale

inferred← citeshttps://doi.org/10.1007/s00425-015-2454-6openalex-snapshot

Identification of a novel hedycaryol synthase gene isolated from Camellia brevistyla flowers and floral scent of Camellia cultivars

inferred← citeshttps://doi.org/10.1007/s00425-018-2986-7openalex-snapshot

In planta and in silico characterization of five sesquiterpene synthases from Vitis vinifera (cv. Shiraz) berries

inferred← citeshttps://doi.org/10.1007/s10295-008-0400-3openalex-snapshot

Expression of a synthetic Artemesia annua amorphadiene synthase in Aspergillus nidulans yields altered product distribution

inferred← citeshttps://doi.org/10.1007/s10295-011-1044-2openalex-snapshot

Protein engineering towards natural product synthesis and diversification

inferred← citeshttps://doi.org/10.1007/s10295-020-02306-3openalex-snapshot

Synthetic biology, combinatorial biosynthesis, and chemo‑enzymatic synthesis of isoprenoids

inferred← citeshttps://doi.org/10.1007/s11103-007-9149-8openalex-snapshot

Tomato linalool synthase is induced in trichomes by jasmonic acid

inferred← citeshttps://doi.org/10.1007/s11103-012-9933-yopenalex-snapshot

Synthesis of ‘cineole cassette’ monoterpenes in Nicotiana section Alatae: gene isolation, expression, functional characterization and phylogenetic analysis

inferred← citeshttps://doi.org/10.1007/s11120-008-9324-zopenalex-snapshot

Directing the evolution of Rubisco and Rubisco activase: first impressions of a new tool for photosynthesis research

inferred← citeshttps://doi.org/10.1007/s11295-014-0796-zopenalex-snapshot

Plasticity residues involved in secondary cyclization of terpene synthesis in Taiwania cryptomerioides

inferred← citeshttps://doi.org/10.1007/s11738-021-03236-yopenalex-snapshot

Genome-wide identification and characterization of the TPS gene family in wheat (Triticum aestivum L.) and expression analysis in response to aphid damage

inferred← citeshttps://doi.org/10.1007/s12033-019-00199-xopenalex-snapshot

The Biogenetic Origin of the Biologically Active Naematolin of Hypholoma Species Involves an Unusual Sesquiterpene Synthase

inferred← citeshttps://doi.org/10.1016/b978-0-08-095167-6.00729-1openalex-snapshot

7.22 Enzyme Catalytic Promiscuity: Expanding the Catalytic Action of Enzymes to New Reactions

inferred← citeshttps://doi.org/10.1016/b978-0-08-097742-3.00931-9openalex-snapshot

9.15 Synthetic Biology Approaches for Organic Synthesis

inferred← citeshttps://doi.org/10.1016/b978-0-12-394290-6.00008-2openalex-snapshot

Platensimycin and Platencin Biosynthesis in Streptomyces platensis, Showcasing Discovery and Characterization of Novel Bacterial Diterpene Synthases

inferred← citeshttps://doi.org/10.1016/b978-0-444-63504-4.00004-9openalex-snapshot

Bioengineering of Secondary Metabolites

inferred← citeshttps://doi.org/10.1016/b978-0-444-64085-7.00013-7openalex-snapshot

Synthetic Biology Approaches for the Production of Isoprenoids in Escherichia coli

inferred← citeshttps://doi.org/10.1016/b978-008045382-8.00005-8openalex-snapshot

Sesquiterpenes

inferred← citeshttps://doi.org/10.1016/bs.mie.2018.05.004openalex-snapshot

Sesquiterpene Synthase-Catalyzed Conversion of a Farnesyl Diphosphate Analogue to a Nonnatural Terpenoid Ether

inferred← citeshttps://doi.org/10.1016/bs.mie.2024.03.015openalex-snapshot

Production of non-natural terpenoids through chemoenzymatic synthesis using substrate analogs

inferred← citeshttps://doi.org/10.1016/bs.mie.2024.04.025openalex-snapshot

Ancestral terpene cyclases: From fundamental science to applications in biosynthesis

inferred← citeshttps://doi.org/10.1016/j.abb.2007.03.016openalex-snapshot

Investigating the roles of putative active site residues in the oxalate decarboxylase from Bacillus subtilis

inferred← citeshttps://doi.org/10.1016/j.abb.2007.06.016openalex-snapshot

Exploring biosynthetic diversity with trichodiene synthase

inferred← citeshttps://doi.org/10.1016/j.abb.2007.10.015openalex-snapshot

Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: Probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233– Mg2+B motif

inferred← citeshttps://doi.org/10.1016/j.abb.2017.12.007openalex-snapshot

Mutational analysis and dynamic simulation of S-limonene synthase reveal the importance of Y573: Insight into the cyclization mechanism in monoterpene synthases

inferred← citeshttps://doi.org/10.1016/j.bbadis.2012.03.009openalex-snapshot

The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism

inferred← citeshttps://doi.org/10.1016/j.bbapap.2012.05.009openalex-snapshot

The structural basis for the narrow substrate specificity of an acetyl esterase from Thermotoga maritima

inferred← citeshttps://doi.org/10.1016/j.bbapap.2012.07.015openalex-snapshot

Efficient, crosswise catalytic promiscuity among enzymes that catalyze phosphoryl transfer

inferred← citeshttps://doi.org/10.1016/j.bcp.2009.07.025openalex-snapshot

Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: Effects of combining beneficial single mutations

inferred← citeshttps://doi.org/10.1016/j.biochi.2016.09.010openalex-snapshot

Structure prediction and functional analysis of a non-permutated lectin from Dioclea grandiflora

inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.106094openalex-snapshot

Molecular mechanism of acceptor selection in cyclodextrin glycosyltransferases catalyzed ginsenoside transglycosylation

inferred← citeshttps://doi.org/10.1016/j.biortech.2017.05.168openalex-snapshot

Metabolic engineering and synthetic biology approaches driving isoprenoid production in Escherichia coli

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2011.09.008openalex-snapshot

The imminent role of protein engineering in synthetic biology

inferred← citeshttps://doi.org/10.1016/j.bpc.2009.12.003openalex-snapshot

Using multi-objective computational design to extend protein promiscuity

inferred← citeshttps://doi.org/10.1016/j.cbpa.2006.08.011openalex-snapshot

Enzyme promiscuity: evolutionary and mechanistic aspects

inferred← citeshttps://doi.org/10.1016/j.cbpa.2007.02.033openalex-snapshot

Pathway engineering by designed divergent evolution

inferred← citeshttps://doi.org/10.1016/j.cbpa.2007.12.008openalex-snapshot

Unearthing the roots of the terpenome

inferred← citeshttps://doi.org/10.1016/j.cbpa.2008.01.027openalex-snapshot

Advances in laboratory evolution of enzymes

inferred← citeshttps://doi.org/10.1016/j.cbpa.2009.01.005openalex-snapshot

Opportunities for enzyme engineering in natural product biosynthesis

inferred← citeshttps://doi.org/10.1016/j.cbpa.2009.01.014openalex-snapshot

Enzyme (re)design: lessons from natural evolution and computation

inferred← citeshttps://doi.org/10.1016/j.cbpa.2009.11.028openalex-snapshot

What makes an enzyme promiscuous?

inferred← citeshttps://doi.org/10.1016/j.cbpa.2012.03.002openalex-snapshot

Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis

inferred← citeshttps://doi.org/10.1016/j.cbpa.2013.01.016openalex-snapshot

Squalene hopene cyclases: highly promiscuous and evolvable catalysts for stereoselective C C and C X bond formation

inferred← citeshttps://doi.org/10.1016/j.cclet.2015.03.018openalex-snapshot

Recent progress in hydrocarbon biofuel synthesis: Pathways and enzymes

inferred← citeshttps://doi.org/10.1016/j.chembiol.2008.05.006openalex-snapshot

Redesigning Enzymes Based on Adaptive Evolution for Optimal Function in Synthetic Metabolic Pathways

inferred← citeshttps://doi.org/10.1016/j.coal.2023.104230openalex-snapshot

Comparative metabolomic reveals chemotaxonomic markers of resin fossils for identification of botanical origins

inferred← citeshttps://doi.org/10.1016/j.copbio.2009.07.007openalex-snapshot

Generation of new protein functions by nonhomologous combinations and rearrangements of domains and modules

inferred← citeshttps://doi.org/10.1016/j.copbio.2011.03.004openalex-snapshot

Protein design in metabolic engineering and synthetic biology

inferred← citeshttps://doi.org/10.1016/j.copbio.2011.03.007openalex-snapshot

Adaptive laboratory evolution — harnessing the power of biology for metabolic engineering

inferred← citeshttps://doi.org/10.1016/j.copbio.2011.04.024openalex-snapshot

Metabolic engineering of microbial pathways for advanced biofuels production

inferred← citeshttps://doi.org/10.1016/j.dci.2020.103807openalex-snapshot

Molecular characterization and expression analysis of the chicken-type and goose-type lysozymes from totoaba (Totoaba macdonaldi)

inferred← citeshttps://doi.org/10.1016/j.exppara.2015.01.013openalex-snapshot

Prediction of substrate specificity and preliminary kinetic characterization of the hypothetical protein PVX_123945 from Plasmodium vivax

inferred← citeshttps://doi.org/10.1016/j.febslet.2011.04.038openalex-snapshot

A non-synonymous nucleotide substitution can account for one evolutionary route to sesquiterpene synthase activity in the TPS-b subgroup

inferred← citeshttps://doi.org/10.1016/j.foodres.2021.110487openalex-snapshot

Genetic engineering of yeast, filamentous fungi and bacteria for terpene production and applications in food industry

inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e27817openalex-snapshot

Identification and expression analysis of TPS family gene in Cannabis sativa L

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.136081openalex-snapshot

Functional characterization of a novel terpene synthase GaTPS1 involved in (E)-α-bergamotene biosynthesis in Gossypium arboreum

inferred← citeshttps://doi.org/10.1016/j.jbiotec.2019.03.006openalex-snapshot

Discovery of three novel sesquiterpene synthases from Streptomyces chartreusis NRRL 3882 and crystal structure of an α-eudesmol synthase

inferred← citeshttps://doi.org/10.1016/j.jmb.2007.08.036openalex-snapshot

Functional Specificity Lies within the Properties and Evolutionary Changes of Amino Acids

inferred← citeshttps://doi.org/10.1016/j.jmb.2009.07.067openalex-snapshot

Structural Basis for Exquisite Specificity of Affinity Clamps, Synthetic Binding Proteins Generated through Directed Domain-interface Evolution

inferred← citeshttps://doi.org/10.1016/j.jtbi.2018.08.006openalex-snapshot

Evolutionary analysis and structural characterization of Aquilaria sinensis sesquiterpene synthase in agarwood formation: A computational study

inferred← citeshttps://doi.org/10.1016/j.mec.2020.e00129openalex-snapshot

Protein engineering strategies for microbial production of isoprenoids

inferred← citeshttps://doi.org/10.1016/j.mib.2009.07.004openalex-snapshot

Mass spectrometry based metabolomics and enzymatic assays for functional genomics

inferred← citeshttps://doi.org/10.1016/j.mimet.2007.09.001openalex-snapshot

PCR-based strategy for construction of multi-site-saturation mutagenic expression library

inferred← citeshttps://doi.org/10.1016/j.phytochem.2006.10.016openalex-snapshot

Functional characterization of the rice kaurene synthase-like gene family

inferred← citeshttps://doi.org/10.1016/j.phytochem.2009.05.020openalex-snapshot

Diversity, regulation, and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteria

inferred← citeshttps://doi.org/10.1016/j.phytochem.2009.06.011openalex-snapshot

Molecular and biochemical evolution of maize terpene synthase 10, an enzyme of indirect defense

inferred← citeshttps://doi.org/10.1016/j.phytochem.2009.07.030openalex-snapshot

Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants

inferred← citeshttps://doi.org/10.1016/j.phytochem.2011.11.004openalex-snapshot

Mutational analysis of white spruce (Picea glauca) ent-kaurene synthase (PgKS) reveals common and distinct mechanisms of conifer diterpene synthases of general and specialized metabolism

inferred← citeshttps://doi.org/10.1016/j.phytochem.2011.12.009openalex-snapshot

A single amino acid determines the site of deprotonation in the active center of sesquiterpene synthases SbTPS1 and SbTPS2 from Sorghum bicolor

inferred← citeshttps://doi.org/10.1016/j.phytochem.2017.02.017openalex-snapshot

Converting S-limonene synthase to pinene or phellandrene synthases reveals the plasticity of the active site

inferred← citeshttps://doi.org/10.1016/j.phytochem.2020.112573openalex-snapshot

Probing of the plasticity of the active site in pinene synthase elucidates its potential evolutionary mechanism

inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113380openalex-snapshot

Heterologous production of Cannabis sativa-derived specialised metabolites of medicinal significance – Insights into engineering strategies

inferred← citeshttps://doi.org/10.1016/j.phytol.2021.12.010openalex-snapshot

Isolation and structure elucidation of caryophyllane sesquiterpenoids from leaves of Eremophila spathulata

inferred← citeshttps://doi.org/10.1016/j.plantsci.2013.05.005openalex-snapshot

Metabolic engineering and in vitro biosynthesis of phytochemicals and non-natural analogues

inferred← citeshttps://doi.org/10.1016/j.plantsci.2016.11.006openalex-snapshot

REVIEW: Epistasis and dominance in the emergence of catalytic function as exemplified by the evolution of plant terpene synthases

inferred← citeshttps://doi.org/10.1016/j.plantsci.2019.110277openalex-snapshot

Phylogenetically distant group of terpene synthases participates in cadinene and cedrane-type sesquiterpenes accumulation in Taiwania cryptomerioides

inferred← citeshttps://doi.org/10.1016/j.plantsci.2022.111315openalex-snapshot

Cloning and functional characterization of three sesquiterpene synthase genes from Chamaecyparis formosensis Matsumura

inferred← citeshttps://doi.org/10.1016/j.plaphy.2020.08.004openalex-snapshot

Identification and characterization of two sesquiterpene synthase genes involved in volatile-mediated defense in tea plant (Camellia sinensis)

inferred← citeshttps://doi.org/10.1016/j.plipres.2011.12.001openalex-snapshot

A raison d’être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?

inferred← citeshttps://doi.org/10.1016/j.procbio.2015.04.018openalex-snapshot

Shaking up ancient scents: Insights into santalol synthesis in engineered Escherichia coli

inferred← citeshttps://doi.org/10.1016/j.sbi.2006.06.013openalex-snapshot

Knowledge-based potentials in protein design

inferred← citeshttps://doi.org/10.1016/j.sbi.2010.02.005openalex-snapshot

How do new proteins arise?

inferred← citeshttps://doi.org/10.1016/j.sbi.2010.06.001openalex-snapshot

Protein engineering for bioenergy and biomass-based chemicals

inferred← citeshttps://doi.org/10.1016/j.str.2012.10.007openalex-snapshot

Design of a Phosphorylatable PDZ Domain with Peptide-Specific Affinity Changes

inferred← citeshttps://doi.org/10.1016/j.str.2019.11.012openalex-snapshot

Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors

inferred← citeshttps://doi.org/10.1016/j.synbio.2023.11.009openalex-snapshot

Cyclization mechanism of monoterpenes catalyzed by monoterpene synthases in dipterocarpaceae

inferred← citeshttps://doi.org/10.1016/j.tet.2014.12.026openalex-snapshot

Opportunities for enzyme catalysis in natural product chemistry

inferred← citeshttps://doi.org/10.1016/j.tibtech.2007.01.003openalex-snapshot

Expanding the metabolic engineering toolbox: more options to engineer cells

inferred← citeshttps://doi.org/10.1016/j.tibtech.2007.12.001openalex-snapshot

Enzyme optimization: moving from blind evolution to statistical exploration of sequence–function space

inferred← citeshttps://doi.org/10.1016/j.tibtech.2008.03.008openalex-snapshot

Biofuel alternatives to ethanol: pumping the microbial well

inferred← citeshttps://doi.org/10.1016/j.tibtech.2015.12.005openalex-snapshot

Microbial Factories for the Production of Benzylisoquinoline Alkaloids

inferred← citeshttps://doi.org/10.1016/j.xplc.2021.100233openalex-snapshot

An extremely promiscuous terpenoid synthase from the Lamiaceae plant Colquhounia coccinea var. mollis catalyzes the formation of sester-/di-/sesqui-/mono-terpenoids

inferred← citeshttps://doi.org/10.1016/j.ymben.2008.07.007openalex-snapshot

Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene

inferred← citeshttps://doi.org/10.1016/j.ymben.2011.05.001openalex-snapshot

Harnessing yeast subcellular compartments for the production of plant terpenoids

inferred← citeshttps://doi.org/10.1016/s0065-2296(08)00004-9openalex-snapshot

Molecular Physiology of Development and Quality of Citrus

inferred← citeshttps://doi.org/10.1016/s1674-6384(14)60033-2openalex-snapshot

Synergistic Effects of CO2 and LED Lighting on Accumulation of Terpenes in Roots of Gynura bicolor

inferred← citeshttps://doi.org/10.1021/ac301590yopenalex-snapshot

Single-Shot Characterization of Enzymatic Reaction Constants Km and kcat by an Acoustic-Driven, Bubble-Based Fast Micromixer

inferred← citeshttps://doi.org/10.1021/acs.biochem.1c00523openalex-snapshot

Structurally Guided Reprogramming of Valerenadiene Synthase

inferred← citeshttps://doi.org/10.1021/acs.biochem.3c00681openalex-snapshot

Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of epi -Isozizaene Synthase into α-Bisabolol Synthase

inferred← citeshttps://doi.org/10.1021/acs.biochem.4c00087openalex-snapshot

Implication of Molecular Constraints Facilitating the Functional Evolution of Pseudomonas aeruginosa KPR2 into a Versatile α-Keto-Acid Reductase

inferred← citeshttps://doi.org/10.1021/acs.biochem.6b01004openalex-snapshot

The T296V Mutant of Amorpha-4,11-diene Synthase Is Defective in Allylic Diphosphate Isomerization but Retains the Ability To Cyclize the Intermediate (3R)-Nerolidyl Diphosphate to Amorpha-4,11-diene

inferred← citeshttps://doi.org/10.1021/acs.biochem.9b00097openalex-snapshot

Overcoming the Challenges of Enzyme Evolution To Adapt Phosphotriesterase for V-Agent Decontamination

inferred← citeshttps://doi.org/10.1021/acs.jafc.0c04814openalex-snapshot

Biotechnological Advances in Lycopene β-Cyclases

inferred← citeshttps://doi.org/10.1021/acs.jafc.2c00754openalex-snapshot

Sesquiterpene Synthase Engineering and Targeted Engineering of α-Santalene Overproduction in Escherichia coli

inferred← citeshttps://doi.org/10.1021/acs.jafc.3c07573openalex-snapshot

Identification and Characterization of a Nerol Synthase in Fungi

inferred← citeshttps://doi.org/10.1021/acs.jafc.4c00030openalex-snapshot

Catalytic Mechanism and Heterologous Biosynthesis Application of Sesquiterpene Synthases

inferred← citeshttps://doi.org/10.1021/acs.jafc.4c02595openalex-snapshot

Comprehensive Engineering Strategies for Heterologous Production of Zealexin A1 in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1021/acs.jafc.4c08560openalex-snapshot

Unraveling the Molecular Determinants of Catalytic Efficiency and Substrate Specificity in l -Amino Acid Decarboxylases

inferred← citeshttps://doi.org/10.1021/acs.jafc.5c08719openalex-snapshot

Green Biosynthesis of Terpenoid-Derived Flavor and Fragrance Compounds: Advances and Strategic Perspectives

inferred← citeshttps://doi.org/10.1021/acs.jafc.5c09273openalex-snapshot

From Plants to Microbes: Harnessing Enzyme Promiscuity for Natural Product Synthesis

inferred← citeshttps://doi.org/10.1021/acs.jafc.6c03126openalex-snapshot

Characterization of a γ-Humulene Synthase from Fungus Ascobolus immersus

inferred← citeshttps://doi.org/10.1021/acs.jafc.8b04541openalex-snapshot

Identification of HydroxypyrazineO-Methyltransferase Genes inCoffea arabica: A Potential Source of Methoxypyrazines That Cause Potato Taste Defect

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6b00236openalex-snapshot

Insights into the Three-Dimensional Structure of Amorpha-4,11-diene Synthase and Probing of Plasticity Residues

inferred← citeshttps://doi.org/10.1021/acs.joc.6b02696openalex-snapshot

Alternate Cyclization Cascade Initiated by Substrate Isomer in Multiproduct Terpene Synthase from Medicago truncatula

inferred← citeshttps://doi.org/10.1021/acscatal.0c04647openalex-snapshot

Redesigning the Molecular Choreography to Prevent Hydroxylation in Germacradien-11-ol Synthase Catalysis

inferred← citeshttps://doi.org/10.1021/acscatal.1c00996openalex-snapshot

Unlocking Iminium Catalysis in Artificial Enzymes to Create a Friedel–Crafts Alkylase

showing the first 200 of 425

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.