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Process analytical technology (PAT) for biopharmaceutical products: Part I. concepts and applications
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/1618-2863(200107)1:1<15::aid-elsc15>3.0.co;2-1openalex-snapshot
Use of Bioanalytical Systems for the Improvement of Industrial Tryptophan Production
inferredcites →https://doi.org/10.1002/bit.10116openalex-snapshot
Chemometric evaluation of on-line high-pressure liquid chromatography in mammalian cell cultures: Analysis of amino acids and glucose
inferredcites →https://doi.org/10.1002/bit.10178openalex-snapshot
Inline characterization of cell concentration and cell volume in agitated bioreactors using in situ microscopy: Application to volume variation induced by osmotic stress
inferredcites →https://doi.org/10.1002/bit.10574openalex-snapshot
Bracketed generic inactivation of rodent retroviruses by low pH treatment for monoclonal antibodies and recombinant proteins
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Fermentation process tracking through enhanced spectral calibration modeling
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On‐line near infrared monitoring of glycerol‐boosted anaerobic digestion processes: Evaluation of process analytical technologies
inferredcites →https://doi.org/10.1002/bit.21725openalex-snapshot
At‐line monitoring of bioreactor protein production by surface plasmon resonance
inferredcites →https://doi.org/10.1002/bit.21920openalex-snapshot
Predicting sporulation events in a bioreactor using an electronic nose
inferredcites →https://doi.org/10.1002/bit.22125openalex-snapshot
In situ 2D fluorometry and chemometric monitoring of mammalian cell cultures
inferredcites →https://doi.org/10.1002/bit.22187openalex-snapshot
Automated, scalable culture of human embryonic stem cells in feeder‐free conditions
inferredcites →https://doi.org/10.1002/bit.22192openalex-snapshot
Disposable bioprocessing: The future has arrived
inferredcites →https://doi.org/10.1002/btpr.67openalex-snapshot
Bioprocess optimization using design‐of‐experiments methodology
inferredcites →https://doi.org/10.1002/cyto.a.10016openalex-snapshot
Automated flow cytometry for acquisition of time-dependent population data.
inferredcites →https://doi.org/10.1007/s10616-005-3587-4openalex-snapshot
On-Line Detection of Microbial Contaminations in Animal Cell Reactor Cultures Using an Electronic Nose Device
inferredcites →https://doi.org/10.1007/s10616-005-3974-xopenalex-snapshot
On-line Measurements and Control of Viable Cell Density in Cell Culture Manufacturing Processes using Radio-frequency Impedance
inferredcites →https://doi.org/10.1007/s10616-006-9020-9openalex-snapshot
Transient gene expression in CHO cells monitored with automated flow cytometry
inferredcites →https://doi.org/10.1016/j.jbiotec.2005.06.031openalex-snapshot
Dynamics of single cell property distributions in Chinese hamster ovary cell cultures monitored and controlled with automated flow cytometry
inferredcites →https://doi.org/10.1016/j.jbiotec.2006.06.004openalex-snapshot
Open-loop control of the biomass concentration within the growth phase of recombinant protein production processes
inferredcites →https://doi.org/10.1016/j.jbiotec.2008.03.019openalex-snapshot
Mammalian cell culture scale-up and fed-batch control using automated flow cytometry
inferredcites →https://doi.org/10.1016/j.tibtech.2009.06.006openalex-snapshot
Roadmap for implementation of quality by design (QbD) for biotechnology products
inferredcites →https://doi.org/10.1016/s0169-409x(02)00026-1openalex-snapshot
PEGylated antibodies and antibody fragments for improved therapy: a review
inferredcites →https://doi.org/10.1016/s0255-2701(01)00122-2openalex-snapshot
Development of a high resolution UV spectrophotometer for at-line monitoring of bioprocesses
inferredcites →https://doi.org/10.1021/bp050274wopenalex-snapshot
Exploitation of the Adsorptive Properties of Depth Filters for Host Cell Protein Removal during Monoclonal Antibody Purification
inferredcites →https://doi.org/10.1021/bp060306vopenalex-snapshot
An On‐Line Approach To Monitor Ethanol Fermentation Using FTIR Spectroscopy
inferredcites →https://doi.org/10.1021/bp0704384openalex-snapshot
Application of Multivariate Data Analysis for Identification and Successful Resolution of a Root Cause for a Bioprocessing Application
inferredcites →https://doi.org/10.1023/a:1021170502775openalex-snapshot
In-situ microscopy: Online process monitoring of mammalian cell cultures
inferredcites →https://doi.org/10.1038/nbt0109-26openalex-snapshot
Quality by design for biopharmaceuticals
inferredcites →https://doi.org/10.1042/ba20040098openalex-snapshot
Rapid characterization of outer‐membrane proteins in Neisseria lactamica by SELDI–TOF‐MS (surface‐enhanced laser desorption ionization–time‐of‐flight MS) for use in a meningococcal vaccine
inferredcites →https://doi.org/10.1042/ba20050056openalex-snapshot
Normal‐flow virus filtration: detection and assessment of the endpoint in bioprocessing
inferredcites →https://doi.org/10.1042/ba20060254openalex-snapshot
Phage passage after extended processing in small‐virus‐retentive filters
inferredcites →https://doi.org/10.1097/00002371-199705000-00007openalex-snapshot
Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use (1997)
inferredcites →https://doi.org/10.1385/1-59259-798-x:077openalex-snapshot
Capillary Electrophoresis in the Analysis and Monitoring of Biotechnological Processes
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Broad Protein Content Determination for Biomanufacturing Real-Time Process Monitoring and Control by Dual-Wavelength Absorbance Photometry
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Real-Time Monitoring, Release and Control Study of Continuous Manufacturing of Amlodipine Besylate Tablets Based on Near Infrared Spectroscopy
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Process Analytical Technology: Strategies for Biopharmaceuticals
inferred← citeshttps://doi.org/10.1002/9780470054581.eib653openalex-snapshot
Scaledown of Biopharmaceutical Purification Operations
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Protein Subunit Vaccine Purification
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Monitoring and Control of Bioreactor: Basic Concepts and Recent Advances
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RELEVANCE AND BIOPHYSICAL ATTRIBUTES OF MONOCLONAL ANTIBODY ISOFORMS
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Process Analytical Chemistry and Nondestructive Analytical Methods: The Green Chemistry Approach for Reaction Monitoring, Control, and Analysis
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Bacterial Suspension Cultures
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Continuous Downstream Processing for Production of Biotech Therapeutics
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Quality Control and Regulatory Aspects for Continuous Biomanufacturing
inferred← citeshttps://doi.org/10.1002/9783527800599.ch13openalex-snapshot
Medium Design, Culture Management, and the PAT Initiative
inferred← citeshttps://doi.org/10.1002/9783527800599.ch6openalex-snapshot
Bioreactor Development and Process Analytical Technology
inferred← citeshttps://doi.org/10.1002/9783527800599.ch8openalex-snapshot
Control of Microbial Processes
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Process Analytical Technology and Quality by Design for Animal Cell Culture
inferred← citeshttps://doi.org/10.1002/9783527827343.ch2openalex-snapshot
Control of Continuous Manufacturing Processes for Production of Monoclonal Antibodies
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Digital Twins for Continuous Biologics Manufacturing
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How Two‐Dimensional Heterocovariance Spectroscopy and Data Fusion Level out the Inadequacies of Compact Spectrometers
inferred← citeshttps://doi.org/10.1002/biot.201500507openalex-snapshot
Bridging the gap between PAT concepts and implementation: An integrated software platform for fermentation
inferred← citeshttps://doi.org/10.1002/biot.201700286openalex-snapshot
Mechanistic Modeling Based PAT Implementation for Ion‐Exchange Process Chromatography of Charge Variants of Monoclonal Antibody Products
inferred← citeshttps://doi.org/10.1002/biot.202300554openalex-snapshot
Explainable deep learning enhances robust and reliable real‐time monitoring of a chromatographic protein A capture step
inferred← citeshttps://doi.org/10.1002/bit.22886openalex-snapshot
Improved process analytical technology for protein a chromatography using predictive principal component analysis tools
inferred← citeshttps://doi.org/10.1002/bit.23131openalex-snapshot
Synchronous fluorescence spectroscopy as a novel tool to enable PAT applications in bioprocesses
inferred← citeshttps://doi.org/10.1002/bit.23138openalex-snapshot
Plasmid DNA production for pharmaceutical use: Role of specific growth rate and impact on process design
inferred← citeshttps://doi.org/10.1002/bit.24548openalex-snapshot
Data fusion‐based assessment of raw materials in mammalian cell culture
inferred← citeshttps://doi.org/10.1002/bit.25161openalex-snapshot
Semisynthetic model calibration for monitoring glucose in mammalian cell culture with in situ near infrared spectroscopy
inferred← citeshttps://doi.org/10.1002/bit.25274openalex-snapshot
Model‐based cell number quantification using online single‐oxygen sensor data for tissue engineering perfusion bioreactors
inferred← citeshttps://doi.org/10.1002/bit.26339openalex-snapshot
Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody–peptide fusion
inferred← citeshttps://doi.org/10.1002/bit.26984openalex-snapshot
Real‐time monitoring and model‐based prediction of purity and quantity during a chromatographic capture of fibroblast growth factor 2
inferred← citeshttps://doi.org/10.1002/bit.27296openalex-snapshot
Process‐wide control and automation of an integrated continuous manufacturing platform for antibodies
inferred← citeshttps://doi.org/10.1002/bit.27532openalex-snapshot
Real‐time monitoring of quality attributes by in‐line Fourier transform infrared spectroscopic sensors at ultrafiltration and diafiltration of bioprocess
inferred← citeshttps://doi.org/10.1002/bit.27681openalex-snapshot
An integrated continuous downstream process with real‐time control: A case study with periodic countercurrent chromatography and continuous virus inactivation
inferred← citeshttps://doi.org/10.1002/bit.27694openalex-snapshot
Development of a rapid polarized total synchronous fluorescence spectroscopy (pTSFS) method for protein quantification in a model bioreactor broth
inferred← citeshttps://doi.org/10.1002/bit.27706openalex-snapshot
Control of surge tanks for continuous manufacturing of monoclonal antibodies
inferred← citeshttps://doi.org/10.1002/bit.27757openalex-snapshot
White paper on high‐throughput process development for integrated continuous biomanufacturing
inferred← citeshttps://doi.org/10.1002/bit.27790openalex-snapshot
Antibody disulfide bond reduction and recovery during biopharmaceutical process development—A review
inferred← citeshttps://doi.org/10.1002/bit.28346openalex-snapshot
Advances in bioreactor control for production of biotherapeutic products
inferred← citeshttps://doi.org/10.1002/btpr.1536openalex-snapshot
Estimation of raw material performance in mammalian cell culture using near infrared spectra combined with chemometrics approaches
inferred← citeshttps://doi.org/10.1002/btpr.1610openalex-snapshot
Chemometrics applications in biotechnology processes: Predicting column integrity and impurity clearance during reuse of chromatography resin
inferred← citeshttps://doi.org/10.1002/btpr.1712openalex-snapshot
Quantification of protein mixture in chromatographic separation using multi‐wavelength UV spectra
inferred← citeshttps://doi.org/10.1002/btpr.1728openalex-snapshot
Fermentanomics informed amino acid supplementation of an antibody producing mammalian cell culture
inferred← citeshttps://doi.org/10.1002/btpr.1845openalex-snapshot
A novel approach for using dielectric spectroscopy to predict viable cell volume (VCV) in early process development
inferred← citeshttps://doi.org/10.1002/btpr.2105openalex-snapshot
Progress toward forecasting product quality and quantity of mammalian cell culture processes by performance‐based modeling
inferred← citeshttps://doi.org/10.1002/btpr.2292openalex-snapshot
Detecting cell lysis using viscosity monitoring in E. coli fermentation to prevent product loss
inferred← citeshttps://doi.org/10.1002/btpr.2480openalex-snapshot
Characterization of mammalian cell culture raw materials by combining spectroscopy and chemometrics
inferred← citeshttps://doi.org/10.1002/btpr.2758openalex-snapshot
Mechanistic modeling based process analytical technology implementation for pooling in hydrophobic interaction chromatography
inferred← citeshttps://doi.org/10.1002/btpr.2813openalex-snapshot
Model‐based monitoring of industrial reversed phase chromatography to predict insulin variants
inferred← citeshttps://doi.org/10.1002/btpr.3177openalex-snapshot
Process analytics 4.0: A paradigm shift in rapid analytics for biologics development
inferred← citeshttps://doi.org/10.1002/btpr.3211openalex-snapshot
Characterization of cell cycle and apoptosis in Chinese hamster ovary cell culture using flow cytometry for bioprocess monitoring
inferred← citeshttps://doi.org/10.1002/btpr.561openalex-snapshot
Chemometrics applications in biotech processes: A review
inferred← citeshttps://doi.org/10.1002/btpr.644openalex-snapshot
Assessment of the manufacturability of Escherichia coli high cell density fermentations
inferred← citeshttps://doi.org/10.1002/btpr.70037openalex-snapshot
Minimizing batch‐to‐batch variability of a live virus vaccine by process analytical technologies
inferred← citeshttps://doi.org/10.1002/btpr.708openalex-snapshot
Characterization and feasibility of a miniaturized stirred tank bioreactor to perform E. coli high cell density fed‐batch fermentations
inferred← citeshttps://doi.org/10.1002/cben.202100022openalex-snapshot
Advances in Bioreactor Systems for the Production of Biologicals in Mammalian Cells
inferred← citeshttps://doi.org/10.1002/elps.201400055openalex-snapshot
Analytical QbD: Development of a native gel electrophoresis method for measurement of monoclonal antibody aggregates
inferred← citeshttps://doi.org/10.1002/elsc.201600155openalex-snapshot
Enabler for process analytical technology implementation in Pichia pastoris fermentation: Fluorescence‐based soft sensors for rapid quantitation of product titer
inferred← citeshttps://doi.org/10.1002/jctb.4447openalex-snapshot
Application of process analytical technology for downstream purification of biotherapeutics
inferred← citeshttps://doi.org/10.1002/jctb.4448openalex-snapshot
Comparison of PAT based approaches for making real‐time pooling decisions for process chromatography – use of feed forward control
inferred← citeshttps://doi.org/10.1002/jctb.4463openalex-snapshot
Online prediction of product titer and solubility of recombinant proteins in Escherichia coli fed‐batch cultivations
inferred← citeshttps://doi.org/10.1002/jctb.4522openalex-snapshot
Dielectric spectroscopy‐based estimation of VCD in CHO cell culture
inferred← citeshttps://doi.org/10.1002/jctb.4591openalex-snapshot
Integrating systems analysis and control for implementing process analytical technology in bioprocess development
inferred← citeshttps://doi.org/10.1002/jctb.5358openalex-snapshot
Implementation of a fluorescence based PAT control for fouling of protein A chromatography resin
inferred← citeshttps://doi.org/10.1002/jctb.6920openalex-snapshot
Process analytical technique ( PAT ) miniaturization for monoclonal antibody aggregate detection in continuous downstream processing
inferred← citeshttps://doi.org/10.1002/jctb.7497openalex-snapshot
Application of PAT in pharmaceutical manufacturing: model‐based control of particle size distribution in anti‐solvent aided crystallization
inferred← citeshttps://doi.org/10.1002/jrs.3141openalex-snapshot
Using surface‐enhanced Raman scattering (SERS) and fluorescence spectroscopy for screening yeast extracts, a complex component of cell culture media
inferred← citeshttps://doi.org/10.1007/10_2010_98openalex-snapshot
Advancing Biopharmaceutical Process Development by System-Level Data Analysis and Integration of Omics Data
inferred← citeshttps://doi.org/10.1007/10_2017_12openalex-snapshot
Downstream Processing Technologies/Capturing and Final Purification
inferred← citeshttps://doi.org/10.1007/10_2026_314openalex-snapshot
Bioreactor Design and Engineering for Cultivated Meat Manufacturing
inferred← citeshttps://doi.org/10.1007/7355_2015_5004openalex-snapshot
Production of Protein Therapeutics in the Quality by Design (QbD) Paradigm
inferred← citeshttps://doi.org/10.1007/978-1-0716-0775-6_2openalex-snapshot
High-Throughput Process Development: I—Process Chromatography
inferred← citeshttps://doi.org/10.1007/978-1-62703-977-2_3openalex-snapshot
High-Throughput Process Development: I. Process Chromatography
inferred← citeshttps://doi.org/10.1007/978-3-030-63389-9_13openalex-snapshot
Regulation of Nanotechnology-Based Products Subject to Health Regulations: Application of Quality by Design (QbD) and Quality Risk Management (QRM)
inferred← citeshttps://doi.org/10.1007/978-3-030-90924-6_12openalex-snapshot
Dynamic Modeling and Control of a Continuous Biopharmaceutical Manufacturing Plant
inferred← citeshttps://doi.org/10.1007/978-3-031-71253-1_18openalex-snapshot
Integration of Raman Spectroscopy, On-Line Microscopic Imaging and Deep Learning-Based Image Analysis for Real-Time Monitoring of Cell Culture Process
inferred← citeshttps://doi.org/10.1007/978-3-319-10320-4_11openalex-snapshot
Mammalian Cell Line Selection Strategies for High-Producers
inferred← citeshttps://doi.org/10.1007/978-3-319-10320-4_21openalex-snapshot
Process Analytical Technology and Quality-by-Design for Animal Cell Culture
inferred← citeshttps://doi.org/10.1007/978-3-319-53880-8_2openalex-snapshot
How Plants Can Contribute to the Supply of Anticancer Compounds
inferred← citeshttps://doi.org/10.1007/978-94-007-1257-7_2openalex-snapshot
Bioreactor Systems for Producing Antibody from Mammalian Cells
inferred← citeshttps://doi.org/10.1007/978-94-007-2217-0_3openalex-snapshot
Molecular Farming Using Bioreactor-Based Plant Cell Suspension Cultures for Recombinant Protein Production
inferred← citeshttps://doi.org/10.1007/978-981-99-8034-5_3openalex-snapshot
Selection of Design of PAT
inferred← citeshttps://doi.org/10.1007/s00216-010-3781-xopenalex-snapshot
Process analytical technology (PAT) for biopharmaceutical products
inferred← citeshttps://doi.org/10.1007/s00216-016-9907-zopenalex-snapshot
A novel toolbox for E. coli lysis monitoring
inferred← citeshttps://doi.org/10.1007/s00253-011-3513-yopenalex-snapshot
Refolding of proteins from inclusion bodies: rational design and recipes
inferred← citeshttps://doi.org/10.1007/s00253-015-7089-9openalex-snapshot
Multi-parameter flow cytometry as a process analytical technology (PAT) approach for the assessment of bacterial ghost production
inferred← citeshttps://doi.org/10.1007/s10295-017-1984-2openalex-snapshot
Use of near-infrared spectroscopy (NIRs) in the biopharmaceutical industry for real-time determination of critical process parameters and integration of advanced feedback control strategies using MIDUS control
inferred← citeshttps://doi.org/10.1007/s10462-022-10306-1openalex-snapshot
Deep learning in drug discovery: an integrative review and future challenges
inferred← citeshttps://doi.org/10.1007/s10529-017-2437-8openalex-snapshot
Examining the sources of variability in cell culture media used for biopharmaceutical production
inferred← citeshttps://doi.org/10.1007/s11274-018-2541-5openalex-snapshot
Wanted: more monitoring and control during inclusion body processing
inferred← citeshttps://doi.org/10.1007/s11705-015-1533-3openalex-snapshot
Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared spectroscopy: Implications for enabling cell culture process analytical technology
inferred← citeshttps://doi.org/10.1007/s12247-026-10914-2openalex-snapshot
Continuous Downstream Processing in Biopharmaceutical Manufacturing: A Review
inferred← citeshttps://doi.org/10.1016/b978-0-08-100623-8.00039-6openalex-snapshot
Next-Generation Process Design for Monoclonal Antibody Purification
inferred← citeshttps://doi.org/10.1016/b978-0-08-100623-8.00048-7openalex-snapshot
Implementation of QbD for Manufacturing of Biologics—Has It Met the Expectations?
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14638-4openalex-snapshot
Chemometrics in the Pharmaceutical Industry
inferred← citeshttps://doi.org/10.1016/b978-0-12-811065-2.00012-6openalex-snapshot
A Systematic Approach to Process Data Analytics in Pharmaceutical Manufacturing
inferred← citeshttps://doi.org/10.1016/b978-0-12-811065-2.00016-3openalex-snapshot
Lifecycle Management of PAT Procedures
inferred← citeshttps://doi.org/10.1016/b978-0-12-812659-2.00016-8openalex-snapshot
Future of microfluidics in research and in the market
inferred← citeshttps://doi.org/10.1016/b978-0-12-818438-7.00004-6openalex-snapshot
Applications of artificial intelligence in drug delivery and pharmaceutical development
inferred← citeshttps://doi.org/10.1016/b978-0-443-15378-5.00022-xopenalex-snapshot
Online monitoring tools for vaccine production in bioreactors
inferred← citeshttps://doi.org/10.1016/b978-0-443-33032-2.00015-0openalex-snapshot
Fermentation process optimization for pharmaceutical production
inferred← citeshttps://doi.org/10.1016/b978-0-444-63663-8.00016-1openalex-snapshot
Advanced Process and Control Strategies for Bioreactors
inferred← citeshttps://doi.org/10.1016/j.ab.2017.04.008openalex-snapshot
Determination of thiol-to-protein ratio and drug-to-antibody ratio by in-line size exclusion chromatography with post-column reaction
inferred← citeshttps://doi.org/10.1016/j.aca.2013.11.028openalex-snapshot
A rapid fluorescence based method for the quantitative analysis of cell culture media photo-degradation
inferred← citeshttps://doi.org/10.1016/j.aca.2025.344894openalex-snapshot
Using Rayleigh-Mie scattered light and polarised multidimensional fluorescence emission in combination for protein quantification in a model clarified bioreactor harvest
inferred← citeshttps://doi.org/10.1016/j.addr.2018.04.004openalex-snapshot
Transforming nanomedicine manufacturing toward Quality by Design and microfluidics
inferred← citeshttps://doi.org/10.1016/j.ajps.2016.07.006openalex-snapshot
Application of quality by design in the current drug development
inferred← citeshttps://doi.org/10.1016/j.biortech.2016.03.168openalex-snapshot
Knowledge management in a waste based biorefinery in the QbD paradigm
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2011.07.016openalex-snapshot
Bioreactor systems for in vitro production of foreign proteins using plant cell cultures
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2015.04.010openalex-snapshot
Extraction and downstream processing of plant-derived recombinant proteins
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2018.02.002openalex-snapshot
Plants as sources of natural and recombinant anti-cancer agents
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2020.107552openalex-snapshot
Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2022.108048openalex-snapshot
Applications of bio-capacitance to cell culture manufacturing
inferred← citeshttps://doi.org/10.1016/j.ces.2015.10.009openalex-snapshot
Continuous refolding of a biotech therapeutic in a novel Coiled Flow Inverter Reactor
inferred← citeshttps://doi.org/10.1016/j.ces.2020.116171openalex-snapshot
Reinforcement learning based optimization of process chromatography for continuous processing of biopharmaceuticals
inferred← citeshttps://doi.org/10.1016/j.ces.2020.116272openalex-snapshot
Continuous downstream bioprocessing for intensified manufacture of biopharmaceuticals and antibodies
inferred← citeshttps://doi.org/10.1016/j.chemolab.2018.08.012openalex-snapshot
Calibration transfer of near infrared spectrometers for the assessment of plasma ethanol precipitation process
inferred← citeshttps://doi.org/10.1016/j.chemolab.2024.105291openalex-snapshot
Exploring NIR spectroscopy data: A practical chemometric tutorial for analyzing freeze-dried pharmaceutical formulations
inferred← citeshttps://doi.org/10.1016/j.chroma.2015.11.062openalex-snapshot
Mechanistic modeling of ion-exchange process chromatography of charge variants of monoclonal antibody products
inferred← citeshttps://doi.org/10.1016/j.chroma.2016.02.011openalex-snapshot
Application of spectral deconvolution and inverse mechanistic modelling as a tool for root cause investigation in protein chromatography
inferred← citeshttps://doi.org/10.1016/j.chroma.2023.463784openalex-snapshot
Continuous manufacturing of monoclonal antibodies: Dynamic control of multiple integrated polishing chromatography steps using BioSMB
inferred← citeshttps://doi.org/10.1016/j.cjche.2022.05.023openalex-snapshot
UV/Vis-based process analytical technology to improve monoclonal antibody and host cell protein separation
inferred← citeshttps://doi.org/10.1016/j.cobme.2022.100405openalex-snapshot
PAT strategies and applications for cell therapy processing
inferred← citeshttps://doi.org/10.1016/j.coche.2014.05.006openalex-snapshot
QbD/PAT for bioprocessing: moving from theory to implementation
inferred← citeshttps://doi.org/10.1016/j.coche.2018.08.008openalex-snapshot
Cell culture media analysis using rapid spectroscopic methods
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2015.05.006openalex-snapshot
Elastic net with Monte Carlo sampling for data-based modeling in biopharmaceutical manufacturing facilities
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2017.12.007openalex-snapshot
Challenges and opportunities in biopharmaceutical manufacturing control
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2022.107896openalex-snapshot
AI-ML applications in bioprocessing: ML as an enabler of real time quality prediction in continuous manufacturing of mAbs
inferred← citeshttps://doi.org/10.1016/j.ddtec.2021.04.001openalex-snapshot
Microbial technologies for biotherapeutics production: Key tools for advanced biopharmaceutical process development and control
inferred← citeshttps://doi.org/10.1016/j.ejps.2012.06.009openalex-snapshot
Strategic funding priorities in the pharmaceutical sciences allied to Quality by Design (QbD) and Process Analytical Technology (PAT)
inferred← citeshttps://doi.org/10.1016/j.ejps.2025.107239openalex-snapshot
Quality by digital design for accelerated sustainable nanomedicine development
inferred← citeshttps://doi.org/10.1016/j.engappai.2023.107621openalex-snapshot
Deep learning-based image analysis for in situ microscopic imaging of cell culture process
inferred← citeshttps://doi.org/10.1016/j.fbp.2016.05.009openalex-snapshot
Implementation of Quality by Design for processing of food products and biotherapeutics
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2012.11.001openalex-snapshot
Melt extrusion with poorly soluble drugs
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2015.03.058openalex-snapshot
Continuous twin screw melt granulation of glyceryl behenate: Development of controlled release tramadol hydrochloride tablets for improved safety
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.124412openalex-snapshot
Process analytical technology in Downstream-Processing of Drug Substances– A review
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2025.125922openalex-snapshot
Proactive-residence time distribution method for determining low-risk setpoints of critical material attributes in pharmaceutical continuous manufacturing
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2013.03.008openalex-snapshot
Robust on-line sampling and analysis during long-term perfusion cultivation of mammalian cells
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2013.10.014openalex-snapshot
Monitoring CHO cell cultures: Cell stress and early apoptosis assessment by mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2015.06.393openalex-snapshot
End-to-end integrated fully continuous production of recombinant monoclonal antibodies
inferred← citeshttps://doi.org/10.1016/j.jchromb.2017.01.021openalex-snapshot
Automated 2D-HPLC method for characterization of protein aggregation with in-line fraction collection device
inferred← citeshttps://doi.org/10.1016/j.jcoa.2024.100166openalex-snapshot
Multi-attribute monitoring applications in biopharmaceutical analysis
inferred← citeshttps://doi.org/10.1016/j.jpba.2012.08.002openalex-snapshot
Rapid quantification of tryptophan and tyrosine in chemically defined cell culture media using fluorescence spectroscopy
inferred← citeshttps://doi.org/10.1016/j.jpba.2016.05.001openalex-snapshot
Analytical characterization of in vitro refolding in the quality by design paradigm: Refolding of recombinant human granulocyte colony stimulating factor
inferred← citeshttps://doi.org/10.1016/j.jpba.2019.113060openalex-snapshot
Attenuated total reflection fourier transform infrared spectroscopy based methods for identification of chromatography media formulations used in downstream processes
inferred← citeshttps://doi.org/10.1016/j.jpba.2020.113169openalex-snapshot
Mass spectrometry-based methods in characterization of the higher order structure of protein therapeutics
inferred← citeshttps://doi.org/10.1016/j.jpba.2023.115581openalex-snapshot
Recent applications of quantitative mass spectrometry in biopharmaceutical process development and manufacturing
inferred← citeshttps://doi.org/10.1016/j.jpba.2024.115965openalex-snapshot
Analytical figures of merit of a dual-wavelength absorbance approach for real-time broad protein content monitoring for biomanufacturing
inferred← citeshttps://doi.org/10.1016/j.jpba.2025.117185openalex-snapshot
Use of Raman spectroscopy and PLS for the quantification of critical quality attributes in biopharmaceutical products
inferred← citeshttps://doi.org/10.1016/j.jpha.2023.12.006openalex-snapshot
Basic regulatory science behind drug substance and drug product specifications of monoclonal antibodies and other protein therapeutics
inferred← citeshttps://doi.org/10.1016/j.jprocont.2019.03.002openalex-snapshot
Industrial batch process monitoring with limited data
inferred← citeshttps://doi.org/10.1016/j.memsci.2015.10.063openalex-snapshot
Enablers for QbD implementation: Mechanistic modeling for ion-exchange membrane chromatography
inferred← citeshttps://doi.org/10.1016/j.pharma.2026.06.001openalex-snapshot
Overview of artificial intelligence (AI) in pharmaceutical analysis: Instrument design and industrial applications
inferred← citeshttps://doi.org/10.1016/j.procbio.2016.06.018openalex-snapshot
Real-time monitoring of protein precipitation in a tubular reactor for continuous bioprocessing
inferred← citeshttps://doi.org/10.1016/j.saa.2013.02.018openalex-snapshot
Application of near-infrared spectroscopy combined with multivariate analysis in monitoring of crude heparin purification process
inferred← citeshttps://doi.org/10.1016/j.tibtech.2010.12.001openalex-snapshot
High-throughput process development for biopharmaceutical drug substances
inferred← citeshttps://doi.org/10.1016/j.tibtech.2016.01.003openalex-snapshot
Quality by Design (QbD)-Based Process Development for Purification of a Biotherapeutic
inferred← citeshttps://doi.org/10.1016/j.tifs.2015.02.010openalex-snapshot
The current status of process analytical technologies in the dairy industry
inferred← citeshttps://doi.org/10.1016/j.ymeth.2012.03.001openalex-snapshot
Automated flow cytometry for monitoring CHO cell cultures
inferred← citeshttps://doi.org/10.1016/j.ymeth.2012.03.004openalex-snapshot
Flow-cytometry and cell sorting: An efficient approach to investigate productivity and cell physiology in mammalian cell factories
inferred← citeshttps://doi.org/10.1017/9781108847209openalex-snapshot
Perfusion Cell Culture Processes for Biopharmaceuticals
inferred← citeshttps://doi.org/10.1017/9781108847209.001openalex-snapshot
Perfusion Mammalian Cell Culture for Recombinant Protein Manufacturing
inferred← citeshttps://doi.org/10.1017/9781108847209.002openalex-snapshot
Perfusion Bioreactors:The Set-Up and Process Characterisation
inferred← citeshttps://doi.org/10.1017/9781108847209.003openalex-snapshot
Scale-Down Models and Sensors for Process Development
inferred← citeshttps://doi.org/10.1017/9781108847209.004openalex-snapshot
Design and Optimisation of Mammalian Cell Perfusion Cultures
inferred← citeshttps://doi.org/10.1017/9781108847209.005openalex-snapshot
Clinical- and Commercial-Scale Reactors
inferred← citeshttps://doi.org/10.1017/9781108847209.006openalex-snapshot
Mechanistic and Statistical Modelling of Bioprocesses
inferred← citeshttps://doi.org/10.1021/ac504502eopenalex-snapshot
Inline Protein A Mass Spectrometry for Characterization of Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b00897openalex-snapshot
Use of HPLC as an Enabler of Process Analytical Technology in Process Chromatography
inferred← citeshttps://doi.org/10.1021/acs.iecr.0c04010openalex-snapshot
Multiobjective Optimization for Enhanced Production of Therapeutic Proteins in Escherichia coli: Application of Real-Time Dielectric Spectroscopy
inferred← citeshttps://doi.org/10.1021/acs.oprd.7b00238openalex-snapshot
Process Analytical Technology (PAT) Aided Identification of Operational Spaces Leading to Tailored Crystal Size Distributions in Azithromycin Crystallization via Coordinated Cooling and Solution Mediated Phase Transition
inferred← citeshttps://doi.org/10.1021/bk-2014-1176.ch001openalex-snapshot
Monoclonal Antibody Therapeutics: The Need for Biopharmaceutical Reference Materials
inferred← citeshttps://doi.org/10.1039/9781788019996-00244openalex-snapshot
Magnetic Resonance Methods Applied to the Study and Development of Cell Cultures and Bioreactors for Biopharmaceutical Production
inferred← citeshttps://doi.org/10.1039/c2ay25448dopenalex-snapshot
Improvement in accuracy and specificity of high-throughput sialic acid assay
inferred← citeshttps://doi.org/10.1039/d0ay00686fopenalex-snapshot
FTIR based kinetic characterisation of an acid-catalysed esterification of 3-methylphthalic anhydride and 2-ethylhexanol
inferred← citeshttps://doi.org/10.1055/a-2913-9621openalex-snapshot
Monitoring an Aromatic Amide Active Pharmaceutical Ingredient in a Reactive Crystallization by in situ Raman Spectroscopy: Comparing Data Analysis between Partial Least Squares Regression and Non-Negative Matrix Factorization
inferred← citeshttps://doi.org/10.1080/07373937.2011.597059openalex-snapshot
Scale-up and Process Transfer of Freeze-Drying Recipes
inferred← citeshttps://doi.org/10.1080/10408347.2025.2601695openalex-snapshot
Process Analytical Technologies (PAT) in the Food Industry: An Agile Tool for Traceability and Sustainability
inferred← citeshttps://doi.org/10.1080/10826068.2011.613976openalex-snapshot
RECENT DEVELOPMENTS IN MEMBRANE-BASED SEPARATIONS IN BIOTECHNOLOGY PROCESSES: REVIEW
inferred← citeshttps://doi.org/10.1080/10826068.2019.1615504openalex-snapshot
An overview of mechanistic modeling of liquid chromatography
inferred← citeshttps://doi.org/10.1080/87559129.2026.2643455openalex-snapshot
Chemometrics, Infrared Sensors and Precision Fermentation – Where are We?
inferred← citeshttps://doi.org/10.1088/1742-6596/2090/1/012035openalex-snapshot
On the asymptotic stability of advection-diffusion equations of mass transport in a bubble column bioreactor
inferred← citeshttps://doi.org/10.1109/ccta54093.2023.10253250openalex-snapshot
Setpoint Determination Method for Pharmaceutical Continuous Manufacturing: Proactive-RTD-based Approach *
inferred← citeshttps://doi.org/10.1109/icemi.2015.7494490openalex-snapshot
A brief review on biotechnological process sensoring
inferred← citeshttps://doi.org/10.1149/1945-7111/ac5799openalex-snapshot
On-Line PAT Monitoring of Lucentis in the Fermenter Using Aptamer-Based Capacitive Microfluidic Chip Biosensor
inferred← citeshttps://doi.org/10.1155/2018/4083921openalex-snapshot
Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization
inferred← citeshttps://doi.org/10.1177/0003702817703270openalex-snapshot
Applications of Raman Spectroscopy in Biopharmaceutical Manufacturing: A Short Review
inferred← citeshttps://doi.org/10.1186/1753-6561-9-s9-p32openalex-snapshot
Monitorization of pH and OTR using a multiple shake flask platform: A tool for metabolism and cell growth assessment in mammalian cell cultures
inferred← citeshttps://doi.org/10.1186/s12934-014-0149-5openalex-snapshot
Phenotyping the quality of complex medium components by simple online-monitored shake flask experiments
inferred← citeshttps://doi.org/10.1201/b11536-2openalex-snapshot
Scientific and Regulatory Overview of Process Analytical Technology in Bioprocesses
inferred← citeshttps://doi.org/10.1201/b11536-4openalex-snapshot
Multivariate Techniques in Biopharmaceutical Process Development
inferred← citeshttps://doi.org/10.1208/s12248-024-00973-zopenalex-snapshot
Exploring the Correlation between LC–MS Multi-Attribute Method and Conventional Chromatographic Product Quality Assays through Multivariate Data Analysis
inferred← citeshttps://doi.org/10.1208/s12249-016-0523-1openalex-snapshot
A Rational Analysis of Uniformity Risk for Agglomerated Drug Substance Using NIR Chemical Imaging
inferred← citeshttps://doi.org/10.1255/jnirs.1222openalex-snapshot
Investigation of Heat-Treated Cultivation Medium for Mammalian Cells with near Infrared Spectroscopy
inferred← citeshttps://doi.org/10.1371/journal.pone.0045891openalex-snapshot
An Automatic Refolding Apparatus for Preparative-Scale Protein Production
inferred← citeshttps://doi.org/10.18174/415645openalex-snapshot
Surface plasmon resonance imaging as a screening platform in biopharmaceutical development
inferred← citeshttps://doi.org/10.18609/vac.2023.64openalex-snapshot
PAT to the future: combining in silico tools and analytics for streamlining process development of aluminum-adjuvanted vaccines
inferred← citeshttps://doi.org/10.2174/2667387817666230425135344openalex-snapshot
Hot Melt Extrusion: A Paradigm–Changing Technology
inferred← citeshttps://doi.org/10.26434/chemrxiv-2024-c1b8wopenalex-snapshot
Uncovering the Impact of Spectroscopic Data Reduction Techniques on the Process Control Mode Pattern Recognition: The Case of Industrial Penicillin Production
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