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Process analytical technique ( PAT ) miniaturization for monoclonal antibody aggregate detection in continuous downstream processing
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Capillary electrophoresis on microchip
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Microfluidic Glass Chips with an Integrated Nanospray Emitter for Coupling to a Mass Spectrometer
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Process analytical technology (PAT) for biopharmaceuticals
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A screening tool for therapeutic monoclonal antibodies: Identifying the most stable protein and its best formulation based on thioflavin T binding
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Minimizing immunogenicity of biopharmaceuticals by controlling critical quality attributes of proteins
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Case study and application of process analytical technology (PAT) towards bioprocessing: Use of on‐line high‐performance liquid chromatography (HPLC) for making real‐time pooling decisions for process chromatography
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Process analytical technology (PAT) for biopharmaceutical products: Part I. concepts and applications
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Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in‐line Raman spectroscopy probe
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Aggregates in monoclonal antibody manufacturing processes
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Continuous downstream processing for high value biological products: A Review
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Progression of continuous downstream processing of monoclonal antibodies: Current trends and challenges
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An NIR‐based PAT approach for real‐time control of loading in Protein A chromatography in continuous manufacturing of monoclonal antibodies
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Understanding mAb aggregation during low pH viral inactivation and subsequent neutralization
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Side‐by‐side comparability of batch and continuous downstream for the production of monoclonal antibodies
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White paper on high‐throughput process development for integrated continuous biomanufacturing
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Evolving trends in mAb production processes
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Mid‐infrared spectroscopy‐based analysis of mammalian cell culture Parameters
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Integrated continuous bioprocessing: Economic, operational, and environmental feasibility for clinical and commercial antibody manufacture
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Microfluidic devices fabricated in Poly(dimethylsiloxane) for biological studies
inferredcites →https://doi.org/10.1002/elps.201600519openalex-snapshot
Establishment and validation of a microfluidic capillary gel electrophoresis platform method for purity analysis of therapeutic monoclonal antibodies
inferredcites →https://doi.org/10.1002/jctb.4477openalex-snapshot
Mini‐review: soft sensors as means for PAT in the manufacture of bio‐therapeutics
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Evaluation of fluorescent dyes to measure protein aggregation within mammalian cell culture supernatants
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Quantitation of Aggregate Levels in a Recombinant Humanized Monoclonal Antibody Formulation by Size-Exclusion Chromatography, Asymmetrical Flow Field Flow Fractionation, and Sedimentation Velocity
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Overlooking Subvisible Particles in Therapeutic Protein Products: Gaps That May Compromise Product Quality
inferredcites →https://doi.org/10.1002/jps.21566openalex-snapshot
Protein aggregation: Pathways, induction factors and analysis
inferredcites →https://doi.org/10.1002/jps.21654openalex-snapshot
Detection of Protein Aggregates by Sedimentation Velocity Analytical Ultracentrifugation (SV-AUC): Sources of Variability and Their Relative Importance
inferredcites →https://doi.org/10.1002/jps.21857openalex-snapshot
Mobile phase containing arginine provides more reliable SEC condition for aggregation analysis
inferredcites →https://doi.org/10.1002/jps.21989openalex-snapshot
Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: Essential need to use orthogonal methods to assure the quality of therapeutic protein products
inferredcites →https://doi.org/10.1002/jps.22036openalex-snapshot
Detection of IgG Aggregation by a High Throughput Method Based on Extrinsic Fluorescence
inferredcites →https://doi.org/10.1002/jps.22123openalex-snapshot
Development of a Microflow Digital Imaging Assay to Characterize Protein Particulates During Storage of a High Concentration IgG1 Monoclonal Antibody Formulation
inferredcites →https://doi.org/10.1002/jps.22275openalex-snapshot
Adsorption of Monoclonal Antibodies to Glass Microparticles
inferredcites →https://doi.org/10.1002/jps.22305openalex-snapshot
Subvisible Particle Counting Provides a Sensitive Method of Detecting and Quantifying Aggregation of Monoclonal Antibody Caused by Freeze-Thawing: Insights Into the Roles of Particles in the Protein Aggregation Pathway
inferredcites →https://doi.org/10.1002/jps.22450openalex-snapshot
High Throughput Formulation Screening for Global Aggregation Behaviors of Three Monoclonal Antibodies
inferredcites →https://doi.org/10.1002/jps.23298openalex-snapshot
Asymmetrical Flow Field-Flow Fractionation Method for the Analysis of Submicron Protein Aggregates
inferredcites →https://doi.org/10.1002/jps.23405openalex-snapshot
High-Throughput Melting-Temperature Analysis of a Monoclonal Antibody by Differential Scanning Fluorimetry in the Presence of Surfactants
inferredcites →https://doi.org/10.1002/jps.23552openalex-snapshot
Micro–Flow Imaging and Resonant Mass Measurement (Archimedes) – Complementary Methods to Quantitatively Differentiate Protein Particles and Silicone Oil Droplets
inferredcites →https://doi.org/10.1002/jps.23788openalex-snapshot
Stability of Monoclonal Antibodies at High-Concentration: Head-to-Head Comparison of the IgG1 and IgG4 Subclass
inferredcites →https://doi.org/10.1002/jps.23839openalex-snapshot
Structural Characterization of IgG1 mAb Aggregates and Particles Generated Under Various Stress Conditions
inferredcites →https://doi.org/10.1002/jps.24156openalex-snapshot
Calculating the Mass of Subvisible Protein Particles with Improved Accuracy Using Microflow Imaging Data
inferredcites →https://doi.org/10.1002/jps.24268openalex-snapshot
White Paper on Continuous Bioprocessing May 20–21 2014 Continuous Manufacturing Symposium
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Microchip technology in mass spectrometry
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Advances in coupling microfluidic chips to mass spectrometry
inferredcites →https://doi.org/10.1007/128_2011_150openalex-snapshot
Micromixing Within Microfluidic Devices
inferredcites →https://doi.org/10.1007/s00216-010-3781-xopenalex-snapshot
Process analytical technology (PAT) for biopharmaceutical products
inferredcites →https://doi.org/10.1007/s00216-011-5585-zopenalex-snapshot
Convenient formation of nanoparticle aggregates on microfluidic chips for highly sensitive SERS detection of biomolecules
inferredcites →https://doi.org/10.1007/s00216-013-7115-7openalex-snapshot
Characterization of oat proteins and aggregates using asymmetric flow field-flow fractionation
inferredcites →https://doi.org/10.1007/s00216-013-7462-4openalex-snapshot
Hollow-fiber flow field-flow fractionation with multi-angle laser scattering detection for aggregation studies of therapeutic proteins
inferredcites →https://doi.org/10.1007/s00216-014-8200-2openalex-snapshot
Quantitative characterization by asymmetrical flow field-flow fractionation of IgG thermal aggregation with and without polymer protective agents
inferredcites →https://doi.org/10.1007/s00216-015-8672-8openalex-snapshot
Fluorescence dye-based detection of mAb aggregates in CHO culture supernatants
inferredcites →https://doi.org/10.1007/s00216-016-9824-1openalex-snapshot
Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing
inferredcites →https://doi.org/10.1007/s00216-017-0362-2openalex-snapshot
High-throughput analysis of sub-visible mAb aggregate particles using automated fluorescence microscopy imaging
inferredcites →https://doi.org/10.1007/s10404-011-0879-1openalex-snapshot
Ultra-sensitive, label-free probing of the conformational characteristics of amyloid beta aggregates with a SERS active nanofluidic device
inferredcites →https://doi.org/10.1007/s10529-010-0469-4openalex-snapshot
Effects of shear on proteins in solution
inferredcites →https://doi.org/10.1007/s11095-006-0283-9openalex-snapshot
A Critical Evaluation of Tm(FTIR) Measurements of High-Concentration IgG1 Antibody Formulations as a Formulation Development Tool
inferredcites →https://doi.org/10.1007/s11095-008-9792-zopenalex-snapshot
Effect of Ions on Agitation- and Temperature-Induced Aggregation Reactions of Antibodies
inferredcites →https://doi.org/10.1007/s11095-009-0020-2openalex-snapshot
Fluorescent Molecular Rotors as Dyes to Characterize Polysorbate-Containing IgG Formulations
inferredcites →https://doi.org/10.1007/s11095-010-0224-5openalex-snapshot
Mass Spectrometric Analysis of Intact Human Monoclonal Antibody Aggregates Fractionated by Size-Exclusion Chromatography
inferredcites →https://doi.org/10.1007/s11095-010-0297-1openalex-snapshot
Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development
inferredcites →https://doi.org/10.1007/s11095-012-0732-6openalex-snapshot
Structure and Function of Purified Monoclonal Antibody Dimers Induced by Different Stress Conditions
inferredcites →https://doi.org/10.1007/s11095-012-0885-3openalex-snapshot
Aggregation Mechanism of an IgG2 and two IgG1 Monoclonal Antibodies at low pH: From Oligomers to Larger Aggregates
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High Throughput Differential Scanning Fluorimetry (DSF) Formulation Screening with Complementary Dyes to Assess Protein Unfolding and Aggregation in Presence of Surfactants
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Analytical Platform for Monitoring Aggregation of Monoclonal Antibody Therapeutics
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Introduction to analytical quality by design
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Submicrometer, micrometer and visible particle analysis in biopharmaceutical research and development
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Miniaturization of asymmetrical flow field-flow fractionation and application to studies on lipoprotein aggregation and fusion
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Sedimentation velocity analytical ultracentrifugation and SEDFIT/c(s): Limits of quantitation for a monoclonal antibody system
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Online fluorescent dye detection method for the characterization of immunoglobulin G aggregation by size exclusion chromatography and asymmetrical flow field flow fractionation
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Using differential scanning calorimetry for the development of non-reduced capillary electrophoresis sodium dodecyl sulfate methods for monoclonal antibodies
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Determination of interactions between antibody biotherapeutics and copper by size exclusion chromatography (SEC) coupled with inductively coupled plasma mass spectrometry (ICP/MS)
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Rapid, quantitative determination of aggregation and particle formation for antibody drug conjugate therapeutics with label-free Raman spectroscopy
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Applications of process analytical technology to crystallization processes
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Characterization of protein aggregation: The case of a therapeutic immunoglobulin
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Aggregation and fibrillation of bovine serum albumin
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Molecular mechanism of Thioflavin-T binding to amyloid fibrils
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Probing Red Blood Cell Morphology Using High-Frequency Photoacoustics
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Mixing performance of a planar micromixer with circular obstructions in a curved microchannel
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Characterisation of colloidal dispersions using ultrasound spectroscopy and multiple-scattering theory inclusive of shear-wave effects
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Impact of asymmetrical flow field-flow fractionation on protein aggregates stability
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Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology
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Perspectives on integrated continuous bioprocessing — opportunities and challenges
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The use of asymmetrical flow field-flow fractionation in pharmaceutics and biopharmaceutics
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Induction and analysis of aggregates in a liquid IgG1-antibody formulation
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Reversible NaCl-induced aggregation of a monoclonal antibody at low pH: Characterization of aggregates and factors affecting aggregation
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Structural properties of monoclonal antibody aggregates induced by freeze–thawing and thermal stress
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pH dependent aggregation and conformation changes of rituximab using SAXS and its comparison with the standard regulatory approach of biophysical characterization
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Detection and characterization of protein aggregates by fluorescence microscopy
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Thermodynamic stability and formation of aggregates of human immunoglobulin G characterised by differential scanning calorimetry and dynamic light scattering
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The business impact of an integrated continuous biomanufacturing platform for recombinant protein production
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Process analytics for purification of monoclonal antibodies
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Downstream processing of human antibodies integrating an extraction capture step and cation exchange chromatography
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Insights from capillary electrophoresis approaches for characterization of monoclonal antibodies and antibody drug conjugates in the period 2016–2018
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Study of low concentrated ionic ferrrofluid stability in magnetic field by ultrasound spectroscopy
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Direct analysis in real time mass spectrometry, a process analytical technology tool for real-time process monitoring in botanical drug manufacturing
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Rapid process development of chromatographic process using direct analysis in real time mass spectrometry as a process analytical technology tool
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Continuous manufacturing process monitoring of pharmaceutical solid dosage form: A case study
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Analytical artifacts in characterization of recombinant monoclonal antibody therapeutics
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Coupling non-denaturing chromatography to mass spectrometry for the characterization of monoclonal antibodies and related products
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Fabrication of a microfluidic platform for investigating dynamic biochemical processes in living samples by FTIR microspectroscopy
inferredcites →https://doi.org/10.1016/j.memsci.2020.118492openalex-snapshot
Implementing PAT for single-pass tangential flow ultrafiltration for continuous manufacturing of monoclonal antibodies
inferredcites →https://doi.org/10.1016/j.seppur.2020.117403openalex-snapshot
Continuous adsorption in food industry: The recovery of sinapic acid from rapeseed meal extract
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Proteins behaving badly: emerging technologies in profiling biopharmaceutical aggregation
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Continuous downstream processing of biopharmaceuticals
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Therapeutic protein aggregation: mechanisms, design, and control
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The Increasingly Human and Profitable Monoclonal Antibody Market
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Analytical approaches to assess the degradation of therapeutic proteins
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Some Lessons Learned From a Comparison Between Sedimentation Velocity Analytical Ultracentrifugation and Size Exclusion Chromatography to Characterize and Quantify Protein Aggregates
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Evaluation of Hydrogen Exchange Mass Spectrometry as a Stability-Indicating Method for Formulation Excipient Screening for an IgG4 Monoclonal Antibody
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Stress Factors in mAb Drug Substance Production Processes: Critical Assessment of Impact on Product Quality and Control Strategy
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Relation of Colloidal and Conformational Stabilities to Aggregate Formation in a Monoclonal Antibody
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Measuring low levels of protein aggregation by sedimentation velocity
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The stabilization of proteins by osmolytes
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Analysis of aggregates of human immunoglobulin G using size-exclusion chromatography, static and dynamic light scattering
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Protein Aggregation Starting From The Native Globular State1
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Factors affecting short-term and long-term stabilities of proteins
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Instability, stabilization, and formulation of liquid protein pharmaceuticals
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The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways
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High-Speed Separations on a Microchip
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A Chip System for Size Separation of Macromolecules and Particles by Hydrodynamic Chromatography
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Mixing Processes in a Zigzag Microchannel: Finite Element Simulations and Optical Study
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On-Chip Hydrodynamic Chromatography Separation and Detection of Nanoparticles and Biomolecules
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Microfluidic Chip for Peptide Analysis with an Integrated HPLC Column, Sample Enrichment Column, and Nanoelectrospray Tip
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Miniaturization of Frit Inlet Asymmetrical Flow Field-Flow Fractionation
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Membrane-Based Emitter for Coupling Microfluidics with Ultrasensitive Nanoelectrospray Ionization-Mass Spectrometry
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High-Throughput Thermal Stability Analysis of a Monoclonal Antibody by Attenuated Total Reflection FT-IR Spectroscopic Imaging
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Circular Dichroism Spectroscopy as a Tool for Monitoring Aggregation in Monoclonal Antibody Therapeutics
inferredcites →https://doi.org/10.1021/ac5038329openalex-snapshot
Monitoring Antibody Aggregation in Early Drug Development Using Raman Spectroscopy and Perturbation-Correlation Moving Windows
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Microfluidic Mixers for the Investigation of Rapid Protein Folding Kinetics Using Synchrotron Radiation Circular Dichroism Spectroscopy
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Development of a Multilane Channel System for Nongel-Based Two-Dimensional Protein Separations Using Isoelectric Focusing and Asymmetrical Flow Field-Flow Fractionation
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Temperature-Programmed Natural Convection for Micromixing and Biochemical Reaction in a Single Microfluidic Chamber
inferredcites →https://doi.org/10.1021/acs.analchem.0c00627openalex-snapshot
Raman Spectroscopy to Monitor Post-Translational Modifications and Degradation in Monoclonal Antibody Therapeutics
inferredcites →https://doi.org/10.1021/acs.analchem.5b03866openalex-snapshot
Characterization of Intact Antibody Drug Conjugate Variants Using Microfluidic Capillary Electrophoresis–Mass Spectrometry
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A Novel Online Four-Dimensional SEC×SEC-IM×MS Methodology for Characterization of Monoclonal Antibody Size Variants
inferredcites →https://doi.org/10.1021/acs.jpcb.6b03878openalex-snapshot
Effects of Protein Conformation, Apparent Solubility, and Protein–Protein Interactions on the Rates and Mechanisms of Aggregation for an IgG1Monoclonal Antibody
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Kinetics and Thermodynamics of Dimer Formation and Dissociation for a Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor
inferredcites →https://doi.org/10.1021/bk-2015-1202.ch005openalex-snapshot
Characterization of Monoclonal Antibody Aggregates and Emerging Technologies
inferredcites →https://doi.org/10.1021/bp0701261openalex-snapshot
Determining Antibody Stability: Creation of Solid-Liquid Interfacial Effects within a High Shear Environment
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Aggregation of Recombinant Human Interferon Gamma: Kinetics and Structural Transitions
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Using circular dichroism spectra to estimate protein secondary structure
inferredcites →https://doi.org/10.1038/s41467-018-07299-3openalex-snapshot
In situ monitoring of molecular aggregation using circular dichroism
inferredcites →https://doi.org/10.1038/s41598-018-25246-6openalex-snapshot
Coupling Multi Angle Light Scattering to Ion Exchange chromatography (IEX-MALS) for protein characterization
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On-chip culture system for observation of isolated individual cells
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A microfluidic platform for integrated synthesis and dynamic light scattering measurement of block copolymer micelles
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Microfluidics with on-line dynamic light scattering for size measurements
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Applications of micromixing technology
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Trends in process analytical technology
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Waveguide confined Raman spectroscopy for microfluidic interrogation
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Surface-enhanced Raman spectroscopy and microfluidic platforms: challenges, solutions and potential applications
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Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism
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Miniaturized dynamic light scattering instrumentation for use in microfluidic applications
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SDS capillary gel electrophoresis of proteins in microfabricated channels
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Dynamic light scattering as a relative tool for assessing the molecular integrity and stability of monoclonal antibodies
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Mass Spectrometry, Review of the Basics: Ionization
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Continuous Processing for Production of Biopharmaceuticals
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