On the public citation graph
Process analytical technology (PAT) for biopharmaceutical products: Part II. Concepts and applications
0 signed · 276 inferred · view as graph
Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.
Is this your work? Sign in with ORCID and put your name on the
claims that are yours.
Reference health. See whether every reference in this work resolves to a
known work and none has been retracted — and get a dated CiteStamped
badge you can embed.
What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/1618-2863(200107)1:1<15::aid-elsc15>3.0.co;2-1openalex-snapshot
Use of Bioanalytical Systems for the Improvement of Industrial Tryptophan Production
inferredcites →https://doi.org/10.1002/9780470466315.ch12openalex-snapshot
Pat Tools for Biologics: Considerations and Challenges
inferredcites →https://doi.org/10.1002/9780470466315.ch13openalex-snapshot
Evolution and Integration of Quality by Design and Process Analytical Technology
inferredcites →https://doi.org/10.1002/9780470466315.ch5openalex-snapshot
Case Study on Definition of Process Design Space for a Microbial Fermentation Step
inferredcites →https://doi.org/10.1002/bit.10116openalex-snapshot
Chemometric evaluation of on-line high-pressure liquid chromatography in mammalian cell cultures: Analysis of amino acids and glucose
inferredcites →https://doi.org/10.1002/bit.10178openalex-snapshot
Inline characterization of cell concentration and cell volume in agitated bioreactors using in situ microscopy: Application to volume variation induced by osmotic stress
inferredcites →https://doi.org/10.1002/bit.10574openalex-snapshot
Bracketed generic inactivation of rodent retroviruses by low pH treatment for monoclonal antibodies and recombinant proteins
inferredcites →https://doi.org/10.1002/bit.1128openalex-snapshot
Assessment of near‐infrared spectral information for rapid monitoring of bioprocess quality
inferredcites →https://doi.org/10.1002/bit.21248openalex-snapshot
Fermentation process tracking through enhanced spectral calibration modeling
inferredcites →https://doi.org/10.1002/bit.21571openalex-snapshot
On‐line near infrared monitoring of glycerol‐boosted anaerobic digestion processes: Evaluation of process analytical technologies
inferredcites →https://doi.org/10.1002/bit.21725openalex-snapshot
At‐line monitoring of bioreactor protein production by surface plasmon resonance
inferredcites →https://doi.org/10.1002/bit.21920openalex-snapshot
Predicting sporulation events in a bioreactor using an electronic nose
inferredcites →https://doi.org/10.1002/bit.22125openalex-snapshot
In situ 2D fluorometry and chemometric monitoring of mammalian cell cultures
inferredcites →https://doi.org/10.1002/bit.22187openalex-snapshot
Automated, scalable culture of human embryonic stem cells in feeder‐free conditions
inferredcites →https://doi.org/10.1002/bit.22192openalex-snapshot
Disposable bioprocessing: The future has arrived
inferredcites →https://doi.org/10.1002/bp070063mopenalex-snapshot
Fault Detection and Diagnosis in an Industrial Fed-Batch Cell Culture Process
inferredcites →https://doi.org/10.1002/btpr.67openalex-snapshot
Bioprocess optimization using design‐of‐experiments methodology
inferredcites →https://doi.org/10.1002/cem.697openalex-snapshot
Multivariate methods in pharmaceutical applications
inferredcites →https://doi.org/10.1002/cem.962openalex-snapshot
Robust methods for multivariate data analysis
inferredcites →https://doi.org/10.1002/cyto.a.10016openalex-snapshot
Automated flow cytometry for acquisition of time-dependent population data.
inferredcites →https://doi.org/10.1002/jps.20416openalex-snapshot
Noninvasive Determination of Protein Conformation in the Solid State Using Near Infrared (NIR) Spectroscopy
inferredcites →https://doi.org/10.1002/jps.20630openalex-snapshot
Infrared microscopy for in situ measurement of protein secondary structure during freezing and freeze-drying
inferredcites →https://doi.org/10.1002/jps.20931openalex-snapshot
Process Analytical Technology: Chemometric Analysis of Raman and Near Infra-Red Spectroscopic Data for Predicting Physical Properties of Extended Release Matrix Tablets
inferredcites →https://doi.org/10.1002/jps.21633openalex-snapshot
In-line and real-time process monitoring of a freeze drying process using Raman and NIR spectroscopy as complementary process analytical technology (PAT) tools
inferredcites →https://doi.org/10.1002/jps.2600730910openalex-snapshot
Mass and Heat Transfer in Vial Freeze-Drying of Pharmaceuticals: Role of the Vial
inferredcites →https://doi.org/10.1007/bf00353925openalex-snapshot
CO2 in large-scale and high-density CHO cell perfusion culture
inferredcites →https://doi.org/10.1007/bf01912221openalex-snapshot
Applications of DSC in the development of improved freeze-drying processes for labile biologicals
inferredcites →https://doi.org/10.1007/s10616-005-3587-4openalex-snapshot
On-Line Detection of Microbial Contaminations in Animal Cell Reactor Cultures Using an Electronic Nose Device
inferredcites →https://doi.org/10.1007/s10616-005-3974-xopenalex-snapshot
On-line Measurements and Control of Viable Cell Density in Cell Culture Manufacturing Processes using Radio-frequency Impedance
inferredcites →https://doi.org/10.1007/s10616-006-9005-8openalex-snapshot
Reactor Engineering in Large Scale Animal Cell Culture
inferredcites →https://doi.org/10.1007/s10616-006-9020-9openalex-snapshot
Transient gene expression in CHO cells monitored with automated flow cytometry
inferredcites →https://doi.org/10.1016/0248-4900(93)90122-uopenalex-snapshot
Application of flow cytometry to rapid microbial analysis in food and drinks industries
inferredcites →https://doi.org/10.1016/j.chemolab.2006.04.024openalex-snapshot
The chemometric analysis of point and dynamic data in pharmaceutical and biotech production (PAT) — some objectives and approaches
inferredcites →https://doi.org/10.1016/j.ijpharm.2008.09.001openalex-snapshot
In situ precipitation and vacuum drying of interferon alpha-2a: Development of a single-step process for obtaining dry, stable protein formulation
inferredcites →https://doi.org/10.1016/j.jbiotec.2005.06.031openalex-snapshot
Dynamics of single cell property distributions in Chinese hamster ovary cell cultures monitored and controlled with automated flow cytometry
inferredcites →https://doi.org/10.1016/j.jbiotec.2006.06.004openalex-snapshot
Open-loop control of the biomass concentration within the growth phase of recombinant protein production processes
inferredcites →https://doi.org/10.1016/j.jbiotec.2008.03.019openalex-snapshot
Mammalian cell culture scale-up and fed-batch control using automated flow cytometry
inferredcites →https://doi.org/10.1016/j.jpba.2007.03.023openalex-snapshot
A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies
inferredcites →https://doi.org/10.1016/j.mimet.2007.10.004openalex-snapshot
Enumeration of airborne bacteria and fungi using solid phase cytometry
inferredcites →https://doi.org/10.1016/j.tibtech.2008.09.003openalex-snapshot
Mining bioprocess data: opportunities and challenges
inferredcites →https://doi.org/10.1016/j.tibtech.2009.06.006openalex-snapshot
Roadmap for implementation of quality by design (QbD) for biotechnology products
inferredcites →https://doi.org/10.1016/j.trac.2006.10.003openalex-snapshot
Avoiding pitfalls with chemometrics and PAT in the pharmaceutical and biotech industries
inferredcites →https://doi.org/10.1016/s0168-1656(02)00212-2openalex-snapshot
Enhanced bio-manufacturing through advanced multivariate statistical technologies
inferredcites →https://doi.org/10.1016/s0169-409x(02)00026-1openalex-snapshot
PEGylated antibodies and antibody fragments for improved therapy: a review
inferredcites →https://doi.org/10.1016/s0255-2701(01)00122-2openalex-snapshot
Development of a high resolution UV spectrophotometer for at-line monitoring of bioprocesses
inferredcites →https://doi.org/10.1021/ac070549hopenalex-snapshot
Implementation of a Process Analytical Technology System in a Freeze-Drying Process Using Raman Spectroscopy for In-Line Process Monitoring
inferredcites →https://doi.org/10.1021/bp0256263openalex-snapshot
Strategies for Improved dCO 2 Removal in Large‐Scale Fed‐Batch Cultures
inferredcites →https://doi.org/10.1021/bp049815sopenalex-snapshot
Effects of Elevated pCO2 and Osmolality on Growth of CHO Cells and Production of Antibody-Fusion Protein B1: A Case Study
inferredcites →https://doi.org/10.1021/bp050274wopenalex-snapshot
Exploitation of the Adsorptive Properties of Depth Filters for Host Cell Protein Removal during Monoclonal Antibody Purification
inferredcites →https://doi.org/10.1021/bp060306vopenalex-snapshot
An On‐Line Approach To Monitor Ethanol Fermentation Using FTIR Spectroscopy
inferredcites →https://doi.org/10.1021/bp060377uopenalex-snapshot
Application of Multivariate Analysis toward Biotech Processes: Case Study of a Cell‐Culture Unit Operation
inferredcites →https://doi.org/10.1021/bp070338yopenalex-snapshot
Defining Process Design Space for Biotech Products: Case Study of Pichia pastoris Fermentation
inferredcites →https://doi.org/10.1021/bp0704384openalex-snapshot
Application of Multivariate Data Analysis for Identification and Successful Resolution of a Root Cause for a Bioprocessing Application
inferredcites →https://doi.org/10.1021/ie0208218openalex-snapshot
Online Batch/Fed-Batch Process Performance Monitoring, Quality Prediction, and Variable-Contribution Analysis for Diagnosis
inferredcites →https://doi.org/10.1023/a:1008010605287openalex-snapshot
Effects of CO2 and osmolality on hybridoma cells: growth, metabolism and monoclonal antibody production
inferredcites →https://doi.org/10.1023/a:1012209007411openalex-snapshot
Phase Transitions of Glycine in Frozen Aqueous Solutions and During Freeze-Drying
inferredcites →https://doi.org/10.1023/a:1014045104525openalex-snapshot
Advanced Granulation Technology (AGTTM). An alternate format for serum-free, chemically-defined and protein-free cell culture media
inferredcites →https://doi.org/10.1023/a:1021170502775openalex-snapshot
In-situ microscopy: Online process monitoring of mammalian cell cultures
inferredcites →https://doi.org/10.1023/a:1022680810474openalex-snapshot
In-Situ Near-Infrared Spectroscopy Monitoring of the Lyophilization Process
inferredcites →https://doi.org/10.1023/b:pham.0000016234.73023.75openalex-snapshot
Design of Freeze-Drying Processes for Pharmaceuticals: Practical Advice
inferredcites →https://doi.org/10.1038/nbt0109-26openalex-snapshot
Quality by design for biopharmaceuticals
inferredcites →https://doi.org/10.1042/ba20040098openalex-snapshot
Rapid characterization of outer‐membrane proteins in Neisseria lactamica by SELDI–TOF‐MS (surface‐enhanced laser desorption ionization–time‐of‐flight MS) for use in a meningococcal vaccine
inferredcites →https://doi.org/10.1042/ba20050056openalex-snapshot
Normal‐flow virus filtration: detection and assessment of the endpoint in bioprocessing
inferredcites →https://doi.org/10.1042/ba20060254openalex-snapshot
Phage passage after extended processing in small‐virus‐retentive filters
inferredcites →https://doi.org/10.1046/j.1537-2995.2001.41040477.xopenalex-snapshot
Evaluation of an automated culture systemfor detecting bacterial contamination of platelets: an analysis with 15 contaminating organisms
inferredcites →https://doi.org/10.1080/10837450500463729openalex-snapshot
Physical Characterization of Pharmaceutical Formulations in Frozen and Freeze-Dried Solid States: Techniques and Applications in Freeze-Drying Development
inferredcites →https://doi.org/10.1080/14653240500361079openalex-snapshot
Roadmap to approval: use of an automated sterility test method as a lot release test for Carticel®, autologous cultured chondrocytes
inferredcites →https://doi.org/10.1080/14653240802075476openalex-snapshot
A multicenter comparison study between the Endosafe® PTS™ rapid-release testing system and traditional methods for detecting endotoxin in cell-therapy products
inferredcites →https://doi.org/10.1109/mcs.2002.1035216openalex-snapshot
Statistical monitoring of multistage, multiphase batch processes
inferredcites →https://doi.org/10.1111/j.1365-2672.2008.03750.xopenalex-snapshot
Detection of bioterror agents in air samples using real-time PCR
inferredcites →https://doi.org/10.1117/12.663476openalex-snapshot
A real-time early warning system for pathogens in water
inferredcites →https://doi.org/10.1128/aem.02125-07openalex-snapshot
Detection of Viable but Nonculturable Escherichia coli O157:H7 Bacteria in Drinking Water and River Water
inferredcites →https://doi.org/10.1128/aem.02489-07openalex-snapshot
Enumeration of Salmonella Bacteria in Food and Feed Samples by Real-Time PCR for Quantitative Microbial Risk Assessment
inferredcites →https://doi.org/10.1128/aem.51.2.349-355.1986openalex-snapshot
Bioluminescence for USP sterility testing of pharmaceutical suspension products
inferredcites →https://doi.org/10.1201/9781315102856-3openalex-snapshot
Pharmaceutical Quality System
inferredcites →https://doi.org/10.1201/9781315371726-7openalex-snapshot
Quality by Design in Biopharmaceuticals
inferredcites →https://doi.org/10.1208/pt070114openalex-snapshot
Evaluation of manometric temperature measurement, a process analytical technology tool for freeze-drying: Part I, product temperature measurement
inferredcites →https://doi.org/10.1208/pt070493openalex-snapshot
Evaluation of manometric temperature measurement, a process analytical technology tool for freeze-drying: Part II measurement of dry-layer resistance
inferredcites →https://doi.org/10.1208/pt070497openalex-snapshot
Evaluation of manometric temperature measurement (MTM), a process analytical technology tool in freeze drying, part III: Heat and mass transfer measurement
inferredcites →https://doi.org/10.1385/1-59259-798-x:077openalex-snapshot
Capillary Electrophoresis in the Analysis and Monitoring of Biotechnological Processes
inferredcites →https://doi.org/10.5860/choice.40-6157openalex-snapshot
Encyclopedia of pharmaceutical technology
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4630931openalex-extracted
Broad Protein Content Determination for Biomanufacturing Real-Time Process Monitoring and Control by Dual-Wavelength Absorbance Photometry
inferred← citeshttps://doi.org/10.1002/9780470054581.eib652openalex-snapshot
Process Analytical Technology: Strategies for Biopharmaceuticals
inferred← citeshttps://doi.org/10.1002/9780470054581.eib653openalex-snapshot
Scaledown of Biopharmaceutical Purification Operations
inferred← citeshttps://doi.org/10.1002/9781119378341.ch6openalex-snapshot
Monitoring and Control of Bioreactor: Basic Concepts and Recent Advances
inferred← citeshttps://doi.org/10.1002/9783527654703.ch38openalex-snapshot
Process Control Using Spectroscopic Tools in Pharmaceutical Industry and Biotechnology
inferred← citeshttps://doi.org/10.1002/9783527683321.ch01openalex-snapshot
Bacterial Suspension Cultures
inferred← citeshttps://doi.org/10.1002/9783527699902.ch10openalex-snapshot
Continuous Downstream Processing for Production of Biotech Therapeutics
inferred← citeshttps://doi.org/10.1002/9783527800599.ch6openalex-snapshot
Bioreactor Development and Process Analytical Technology
inferred← citeshttps://doi.org/10.1002/9783527800599.ch8openalex-snapshot
Control of Microbial Processes
inferred← citeshttps://doi.org/10.1002/9783527807390.ch3openalex-snapshot
Applications of Freeze‐drying in Pharmaceuticals, Biopharmaceuticals, and Foods
inferred← citeshttps://doi.org/10.1002/9783527811410.ch15openalex-snapshot
Process Analytical Technology and Quality by Design for Animal Cell Culture
inferred← citeshttps://doi.org/10.1002/9783527827343.ch9openalex-snapshot
Digital Twins for Continuous Biologics Manufacturing
inferred← citeshttps://doi.org/10.1002/biot.201500507openalex-snapshot
Bridging the gap between PAT concepts and implementation: An integrated software platform for fermentation
inferred← citeshttps://doi.org/10.1002/biot.201700286openalex-snapshot
Mechanistic Modeling Based PAT Implementation for Ion‐Exchange Process Chromatography of Charge Variants of Monoclonal Antibody Products
inferred← citeshttps://doi.org/10.1002/biot.201800556openalex-snapshot
Implementing Process Analytical Technology for the Production of Recombinant Proteins in Escherichia coli Using an Advanced Controller Scheme
inferred← citeshttps://doi.org/10.1002/bit.25274openalex-snapshot
Model‐based cell number quantification using online single‐oxygen sensor data for tissue engineering perfusion bioreactors
inferred← citeshttps://doi.org/10.1002/bit.26339openalex-snapshot
Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody–peptide fusion
inferred← citeshttps://doi.org/10.1002/bit.26900openalex-snapshot
Process analytical technology implementation for protein refolding: GCSF as a case study
inferred← citeshttps://doi.org/10.1002/bit.26984openalex-snapshot
Real‐time monitoring and model‐based prediction of purity and quantity during a chromatographic capture of fibroblast growth factor 2
inferred← citeshttps://doi.org/10.1002/bit.27115openalex-snapshot
Cytoplasmic conductivity as a marker for bioprocess monitoring: Study of Chinese hamster ovary cells under nutrient deprivation and reintroduction
inferred← citeshttps://doi.org/10.1002/bit.27296openalex-snapshot
Process‐wide control and automation of an integrated continuous manufacturing platform for antibodies
inferred← citeshttps://doi.org/10.1002/bit.27532openalex-snapshot
Real‐time monitoring of quality attributes by in‐line Fourier transform infrared spectroscopic sensors at ultrafiltration and diafiltration of bioprocess
inferred← citeshttps://doi.org/10.1002/bit.27681openalex-snapshot
An integrated continuous downstream process with real‐time control: A case study with periodic countercurrent chromatography and continuous virus inactivation
inferred← citeshttps://doi.org/10.1002/bit.27706openalex-snapshot
Control of surge tanks for continuous manufacturing of monoclonal antibodies
inferred← citeshttps://doi.org/10.1002/bit.27757openalex-snapshot
White paper on high‐throughput process development for integrated continuous biomanufacturing
inferred← citeshttps://doi.org/10.1002/bit.27790openalex-snapshot
Antibody disulfide bond reduction and recovery during biopharmaceutical process development—A review
inferred← citeshttps://doi.org/10.1002/bit.27990openalex-snapshot
Systematic assessment of process analytical technologies for biologics
inferred← citeshttps://doi.org/10.1002/bit.28235openalex-snapshot
Continuous integrated manufacturing for biopharmaceuticals: A new paradigm or an empty promise?
inferred← citeshttps://doi.org/10.1002/btpr.1610openalex-snapshot
Chemometrics applications in biotechnology processes: Predicting column integrity and impurity clearance during reuse of chromatography resin
inferred← citeshttps://doi.org/10.1002/btpr.1664openalex-snapshot
Process model comparison and transferability across bioreactor scales and modes of operation for a mammalian cell bioprocess
inferred← citeshttps://doi.org/10.1002/btpr.1845openalex-snapshot
A novel approach for using dielectric spectroscopy to predict viable cell volume (VCV) in early process development
inferred← citeshttps://doi.org/10.1002/btpr.1870openalex-snapshot
Single‐step affinity purification of enzyme biotherapeutics: A platform methodology for accelerated process development
inferred← citeshttps://doi.org/10.1002/btpr.2292openalex-snapshot
Detecting cell lysis using viscosity monitoring in E. coli fermentation to prevent product loss
inferred← citeshttps://doi.org/10.1002/btpr.2480openalex-snapshot
Characterization of mammalian cell culture raw materials by combining spectroscopy and chemometrics
inferred← citeshttps://doi.org/10.1002/btpr.3177openalex-snapshot
Process analytics 4.0: A paradigm shift in rapid analytics for biologics development
inferred← citeshttps://doi.org/10.1002/btpr.561openalex-snapshot
Chemometrics applications in biotech processes: A review
inferred← citeshttps://doi.org/10.1002/btpr.706openalex-snapshot
Hybrid modeling framework for process analytical technology: Application to Bordetella pertussis cultures
inferred← citeshttps://doi.org/10.1002/elps.201400055openalex-snapshot
Analytical QbD: Development of a native gel electrophoresis method for measurement of monoclonal antibody aggregates
inferred← citeshttps://doi.org/10.1002/elsc.201600155openalex-snapshot
Enabler for process analytical technology implementation in Pichia pastoris fermentation: Fluorescence‐based soft sensors for rapid quantitation of product titer
inferred← citeshttps://doi.org/10.1002/jctb.4447openalex-snapshot
Application of process analytical technology for downstream purification of biotherapeutics
inferred← citeshttps://doi.org/10.1002/jctb.4448openalex-snapshot
Comparison of PAT based approaches for making real‐time pooling decisions for process chromatography – use of feed forward control
inferred← citeshttps://doi.org/10.1002/jctb.4463openalex-snapshot
Online prediction of product titer and solubility of recombinant proteins in Escherichia coli fed‐batch cultivations
inferred← citeshttps://doi.org/10.1002/jctb.4591openalex-snapshot
Integrating systems analysis and control for implementing process analytical technology in bioprocess development
inferred← citeshttps://doi.org/10.1002/jctb.4743openalex-snapshot
Analysis of the crystallization process of a biopharmaceutical compound in the presence of impurities using process analytical technology ( PAT ) tools
inferred← citeshttps://doi.org/10.1002/jctb.6920openalex-snapshot
Process analytical technique ( PAT ) miniaturization for monoclonal antibody aggregate detection in continuous downstream processing
inferred← citeshttps://doi.org/10.1002/jctb.7497openalex-snapshot
Application of PAT in pharmaceutical manufacturing: model‐based control of particle size distribution in anti‐solvent aided crystallization
inferred← citeshttps://doi.org/10.1002/jev2.70330openalex-snapshot
Integrating Nuclear Magnetic Resonance into Bioprocess Control of Clinical‐Grade Extracellular Vesicle Manufacturing
inferred← citeshttps://doi.org/10.1002/jrs.3141openalex-snapshot
Using surface‐enhanced Raman scattering (SERS) and fluorescence spectroscopy for screening yeast extracts, a complex component of cell culture media
inferred← citeshttps://doi.org/10.1007/10_2010_98openalex-snapshot
Advancing Biopharmaceutical Process Development by System-Level Data Analysis and Integration of Omics Data
inferred← citeshttps://doi.org/10.1007/10_2012_169openalex-snapshot
An Advanced Monitoring Platform for Rational Design of Recombinant Processes
inferred← citeshttps://doi.org/10.1007/10_2017_12openalex-snapshot
Downstream Processing Technologies/Capturing and Final Purification
inferred← citeshttps://doi.org/10.1007/7355_2015_5004openalex-snapshot
Production of Protein Therapeutics in the Quality by Design (QbD) Paradigm
inferred← citeshttps://doi.org/10.1007/978-1-0716-0775-6_2openalex-snapshot
High-Throughput Process Development: I—Process Chromatography
inferred← citeshttps://doi.org/10.1007/978-1-4939-2316-8_1openalex-snapshot
Challenges and Opportunities for Biotech Quality by Design
inferred← citeshttps://doi.org/10.1007/978-1-4939-2383-0_8openalex-snapshot
Advances in Process Analytical Technology in Freeze-Drying
inferred← citeshttps://doi.org/10.1007/978-1-4939-2383-0_9openalex-snapshot
Process Scale-Up and Optimization of Lyophilized Vaccine Products
inferred← citeshttps://doi.org/10.1007/978-1-62703-977-2_3openalex-snapshot
High-Throughput Process Development: I. Process Chromatography
inferred← citeshttps://doi.org/10.1007/978-3-030-63389-9_13openalex-snapshot
Regulation of Nanotechnology-Based Products Subject to Health Regulations: Application of Quality by Design (QbD) and Quality Risk Management (QRM)
inferred← citeshttps://doi.org/10.1007/978-3-030-79871-0_17openalex-snapshot
Industrial Monitoring of Cell Culture
inferred← citeshttps://doi.org/10.1007/978-3-319-10320-4_11openalex-snapshot
Mammalian Cell Line Selection Strategies for High-Producers
inferred← citeshttps://doi.org/10.1007/978-3-319-10320-4_21openalex-snapshot
Process Analytical Technology and Quality-by-Design for Animal Cell Culture
inferred← citeshttps://doi.org/10.1007/978-3-319-10320-4_7openalex-snapshot
Monitoring of Cell Culture
inferred← citeshttps://doi.org/10.1007/978-3-319-53880-8_2openalex-snapshot
How Plants Can Contribute to the Supply of Anticancer Compounds
inferred← citeshttps://doi.org/10.1007/978-94-007-1257-7_2openalex-snapshot
Bioreactor Systems for Producing Antibody from Mammalian Cells
inferred← citeshttps://doi.org/10.1007/978-94-007-2217-0_3openalex-snapshot
Molecular Farming Using Bioreactor-Based Plant Cell Suspension Cultures for Recombinant Protein Production
inferred← citeshttps://doi.org/10.1007/s00216-010-3781-xopenalex-snapshot
Process analytical technology (PAT) for biopharmaceutical products
inferred← citeshttps://doi.org/10.1007/s00216-016-9711-9openalex-snapshot
Propagation of measurement accuracy to biomass soft-sensor estimation and control quality
inferred← citeshttps://doi.org/10.1007/s00216-016-9907-zopenalex-snapshot
A novel toolbox for E. coli lysis monitoring
inferred← citeshttps://doi.org/10.1007/s00253-011-3513-yopenalex-snapshot
Refolding of proteins from inclusion bodies: rational design and recipes
inferred← citeshttps://doi.org/10.1007/s00253-015-7089-9openalex-snapshot
Multi-parameter flow cytometry as a process analytical technology (PAT) approach for the assessment of bacterial ghost production
inferred← citeshttps://doi.org/10.1007/s10295-017-1984-2openalex-snapshot
Use of near-infrared spectroscopy (NIRs) in the biopharmaceutical industry for real-time determination of critical process parameters and integration of advanced feedback control strategies using MIDUS control
inferred← citeshttps://doi.org/10.1007/s10529-017-2437-8openalex-snapshot
Examining the sources of variability in cell culture media used for biopharmaceutical production
inferred← citeshttps://doi.org/10.1007/s11274-018-2541-5openalex-snapshot
Wanted: more monitoring and control during inclusion body processing
inferred← citeshttps://doi.org/10.1007/s11705-015-1533-3openalex-snapshot
Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared spectroscopy: Implications for enabling cell culture process analytical technology
inferred← citeshttps://doi.org/10.1007/s13346-021-01024-2openalex-snapshot
Current hurdles to the translation of nanomedicines from bench to the clinic
inferred← citeshttps://doi.org/10.1016/b978-0-08-100623-8.00048-7openalex-snapshot
Implementation of QbD for Manufacturing of Biologics—Has It Met the Expectations?
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14638-4openalex-snapshot
Chemometrics in the Pharmaceutical Industry
inferred← citeshttps://doi.org/10.1016/b978-0-12-809633-8.09103-2openalex-snapshot
Lab on a Chip – Future Technology for Characterizing Biotechnology Products
inferred← citeshttps://doi.org/10.1016/b978-0-12-811065-2.00012-6openalex-snapshot
A Systematic Approach to Process Data Analytics in Pharmaceutical Manufacturing
inferred← citeshttps://doi.org/10.1016/b978-0-12-814357-5.00010-6openalex-snapshot
Control strategy development guide for vaccine drug product
inferred← citeshttps://doi.org/10.1016/b978-0-12-820043-8.00007-4openalex-snapshot
Process analytical technology (PAT) tools: Uses in pharmaceutical manufacturing
inferred← citeshttps://doi.org/10.1016/b978-0-323-89925-3.00023-xopenalex-snapshot
AI applications for multivariate control in drug manufacturing
inferred← citeshttps://doi.org/10.1016/b978-0-444-63663-8.00016-1openalex-snapshot
Advanced Process and Control Strategies for Bioreactors
inferred← citeshttps://doi.org/10.1016/j.ab.2017.04.008openalex-snapshot
Determination of thiol-to-protein ratio and drug-to-antibody ratio by in-line size exclusion chromatography with post-column reaction
inferred← citeshttps://doi.org/10.1016/j.aca.2013.11.028openalex-snapshot
A rapid fluorescence based method for the quantitative analysis of cell culture media photo-degradation
inferred← citeshttps://doi.org/10.1016/j.addr.2018.04.004openalex-snapshot
Transforming nanomedicine manufacturing toward Quality by Design and microfluidics
inferred← citeshttps://doi.org/10.1016/j.ajps.2016.07.006openalex-snapshot
Application of quality by design in the current drug development
inferred← citeshttps://doi.org/10.1016/j.biortech.2016.03.168openalex-snapshot
Knowledge management in a waste based biorefinery in the QbD paradigm
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2011.07.016openalex-snapshot
Bioreactor systems for in vitro production of foreign proteins using plant cell cultures
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2015.04.010openalex-snapshot
Extraction and downstream processing of plant-derived recombinant proteins
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2018.02.002openalex-snapshot
Plants as sources of natural and recombinant anti-cancer agents
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2020.107552openalex-snapshot
Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing
inferred← citeshttps://doi.org/10.1016/j.cej.2026.179924openalex-snapshot
A data-driven multimodal diagnostic framework for quality evaluation of artificial calculus bovis based on HEMT biosensors and systematic quality data engineering
inferred← citeshttps://doi.org/10.1016/j.ces.2015.10.009openalex-snapshot
Continuous refolding of a biotech therapeutic in a novel Coiled Flow Inverter Reactor
inferred← citeshttps://doi.org/10.1016/j.ces.2020.116171openalex-snapshot
Reinforcement learning based optimization of process chromatography for continuous processing of biopharmaceuticals
inferred← citeshttps://doi.org/10.1016/j.ces.2020.116272openalex-snapshot
Continuous downstream bioprocessing for intensified manufacture of biopharmaceuticals and antibodies
inferred← citeshttps://doi.org/10.1016/j.chemolab.2018.08.012openalex-snapshot
Calibration transfer of near infrared spectrometers for the assessment of plasma ethanol precipitation process
inferred← citeshttps://doi.org/10.1016/j.chroma.2015.11.062openalex-snapshot
Mechanistic modeling of ion-exchange process chromatography of charge variants of monoclonal antibody products
inferred← citeshttps://doi.org/10.1016/j.chroma.2016.02.011openalex-snapshot
Application of spectral deconvolution and inverse mechanistic modelling as a tool for root cause investigation in protein chromatography
inferred← citeshttps://doi.org/10.1016/j.chroma.2022.463496openalex-snapshot
Continuous manufacturing of monoclonal antibodies: Automated downstream control strategy for dynamic handling of titer variations
inferred← citeshttps://doi.org/10.1016/j.coche.2014.05.006openalex-snapshot
QbD/PAT for bioprocessing: moving from theory to implementation
inferred← citeshttps://doi.org/10.1016/j.coche.2018.08.008openalex-snapshot
Cell culture media analysis using rapid spectroscopic methods
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2015.05.006openalex-snapshot
Elastic net with Monte Carlo sampling for data-based modeling in biopharmaceutical manufacturing facilities
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2017.12.007openalex-snapshot
Challenges and opportunities in biopharmaceutical manufacturing control
inferred← citeshttps://doi.org/10.1016/j.ddtec.2021.04.001openalex-snapshot
Microbial technologies for biotherapeutics production: Key tools for advanced biopharmaceutical process development and control
inferred← citeshttps://doi.org/10.1016/j.ejps.2012.06.009openalex-snapshot
Strategic funding priorities in the pharmaceutical sciences allied to Quality by Design (QbD) and Process Analytical Technology (PAT)
inferred← citeshttps://doi.org/10.1016/j.ejps.2025.107175openalex-snapshot
Unveiling the transformative power of near-infrared spectroscopy in biomedical and pharmaceutical analysis: Trends, advancements, and applications
inferred← citeshttps://doi.org/10.1016/j.fbp.2016.05.009openalex-snapshot
Implementation of Quality by Design for processing of food products and biotherapeutics
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2012.11.001openalex-snapshot
Melt extrusion with poorly soluble drugs
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2015.03.058openalex-snapshot
Continuous twin screw melt granulation of glyceryl behenate: Development of controlled release tramadol hydrochloride tablets for improved safety
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.124163openalex-snapshot
Is it advantageous to use quality by design (QbD) to develop nanoparticle-based dosage forms for parenteral drug administration?
inferred← citeshttps://doi.org/10.1016/j.jbiosc.2016.12.011openalex-snapshot
Medium optimization based on yeast's elemental composition for glutathione production in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2013.03.008openalex-snapshot
Robust on-line sampling and analysis during long-term perfusion cultivation of mammalian cells
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2013.10.014openalex-snapshot
Monitoring CHO cell cultures: Cell stress and early apoptosis assessment by mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2015.06.393openalex-snapshot
End-to-end integrated fully continuous production of recombinant monoclonal antibodies
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2018.12.002openalex-snapshot
Comparison and implementation of different control strategies for improving production of rHSA using Pichia pastoris
inferred← citeshttps://doi.org/10.1016/j.jchromb.2017.01.021openalex-snapshot
Automated 2D-HPLC method for characterization of protein aggregation with in-line fraction collection device
inferred← citeshttps://doi.org/10.1016/j.jconrel.2021.06.042openalex-snapshot
Preservation of biomaterials and cells by freeze-drying: Change of paradigm
inferred← citeshttps://doi.org/10.1016/j.jpba.2012.08.002openalex-snapshot
Rapid quantification of tryptophan and tyrosine in chemically defined cell culture media using fluorescence spectroscopy
inferred← citeshttps://doi.org/10.1016/j.jpba.2016.05.001openalex-snapshot
Analytical characterization of in vitro refolding in the quality by design paradigm: Refolding of recombinant human granulocyte colony stimulating factor
inferred← citeshttps://doi.org/10.1016/j.jpba.2019.113060openalex-snapshot
Attenuated total reflection fourier transform infrared spectroscopy based methods for identification of chromatography media formulations used in downstream processes
inferred← citeshttps://doi.org/10.1016/j.jpba.2020.113169openalex-snapshot
Mass spectrometry-based methods in characterization of the higher order structure of protein therapeutics
inferred← citeshttps://doi.org/10.1016/j.jpba.2023.115581openalex-snapshot
Recent applications of quantitative mass spectrometry in biopharmaceutical process development and manufacturing
inferred← citeshttps://doi.org/10.1016/j.jpba.2024.115965openalex-snapshot
Analytical figures of merit of a dual-wavelength absorbance approach for real-time broad protein content monitoring for biomanufacturing
inferred← citeshttps://doi.org/10.1016/j.jpha.2023.12.006openalex-snapshot
Basic regulatory science behind drug substance and drug product specifications of monoclonal antibodies and other protein therapeutics
inferred← citeshttps://doi.org/10.1016/j.jprocont.2019.03.002openalex-snapshot
Industrial batch process monitoring with limited data
inferred← citeshttps://doi.org/10.1016/j.memsci.2015.10.063openalex-snapshot
Enablers for QbD implementation: Mechanistic modeling for ion-exchange membrane chromatography
inferred← citeshttps://doi.org/10.1016/j.molstruc.2019.126942openalex-snapshot
Assessment of the human albumin in acid precipitation process using NIRS and multi-variable selection methods combined with SPA
inferred← citeshttps://doi.org/10.1016/j.procbio.2016.06.018openalex-snapshot
Real-time monitoring of protein precipitation in a tubular reactor for continuous bioprocessing
inferred← citeshttps://doi.org/10.1016/j.saa.2013.02.018openalex-snapshot
Application of near-infrared spectroscopy combined with multivariate analysis in monitoring of crude heparin purification process
inferred← citeshttps://doi.org/10.1016/j.tibtech.2010.12.001openalex-snapshot
High-throughput process development for biopharmaceutical drug substances
inferred← citeshttps://doi.org/10.1016/j.tibtech.2016.01.003openalex-snapshot
Quality by Design (QbD)-Based Process Development for Purification of a Biotherapeutic
inferred← citeshttps://doi.org/10.1016/j.tibtech.2018.08.008openalex-snapshot
The Current Scientific and Regulatory Landscape in Advancing Integrated Continuous Biopharmaceutical Manufacturing
inferred← citeshttps://doi.org/10.1016/j.tibtech.2023.08.008openalex-snapshot
What should next-generation analytical platforms for biopharmaceutical production look like?
inferred← citeshttps://doi.org/10.1016/j.tifs.2015.02.010openalex-snapshot
The current status of process analytical technologies in the dairy industry
inferred← citeshttps://doi.org/10.1016/j.ymeth.2012.03.001openalex-snapshot
Automated flow cytometry for monitoring CHO cell cultures
inferred← citeshttps://doi.org/10.1017/9781108847209openalex-snapshot
Perfusion Cell Culture Processes for Biopharmaceuticals
inferred← citeshttps://doi.org/10.1017/9781108847209.001openalex-snapshot
Perfusion Mammalian Cell Culture for Recombinant Protein Manufacturing
inferred← citeshttps://doi.org/10.1017/9781108847209.002openalex-snapshot
Perfusion Bioreactors:The Set-Up and Process Characterisation
inferred← citeshttps://doi.org/10.1017/9781108847209.003openalex-snapshot
Scale-Down Models and Sensors for Process Development
inferred← citeshttps://doi.org/10.1017/9781108847209.004openalex-snapshot
Design and Optimisation of Mammalian Cell Perfusion Cultures
inferred← citeshttps://doi.org/10.1017/9781108847209.005openalex-snapshot
Clinical- and Commercial-Scale Reactors
inferred← citeshttps://doi.org/10.1017/9781108847209.006openalex-snapshot
Mechanistic and Statistical Modelling of Bioprocesses
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b00897openalex-snapshot
Use of HPLC as an Enabler of Process Analytical Technology in Process Chromatography
inferred← citeshttps://doi.org/10.1021/acs.analchem.9b05273openalex-snapshot
Process Analytical Technology Implementation for Peptide Manufacturing: Cleavage Reaction of Recombinant Lethal Toxin Neutralizing Factor Concatemer as a Case Study
inferred← citeshttps://doi.org/10.1021/acs.cgd.5b00337openalex-snapshot
Application of Process Analytical Technology-Based Feedback Control Strategies To Improve Purity and Size Distribution in Biopharmaceutical Crystallization
inferred← citeshttps://doi.org/10.1021/acs.oprd.4c00168openalex-snapshot
Development of a 3D Printed Flow Cell for Application as an In-line Optical Particle Analysis Tool
inferred← citeshttps://doi.org/10.1021/acs.oprd.7b00238openalex-snapshot
Process Analytical Technology (PAT) Aided Identification of Operational Spaces Leading to Tailored Crystal Size Distributions in Azithromycin Crystallization via Coordinated Cooling and Solution Mediated Phase Transition
inferred← citeshttps://doi.org/10.1021/bk-2014-1176.ch001openalex-snapshot
Monoclonal Antibody Therapeutics: The Need for Biopharmaceutical Reference Materials
inferred← citeshttps://doi.org/10.1055/a-2913-9621openalex-snapshot
Monitoring an Aromatic Amide Active Pharmaceutical Ingredient in a Reactive Crystallization by in situ Raman Spectroscopy: Comparing Data Analysis between Partial Least Squares Regression and Non-Negative Matrix Factorization
inferred← citeshttps://doi.org/10.1080/07373937.2011.597059openalex-snapshot
Scale-up and Process Transfer of Freeze-Drying Recipes
inferred← citeshttps://doi.org/10.1080/10826068.2011.613976openalex-snapshot
RECENT DEVELOPMENTS IN MEMBRANE-BASED SEPARATIONS IN BIOTECHNOLOGY PROCESSES: REVIEW
inferred← citeshttps://doi.org/10.1080/17425247.2022.2105317openalex-snapshot
Bridging the gap between fundamental research and product development of long acting injectable PLGA microspheres
inferred← citeshttps://doi.org/10.1088/1742-6596/2090/1/012035openalex-snapshot
On the asymptotic stability of advection-diffusion equations of mass transport in a bubble column bioreactor
inferred← citeshttps://doi.org/10.1109/icemi.2015.7494490openalex-snapshot
A brief review on biotechnological process sensoring
inferred← citeshttps://doi.org/10.1155/2018/4083921openalex-snapshot
Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization
inferred← citeshttps://doi.org/10.1155/tswj/6619616openalex-snapshot
Physicochemical Characterization and Bibliometric Analysis of Malaysian Paracetamol Tablets in Compliance With MS ISO/IEC 17025 Standards
inferred← citeshttps://doi.org/10.11606/d.9.2014.tde-21052015-152336openalex-snapshot
Doseamento microbiológico de nistatina: desenvolvimento e validação de método empregando leitura cinética em microplaca
inferred← citeshttps://doi.org/10.11606/d.9.2014.tde-26052015-135426openalex-snapshot
Estudo para validação de método rápido microbiológico aplicado a teste de esterilidade: técnica de bioluminescência de ATP
inferred← citeshttps://doi.org/10.1177/0003702817703270openalex-snapshot
Applications of Raman Spectroscopy in Biopharmaceutical Manufacturing: A Short Review
inferred← citeshttps://doi.org/10.1186/1753-6561-9-s9-p32openalex-snapshot
Monitorization of pH and OTR using a multiple shake flask platform: A tool for metabolism and cell growth assessment in mammalian cell cultures
inferred← citeshttps://doi.org/10.1186/s12934-014-0149-5openalex-snapshot
Phenotyping the quality of complex medium components by simple online-monitored shake flask experiments
inferred← citeshttps://doi.org/10.1201/b11536-2openalex-snapshot
Scientific and Regulatory Overview of Process Analytical Technology in Bioprocesses
inferred← citeshttps://doi.org/10.1201/b11536-4openalex-snapshot
Multivariate Techniques in Biopharmaceutical Process Development
inferred← citeshttps://doi.org/10.1208/s12248-024-00973-zopenalex-snapshot
Exploring the Correlation between LC–MS Multi-Attribute Method and Conventional Chromatographic Product Quality Assays through Multivariate Data Analysis
inferred← citeshttps://doi.org/10.1208/s12249-016-0523-1openalex-snapshot
A Rational Analysis of Uniformity Risk for Agglomerated Drug Substance Using NIR Chemical Imaging
inferred← citeshttps://doi.org/10.1255/jnirs.1222openalex-snapshot
Investigation of Heat-Treated Cultivation Medium for Mammalian Cells with near Infrared Spectroscopy
inferred← citeshttps://doi.org/10.1371/journal.pone.0045891openalex-snapshot
An Automatic Refolding Apparatus for Preparative-Scale Protein Production
inferred← citeshttps://doi.org/10.18174/415645openalex-snapshot
Surface plasmon resonance imaging as a screening platform in biopharmaceutical development
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3532087/v1openalex-snapshot
A hierarchical model combining process and Raman spectroscopic data for real-time monitoring of cell culture process
inferred← citeshttps://doi.org/10.2174/0115748855317233250121064331openalex-snapshot
A Review on Nanoparticle-mediated Drug Delivery for Targeted Cancer Therapy: Impact of Lyophilization on Formulation Stability
inferred← citeshttps://doi.org/10.2174/1567201811666140211110943openalex-snapshot
Quality by Design: Discussing and Assessing the Solid Dispersions Risk
inferred← citeshttps://doi.org/10.3182/20140824-6-za-1003.02589openalex-snapshot
Control of an Industrial Scale Bioreactor using a PAT Analyser
inferred← citeshttps://doi.org/10.33263/briac124.43174336openalex-snapshot
Explicating the Applications of Quality by Design Tools in Optimization of Microparticles and Nanotechnology Based Drug Delivery Systems
inferred← citeshttps://doi.org/10.3384/diss.diva-165116openalex-snapshot
Advancement of sensor technology for monitoring and control of upstream bioprocesses
inferred← citeshttps://doi.org/10.3389/fbioe.2024.1228846openalex-snapshot
Generative data augmentation and automated optimization of convolutional neural networks for process monitoring
inferred← citeshttps://doi.org/10.3389/fbioe.2024.1439638openalex-snapshot
Continuous Process Verification 4.0 application in upstream: adaptiveness implementation managed by AI in the hypoxic bioprocess of the Pichia pastoris cell factory
inferred← citeshttps://doi.org/10.3390/chemosensors11050298openalex-snapshot
Methods and Analysis of Biological Contaminants in the Biomanufacturing Industry
inferred← citeshttps://doi.org/10.3390/jimaging11020059openalex-snapshot
Applications of Artificial Intelligence, Deep Learning, and Machine Learning to Support the Analysis of Microscopic Images of Cells and Tissues
inferred← citeshttps://doi.org/10.3390/ph18081157openalex-snapshot
Continuous Manufacturing of Recombinant Drugs: Comprehensive Analysis of Cost Reduction Strategies, Regulatory Pathways, and Global Implementation
inferred← citeshttps://doi.org/10.3390/pharmaceutics15112623openalex-snapshot
Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems
inferred← citeshttps://doi.org/10.3390/pharmaceutics17050623openalex-snapshot
Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications
inferred← citeshttps://doi.org/10.3390/pr10102059openalex-snapshot
Emerging PAT for Freeze-Drying Processes for Advanced Process Control
inferred← citeshttps://doi.org/10.3390/pr9010172openalex-snapshot
Towards Autonomous Operation by Advanced Process Control—Process Analytical Technology for Continuous Biologics Antibody Manufacturing
inferred← citeshttps://doi.org/10.34626/bdg2-x596openalex-snapshot
Novel strategies for process control based on hybrid semi-parametric mathematical systems
inferred← citeshttps://doi.org/10.3990/1.9789036551052openalex-snapshot
Detection of microbes and microbial infection
inferred← citeshttps://doi.org/10.4028/www.scientific.net/amr.968.226openalex-snapshot
The Research of Coated Product Quality Control System Based on PAT
inferred← citeshttps://doi.org/10.4155/pbp.15.10openalex-snapshot
Application of mass spectrometry to facilitate advanced process controls of biopharmaceutical manufacture
inferred← citeshttps://doi.org/10.52711/0974-4150.2026.00071openalex-snapshot
Impurity Profiling in Active Pharmaceutical Ingredients and Finished Products: Trends, Tools, and Quality Risk Management Approaches
inferred← citeshttps://doi.org/10.5731/pdajpst.2012.00883openalex-snapshot
Application of Flow Cytometry for Rapid Bioburden Screening in Vaccine Virus Production
inferred← citeshttps://doi.org/10.59551/ijhmp.25832069.2023.4.1.1openalex-snapshot
A DESCRIPTIVE REVIEW ON PROCESS ANALYTICAL TECHNOLOGY
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.