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Pharmacokinetics and tissue distribution of coptisine in rats after oral administration by liquid chromatography–mass spectrometry

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s11130-006-0023-7openalex-snapshot

Hypoglycemic and Hypocholesterolemic Effects of Coptis chinensis Franch Inflorescence

inferredcites →https://doi.org/10.1007/s11130-011-0225-5openalex-snapshot

In vitro and In vivo Antioxidant Properties of Extracts from Coptis chinensis Inflorescence

inferredcites →https://doi.org/10.1007/s11745-014-3983-7openalex-snapshot

The Safety and Anti‐Hypercholesterolemic Effect of Coptisine in Syrian Golden Hamsters

inferredcites →https://doi.org/10.1016/j.apsb.2015.03.015openalex-snapshot

Pharmacokinetic study of salvianolic acid D after oral and intravenous administration in rats

inferredcites →https://doi.org/10.1016/j.atherosclerosis.2012.01.046openalex-snapshot

Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats

inferredcites →https://doi.org/10.1016/j.atherosclerosis.2013.10.003openalex-snapshot

Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation

inferredcites →https://doi.org/10.1016/j.fitote.2014.08.006openalex-snapshot

Coptis chinensis alkaloids exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBP-α and PPAR-γ

inferredcites →https://doi.org/10.1016/j.fitote.2015.06.005openalex-snapshot

Coptisine attenuates obesity-related inflammation through LPS/TLR-4-mediated signaling pathway in Syrian golden hamsters

inferredcites →https://doi.org/10.1016/j.jep.2011.04.007openalex-snapshot

Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome

inferredcites →https://doi.org/10.1016/j.jep.2013.07.008openalex-snapshot

Inhibitory effect of Coptis chinensis on inflammation in LPS-induced endotoxemia

inferredcites →https://doi.org/10.1016/j.jep.2014.06.004openalex-snapshot

Coptis chinensis Franch. exhibits neuroprotective properties against oxidative stress in human neuroblastoma cells

inferredcites →https://doi.org/10.1016/j.jpba.2006.03.029openalex-snapshot

Bioavailabilty and pharmacokinetics of four active alkaloids of traditional Chinese medicine Yanhuanglian in rats following intravenous and oral administration

inferredcites →https://doi.org/10.1016/j.jpba.2009.02.028openalex-snapshot

A rapid and simple determination of protoberberine alkaloids in Rhizoma Coptidis by 1H NMR and its application for quality control of commercial prescriptions

inferredcites →https://doi.org/10.1016/j.phymed.2005.02.001openalex-snapshot

Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in

inferredcites →https://doi.org/10.1023/a:1026451721686openalex-snapshot

Confidence Interval Criteria for Assessment of Dose Proportionality

inferredcites →https://doi.org/10.1142/s0192415x12500243openalex-snapshot

Analysis of the Mechanisms Underlying the Vasorelaxant Action of Coptisine in Rat Aortic Rings

inferredcites →https://doi.org/10.1155/2014/510157openalex-snapshot

Coptis chinensis and Myrobalan ( Terminalia chebula ) Can Synergistically Inhibit Inflammatory Response In Vitro and In Vivo

inferredcites →https://doi.org/10.1155/2015/827308openalex-snapshot

Neuroprotective Activity of Coptisine fromCoptis chinensis(Franch)

inferredcites →https://doi.org/10.1248/bpb.b15-00293openalex-snapshot

Pharmacokinetics and Brain Distribution and Metabolite Identification of Coptisine, a Protoberberine Alkaloid with Therapeutic Potential for CNS Disorders, in Rats

inferredcites →https://doi.org/10.3109/00498254.2014.979270openalex-snapshot

Metabolic profiling analysis of berberine, palmatine, jatrorrhizine, coptisine and epiberberine in zebrafish by ultra-high performance liquid chromatography coupled with LTQ Orbitrap mass spectrometer

inferredcites →https://doi.org/10.3109/13880209.2014.952838openalex-snapshot

Antidiabetic mechanism of Coptis chinensis polysaccharide through its antioxidant property involving the JNK pathway

inferredcites →https://doi.org/10.3233/jad-140414openalex-snapshot

The IDO Inhibitor Coptisine Ameliorates Cognitive Impairment in a Mouse Model of Alzheimer's Disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4743962openalex-extracted

Coptisine Improves Anxiety-Like Behaviors by Regulating the Warburg Effect in Microglia Via Pkm2

inferred← citeshttps://doi.org/10.1002/advs.202308786openalex-snapshot

Inhibition of METTL3 Alleviates NLRP3 Inflammasome Activation via Increasing Ubiquitination of NEK7

inferred← citeshttps://doi.org/10.1002/cbdv.202000265openalex-snapshot

Syntheses and Structure–Activity Relationships in Antibacterial Activity against Clostridium difficile and XBP1 Activation Property of 13‐[(N‐Alkylamino)methyl]‐8‐oxodihydrocoptisines

inferred← citeshttps://doi.org/10.1002/cbdv.202300230openalex-snapshot

Chemoproteomics Reveals That Quaternary Protoberberine Alkaloids Inhibit Telomerase Activity Oncologically by Binding to PES1

inferred← citeshttps://doi.org/10.1002/ddr.70071openalex-snapshot

Anticancer and Anti‐Inflammatory Potential of Coptisine as a Planar Quaternary Benzo[C]Phenanthridine Alkaloid With G‐Quadruplex DNA Telomeric Induction Activity

inferred← citeshttps://doi.org/10.1002/ps.6233openalex-snapshot

Laboratory bioassay, greenhouse experiment and 3D‐QSAR studies on berberine analogues: a search for new herbicides based on natural products

inferred← citeshttps://doi.org/10.1002/ptr.70063openalex-snapshot

Coptisine Improves Liver Inflammation in Sepsis by Regulating STAT1 / IRF1 / GPX4 Signaling‐Mediated Kupffer Cells Ferroptosis

inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2024.117480openalex-snapshot

Coptisine inhibits neointimal hyperplasia through attenuating Pak1/Pak2 signaling in vascular smooth muscle cells without retardation of re-endothelialization

inferred← citeshttps://doi.org/10.1016/j.biopha.2025.117837openalex-snapshot

Coptisine improves LPS-induced anxiety-like behaviors by regulating the Warburg effect in microglia via PKM2

inferred← citeshttps://doi.org/10.1016/j.cbi.2018.11.005openalex-snapshot

8-Cetylcoptisine, a new coptisine derivative, induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest in human A549 cells

inferred← citeshttps://doi.org/10.1016/j.ejphar.2019.172523openalex-snapshot

Glucose consumption assay discovers coptisine with beneficial effect on diabetic mice

inferred← citeshttps://doi.org/10.1016/j.intimp.2022.108965openalex-snapshot

Berberine regulates PADI4-related macrophage function to prevent lung cancer

inferred← citeshttps://doi.org/10.1016/j.jare.2025.09.004openalex-snapshot

Discovery of natural RORγt inhibitor using machine learning, virtual screening, and in vivo validation

inferred← citeshttps://doi.org/10.1016/j.jep.2021.114617openalex-snapshot

Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis

inferred← citeshttps://doi.org/10.1016/j.jep.2025.119627openalex-snapshot

Exploring the tissue distribution propensity of active alkaloids in normal and stomach heat syndrome rats following oral administration of Zuojin Pill based on pharmacokinetics and mass spectrometry imaging

inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155444openalex-snapshot

Protoberberine alkaloids: A review of the gastroprotective effects, pharmacokinetics, and toxicity

inferred← citeshttps://doi.org/10.1038/s41598-018-38164-4openalex-snapshot

Pharmacokinetic-Pharmacodynamic Modeling for Coptisine Challenge of Inflammation in LPS-Stimulated Rats

inferred← citeshttps://doi.org/10.1111/jcmm.14725openalex-snapshot

Coptisine fromCoptis chinensisexerts diverse beneficial properties: A concise review

inferred← citeshttps://doi.org/10.1142/s0192415x2350091xopenalex-snapshot

Coptisine, the Characteristic Constituent from Coptis chinensis , Exhibits Significant Therapeutic Potential in Treating Cancers, Metabolic and Inflammatory Diseases

inferred← citeshttps://doi.org/10.1155/2024/8843855openalex-snapshot

Botanical Sources, Pharmacokinetics, and Therapeutic Efficacy of Palmatine and Its Derivatives in the Management of Cancer: A Comprehensive Mechanistic Analysis

inferred← citeshttps://doi.org/10.1177/13872877261470114openalex-snapshot

Neurolymphatic formula restores meningeal and peripheral lymphatic function via VEGFR3 activation: Mechanistic validation of coptisine as a key anti-Alzheimer's compound

inferred← citeshttps://doi.org/10.1186/s12936-020-03273-xopenalex-snapshot

Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds

inferred← citeshttps://doi.org/10.3389/fnut.2025.1669557openalex-snapshot

Natural compounds regulating fatty acid oxidation in the treatment of diabetic kidney disease

inferred← citeshttps://doi.org/10.6084/m9.figshare.12450440openalex-snapshot

Additional file 1 of Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds

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