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Coptisine Improves Anxiety-Like Behaviors by Regulating the Warburg Effect in Microglia Via Pkm2
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Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: In vitro and in vivo studies
inferredcites →https://doi.org/10.1002/bmc.3918openalex-extracted
Pharmacokinetics and tissue distribution of coptisine in rats after oral administration by liquid chromatography–mass spectrometry
inferredcites →https://doi.org/10.1002/glia.22966openalex-extracted
Dark microglia: A new phenotype predominantly associated with pathological states
inferredcites →https://doi.org/10.1002/glia.23271openalex-extracted
Bioenergetic regulation of microglia
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Berberine: A potential adjunct for the treatment of gastrointestinal cancers?
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Inhibition of glycolysis alleviates lipopolysaccharide‐induced acute lung injury in a mouse model
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The Bioactive Dietary Polyphenol Preparation Alleviates Depression and Anxiety‐Like Behaviors by Modulating the Regional Heterogeneity of Microglia Morphology
inferredcites →https://doi.org/10.1002/stem.1552openalex-extracted
HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1–3 and PKM2
inferredcites →https://doi.org/10.1007/s10753-016-0391-6openalex-extracted
Coptisine Prevented IL-β-Induced Expression of Inflammatory Mediators in Chondrocytes
inferredcites →https://doi.org/10.1007/s13238-015-0132-xopenalex-extracted
Structural insight into mechanisms for dynamic regulation of PKM2
inferredcites →https://doi.org/10.1016/j.bbi.2017.01.021openalex-extracted
Peripheral inflammatory cytokines and immune balance in Generalised Anxiety Disorder: Case-controlled study
inferredcites →https://doi.org/10.1016/j.bbi.2017.10.017openalex-extracted
Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice
inferredcites →https://doi.org/10.1016/j.bbi.2020.01.012openalex-extracted
Exercise-induced re-programming of age-related metabolic changes in microglia is accompanied by a reduction in senescent cells
inferredcites →https://doi.org/10.1016/j.bbi.2020.11.007openalex-extracted
Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala
inferredcites →https://doi.org/10.1016/j.bbi.2021.10.009openalex-extracted
Microglial glutaminase 1 deficiency mitigates neuroinflammation associated depression
inferredcites →https://doi.org/10.1016/j.canlet.2015.01.039openalex-extracted
Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia
inferredcites →https://doi.org/10.1016/j.cell.2016.08.064openalex-extracted
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
inferredcites →https://doi.org/10.1016/j.cell.2017.05.018openalex-extracted
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
inferredcites →https://doi.org/10.1016/j.clinbiochem.2017.12.007openalex-extracted
Elevation of serum pyruvate kinase M2 (PKM2) in IBD and its relationship to IBD indices
inferredcites →https://doi.org/10.1016/j.cmet.2014.12.005openalex-extracted
Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages
inferredcites →https://doi.org/10.1016/j.ejphar.2016.03.037openalex-extracted
Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells
inferredcites →https://doi.org/10.1016/j.ejphar.2019.172523openalex-extracted
Glucose consumption assay discovers coptisine with beneficial effect on diabetic mice
inferredcites →https://doi.org/10.1016/j.immuni.2015.02.005openalex-extracted
Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization
inferredcites →https://doi.org/10.1016/j.jep.2023.116618openalex-extracted
Coptisine inhibits Helicobacter pylori and reduces the expression of CagA to alleviate host inflammation in vitro and in vivo
inferredcites →https://doi.org/10.1016/j.jpsychores.2016.06.001openalex-extracted
Depression and anxiety in patients with Inflammatory Bowel Disease: A systematic review
inferredcites →https://doi.org/10.1016/j.molimm.2021.10.017openalex-extracted
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia
inferredcites →https://doi.org/10.1016/j.phrs.2019.104348openalex-extracted
Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1
inferredcites →https://doi.org/10.1016/j.phrs.2022.106204openalex-extracted
Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis
inferredcites →https://doi.org/10.1016/j.redox.2020.101634openalex-extracted
Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH
inferredcites →https://doi.org/10.1038/cdd.2013.159openalex-extracted
Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease
inferredcites →https://doi.org/10.1038/mtm.2016.26openalex-extracted
Microglia-specific targeting by novel capsid-modified AAV6 vectors
inferredcites →https://doi.org/10.1038/nature11986openalex-extracted
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
inferredcites →https://doi.org/10.1038/ncb2629openalex-extracted
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
inferredcites →https://doi.org/10.1038/nchembio.1060openalex-extracted
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
inferredcites →https://doi.org/10.1038/ni.3796openalex-extracted
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
inferredcites →https://doi.org/10.1038/nrn2297openalex-extracted
From inflammation to sickness and depression: when the immune system subjugates the brain
inferredcites →https://doi.org/10.1038/s41582-019-0174-4openalex-extracted
Immunoneuropsychiatry — novel perspectives on brain disorders
inferredcites →https://doi.org/10.1038/s41598-018-38164-4openalex-extracted
Pharmacokinetic-Pharmacodynamic Modeling for Coptisine Challenge of Inflammation in LPS-Stimulated Rats
inferredcites →https://doi.org/10.1038/s41598-022-05408-3openalex-extracted
Bile acids attenuate PKM2 pathway activation in proinflammatory microglia
inferredcites →https://doi.org/10.1042/bj2390121openalex-extracted
Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages
inferredcites →https://doi.org/10.1074/jbc.m115.676817openalex-extracted
Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression
inferredcites →https://doi.org/10.1093/abbs/gms106openalex-extracted
Dual roles of PKM2 in cancer metabolism
inferredcites →https://doi.org/10.1111/bph.13139openalex-extracted
Microglial M1/M2 polarization and metabolic states
inferredcites →https://doi.org/10.1111/cbdd.13197openalex-extracted
Coptisine, a natural alkaloid from Coptidis Rhizoma, inhibits plasmodium falciparum dihydroorotate dehydrogenase
inferredcites →https://doi.org/10.1111/febs.15327openalex-extracted
Glycolysis – a key player in the inflammatory response
inferredcites →https://doi.org/10.1111/jcmm.13930openalex-extracted
Pharmacological effects of berberine on mood disorders
inferredcites →https://doi.org/10.1111/jcmm.14568openalex-extracted
Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation
inferredcites →https://doi.org/10.1111/jnc.14267openalex-extracted
Hexokinase 2‐dependent hyperglycolysis driving microglial activation contributes to ischemic brain injury
inferredcites →https://doi.org/10.1126/science.1160809openalex-extracted
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
inferredcites →https://doi.org/10.1126/science.123.3191.309openalex-extracted
On the Origin of Cancer Cells
inferredcites →https://doi.org/10.1126/scisignal.2000431openalex-extracted
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
inferredcites →https://doi.org/10.1182/blood-2009-10-249540openalex-extracted
Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation
inferredcites →https://doi.org/10.1186/s12974-018-1054-3openalex-extracted
Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats
inferredcites →https://doi.org/10.1186/s12974-018-1281-7openalex-extracted
Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid
inferredcites →https://doi.org/10.1186/s13024-019-0305-9openalex-extracted
Glucose transporter 1 critically controls microglial activation through facilitating glycolysis
inferredcites →https://doi.org/10.1186/s13578-019-0317-8openalex-extracted
PKM2, function and expression and regulation
inferredcites →https://doi.org/10.15252/embr.201643300openalex-extracted
PKM2, cancer metabolism, and the road ahead
inferredcites →https://doi.org/10.2147/dddt.s342028openalex-extracted
Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis
inferredcites →https://doi.org/10.3109/13651501.2012.667114openalex-extracted
Guidelines for the pharmacological treatment of anxiety disorders, obsessive–compulsive disorder and posttraumatic stress disorder in primary care
inferredcites →https://doi.org/10.3233/jad-140414openalex-extracted
The IDO Inhibitor Coptisine Ameliorates Cognitive Impairment in a Mouse Model of Alzheimer's Disease
inferredcites →https://doi.org/10.3389/fphar.2018.00557openalex-extracted
Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders
inferredcites →https://doi.org/10.3389/fphar.2021.619288openalex-extracted
Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics
inferredcites →https://doi.org/10.3390/cells10061547openalex-extracted
Pentose Phosphate Pathway Reactions in Photosynthesizing Cells
inferredcites →https://doi.org/10.3390/molecules27041412openalex-extracted
Coptisine Alleviates Imiquimod-Induced Psoriasis-like Skin Lesions and Anxiety-like Behavior in Mice
inferredcites →https://doi.org/10.3390/toxins10110441openalex-extracted
Investigation into Cellular Glycolysis for the Mechanism Study of Energy Metabolism Disorder Triggered by Lipopolysaccharide
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