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Effective bioreactor pH control using only sparging gases
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1097-0290(1999)66:3<171::aid-bit5>3.0.co;2-topenalex-snapshot
Control of pH in large-scale, free suspension animal cell bioreactors: Alkali addition and pH excursions
inferredcites →https://doi.org/10.1002/bit.10198openalex-snapshot
The response of GS‐NS0 myeloma cells to single and multiple pH perturbations
inferredcites →https://doi.org/10.1002/bit.23072openalex-snapshot
High‐End pH‐controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed‐batch cultures
inferredcites →https://doi.org/10.1002/bit.24389openalex-snapshot
Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance
inferredcites →https://doi.org/10.1002/bit.25491openalex-snapshot
Evaluating the impact of high Pluronic® F68 concentrations on antibody producing CHO cell lines
inferredcites →https://doi.org/10.1002/bit.26018openalex-snapshot
Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production
inferredcites →https://doi.org/10.1002/bit.260371015openalex-snapshot
Effect of medium osmolarity on hybridoma growth, metabolism, and antibody production
inferredcites →https://doi.org/10.1002/bit.260460605openalex-snapshot
Intracellular responses of productive hybridomas subjected to high osmotic pressure
inferredcites →https://doi.org/10.1002/btpr.2415openalex-snapshot
Bioreactor productivity and media cost comparison for different intensified cell culture processes
inferredcites →https://doi.org/10.1002/btpr.2489openalex-snapshot
A practical approach in bioreactor scale‐up and process transfer using a combination of constant P/V and vvm as the criterion
inferredcites →https://doi.org/10.1002/btpr.2620openalex-snapshot
Probing lactate metabolism variations in large‐scale bioreactors
inferredcites →https://doi.org/10.1007/bf00353919openalex-snapshot
Engineering challenges in high density cell culture systems
inferredcites →https://doi.org/10.1007/s00449-016-1644-3openalex-snapshot
Improving lactate metabolism in an intensified CHO culture process: productivity and product quality considerations
inferredcites →https://doi.org/10.1007/s00449-016-1669-7openalex-snapshot
Immobilization of proline-specific endoprotease on nonporous silica nanoparticles functionalized with amino group
inferredcites →https://doi.org/10.1007/s00449-017-1790-2openalex-snapshot
Impact of Pluronic® F68 on hollow fiber filter-based perfusion culture performance
inferredcites →https://doi.org/10.1007/s10616-006-9005-8openalex-snapshot
Reactor Engineering in Large Scale Animal Cell Culture
inferredcites →https://doi.org/10.1007/s10616-015-9899-0openalex-snapshot
Equipment characterization to mitigate risks during transfers of cell culture manufacturing processes
inferredcites →https://doi.org/10.1016/j.jbiotec.2012.08.021openalex-snapshot
Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator
inferredcites →https://doi.org/10.1016/j.jbiotec.2014.12.003openalex-snapshot
Determination of the maximum operating range of hydrodynamic stress in mammalian cell culture
inferredcites →https://doi.org/10.1016/j.jbiotec.2016.06.019openalex-snapshot
High-density mammalian cell cultures in stirred-tank bioreactor without external pH control
inferredcites →https://doi.org/10.1021/bp000089copenalex-snapshot
Measurement and Control of Dissolved Carbon Dioxide in Mammalian Cell Culture Processes Using an in Situ Fiber Optic Chemical Sensor
inferredcites →https://doi.org/10.1021/bp049815sopenalex-snapshot
Effects of Elevated pCO2 and Osmolality on Growth of CHO Cells and Production of Antibody-Fusion Protein B1: A Case Study
inferredcites →https://doi.org/10.1023/a:1008171921282openalex-snapshot
The effect of osmolarity on metabolism and morphology in adhesion and suspension chinese hamster ovary cells producing tissue plasminogen activator
inferredcites →https://doi.org/10.3390/bioengineering3010005openalex-snapshot
Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustness
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/amp2.10106openalex-snapshot
Process analytical technologies in cell therapy manufacturing: State‐of‐the‐art and future directions
inferred← citeshttps://doi.org/10.1002/biot.201900172openalex-snapshot
Bioprocessing in the Digital Age: The Role of Process Models
inferred← citeshttps://doi.org/10.1002/bit.27998openalex-snapshot
Using MVDA with stoichiometric balances to optimize amino acid concentrations in chemically defined CHO cell culture medium for improved culture performance
inferred← citeshttps://doi.org/10.1002/btpr.2975openalex-snapshot
Feeding tricarboxylic acid cycle intermediates improves lactate consumption and antibody production in Chinese hamster ovary cell cultures
inferred← citeshttps://doi.org/10.1002/btpr.3038openalex-snapshot
Osmolality as a lever to modulate the N ‐glycolylneuraminicacid (Neu5Gc) level of a recombinant glycoprotein produced in Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1002/btpr.3458openalex-snapshot
Development of a high‐throughput scale‐down model in Ambr® 250 HT for plasmid DNA fermentation processes
inferred← citeshttps://doi.org/10.1002/btpr.3467openalex-snapshot
Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary cell pools expressing SARS‐CoV ‐2 spike protein as vaccine antigen in early process development
inferred← citeshttps://doi.org/10.1002/btpr.3507openalex-snapshot
CHO stable pool fed‐batch process development of SARS ‐ CoV ‐2 spike protein production: Impact of aeration conditions and feeding strategies
inferred← citeshttps://doi.org/10.1002/elsc.202000034openalex-snapshot
Investigation of cell line specific responses to pH inhomogeneity and consequences for process design
inferred← citeshttps://doi.org/10.1007/7651_2021_441openalex-snapshot
Benchtop Bioreactors in Mammalian Cell Culture: Overview and Guidelines
inferred← citeshttps://doi.org/10.1007/978-3-030-79871-0_12openalex-snapshot
Practical Considerations for the Scale-Up of Chinese Hamster Ovary (CHO) Cell Cultures
inferred← citeshttps://doi.org/10.1007/978-3-031-45669-5_4openalex-snapshot
Continuous Bioprocessing for Upstream Process: Perfusion Process
inferred← citeshttps://doi.org/10.1007/s00449-021-02661-0openalex-snapshot
Biodegradation of waste cooking oil and simultaneous production of rhamnolipid biosurfactant by Pseudomonas aeruginosa P7815 in batch and fed-batch bioreactor
inferred← citeshttps://doi.org/10.1007/s10529-023-03404-9openalex-snapshot
Low CO2 partial pressure steers CHO cells into a defective metabolic state
inferred← citeshttps://doi.org/10.1007/s11483-026-10170-4openalex-snapshot
Engineering Complexity in Cellular Agriculture: Bridging the Gap to Structured Meat and Marine Fillets
inferred← citeshttps://doi.org/10.1007/s43938-022-00008-zopenalex-snapshot
PID controls: the forgotten bioprocess parameters
inferred← citeshttps://doi.org/10.1016/j.bej.2019.107307openalex-snapshot
Systematic evaluation of high-throughput scale-down models for single-use bioreactors (SUB) using volumetric gas flow rate as the criterion
inferred← citeshttps://doi.org/10.1016/j.cej.2022.139099openalex-snapshot
Automated pH Adjustment Driven by Robotic Workflows and Active Machine Learning
inferred← citeshttps://doi.org/10.1016/j.ceja.2026.101476openalex-snapshot
Comparative evaluation of ST-PBR and airlift photobioreactors for astaxanthin production from Haematococcus pluvialis with potential nutraceutical applications
inferred← citeshttps://doi.org/10.1016/j.fufo.2026.101213openalex-snapshot
When materials fail at scale: Compatibility risks in cultured meat and seafood manufacturing
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e25512openalex-snapshot
Evaluation of single-use optical and electrochemical pH sensors in upstream bioprocessing
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2025.01.008openalex-snapshot
Investigating the metabolic load of monoclonal antibody production conveyed to an inducible CHO cell line using a transfer-rate online monitoring system
inferred← citeshttps://doi.org/10.1016/j.procbio.2025.05.023openalex-snapshot
On digital twins in bioprocessing: Opportunities and limitations
inferred← citeshttps://doi.org/10.1021/acs.iecr.3c01212openalex-snapshot
Deep Learning Based System Identification and Nonlinear Model Predictive Control of pH Neutralization Process
inferred← citeshttps://doi.org/10.1021/acs.iecr.6c00912openalex-snapshot
CO 2 -Driven pH Control in the Enzymatic Hydrolysis of Urea: A Coupled Modeling-Experiment Approach
inferred← citeshttps://doi.org/10.1021/acs.oprd.0c00439openalex-snapshot
Synthesis of Rovafovir Etalafenamide (Part II): Dynamic Control for Successful Scale-Up of an Oxygen-Releasing Elimination Reaction Mediated by Oxone
inferred← citeshttps://doi.org/10.1021/cbe.6c00077openalex-snapshot
Strategies for High-Titer and High-Quality Monoclonal Antibody Production: Cell Line Construction, Culture Medium Development, and Process Regulation in Bioreactors
inferred← citeshttps://doi.org/10.1038/s42003-026-10013-5openalex-snapshot
Stable bioreactor control reveals acidic pH–driven metabolic reprogramming and mitochondrial dysfunction in human lymphoblastoid cells
inferred← citeshttps://doi.org/10.1039/d6cp00154hopenalex-snapshot
A low-cost automated platform for fast and accurate pH control via physics-informed active learning
inferred← citeshttps://doi.org/10.1080/19420862.2026.2643039openalex-snapshot
Impact of process parameters on IgG glycosylation in CHO systems: a comprehensive quantitative analysis
inferred← citeshttps://doi.org/10.1093/lifemedi/lnac056openalex-snapshot
A gas-only bioreactor system maintains stable culture environments and reveals that moderate pH deviations trigger transcriptome-wide responses in human cells cultured in physioxia and physiological buffers
inferred← citeshttps://doi.org/10.1186/s13568-022-01436-4openalex-snapshot
Use of ambr®250 to assess mucic acid production in fed-batch cultures of a marine Trichoderma sp. D-221704
inferred← citeshttps://doi.org/10.18502/ajmb.v13i3.6365openalex-snapshot
Designing a Strategy for pH Control to Improve CHO Cell Productivity in Bioreactor
inferred← citeshttps://doi.org/10.3389/fbioe.2020.00640openalex-snapshot
Influence of Microenvironment on Mesenchymal Stem Cell Therapeutic Potency: From Planar Culture to Microcarriers
inferred← citeshttps://doi.org/10.3390/life11060557openalex-snapshot
Bioprocess Control: Current Progress and Future Perspectives
inferred← citeshttps://doi.org/10.3390/pr10020189openalex-snapshot
Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes
inferred← citeshttps://doi.org/10.3390/pr12091795openalex-snapshot
PID Controller Design for an E. coli Fed-Batch Fermentation Process System Using Chaotic Electromagnetic Field Optimization
inferred← citeshttps://doi.org/10.3390/pr14081230openalex-snapshot
Development and Validation of an Automated Stirred-Tank Photobioreactor for Astaxanthin Production from Haematococcus pluvialis
inferred← citeshttps://doi.org/10.36468/pharmaceutical-sciences.129314openalex-snapshot
Strategies Used in Manufacturing Processes to Drive and Control Mammalian Cells to Undergo a Lactate Metabolic Shift
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