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The response of GS‐NS0 myeloma cells to single and multiple pH perturbations
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1097-0290(1999)66:3<171::aid-bit5>3.0.co;2-topenalex-snapshot
Control of pH in large-scale, free suspension animal cell bioreactors: Alkali addition and pH excursions
inferredcites →https://doi.org/10.1002/1097-0290(20001120)70:4<381::aid-bit3>3.0.co;2-0openalex-snapshot
Studies related to the scale-up of high-cell-densityE. coli fed-batch fermentations using multiparameter flow cytometry: Effect of a changing microenvironment with respect to glucose and dissolved oxygen concentration
inferredcites →https://doi.org/10.1002/aic.690361121openalex-snapshot
Gas–liquid mass transfer in stirred tanks
inferredcites →https://doi.org/10.1002/bit.1165openalex-snapshot
The response of GS‐NS0 myeloma cells to pH shifts and pH perturbations
inferredcites →https://doi.org/10.1002/bit.260270521openalex-snapshot
Scale‐down and optimization studies of the gluconic acid fermentation by Gluconobacter oxydans
inferredcites →https://doi.org/10.1002/bit.260320803openalex-snapshot
A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH
inferredcites →https://doi.org/10.1002/bit.260350912openalex-snapshot
Effects of stirring and sparging on cultured hybridoma cells
inferredcites →https://doi.org/10.1002/bit.260371015openalex-snapshot
Effect of medium osmolarity on hybridoma growth, metabolism, and antibody production
inferredcites →https://doi.org/10.1002/bit.260381012openalex-snapshot
Experimental simulation of dissolved oxygen fluctuations in large fermentors: Effect on Streptomyces clavuligerus
inferredcites →https://doi.org/10.1002/bit.260420508openalex-snapshot
Substantial overproduction of antibodies by applying osmotic pressure and sodium butyrate
inferredcites →https://doi.org/10.1002/bit.260460112openalex-snapshot
Cell cycle and cell size dependence of susceptibility to hydrodynamic forces
inferredcites →https://doi.org/10.1002/bit.260460605openalex-snapshot
Intracellular responses of productive hybridomas subjected to high osmotic pressure
inferredcites →https://doi.org/10.1002/bit.260470605openalex-snapshot
The effect of oscillating dissolved oxygen concentrations on the metabolism of a Spodoptera frugiperda IPLB‐Sf21‐AE clonal isolate
inferredcites →https://doi.org/10.1002/cjce.5450690216openalex-snapshot
Experimental simulation of large‐scale bioreaetor environments using a Monte Carlo method
inferredcites →https://doi.org/10.1007/bf00131892openalex-snapshot
Scale-down aspects of the gluconic acid fermentation
inferredcites →https://doi.org/10.1007/bf00295127openalex-snapshot
Influence of oxygen starvation on the respiratory capacity of Penicillium chrysogenum
inferredcites →https://doi.org/10.1007/bf00353919openalex-snapshot
Engineering challenges in high density cell culture systems
inferredcites →https://doi.org/10.1007/bf00353927openalex-snapshot
Homogenisation and oxygen transfer rates in large agitated and sparged animal cell bioreactors: Some implications for growth and production
inferredcites →https://doi.org/10.1007/bf00389925openalex-snapshot
Kinetics of escherichia coli hydrogen production during short term repeated aerobic-anaerobic fluctuations
inferredcites →https://doi.org/10.1007/bf00518739openalex-snapshot
Reactor comparison and scale-up for the microaerobic production of 2,3-butanediol by Enterobacter aerogenes at constant oxygen transfer rate
inferredcites →https://doi.org/10.1007/bf00694297openalex-snapshot
Experimental simulation of glucose fluctuations
inferredcites →https://doi.org/10.1007/bf01028490openalex-snapshot
Simulated scale-up of a yeast fermentation using a loop bioreactor
inferredcites →https://doi.org/10.1007/bf01061530openalex-snapshot
A scale-down two-compartment reactor with controlled substrate oscillations: Metabolic response of Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1007/bf01767464openalex-snapshot
The effect of cycling dissolved oxygen tension on the synthesis of the antibiotic difficidin by bacillus subtilis
inferredcites →https://doi.org/10.1007/s004490050606openalex-snapshot
Scale down of recombinant protein production: a comparative study of scaling performance
inferredcites →https://doi.org/10.1016/0168-1656(95)00130-1openalex-snapshot
Response of guanosine tetraphosphate to glucose fluctuations in fed-batch cultivations of Escherichia coli
inferredcites →https://doi.org/10.1016/0269-7483(88)90107-3openalex-snapshot
Bioreactors and biotransformations
inferredcites →https://doi.org/10.1016/0922-338x(91)90145-7openalex-snapshot
Device for fermentations with oscillations of dissolved oxygen
inferredcites →https://doi.org/10.1021/bp00026a006openalex-snapshot
Effects of Abrupt and Gradual Osmotic Stress on Antibody Production and Content in Hybridoma Cells That Differ in Production Kinetics
inferredcites →https://doi.org/10.1023/a:1008008021481openalex-snapshot
Reactor design for large scale suspension animal cell culture
inferredcites →https://doi.org/10.1023/a:1008016806599openalex-snapshot
Enhanced monoclonal antibody production by gradual increase of osmotic pressure
inferredcites →https://doi.org/10.1038/nbt0292-169openalex-snapshot
High-Level Expression of a Recombinant Antibody from Myeloma Cells Using a Glutamine Synthetase Gene as an Amplifiable Selectable Marker
inferredcites →https://doi.org/10.1111/j.1749-6632.1994.tb44382.xopenalex-snapshot
Investigation of NS0 Cell Metabolic Behavior in Monoclonal Antibody Producing Clones
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/9780470054581.eib535openalex-snapshot
Scale‐Up, Stirred Tank Reactors
inferred← citeshttps://doi.org/10.1002/9780470054581.eib557openalex-snapshot
Suspension Culture, Animal Cells
inferred← citeshttps://doi.org/10.1002/9783527683321.ch12openalex-snapshot
Large Scale Suspension Culture of Mammalian Cells
inferred← citeshttps://doi.org/10.1002/9783527683369.ch11openalex-snapshot
Scale‐Up and Scale‐Down Methodologies for Bioreactors
inferred← citeshttps://doi.org/10.1002/9783527807833.ch2openalex-snapshot
Scale‐Down: Simulating Large‐Scale Cultures in the Laboratory
inferred← citeshttps://doi.org/10.1002/biot.201600633openalex-snapshot
The impact of pH inhomogeneities on CHO cell physiology and fed‐batch process performance – two‐compartment scale‐down modelling and intracellular pH excursion
inferred← citeshttps://doi.org/10.1002/bit.10805openalex-snapshot
Further studies related to the scale‐up of high cell density escherichia coli fed‐batch fermentations:
inferred← citeshttps://doi.org/10.1002/bit.20383openalex-snapshot
Culture of Escherichia coli under dissolved oxygen gradients simulated in a two‐compartment scale‐down system: Metabolic response and production of recombinant protein
inferred← citeshttps://doi.org/10.1002/bit.20429openalex-snapshot
Large‐scale gene expression analysis of cholesterol dependence in NS0 cells
inferred← citeshttps://doi.org/10.1002/bit.20704openalex-snapshot
Transcriptional and metabolic response of recombinant Escherichia coli to spatial dissolved oxygen tension gradients simulated in a scale‐down system
inferred← citeshttps://doi.org/10.1002/bit.22287openalex-snapshot
Scale‐up analysis for a CHO cell culture process in large‐scale bioreactors
inferred← citeshttps://doi.org/10.1002/bit.22531openalex-snapshot
Microwell engineering characterization for mammalian cell culture process development
inferred← citeshttps://doi.org/10.1002/bit.25817openalex-snapshot
Physiological effects of pH gradients on Escherichia coli during plasmid DNA production
inferred← citeshttps://doi.org/10.1002/btpr.2620openalex-snapshot
Probing lactate metabolism variations in large‐scale bioreactors
inferred← citeshttps://doi.org/10.1002/btpr.2743openalex-snapshot
Effective bioreactor pH control using only sparging gases
inferred← citeshttps://doi.org/10.1002/btpr.3264openalex-snapshot
Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performance as a tool to understanding heterogeneity effects at large‐scale
inferred← citeshttps://doi.org/10.1002/btpr.348openalex-snapshot
Technological progresses in monoclonal antibody production systems
inferred← citeshttps://doi.org/10.1002/elsc.200800074openalex-snapshot
CFD simulation coupled with population balance equations for aerated stirred bioreactors
inferred← citeshttps://doi.org/10.1002/elsc.201200026openalex-snapshot
Dynamic process conditions in bioprocess development
inferred← citeshttps://doi.org/10.1002/elsc.201900162openalex-snapshot
Scale‐down simulators for mammalian cell culture as tools to access the impact of inhomogeneities occurring in large‐scale bioreactors
inferred← citeshttps://doi.org/10.1002/elsc.202000009openalex-snapshot
Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities in large‐scale CHO‐based processes
inferred← citeshttps://doi.org/10.1002/jctb.4302openalex-snapshot
Development of a mathematical model for animal cell culture without pH control and its application for evaluation of clone screening outcomes in shake flask culture
inferred← citeshttps://doi.org/10.1007/10_2013_187openalex-snapshot
Dynamic Single-Use Bioreactors Used in Modern Liter- and m3- Scale Biotechnological Processes: Engineering Characteristics and Scaling Up
inferred← citeshttps://doi.org/10.1007/978-3-319-10320-4_5openalex-snapshot
Mass Transfer and Mixing Across the Scales in Animal Cell Culture
inferred← citeshttps://doi.org/10.1007/978-94-007-0884-6_49openalex-snapshot
Study of the Effect of High pH and Alkali Addition in a Cultivation of Chinese Hamster Ovary Cell
inferred← citeshttps://doi.org/10.1007/s00253-015-7193-xopenalex-snapshot
Pilot-scale verification of maximum tolerable hydrodynamic stress for mammalian cell culture
inferred← citeshttps://doi.org/10.1007/s00253-023-12434-2openalex-snapshot
Is heterogeneity in large-scale bioreactors a real problem in recombinant protein synthesis by Pichia pastoris?
inferred← citeshttps://doi.org/10.1007/s00449-016-1644-3openalex-snapshot
Improving lactate metabolism in an intensified CHO culture process: productivity and product quality considerations
inferred← citeshttps://doi.org/10.1007/s00449-018-1996-yopenalex-snapshot
pH excursions impact CHO cell culture performance and antibody N-linked glycosylation
inferred← citeshttps://doi.org/10.1007/s10616-006-9005-8openalex-snapshot
Reactor Engineering in Large Scale Animal Cell Culture
inferred← citeshttps://doi.org/10.1007/s11814-022-1062-yopenalex-snapshot
Energy metabolism in Chinese hamster ovary (CHO) cells: Productivity and beyond
inferred← citeshttps://doi.org/10.1016/b978-0-12-398358-9.00078-1openalex-snapshot
Principles of Tissue Engineering for Food
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14356-2openalex-snapshot
Modeling for Process Risk Assessment in Industrial Bioprocesses
inferred← citeshttps://doi.org/10.1016/b978-0-12-818422-6.00074-5openalex-snapshot
Principles of tissue engineering for food
inferred← citeshttps://doi.org/10.1016/j.bej.2019.107307openalex-snapshot
Systematic evaluation of high-throughput scale-down models for single-use bioreactors (SUB) using volumetric gas flow rate as the criterion
inferred← citeshttps://doi.org/10.1016/j.bej.2020.107870openalex-snapshot
Scale-down cultivation in mammalian cell bioreactors—The effect of bioreactor mixing time on the response of CHO cells to dissolved oxygen gradients
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2019.02.012openalex-snapshot
Apoptosis: A mammalian cell bioprocessing perspective
inferred← citeshttps://doi.org/10.1016/j.ces.2013.02.069openalex-snapshot
Soft sensor assisted dynamic bioprocess control: Efficient tools for bioprocess development
inferred← citeshttps://doi.org/10.1016/j.ces.2015.05.045openalex-snapshot
Euler–Lagrange approach to model heterogeneities in stirred tank bioreactors – Comparison to experimental flow characterization and particle tracking
inferred← citeshttps://doi.org/10.1016/j.ces.2018.01.034openalex-snapshot
Comparison of hydrodynamics in standard stainless steel and single-use bioreactors by means of an Euler-Lagrange approach
inferred← citeshttps://doi.org/10.1016/j.ces.2023.118545openalex-snapshot
Power, mixing and flow dynamics of the novel Allegro™ stirred tank reactor
inferred← citeshttps://doi.org/10.1016/j.cherd.2013.04.002openalex-snapshot
Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture
inferred← citeshttps://doi.org/10.1016/j.copbio.2004.08.002openalex-snapshot
Production technologies for monoclonal antibodies and their fragments
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e25512openalex-snapshot
Evaluation of single-use optical and electrochemical pH sensors in upstream bioprocessing
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Re “Development of a scale-down model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions” [Sieck, J.B., Cordes, T., Budach, W.E., Rhiel, M.H., Suemeghy, Z., Leist, C., Villiger, T.K., Morbidelli, M., Soos, M., 2013.…
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Adaptation for survival: Phenotype and transcriptome response of CHO cells to elevated stress induced by agitation and sparging
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2016.06.019openalex-snapshot
High-density mammalian cell cultures in stirred-tank bioreactor without external pH control
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Soft-sensor assisted dynamic investigation of mixed feed bioprocesses
inferred← citeshttps://doi.org/10.1016/j.ymben.2013.06.002openalex-snapshot
Modeling the coupled extracellular and intracellular environments in mammalian cell culture
inferred← citeshttps://doi.org/10.1042/ba20070001openalex-snapshot
A semi‐empirical mathematical model useful for describing the relationship between carbon dioxide, pH, lactate and base in a bicarbonate‐buffered cell‐culture process
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Optimisation and Scale‐Up of the Heterologous Production of the Antifungal Protein PeAfpA From Penicillium expansum in Stirred‐Tank Bioreactors
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Scale-Up Considerations Based on Studies at the Bench Scale in Stirred Bioreactors
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Living With Heterogeneities in Bioreactors: Understanding the Effects of Environmental Gradients on Cells
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Engineering Considerations for Process Development in Mammalian Cell Cultivation
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Dynamic Modeling of Apoptosis and its Interaction with Cell Growth in Mammalian Cell Culture
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Criteria for scale-up and scale-down of bioreactors for cultivation of mammalian cells
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