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Crystallization and liquid‐liquid phase separation of monoclonal antibodies and fc‐fusion proteins: Screening results

https://doi.org/10.1002/btpr.621
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Enzymes in Industry
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Challenges in the development of high protein concentration formulations
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Self-Buffering Antibody Formulations
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Crystallization of intact monoclonal antibodies
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Challenges in the Development of High Protein Concentration Formulations
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Polymer Science Dictionary
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Crystallization of proteins
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Effects of pH on protein–protein interactions and implications for protein phase behavior
inferredcites →https://doi.org/10.1016/j.bbrc.2007.02.040openalex-snapshot
Prediction of protein crystallization using collocation of amino acid pairs
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Self-assembly and aggregation of proteins
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Alternative bioseparation operations: life beyond packed-bed chromatography
inferredcites →https://doi.org/10.1016/j.jchromb.2006.10.033openalex-snapshot
Future of antibody purification
inferredcites →https://doi.org/10.1016/j.jconrel.2004.01.019openalex-snapshot
Injectable controlled release formulations incorporating protein crystals
inferredcites →https://doi.org/10.1016/j.jcrysgro.2007.01.028openalex-snapshot
Crystallization conditions of membrane protein CLC-ec1: An example outside the crystallization slot
inferredcites →https://doi.org/10.1016/j.pep.2004.09.011openalex-snapshot
Implementation of a crystallization step into the purification process of a recombinant protein
inferredcites →https://doi.org/10.1016/j.ymeth.2004.03.031openalex-snapshot
Predictive models for protein crystallization
inferredcites →https://doi.org/10.1016/s0021-9258(18)76355-2openalex-snapshot
STUDIES IN THE PHYSICAL CHEMISTRY OF THE PROTEINS
inferredcites →https://doi.org/10.1016/s0022-0248(01)01054-5openalex-snapshot
Interactions in solution and crystallization of Aspergillus flavus urate oxidase
inferredcites →https://doi.org/10.1016/s0022-0248(01)01058-2openalex-snapshot
The liquid protein phase in crystallization: a case study—intact immunoglobulins
inferredcites →https://doi.org/10.1016/s0022-0248(98)00855-0openalex-snapshot
Why is the osmotic second virial coefficient related to protein crystallization?
inferredcites →https://doi.org/10.1016/s0378-4371(97)00184-2openalex-snapshot
Transient gelation by spinodal decomposition in colloid-polymer mixtures
inferredcites →https://doi.org/10.1016/s1047-8477(03)00046-7openalex-snapshot
High-throughput protein crystallization
inferredcites →https://doi.org/10.1021/bp0603661openalex-snapshot
Alternatives to Chromatographic Separations
inferredcites →https://doi.org/10.1021/ja0576637openalex-snapshot
A Microfluidic Device for Kinetic Optimization of Protein Crystallization and In Situ Structure Determination
inferredcites →https://doi.org/10.1038/nature03109openalex-snapshot
Equilibrium cluster formation in concentrated protein solutions and colloids
inferredcites →https://doi.org/10.1039/b204453fopenalex-snapshot
Ergodic and non-ergodic phase transitions in globular protein suspensions
inferredcites →https://doi.org/10.1063/1.471843openalex-snapshot
A model of attractive interactions to account for fluid–fluid phase separation of protein solutions
inferredcites →https://doi.org/10.1073/pnas.1131899100openalex-snapshot
Crystalline monoclonal antibodies for subcutaneous delivery
inferredcites →https://doi.org/10.1074/jbc.m110.204362openalex-snapshot
In Vivo Crystallization of Human IgG in the Endoplasmic Reticulum of Engineered Chinese Hamster Ovary (CHO) Cells
inferredcites →https://doi.org/10.1093/bioinformatics/bth066openalex-snapshot
Protein isoelectric point as a predictor for increased crystallization screening efficiency
inferredcites →https://doi.org/10.1093/bioinformatics/btn055openalex-snapshot
ParCrys: a Parzen window density estimation approach to protein crystallization propensity prediction
inferredcites →https://doi.org/10.1093/oso/9780199632459.001.0001openalex-snapshot
Crystallization of Nucleic Acids and Proteins
inferredcites →https://doi.org/10.1098/rstb.1981.0068openalex-snapshot
Glucose - 6 - phosphate isomerase
inferredcites →https://doi.org/10.1103/physrevb.18.2185openalex-snapshot
Real-space renormalization of bond-disordered conductance lattices
inferredcites →https://doi.org/10.1107/s0907444908028060openalex-snapshot
The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS)
inferredcites →https://doi.org/10.1107/s0907444994001216openalex-snapshot
Predicting protein crystallization from a dilute solution property
inferredcites →https://doi.org/10.1110/ps.04688204openalex-snapshot
Average protein density is a molecular‐weight‐dependent function
inferredcites →https://doi.org/10.1186/1472-6807-9-50openalex-snapshot
CRYSTALP2: sequence-based protein crystallization propensity prediction
inferredcites →https://doi.org/10.1529/biophysj.106.098293openalex-snapshot
Phase Behavior of an Intact Monoclonal Antibody
inferredcites →https://doi.org/10.4161/mabs.1.5.9448openalex-snapshot
Industrialization of mAb production technology: The bioprocessing industry at a crossroads
inferredcites →https://doi.org/10.5860/choice.26-0323openalex-snapshot
Bioseparations: downstream processing for biotechnology

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Surface-Catalysed Liquid-Liquid Phase Separation and Amyloid-Like Assembly in Microscale Compartments
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Fast and scalable purification of a therapeutic full‐length antibody based on process crystallization
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Buffer capacity of biologics—from buffer salts to buffering by antibodies
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A comparative study of monoclonal antibodies. 1. phase behavior and protein–protein interactions
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The role of more than 40 years of improvement in protein A chromatography in the growth of the therapeutic antibody industry
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Investigating High-Concentration Monoclonal Antibody Powder Suspension in Nonaqueous Suspension Vehicles for Subcutaneous Injection
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Biomolecular Crystallisation Through Soft Templates and Seeding
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Case Studies and Examples of Biopharmaceutical Modalities Processed by Bulk Crystallization or Bulk Freeze-Drying
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Chapter 3: Enabling Biologics Combination Products: Device Ability in Protein Therapeutics
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Large-scale crystallization of proteins for purification and formulation
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Viscosity-Reducing Bulky-Salt Excipients Prevent Gelation of Protein, but Not Carbohydrate, Solutions
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Alternative Separation Methods: Crystallization and Aqueous Polymer Two-Phase Extraction
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Post-Licensure Purification Process Improvements for Therapeutic Antibodies: Current and Future States
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Protein stability and viscosity in molecularly crowded high-concentration biologics
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Light chain subunit of a poorly soluble human IgG2λ crystallizes in physiological pH environment both in cellulo and in vitro
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Liquid-liquid phase separation of a monoclonal antibody at low ionic strength: Influence of anion charge and concentration
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A phase diagram for crystallization of a complex macromolecular assembly
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Liquid-liquid phase separation causes high turbidity and pressure during low pH elution process in Protein A chromatography
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Enabling global access to high-quality biopharmaceuticals
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Stirred batch crystallization of a therapeutic antibody fragment
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Surface-catalyzed liquid–liquid phase separation and amyloid-like assembly in microscale compartments
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Biopurification of monoclonal antibody (mAb) through crystallisation
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Using X-Ray Crystallography to Simplify and Accelerate Biologics Drug Development
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Resolving Liquid-Liquid Phase Separation for a Peptide Fused Monoclonal Antibody by Formulation Optimization
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Conformational Changes and Drivers of Monoclonal Antibody Liquid-Liquid Phase Separation
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Biophysical investigations into the impact of crystallization conditions on monoclonal antibody properties and purification
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Modulating α-Synuclein Liquid–Liquid Phase Separation
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An Integrated Experimental and Modeling Approach for Crystallization of Complex Biotherapeutics
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Protein Crystallization As a Process Step in a Novel Meso Oscillatory Flow Reactor: Study of Lysozyme Phase Behavior
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Continuous Crystallization of Proteins in a Stirred Classified Product Removal Tank with a Tubular Reactor in Bypass
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Effective Control of Liquid–Liquid Phase Separation and Nucleation of Vanillin Single Crystals through a Vapor Diffusion Crystallization Process in Selected Solvent Environments
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Liquid–Liquid Phase Separation in Oligomeric Peptide Solutions
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Spray-Dried Monoclonal Antibody Suspension for High-Concentration and Low-Viscosity Subcutaneous Injection
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Predicting Colloidal Stability of High-Concentration Monoclonal Antibody Formulations in Common Pharmaceutical Buffers Using Improved Polyethylene Glycol Induced Protein Precipitation Assay
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Liquid–Liquid Phase Separation in a Dual Variable Domain Immunoglobulin Protein Solution: Effect of Formulation Factors and Protein–Protein Interactions
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Pharmaceutical Perspective on Opalescence and Liquid–Liquid Phase Separation in Protein Solutions
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Characterization and Suitability of Therapeutic Antibody Dense Phases for Subcutaneous Delivery
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Quantitative Evaluation of Colloidal Stability of Antibody Solutions using PEG-Induced Liquid–Liquid Phase Separation
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A workflow for the development of template-assisted membrane crystallization downstream processing for monoclonal antibody purification
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On the Aggregation and Nucleation Mechanism of the Monoclonal Antibody Anti-CD20 Near Liquid-Liquid Phase Separation (LLPS)
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Investigation of the effect of liquid–liquid phase separation (LLPS) on nucleation and different growth stages of vanillin and bulk growth of defect-free single crystals from aqueous solution – a new approach
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Phase transitions in human IgG solutions
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Evaluation of effects of pH and ionic strength on colloidal stability of IgG solutions by PEG-induced liquid-liquid phase separation
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Phase separation in solutions of monoclonal antibodies and the effect of human serum albumin
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Pathological crystallization of human immunoglobulins
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A stepwise mechanism for aqueous two-phase system formation in concentrated antibody solutions
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Molecular simulation study on phase separation of immunoglobulin G
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Overexpression of cryoglobulin‐like single‐chain antibody induces morular cell phenotype via liquid–liquid phase separation in the secretory pathway organelles
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Prediction of liquid–liquid phase separating proteins using machine learning
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Reentrant condensation, liquid–liquid phase separation and crystallization in protein solutions induced by multivalent metal ions
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Prediction of Liquid-Liquid Phase Separation Proteins Using Machine Learning
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Exploring Nucleation Pathways in Distinct Physicochemical Environments Unveiling Novel Options to Modulate and Optimize Protein Crystallization
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Russell body phenotype is preferentially induced by IgG mAb clones with high intrinsic condensation propensity: Relations between the biosynthetic events in the ER and solution behaviors in vitro
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Phase Transition in a Model of Y-Shaped Molecules
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Predicting and evaluating monoclonal antibody protein-protein interactions and aggregation: a combined experimental and computational approach
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