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Natural Triterpenoids Isolated from Akebia trifoliata Stem Explants Exert a Hypoglycemic Effect via α‐Glucosidase Inhibition and Glucose Uptake Stimulation in Insulin‐Resistant HepG2 Cells
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jama.2010.405openalex-snapshot
Effect of Noninsulin Antidiabetic Drugs Added to Metformin Therapy on Glycemic Control, Weight Gain, and Hypoglycemia in Type 2 Diabetes
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Complete assignments of1H and13C NMR spectra of the pentacyclic triterpene hederagenin fromNigella sativa Linn
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Complete assignments of 1H and 13C NMR spectra of the pentacyclic triterpene hederagenin from Nigella sativa Linn
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Determination of d ‐limonene in mice plasma and tissues by a new GC–MS/MS method: Comparison of the pharmacokinetics and tissue distribution by oral and inhalation administration in mice
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Validated UHPLC–MS/MS method for simultaneous determination of four triterpene saponins from Akebia trifoliata extract in rat plasma and its application to a pharmacokinetic study
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Modulation of cellular glucose metabolism in human HepG2 cells by combinations of structurally related flavonoids
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Casein glycomacropeptide‐derived peptide IPPKKNQDKTE ameliorates high glucose‐induced insulin resistance in HepG2 cells via activation of AMPK signaling
inferredcites →https://doi.org/10.1002/mrc.2152openalex-snapshot
Structure elucidation and NMR spectral assignments of three new lignan glycosides from Akebia trifoliata
inferredcites →https://doi.org/10.1007/978-3-642-73461-8_2openalex-snapshot
Microbial α-Glucosidase Inhibitors: Chemistry, Biochemistry, and Therapeutic Potential
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Insulin resistance and insulin deficiency in the pathogenesis of Type 2 (non-insulin-dependent) diabetes mellitus: errors of metabolism or of methods?
inferredcites →https://doi.org/10.1007/s00204-017-2079-6openalex-snapshot
Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells
inferredcites →https://doi.org/10.1007/s11030-020-10137-8openalex-snapshot
Synthesis of 4-alkylaminoimidazo[1,2-a]pyridines linked to carbamate moiety as potent α-glucosidase inhibitors
inferredcites →https://doi.org/10.1016/j.bbrc.2017.09.080openalex-snapshot
Investigation of antidiabetic potential of Phyllanthus niruri L. using assays for α-glucosidase, muscle glucose transport, liver glucose production, and adipogenesis
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Type II diabetes mellitus: a review on recent drug based therapeutics
inferredcites →https://doi.org/10.1016/j.bmcl.2009.08.012openalex-snapshot
Amplification of the inhibitory activity of miglitol by monofluorination
inferredcites →https://doi.org/10.1016/j.carres.2016.04.014openalex-snapshot
Voglibose-inspired synthesis of new potent α-glucosidase inhibitors N-1,3-dihydroxypropylaminocyclitols
inferredcites →https://doi.org/10.1016/j.cbi.2019.03.018openalex-snapshot
Didymin, a dietary citrus flavonoid exhibits anti-diabetic complications and promotes glucose uptake through the activation of PI3K/Akt signaling pathway in insulin-resistant HepG2 cells
inferredcites →https://doi.org/10.1016/j.cbpc.2006.04.002openalex-snapshot
Effect of ethanolic extracts of Ananas comosus L. leaves on insulin sensitivity in rats and HepG2
inferredcites →https://doi.org/10.1016/j.cmpb.2019.105302openalex-snapshot
Analysis for warning factors of type 2 diabetes mellitus complications with Markov blanket based on a Bayesian network model
inferredcites →https://doi.org/10.1016/j.diabres.2018.02.023openalex-snapshot
IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045
inferredcites →https://doi.org/10.1016/j.ejphar.2019.04.005openalex-snapshot
Baicalein improves glucose metabolism in insulin resistant HepG2 cells
inferredcites →https://doi.org/10.1016/j.ejphar.2020.173252openalex-snapshot
Oleanolic acid induces a dual agonist action on PPARγ/α and GLUT4 translocation: A pentacyclic triterpene for dyslipidemia and type 2 diabetes
inferredcites →https://doi.org/10.1016/j.fct.2019.03.038openalex-snapshot
Chlorogenic acid and caffeic acid from Sonchus oleraceus Linn synergistically attenuate insulin resistance and modulate glucose uptake in HepG2 cells
inferredcites →https://doi.org/10.1016/j.foodchem.2017.05.034openalex-snapshot
C-geranylated flavanones from YingDe black tea and their antioxidant and α -glucosidase inhibition activities
inferredcites →https://doi.org/10.1016/j.ijbiomac.2019.09.010openalex-snapshot
Inhibition of α-glucosidase activity and non-enzymatic glycation by tannic acid: Inhibitory activity and molecular mechanism
inferredcites →https://doi.org/10.1016/j.ijbiomac.2019.12.021openalex-snapshot
Interaction mechanism between α-glucosidase and A-type trimer procyanidin revealed by integrated spectroscopic analysis techniques
inferredcites →https://doi.org/10.1016/j.indcrop.2015.02.046openalex-snapshot
Comparative analysis of 1-deoxynojirimycin contribution degree to α-glucosidase inhibitory activity and physiological distribution in Morus alba L
inferredcites →https://doi.org/10.1016/j.indcrop.2015.08.031openalex-snapshot
Antioxidant and α-glucosidase inhibitory activities of constituents from Euonymus alatus twigs
inferredcites →https://doi.org/10.1016/j.jcjd.2019.09.001openalex-snapshot
Prevalence of Type 1 and Type 2 Diabetes-Related Complications and Their Association With Determinants Identified in Canada’s Survey on Living With Chronic Diseases—Diabetes Component
inferredcites →https://doi.org/10.1016/j.jep.2020.112877openalex-snapshot
Evaluation of the antidiabetic potential of Psidium guajava L. (Myrtaceae) using assays for α-glucosidase, α-amylase, muscle glucose uptake, liver glucose production, and triglyceride accumulation in adipocytes
inferredcites →https://doi.org/10.1016/j.mam.2015.09.003openalex-snapshot
Molecular pathophysiology of hepatic glucose production
inferredcites →https://doi.org/10.1016/j.molstruc.2018.08.055openalex-snapshot
Cocrystals of pyrazinamide with p-toluenesulfonic and ferulic acids: DFT investigations and molecular docking studies
inferredcites →https://doi.org/10.1016/j.molstruc.2020.129243openalex-snapshot
Insights into the pharmacophore-based 3D-QSAR modeling, molecular dynamics simulation studies of certain dihydroxy pyrrolidine/piperidine and aza-flavanone derivatives as α-glucosidase inhibitors
inferredcites →https://doi.org/10.1016/j.phytochem.2015.12.007openalex-snapshot
A potent alpha-glucosidase inhibitor from Myristica cinnamomea King
inferredcites →https://doi.org/10.1016/j.yexmp.2019.104349openalex-snapshot
RETRACTED: Geniposide plays anti-tumor effects by down-regulation of microRNA-224 in HepG2 and Huh7 cell lines
inferredcites →https://doi.org/10.1016/s0016-5085(97)70096-9openalex-snapshot
Inhibition of glucose absorption in the rat jejunum: A novel action of alpha-D-glucosidase inhibitors
inferredcites →https://doi.org/10.1016/s0031-9422(97)00588-8openalex-snapshot
A phenolic glycoside and triterpenoids from Stauntonia hexaphylla
inferredcites →https://doi.org/10.1021/acs.jcim.9b00383openalex-snapshot
Getting Docking into Shape Using Negative Image-Based Rescoring
inferredcites →https://doi.org/10.1038/nrendo.2017.151openalex-snapshot
Global aetiology and epidemiology of type 2 diabetes mellitus and its complications
inferredcites →https://doi.org/10.1038/s41598-019-39329-5openalex-snapshot
Insulin secretory granules labelled with phogrin-fluorescent proteins show alterations in size, mobility and responsiveness to glucose stimulation in living β-cells
inferredcites →https://doi.org/10.1039/c8ra08894bopenalex-snapshot
Triterpenoids with α-glucosidase inhibitory activity and cytotoxic activity from the leaves of Akebia trifoliata
inferredcites →https://doi.org/10.1080/14786419.2011.566870openalex-snapshot
Isolation, characterisation and cytotoxicity study of arjunolic acid fromTerminalia arjuna
inferredcites →https://doi.org/10.1080/21548331.1999.11443912openalex-snapshot
Improving Management of Type 2 Diabetes Mellitus: 1. α-Glucosidase Inhibitors
inferredcites →https://doi.org/10.1093/bioinformatics/bti770openalex-snapshot
The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling
inferredcites →https://doi.org/10.1093/nar/gkw1042openalex-snapshot
Control of the negative IREStrans-acting factor KHSRP by ubiquitination
inferredcites →https://doi.org/10.1097/mbp.0000000000000160openalex-snapshot
Acarbose, the α-glucosidase inhibitor, attenuates the blood pressure and splanchnic blood flow responses to meal in elderly patients with postprandial hypotension concomitant with abnormal glucose metabolism
inferredcites →https://doi.org/10.1172/jci10582openalex-snapshot
Signaling pathways in insulin action: molecular targets of insulin resistance
inferredcites →https://doi.org/10.1186/s13065-019-0631-6openalex-snapshot
Designing, synthesis and characterization of 2-aminothiazole-4-carboxylate Schiff bases; antimicrobial evaluation against multidrug resistant strains and molecular docking
inferredcites →https://doi.org/10.1371/journal.pone.0026583openalex-snapshot
Comparative Effects of Fructose and Glucose on Lipogenic Gene Expression and Intermediary Metabolism in HepG2 Liver Cells
inferredcites →https://doi.org/10.21273/hortsci.45.1.4openalex-snapshot
Akebia: A Potential New Fruit Crop in China
inferredcites →https://doi.org/10.2174/1389557520666200204121129openalex-snapshot
Consensus Analyses in Molecular Docking Studies Applied to Medicinal Chemistry
inferredcites →https://doi.org/10.3390/ijms150610446openalex-snapshot
Triterpenoid Saponins from Stauntonia chinensis Ameliorate Insulin Resistance via the AMP-Activated Protein Kinase and IR/IRS-1/PI3K/Akt Pathways in Insulin-Resistant HepG2 Cells
inferredcites →https://doi.org/10.4103/0973-7847.79096openalex-snapshot
α-glucosidase inhibitors from plants: A natural approach to treat diabetes
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4673932openalex-extracted
Alterations in Metabolic Profile Unveiled Through Untargeted and Targeted Metabolomics Approaches and Sensory Characteristics of Akebia Trifoliata Fruits Fermented Juice
inferred← citeshttps://doi.org/10.1002/ardp.202000471openalex-snapshot
New quinoxalin‐1,3,4‐oxadiazole derivatives: Synthesis, characterization, in vitro biological evaluations, and molecular modeling studies
inferred← citeshttps://doi.org/10.1002/cbdv.202200383openalex-snapshot
Insight into the Potential of Meehania fargesii var. Radicans against Hp‐Induced Gastric Carcinoma Based on Phytochemical and Molecular Docking Studies
inferred← citeshttps://doi.org/10.1002/ptr.70030openalex-snapshot
Unveiling the Molecular Mechanisms of Natural Triterpenoids From Mushrooms Against Type 2 Diabetes: A Critical Review
inferred← citeshttps://doi.org/10.1007/s11101-021-09773-1openalex-snapshot
A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes
inferred← citeshttps://doi.org/10.1016/b978-0-443-45775-3.00003-xopenalex-snapshot
Natural products with anti-type 2 diabetes mellitus activity and their structure–activity relationships
inferred← citeshttps://doi.org/10.1016/j.arabjc.2023.104549openalex-snapshot
Comparative chemical diversity and antioxidant activities of three species of Akebia herbal medicines
inferred← citeshttps://doi.org/10.1016/j.fitote.2026.107113openalex-snapshot
Role of terpenes and terpenoids in cross-talk between adipocyte browning and gut microbiome in obesity
inferred← citeshttps://doi.org/10.1080/87559129.2025.2566150openalex-snapshot
Integrated Review of Akebia Fruits: Botany, Bioactive Properties, Processing Innovations, and Post-Harvest Cracking Challenges
inferred← citeshttps://doi.org/10.1155/2022/1790826openalex-snapshot
Optimization of Flash Extraction of Akebia trifoliata Seed Oil by the Box-Behnken Response Surface Methodology and Comparison of Oil Yields from Different Origins
inferred← citeshttps://doi.org/10.1166/jbmb.2024.2418openalex-snapshot
Plant Extracts for Type 2 Diabetes: Mechanisms, Clinical Implications and Future Directions—A Systematic Review
inferred← citeshttps://doi.org/10.2174/1871530322666220510093720openalex-snapshot
Antidiabetic Phytocompounds Acting as Glucose Transport Stimulators
inferred← citeshttps://doi.org/10.3389/fphar.2023.1129874openalex-snapshot
Coicis Semen for the treatment of malignant tumors of the female reproductive system: A review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics, and pharmacodynamics
inferred← citeshttps://doi.org/10.3390/fermentation9050432openalex-snapshot
Improved Antioxidant Capacity of Akebia trifoliata Fruit Inoculated Fermentation by Plantilactobacillus plantarum, Mechanism of Anti-Oxidative Stress through Network Pharmacology, Molecular Docking and Experiment Validation by HepG2 Cells
inferred← citeshttps://doi.org/10.3390/molecules26247629openalex-snapshot
Carpachromene Ameliorates Insulin Resistance in HepG2 Cells via Modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 Pathway
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