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Auranofin sensitizes breast cancer cells to paclitaxel mediated cell death via regulating FOXO3/Nrf2/Keap1 signaling pathway

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Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

1 of the 37 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-11): 10.1158/1535-7163.mct-08-0398 (notice 2026-03-02).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cam4.2101openalex-snapshot
Nrf2 in cancers: A double‐edged sword
inferredcites →https://doi.org/10.1002/cbf.3865openalex-snapshot
Auranofin sensitizes breast cancer cells to paclitaxel chemotherapy by disturbing the cellular redox system
inferredcites →https://doi.org/10.1002/hep.28496openalex-snapshot
FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance through Keap1‐Nrf2 signaling
inferredcites →https://doi.org/10.1002/jcc.21334openalex-snapshot
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
inferredcites →https://doi.org/10.1007/s10555-020-09883-wopenalex-snapshot
FOXO transcription factor family in cancer and metastasis
inferredcites →https://doi.org/10.1007/s12551-016-0244-4openalex-snapshot
The Keap1–Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases
inferredcites →https://doi.org/10.1016/0006-2952(85)90341-7openalex-snapshot
Effects of coordinated gold compounds on in vitro and in situ DNA replication
inferredcites →https://doi.org/10.1016/0006-2952(90)90027-iopenalex-snapshot
Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin
inferredcites →https://doi.org/10.1016/j.bbamcr.2011.03.010openalex-snapshot
Akt, FoxO and regulation of apoptosis
inferredcites →https://doi.org/10.1016/j.canlet.2019.11.042openalex-snapshot
FoxO3 reverses 5-fluorouracil resistance in human colorectal cancer cells by inhibiting the Nrf2/TR1 signaling pathway
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2021.10.020openalex-snapshot
Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer
inferredcites →https://doi.org/10.1016/j.jnutbio.2018.09.022openalex-snapshot
Ferulic acid reverses P-glycoprotein-mediated multidrug resistance via inhibition of PI3K/Akt/NF-κB signaling pathway
inferredcites →https://doi.org/10.1016/j.redox.2022.102389openalex-snapshot
Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway
inferredcites →https://doi.org/10.1016/j.taap.2018.09.038openalex-snapshot
Roles of the KEAP1-NRF2 system in mammalian skin exposed to UV radiation
inferredcites →https://doi.org/10.1038/35099574openalex-snapshot
Forkhead transcription factors contribute to execution of the mitotic programme in mammals
inferredcites →https://doi.org/10.1038/sj.bjp.0705708openalex-snapshot
Auranofin induces apoptosis and when combined with retinoic acid enhances differentiation of acute promyelocytic leukaemia cells in vitro
inferredcites →https://doi.org/10.1080/09537104.2017.1378809openalex-snapshot
Auranofin, a thioredoxin reductase inhibitor, causes platelet death through calcium overload
inferredcites →https://doi.org/10.1111/j.1365-2443.2010.01473.xopenalex-snapshot
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
inferredcites →https://doi.org/10.1111/jcmm.14241openalex-snapshot
Nrf2 promotes breast cancer cell migration via up‐regulation of G6PD/HIF‐1α/Notch1 axis
inferredcites →https://doi.org/10.1146/annurev-pharmtox-011112-140320openalex-snapshot
Role of Nrf2 in Oxidative Stress and Toxicity
inferredcites →https://doi.org/10.1158/1535-7163.mct-08-0398openalex-snapshot
RETRACTED: FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells
inferredcites →https://doi.org/10.1186/s12906-016-1136-7openalex-snapshot
Decatropis bicolor (Zucc.) Radlk essential oil induces apoptosis of the MDA-MB-231 breast cancer cell line
inferredcites →https://doi.org/10.1186/s12943-018-0856-3openalex-snapshot
Critical role of FOXO3a in carcinogenesis
inferredcites →https://doi.org/10.1248/cpb.c18-00767openalex-snapshot
Potential Anticancer Activity of Auranofin
inferredcites →https://doi.org/10.1248/yakushi.20-00179-2openalex-snapshot
Potential Anticancer Activity of Auranofin
inferredcites →https://doi.org/10.18632/oncotarget.4828openalex-snapshot
High throughput screening of cytokines, chemokines and matrix metalloproteinases in wound fluid induced by mammary surgery
inferredcites →https://doi.org/10.18632/oncotarget.5364openalex-snapshot
Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer
inferredcites →https://doi.org/10.3389/fonc.2017.00085openalex-snapshot
The KEAP1–NRF2 System in Cancer
inferredcites →https://doi.org/10.3390/cancers6042243openalex-snapshot
Auranofin, an Anti-Rheumatic Gold Compound, Modulates Apoptosis by Elevating the Intracellular Calcium Concentration ([Ca2+]i) in MCF-7 Breast Cancer Cells
inferredcites →https://doi.org/10.3892/ijo.2014.2579openalex-snapshot
Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53
inferredcites →https://doi.org/10.3892/ijo.25.5.1495openalex-snapshot
Human FOX gene family (Review)
inferredcites →https://doi.org/10.3892/or.2017.5853openalex-snapshot
Attenuation of MUC4 potentiates the anticancer activity of auranofin via regulation of the Her2/Akt/FOXO3 pathway in ovarian cancer cells
inferredcites →https://doi.org/10.3892/or.2020.7818openalex-snapshot
Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspase‑dependent apoptosis
inferredcites →https://doi.org/10.3906/biy-1901-19openalex-snapshot
A novel 1,4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cells
inferredcites →https://doi.org/10.4062/biomolther.2020.051openalex-snapshot
Synergistic Induction of Apoptosis by the Combination of an Axl Inhibitor and Auranofin in Human Breast Cancer Cells
inferredcites →https://doi.org/10.4062/biomolther.2020.122openalex-snapshot
Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway
inferredcites →https://doi.org/10.47853/fas.2023.e11openalex-snapshot
Auranofin accelerates spermidine-induced apoptosis via reactive oxygen species generation and suppression of PI3K/Akt signaling pathway in hepatocellular carcinoma

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4821603openalex-extracted
The Inhibition Mechanism of Auranofin on Thioredoxin Reductase 1 at the Molecular Level: A New Use of the Old Drug
inferred← citeshttps://doi.org/10.1002/ijc.70429openalex-snapshot
Drug repurposing in oncology: Bridging computational discovery to clinical application
inferred← citeshttps://doi.org/10.1007/s10495-026-02274-6openalex-snapshot
Research progress on the mechanism of FOXO protein in sepsis
inferred← citeshttps://doi.org/10.1007/s10787-026-02225-2openalex-snapshot
Auranofin reimagined: an emerging therapeutic candidate for neurodegenerative diseases through molecular mechanistic insights
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2025.113161openalex-snapshot
Combined computational and bioinformatic approach to uncover the pre-covalent protein interactions of auranofin and its chlorido derivative Au(PEt₃)Cl
inferred← citeshttps://doi.org/10.1016/j.reprotox.2026.109292openalex-snapshot
Protective effects of selenium against paclitaxel-induced testicular damage via modulation of oxidative stress, inflammation, and apoptotic pathways
inferred← citeshttps://doi.org/10.1016/j.tranon.2024.102199openalex-snapshot
4′-Demethylpodophyllotoxin functions as a mechanism-driven therapy by targeting the PI3K-AKT pathway in Colorectal cancer
inferred← citeshttps://doi.org/10.1038/s41388-026-03765-1openalex-snapshot
Dual inhibition of glycolysis and glutaminolysis by targeting FOXO3 for hepatocellular carcinoma treatment
inferred← citeshttps://doi.org/10.1038/s41598-025-92790-3openalex-snapshot
Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise
inferred← citeshttps://doi.org/10.3390/molecules31030571openalex-snapshot
Auranofin Combination Therapy: A New Frontier in Cancer Treatment
inferred← citeshttps://doi.org/10.64898/2026.05.27.728338openalex-snapshot
Auranofin potentiates cisplatin response through context-dependent NOTCH-associated signaling states in endometrial cancer
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