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The Inhibition Mechanism of Auranofin on Thioredoxin Reductase 1 at the Molecular Level: A New Use of the Old Drug

https://doi.org/10.2139/ssrn.4821603
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Auranofin sensitizes breast cancer cells to paclitaxel mediated cell death via regulating FOXO3/Nrf2/Keap1 signaling pathway
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Development and testing of a general amber force field
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Scalable molecular dynamics with NAMD
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CHARMM general force field: A force field for drug‐like molecules compatible with the CHARMM all‐atom additive biological force fields
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Upgrade of an old drug: Auranofin in innovative cancer therapies to overcome drug resistance and to increase drug effectiveness
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The synergistic strategies for the immuno‐oncotherapy with photothermal nanoagents
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The importance of the IL ‐1 family of cytokines in nanoimmunosafety and nanotoxicology
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A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition
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Clinical pharmacology of gold
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Auranofin: Experience to date
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Cellular association, intracellular distribution, and efflux of auranofin via sequential ligand exchange reactions
inferredcites →https://doi.org/10.1016/0009-2614(84)80098-6openalex-extracted
Stochastic boundary conditions for molecular dynamics simulations of ST2 water
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Hydrogen bonding in globular proteins
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VMD: Visual molecular dynamics
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Organogold complexes probe a large β-barrel cavity for human serum α1-acid glycoprotein
inferredcites →https://doi.org/10.1016/j.bcp.2009.07.023openalex-extracted
Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase
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In-vitro and in-vivo monitoring of gold(III) ions from intermediate metabolite of sodium aurothiomalate through water-soluble ruthenium (II) complex-based luminescent probe
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Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer
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Omics-based identification of an NRF2-related auranofin resistance signature in cancer: Insights into drug repurposing
inferredcites →https://doi.org/10.1016/j.drudis.2022.02.010openalex-extracted
Repurposing of the gold drug auranofin and a review of its derivatives as antibacterial therapeutics
inferredcites →https://doi.org/10.1016/j.ijantimicag.2022.106582openalex-extracted
Repurposing Non-Antibiotic Drugs Auranofin and Pentamidine in Combination to Combat Multidrug-Resistant Gram-Negative Bacteria
inferredcites →https://doi.org/10.1016/j.jinorgbio.2014.09.013openalex-extracted
An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase
inferredcites →https://doi.org/10.1016/j.jsb.2016.02.015openalex-extracted
X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action
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Nanoparticles insert a three dimensional cavity structure of proteins for function inhibition: The Case of CeO2 and SARS-CoV-2
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Redox proteome analysis of auranofin exposed ovarian cancer cells (A2780)
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Auranofin in the treatment of juvenile rheumatoid arthritis
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Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications
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Reinforcing the Combinational Immuno-Oncotherapy of Switching “Cold” Tumor to “Hot” by Responsive Penetrating Nanogels
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Tea Polyphenol Coordinated with Nanoparticles of ZIF-8 and Coated with Polydopamine and PEG for Immuno-Oncotherapy
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Reversing Ferroptosis Resistance in Breast Cancer via Tailored Lipid and Iron Presentation
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LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery
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Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ 1 and χ 2 Dihedral Angles
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A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: the RESP model
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Gold(I) Carbene Complexes Causing Thioredoxin 1 and Thioredoxin 2 Oxidation as Potential Anticancer Agents
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Toward a Novel Metal-Based Chemotherapy against Tropical Diseases. 3. Synthesis and Antimalarial Activity in Vitro and in Vivo of the New Gold−Chloroquine Complex [Au(PPh3)(CQ)]PF6
inferredcites →https://doi.org/10.1038/cddis.2017.100openalex-extracted
Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer
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Crystal structure of the human thioredoxin reductase–thioredoxin complex
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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target
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Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
inferredcites →https://doi.org/10.1038/s41565-021-00952-xopenalex-extracted
Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase
inferredcites →https://doi.org/10.1038/s41565-022-01177-2openalex-extracted
A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination
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Thioredoxin reductase, an emerging target for anticancer metallodrugs. Enzyme inhibition by cytotoxic gold(iii) compounds studied with combined mass spectrometry and biochemical assays
inferredcites →https://doi.org/10.1039/d1cs00933hopenalex-extracted
Recent development of gold( i ) and gold( iii ) complexes as therapeutic agents for cancer diseases
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The formation and release of aurothioglucose from thioglucose-loaded gold nanoparticles by NIR irradiation: a combined anti-cancer effect of thermotherapy and chemotherapy without the risk of uncontrollable drug burst release and leakage
inferredcites →https://doi.org/10.1046/j.1432-1327.2000.01701.xopenalex-extracted
Physiological functions of thioredoxin and thioredoxin reductase
inferredcites →https://doi.org/10.1046/j.1432-1327.2000.01703.xopenalex-extracted
Thioredoxin reductase as a pathophysiological factor and drug target
inferredcites →https://doi.org/10.1063/1.445869openalex-extracted
Comparison of simple potential functions for simulating liquid water
inferredcites →https://doi.org/10.1063/1.464397openalex-extracted
Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems
inferredcites →https://doi.org/10.1073/pnas.89.7.3070openalex-extracted
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
inferredcites →https://doi.org/10.1073/pnas.92.10.4497openalex-extracted
Inhibition of AP-1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun and Fos.
inferredcites →https://doi.org/10.1074/jbc.273.32.20096openalex-extracted
Human Placenta Thioredoxin Reductase
inferredcites →https://doi.org/10.1074/jbc.m414645200openalex-extracted
Thioredoxin Reductase Is Irreversibly Modified by Curcumin
inferredcites →https://doi.org/10.1093/bioinformatics/btu097openalex-extracted
ZDOCK server: interactive docking prediction of protein–protein complexes and symmetric multimers
inferredcites →https://doi.org/10.1093/ije/djy149openalex-extracted
Auranofin/Vitamin C: A Novel Drug Combination Targeting Triple-Negative Breast Cancer
inferredcites →https://doi.org/10.1093/jnci/djy149openalex-extracted
Auranofin/Vitamin C: A Novel Drug Combination Targeting Triple-Negative Breast Cancer
inferredcites →https://doi.org/10.1097/cad.0000000000001540openalex-extracted
Auranofin inhibits the occurrence of colorectal cancer by promoting mTOR-dependent autophagy and inhibiting epithelial-mesenchymal transformation
inferredcites →https://doi.org/10.1155/mbd.1994.433openalex-extracted
Transport of the Dicyanogold(I) Anion
inferredcites →https://doi.org/10.1158/0008-5472.can-13-2033openalex-extracted
Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia
inferredcites →https://doi.org/10.1158/0008-5472.can-18-1938openalex-extracted
Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis
inferredcites →https://doi.org/10.1158/1538-7445.am2023-5505openalex-extracted
Abstract 5505: Combination nitazoxanide and auranofin treatment has synergistic anticancer activity in anaplastic thyroid cancer and act by enhanced activation of multiple cell death pathways
inferredcites →https://doi.org/10.1172/jci101235openalex-extracted
METABOLISM, TOXICITY AND MANNER OF ACTION OF GOLD COMPOUNDS USED IN THE TREATMENT OF ARTHRITIS. I. HUMAN PLASMA AND SYNOVIAL FLUID CONCENTRATION AND URINARY EXCRETION OF GOLD DURING AND FOLLOWING TREATMENT WITH GOLD SODIUM THIOMALATE, GOLD SODIUM THIOSULFATE, AND COLLOIDAL GOLD SULFIDE
inferredcites →https://doi.org/10.1186/s12951-022-01286-zopenalex-extracted
Black phosphorus-Au-thiosugar nanosheets mediated photothermal induced anti-tumor effect enhancement by promoting infiltration of NK cells in hepatocellular carcinoma
inferredcites →https://doi.org/10.1186/s13045-022-01313-4openalex-extracted
Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
inferredcites →https://doi.org/10.1186/s13046-024-03012-zopenalex-extracted
Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition
inferredcites →https://doi.org/10.18632/oncotarget.16113openalex-extracted
Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species
inferredcites →https://doi.org/10.18632/oncotarget.5364openalex-extracted
Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer
inferredcites →https://doi.org/10.3389/fonc.2022.891652openalex-extracted
Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches
inferredcites →https://doi.org/10.3390/cancers15215136openalex-extracted
Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells
inferredcites →https://doi.org/10.3390/ijms21093233openalex-extracted
Mechanisms of Multidrug Resistance in Cancer Chemotherapy
inferredcites →https://doi.org/10.3390/met7060222openalex-extracted
A Review of Thiosulfate Leaching of Gold: Focus on Thiosulfate Consumption and Gold Recovery from Pregnant Solution
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.