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tert‐Butylhydroquinone‐induced formation of high‐molecular‐weight p62: A novel mechanism in the activation of Nrf2‐Keap1

https://doi.org/10.1002/cbin.11849
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/0009-9120(93)90111-iopenalex-snapshot
Human disease, free radicals, and the oxidant/antioxidant balance
inferredcites →https://doi.org/10.1016/j.cell.2009.05.023openalex-snapshot
p62 at the Crossroads of Autophagy, Apoptosis, and Cancer
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2011.04.031openalex-snapshot
Protein sulfenic acid formation: From cellular damage to redox regulation
inferredcites →https://doi.org/10.1016/j.molcel.2006.03.004openalex-snapshot
The Double-Edged Sword of Nrf2: Subversion of Redox Homeostasis during the Evolution of Cancer
inferredcites →https://doi.org/10.1016/j.molcel.2011.06.038openalex-snapshot
p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway
inferredcites →https://doi.org/10.1016/j.taap.2009.12.012openalex-snapshot
Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound
inferredcites →https://doi.org/10.1016/j.tips.2013.04.005openalex-snapshot
Toward clinical application of the Keap1–Nrf2 pathway
inferredcites →https://doi.org/10.1016/j.trsl.2017.11.007openalex-snapshot
Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma
inferredcites →https://doi.org/10.1021/jm301182jopenalex-snapshot
Small Molecules That Target Protein Misfolding
inferredcites →https://doi.org/10.1038/nature11404openalex-snapshot
Comprehensive genomic characterization of squamous cell lung cancers
inferredcites →https://doi.org/10.1038/ncb2021openalex-snapshot
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
inferredcites →https://doi.org/10.1038/ncomms12490openalex-snapshot
Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding
inferredcites →https://doi.org/10.1038/s41467-017-02746-zopenalex-snapshot
Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis
inferredcites →https://doi.org/10.1038/s41580-018-0003-4openalex-snapshot
Mechanism and medical implications of mammalian autophagy
inferredcites →https://doi.org/10.1038/s41598-017-10574-wopenalex-snapshot
Onset of disorder and protein aggregation due to oxidation-induced intermolecular disulfide bonds: case study of RRM2 domain from TDP-43
inferredcites →https://doi.org/10.1074/jbc.m206911200openalex-snapshot
Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription
inferredcites →https://doi.org/10.1083/jcb.201102031openalex-snapshot
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
inferredcites →https://doi.org/10.1093/emboj/19.7.1576openalex-snapshot
The atypical PKC‐interacting protein p62 channels NF‐κB activation by the IL‐1–TRAF6 pathway
inferredcites →https://doi.org/10.1101/gad.13.1.76openalex-snapshot
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
inferredcites →https://doi.org/10.1111/cas.13537openalex-snapshot
NRF2 addiction in cancer cells
inferredcites →https://doi.org/10.1111/febs.14712openalex-snapshot
p62/ SQSTM 1: ‘Jack of all trades’ in health and cancer
inferredcites →https://doi.org/10.1124/pr.110.004333openalex-snapshot
Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2
inferredcites →https://doi.org/10.1126/scisignal.2004088openalex-snapshot
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
inferredcites →https://doi.org/10.1128/mcb.00248-10openalex-snapshot
A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
inferredcites →https://doi.org/10.1128/mcb.00642-17openalex-snapshot
Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant
inferredcites →https://doi.org/10.1152/ajpcell.00031.2015openalex-snapshot
tert-Butylhydroquinone mobilizes intracellular-bound zinc to stabilize Nrf2 through inhibiting phosphatase activity
inferredcites →https://doi.org/10.1158/2159-8290.cd-12-0095openalex-snapshot
The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
inferredcites →https://doi.org/10.15252/embj.201798358openalex-snapshot
TRIM16 controls assembly and degradation of protein aggregates by modulating the p62‐NRF2 axis and autophagy
inferredcites →https://doi.org/10.3389/fonc.2018.00210openalex-snapshot
Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer
inferredcites →https://doi.org/10.3390/ijms20040901openalex-snapshot
Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4638517openalex-extracted
Activation of APE1 Modulates Nrf2, Inhibits Hepatocyte Ferroptosis and Promotes Hepatocyte Autophagy, Thereby Protecting Against Acute Liver Injury
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.111529openalex-snapshot
Activation of APE1 modulates Nrf2 protected against acute liver injury by inhibit hepatocyte ferroptosis and promote hepatocyte autophagy
inferred← citeshttps://doi.org/10.1016/j.redox.2026.104274openalex-snapshot
Ascorbate-driven quinone redox cycling as a pro-oxidant anticancer strategy
inferred← citeshttps://doi.org/10.1093/toxres/tfae080openalex-snapshot
The role of Nrf2 signaling pathways in nerve damage repair
inferred← citeshttps://doi.org/10.3389/fphar.2023.1092475openalex-snapshot
Astragaloside IV alleviates 1-deoxysphinganine-induced mitochondrial dysfunction during the progression of chronic kidney disease through p62-Nrf2 antioxidant pathway
inferred← citeshttps://doi.org/10.3390/toxics12120869openalex-snapshot
Applications of Tert-Butyl-Phenolic Antioxidants in Consumer Products and Their Potential Toxicities in Humans
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