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APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old‐aged adults

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia
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Apolipoprotein E–dependent accumulation of Alzheimer disease–related lesions begins in middle age
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APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging
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Variants at APOE influence risk of deep and lobar intracerebral hemorrhage
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APOE4 moderates effects of cortical iron on synchronized default mode network activity in cognitively healthy old‐aged adults
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A method for making group inferences from functional MRI data using independent component analysis
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Regional distribution of iron and iron‐regulatory proteins in the brain in aging and Alzheimer's disease
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Functional connectivity in the motor cortex of resting human brain using echo‐planar mri
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Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia
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Appraising the Role of Iron in Brain Aging and Cognition: Promises and Limitations of MRI Methods
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Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau
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“Mini-mental state”
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Activated microglia cause superoxide-mediated release of iron from ferritin
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The Neuropathology of Neurodegeneration with Brain Iron Accumulation
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Resting State Functional Connectivity in Preclinical Alzheimer’s Disease
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease
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Association between Apolipoprotein E polymorphism and myocardial infarction risk: A systematic review and meta‐analysis
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Aβ amyloid, cognition, and APOE genotype in healthy older adults
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Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain
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Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease
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Determinants of iron accumulation in the normal aging brain
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2017.12.014openalex-snapshot
Low cortical iron and high entorhinal cortex volume promote cognitive functioning in the oldest-old
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Quantitative imaging of intrinsic magnetic tissue properties using MRI signal phase: An approach to in vivo brain iron metabolism?
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Quantitative susceptibility mapping of human brain reflects spatial variation in tissue composition
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Fast and tissue-optimized mapping of magnetic susceptibility and T2* with multi-echo and multi-shot spirals
inferredcites →https://doi.org/10.1016/j.neuroimage.2011.08.045openalex-snapshot
Susceptibility induced gray–white matter MRI contrast in the human brain
inferredcites →https://doi.org/10.1016/j.neuroimage.2012.05.049openalex-snapshot
Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study
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Quantitative susceptibility mapping for investigating subtle susceptibility variations in the human brain
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Toward in vivo histology: A comparison of quantitative susceptibility mapping (QSM) with magnitude-, phase-, and R2⁎-imaging at ultra-high magnetic field strength
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Human brain atlas for automated region of interest selection in quantitative susceptibility mapping: Application to determine iron content in deep gray matter structures
inferredcites →https://doi.org/10.1016/j.neuroimage.2014.08.003openalex-snapshot
Characteristics of the default mode functional connectivity in normal ageing and Alzheimer's disease using resting state fMRI with a combined approach of entropy-based and graph theoretical measurements
inferredcites →https://doi.org/10.1016/j.neuroimage.2014.11.010openalex-snapshot
Validation of quantitative susceptibility mapping with Perls' iron staining for subcortical gray matter
inferredcites →https://doi.org/10.1016/j.neuroimage.2014.12.043openalex-snapshot
A method for estimating and removing streaking artifacts in quantitative susceptibility mapping
inferredcites →https://doi.org/10.1016/j.neuroimage.2018.03.021openalex-snapshot
Simultaneous quantitative susceptibility mapping and Flutemetamol-PET suggests local correlation of iron and β-amyloid as an indicator of cognitive performance at high age
inferredcites →https://doi.org/10.1016/j.neuroimage.2018.06.007openalex-snapshot
The influence of brain iron and myelin on magnetic susceptibility and effective transverse relaxation - A biochemical and histological validation study
inferredcites →https://doi.org/10.1016/j.neuron.2019.01.056openalex-snapshot
A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward
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Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease
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Ferroptosis Inhibition: Mechanisms and Opportunities
inferredcites →https://doi.org/10.1016/s0887-6177(03)00039-8openalex-snapshot
Trail Making Test A and B: Normative data stratified by age and education
inferredcites →https://doi.org/10.1017/s1355617701755105openalex-snapshot
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inferredcites →https://doi.org/10.1038/418932aopenalex-snapshot
Cognitive change and the APOE ɛ4 allele
inferredcites →https://doi.org/10.1038/nchembio.1416openalex-snapshot
The role of iron and reactive oxygen species in cell death
inferredcites →https://doi.org/10.1038/ncomms7760openalex-snapshot
Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE
inferredcites →https://doi.org/10.1038/nrn1537openalex-snapshot
Iron, brain ageing and neurodegenerative disorders
inferredcites →https://doi.org/10.1038/nrneurol.2015.96openalex-snapshot
Iron—the missing link between ApoE and Alzheimer disease?
inferredcites →https://doi.org/10.1038/s41380-019-0375-7openalex-snapshot
Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology
inferredcites →https://doi.org/10.1038/s41467-017-01150-xopenalex-snapshot
Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
inferredcites →https://doi.org/10.1038/srep35514openalex-snapshot
Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment
inferredcites →https://doi.org/10.1056/nejmoa054625openalex-snapshot
PET of Brain Amyloid and Tau in Mild Cognitive Impairment
inferredcites →https://doi.org/10.1073/pnas.0308627101openalex-snapshot
Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
inferredcites →https://doi.org/10.1073/pnas.0504136102openalex-snapshot
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
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Consistent resting-state networks across healthy subjects
inferredcites →https://doi.org/10.1073/pnas.0708803104openalex-snapshot
Selective changes of resting-state networks in individuals at risk for Alzheimer's disease
inferredcites →https://doi.org/10.1073/pnas.0811879106openalex-snapshot
Distinct patterns of brain activity in young carriers of the APOE -ε4 allele
inferredcites →https://doi.org/10.1073/pnas.0900345106openalex-snapshot
Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
inferredcites →https://doi.org/10.1073/pnas.0911855107openalex-snapshot
Toward discovery science of human brain function
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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
inferredcites →https://doi.org/10.1073/pnas.94.18.9866openalex-snapshot
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
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Conn : A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks
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Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline
inferredcites →https://doi.org/10.1093/brain/awy146openalex-snapshot
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated
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Functional connectivity associated with tau levels in ageing, Alzheimer’s, and small vessel disease
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The Role of Hippocampal Iron Concentration and Hippocampal Volume in Age-Related Differences in Memory
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Association Between Earliest Amyloid Uptake and Functional Connectivity in Cognitively Unimpaired Elderly
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On the Possible Role of Iron‐Induced Free Radical Peroxidation in Neural Degeneration in Alzheimer's Diseasea
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Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
inferredcites →https://doi.org/10.1126/scitranslmed.3002156openalex-snapshot
Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance
inferredcites →https://doi.org/10.1152/jn.00783.2009openalex-snapshot
Intrinsic Functional Connectivity As a Tool For Human Connectomics: Theory, Properties, and Optimization
inferredcites →https://doi.org/10.1159/000353441openalex-snapshot
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Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
inferredcites →https://doi.org/10.1159/000430949openalex-snapshot
Older Adults' Reasons for Using Technology while Aging in Place
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An Information-Maximization Approach to Blind Separation and Blind Deconvolution
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The Brain's Default Network
inferredcites →https://doi.org/10.1212/01.wnl.0000144279.21502.b7openalex-snapshot
Impact of APOE in mild cognitive impairment
inferredcites →https://doi.org/10.1212/wnl.0b013e31824365abopenalex-snapshot
APOE modifies the association between Aβ load and cognition in cognitively normal older adults
inferredcites →https://doi.org/10.1371/journal.pone.0081093openalex-snapshot
In Vivo Quantitative Susceptibility Mapping (QSM) in Alzheimer's Disease
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In Vivo MRI Mapping of Brain Iron Deposition across the Adult Lifespan
inferredcites →https://doi.org/10.1523/jneurosci.3987-10.2010openalex-snapshot
APOE4 Allele Disrupts Resting State fMRI Connectivity in the Absence of Amyloid Plaques or Decreased CSF Aβ42
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Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease
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Cortical Iron Reflects Severity of Alzheimer’s Disease
inferredcites →https://doi.org/10.3233/jad-2012-129011openalex-snapshot
The Metal Theory of Alzheimer's Disease
inferredcites →https://doi.org/10.3389/fnins.2019.00180openalex-snapshot
Iron in Neurodegeneration – Cause or Consequence?
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Untangling Tau and Iron: Exploring the Interaction Between Iron and Tau in Neurodegeneration
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Apolipoprotein E ε4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Functional Network Centrality Indicates Interactions between APOE4 and Aging Across the Clinical Spectrum of AD
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Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review
inferred← citeshttps://doi.org/10.1002/dad2.12504openalex-snapshot
Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms
inferred← citeshttps://doi.org/10.1007/s11682-021-00610-9openalex-snapshot
Cholinergic relevant functional reactivity is associated with dopamine responsiveness of tremor in Parkinson’s disease
inferred← citeshttps://doi.org/10.1007/s12031-024-02224-4openalex-snapshot
Multiple Roles of Apolipoprotein E4 in Oxidative Lipid Metabolism and Ferroptosis During the Pathogenesis of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/s12035-023-03245-7openalex-snapshot
The Role of Iron Metabolism, Lipid Metabolism, and Redox Homeostasis in Alzheimer’s Disease: from the Perspective of Ferroptosis
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How molecular imaging studies can disentangle disease mechanisms in age-related neurodegenerative disorders
inferred← citeshttps://doi.org/10.1016/j.nbd.2022.105824openalex-snapshot
Current understanding of the interactions between metal ions and Apolipoprotein E in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.neuint.2024.105773openalex-snapshot
Ferroptosis: A new strategy for targeting Alzheimer’s disease
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Functional network centrality indicates interactions between APOE4 and age across the clinical spectrum of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1038/s41380-022-01568-wopenalex-snapshot
Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy
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Alterations of Brain Functional Networks in Older Adults: A Resting-state fMRI Study Using Graph Theory
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Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease
inferred← citeshttps://doi.org/10.1136/jnnp-2022-330052openalex-snapshot
CSF ferritin in the clinicopathological progression of Alzheimer’s disease and associations with APOE and inflammation biomarkers
inferred← citeshttps://doi.org/10.1142/9789811250477_0012openalex-snapshot
Effects of ApoE4 and ApoE2 genotypes on subcortical magnetic susceptibility and microstructure in 27,535 participants from the UK Biobank
inferred← citeshttps://doi.org/10.1159/000510083openalex-snapshot
Ferroptosis Is Regulated by Mitochondria in Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.1177/10738584231191743openalex-snapshot
The Azalea Hypothesis of Alzheimer Disease: A Functional Iron Deficiency Promotes Neurodegeneration
inferred← citeshttps://doi.org/10.1177/1535370220953065openalex-snapshot
Overdosing on iron: Elevated iron and degenerative brain disorders
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Apolipoprotein E in Alzheimer’s disease: molecular insights and therapeutic opportunities
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Heritability of R2* iron in the basal ganglia and cortex
inferred← citeshttps://doi.org/10.3233/jad-210158openalex-snapshot
The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3233/jpd-223372openalex-snapshot
Nigral Iron Deposition Influences Disease Severity by Modulating the Effect of Parkinson’s Disease on Brain Networks
inferred← citeshttps://doi.org/10.3389/fnagi.2020.00196openalex-snapshot
Spotlight on Ferroptosis: Iron-Dependent Cell Death in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3389/fnagi.2022.830569openalex-snapshot
Iron Dyshomeostasis and Ferroptosis: A New Alzheimer’s Disease Hypothesis?
inferred← citeshttps://doi.org/10.3389/fnagi.2022.888989openalex-snapshot
The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron Metabolism
inferred← citeshttps://doi.org/10.3389/fnagi.2025.1483913openalex-snapshot
Iron responsive elements mRNA regulate Alzheimer’s amyloid precursor protein translation through iron sensing
inferred← citeshttps://doi.org/10.3389/fnagi.2025.1598859openalex-snapshot
Hippocampal iron patterns in aging and mild cognitive impairment
inferred← citeshttps://doi.org/10.3389/fnins.2021.618435openalex-snapshot
Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.3389/fnins.2022.904816openalex-snapshot
Bromodomains in Human-Immunodeficiency Virus-Associated Neurocognitive Disorders: A Model of Ferroptosis-Induced Neurodegeneration
inferred← citeshttps://doi.org/10.3389/fnins.2022.931173openalex-snapshot
Genetic association of apolipoprotein E genotype with EEG alpha rhythm slowing and functional brain network alterations during normal aging
inferred← citeshttps://doi.org/10.3389/fnins.2022.938092openalex-snapshot
Quantitative susceptibility mapping as an imaging biomarker for Alzheimer’s disease: The expectations and limitations
inferred← citeshttps://doi.org/10.3390/antiox11020405openalex-snapshot
CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases
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Iron-Mediated Overexpression of Amyloid Precursor Protein via Iron Responsive mRNA in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/nu15020260openalex-snapshot
The Association between Dietary Iron Intake and Incidence of Dementia in Adults Aged 60 Years or over in the UK Biobank
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Targeting Iron Responsive Elements (IREs) of APP mRNA into Novel Therapeutics to Control the Translation of Amyloid-β Precursor Protein in Alzheimer’s Disease
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