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Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/dvdy.20892openalex-snapshot
Kinetics of tamoxifen‐regulated Cre activity in mice using a cartilage‐specific CreERT to assay temporal activity windows along the proximodistal limb skeleton
inferredcites →https://doi.org/10.1002/dvdy.21846openalex-snapshot
Tamoxifen‐dependent, inducible Hoxb6CreERT recombinase function in lateral plate and limb mesoderm, CNS isthmic organizer, posterior trunk neural crest, hindgut, and tailbud
inferredcites →https://doi.org/10.1002/dvg.20293openalex-snapshot
Eomes::GFP—a tool for live imaging cells of the trophoblast, primitive streak, and telencephalon in the mouse embryo
inferredcites →https://doi.org/10.1002/gene.10092openalex-snapshot
Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer
inferredcites →https://doi.org/10.1016/0092-8674(95)90297-xopenalex-snapshot
Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning
inferredcites →https://doi.org/10.1016/j.cell.2004.07.023openalex-snapshot
Dynamic Changes in the Response of Cells to Positive Hedgehog Signaling during Mouse Limb Patterning
inferredcites →https://doi.org/10.1016/j.cell.2004.07.024openalex-snapshot
Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities
inferredcites →https://doi.org/10.1016/j.devcel.2008.01.008openalex-snapshot
Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud
inferredcites →https://doi.org/10.1016/j.ydbio.2007.05.030openalex-snapshot
Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb
inferredcites →https://doi.org/10.1016/s0092-8674(01)00369-5openalex-snapshot
Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1
inferredcites →https://doi.org/10.1016/s0925-4773(98)00244-5openalex-snapshot
Mapping and expression analysis of the mouse ortholog of Xenopus Eomesodermin
inferredcites →https://doi.org/10.1016/s1534-5807(03)00401-5openalex-snapshot
Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling
inferredcites →https://doi.org/10.1038/374350a0openalex-snapshot
Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb
inferredcites →https://doi.org/10.1038/383407a0openalex-snapshot
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
inferredcites →https://doi.org/10.1038/nature06718openalex-snapshot
Integration of growth and specification in chick wing digit-patterning
inferredcites →https://doi.org/10.1073/pnas.0600124103openalex-snapshot
Cholesterol modification restricts the spread of Shh gradient in the limb bud
inferredcites →https://doi.org/10.1073/pnas.0912818107openalex-snapshot
Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning
inferredcites →https://doi.org/10.1088/1478-3975/6/4/046020openalex-snapshot
When it pays to rush: interpreting morphogen gradients prior to steady-state
inferredcites →https://doi.org/10.1126/science.280.5368.1455openalex-snapshot
Noggin, Cartilage Morphogenesis, and Joint Formation in the Mammalian Skeleton
inferredcites →https://doi.org/10.1126/stke.2592004pe53openalex-snapshot
It Takes Time to Make a Pinky: Unexpected Insights into How SHH Patterns Vertebrate Digits
inferredcites →https://doi.org/10.1242/dev.02001openalex-snapshot
Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning
inferredcites →https://doi.org/10.1242/dev.024158openalex-snapshot
Growing models of vertebrate limb development
inferredcites →https://doi.org/10.1242/dev.036418openalex-snapshot
A BMP-Shhnegative-feedback loop restrictsShhexpression during limb development
inferredcites →https://doi.org/10.1371/journal.pbio.1000202openalex-snapshot
Dynamic Interpretation of Hedgehog Signaling in the Drosophila Wing Disc
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.15298/arctoa.27.01zenodo-depositor-declared
Peristome development pattern in Encalypta poses a problem: what is the primary peristomial layer in mosses?
inferred← citeshttps://doi.org/10.1002/wdev.270openalex-snapshot
The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies
inferred← citeshttps://doi.org/10.1016/j.cell.2013.09.002openalex-snapshot
Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.06.100openalex-snapshot
The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles
inferred← citeshttps://doi.org/10.1016/j.cub.2013.04.071openalex-snapshot
Tracing the Evolution of Avian Wing Digits
inferred← citeshttps://doi.org/10.1016/j.semcdb.2015.12.018openalex-snapshot
The many lives of SHH in limb development and evolution
inferred← citeshttps://doi.org/10.1016/j.ydbio.2013.06.032openalex-snapshot
Evidence that the limb bud ectoderm is required for survival of the underlying mesoderm
inferred← citeshttps://doi.org/10.1016/j.ydbio.2017.02.001openalex-snapshot
John Saunders' ZPA, Sonic hedgehog and digit identity – How does it really all work?
inferred← citeshttps://doi.org/10.1016/j.ydbio.2020.04.009openalex-snapshot
The tissues and regulatory pattern of limb chondrogenesis
inferred← citeshttps://doi.org/10.1038/ncomms12903openalex-snapshot
An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism
inferred← citeshttps://doi.org/10.1038/ncomms1437openalex-snapshot
Insights into bird wing evolution and digit specification from polarizing region fate maps
inferred← citeshttps://doi.org/10.1098/rstb.2019.0660openalex-snapshot
Of mitogens and morphogens: modelling Sonic Hedgehog mechanisms in vertebrate development
inferred← citeshttps://doi.org/10.1101/2020.06.17.158501openalex-snapshot
HES1 is a Critical Mediator of the SHH-GLI3 Axis in Regulating Digit Number
inferred← citeshttps://doi.org/10.1242/dev.200182openalex-snapshot
SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning
inferred← citeshttps://doi.org/10.1371/journal.pgen.1009982openalex-snapshot
HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly
inferred← citeshttps://doi.org/10.3390/diagnostics16020275openalex-snapshot
Anatomical Variations in Bilateral Hand Oligodactyly: A Case Analysis of Cleft Hand
inferred← citeshttps://doi.org/10.64898/2026.04.28.721472openalex-snapshot
Adult regenerative defects arise from discordant scaling of signal dependent growth and patterning
inferred← citeshttps://doi.org/10.7554/elife.07897openalex-snapshot
T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number
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