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HES1 is a Critical Mediator of the SHH-GLI3 Axis in Regulating Digit Number

https://doi.org/10.1101/2020.06.17.158501

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/art.23730openalex-snapshot

Repression of chondrogenesis through binding of notch signaling proteins HES‐1 and HEY‐1 to N‐box domains in the COL2A1 enhancer site

inferredcites →https://doi.org/10.1002/dvdy.20121openalex-snapshot

Levels of Gli3 repressor correlate with Bmp4 expression and apoptosis during limb development

inferredcites →https://doi.org/10.1002/dvdy.22619openalex-snapshot

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

inferredcites →https://doi.org/10.1002/dvdy.22637openalex-snapshot

Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen

inferredcites →https://doi.org/10.1002/gene.10092openalex-snapshot

Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer

inferredcites →https://doi.org/10.1006/dbio.1996.8487openalex-snapshot

SOX9 Binds DNA, Activates Transcription, and Coexpresses with Type II Collagen during Chondrogenesis in the Mouse

inferredcites →https://doi.org/10.1006/dbio.1997.8664openalex-snapshot

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

inferredcites →https://doi.org/10.1006/dbio.2001.0346openalex-snapshot

Manifestation of the Limb Prepattern: Limb Development in the Absence of Sonic Hedgehog Function

inferredcites →https://doi.org/10.1007/978-1-62703-989-5_14openalex-snapshot

Whole-Mount In Situ Hybridization on Murine Skeletogenic Tissues

inferredcites →https://doi.org/10.1007/978-1-62703-989-5_9openalex-snapshot

Whole-Mount Skeletal Staining

inferredcites →https://doi.org/10.1007/s00335-001-2115-xopenalex-snapshot

High-resolution mapping of the Gli3 mutation Extra-toesJ reveals a 51.5-kb deletion

inferredcites →https://doi.org/10.1016/0092-8674(93)90626-2openalex-snapshot

Sonic hedgehog mediates the polarizing activity of the ZPA

inferredcites →https://doi.org/10.1016/0092-8674(94)90030-2openalex-snapshot

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

inferredcites →https://doi.org/10.1016/j.cell.2004.07.024openalex-snapshot

Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

inferredcites →https://doi.org/10.1016/j.devcel.2008.01.008openalex-snapshot

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

inferredcites →https://doi.org/10.1016/j.devcel.2009.02.008openalex-snapshot

FGF-Regulated Etv Genes Are Essential for Repressing Shh Expression in Mouse Limb Buds

inferredcites →https://doi.org/10.1016/j.devcel.2012.01.006openalex-snapshot

GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis

inferredcites →https://doi.org/10.1016/j.mod.2005.06.012openalex-snapshot

Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development

inferredcites →https://doi.org/10.1016/j.ydbio.2004.08.024openalex-snapshot

Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development

inferredcites →https://doi.org/10.1016/j.ydbio.2005.06.017openalex-snapshot

Function and regulation of Alx4 in limb development: Complex genetic interactions with Gli3 and Shh

inferredcites →https://doi.org/10.1016/j.ydbio.2009.02.017openalex-snapshot

A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud

inferredcites →https://doi.org/10.1016/j.ydbio.2014.07.003openalex-snapshot

Dynamics of BMP signaling in limb bud mesenchyme and polydactyly

inferredcites →https://doi.org/10.1016/j.ydbio.2015.07.022openalex-snapshot

Spatiotemporal regulation of GLI target genes in the mammalian limb bud

inferredcites →https://doi.org/10.1016/s0012-1606(03)00360-9openalex-snapshot

A role for hairy1 in regulating chick limb bud growth

inferredcites →https://doi.org/10.1016/s0092-8674(00)80678-9openalex-snapshot

Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

inferredcites →https://doi.org/10.1016/s0092-8674(01)00369-5openalex-snapshot

Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1

inferredcites →https://doi.org/10.1016/s0925-4773(00)00492-5openalex-snapshot

Some distal limb structures develop in mice lacking Sonic hedgehog signaling

inferredcites →https://doi.org/10.1016/s1534-5807(03)00401-5openalex-snapshot

Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling

inferredcites →https://doi.org/10.1038/371609a0openalex-snapshot

A positive feedback loop coordinates growth and patterning in the vertebrate limb

inferredcites →https://doi.org/10.1038/383407a0openalex-snapshot

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

inferredcites →https://doi.org/10.1038/82601openalex-snapshot

Fgf8 is required for outgrowth and patterning of the limbs

inferredcites →https://doi.org/10.1038/nature00902openalex-snapshot

Functions of FGF signalling from the apical ectodermal ridge in limb development

inferredcites →https://doi.org/10.1038/nature01033openalex-snapshot

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

inferredcites →https://doi.org/10.1038/nature05247openalex-snapshot

Regulatory constraints in the evolution of the tetrapod limb anterior–posterior polarity

inferredcites →https://doi.org/10.1038/nature06718openalex-snapshot

Integration of growth and specification in chick wing digit-patterning

inferredcites →https://doi.org/10.1038/ng0393-241openalex-snapshot

A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene

inferredcites →https://doi.org/10.1083/jcb.200805155openalex-snapshot

Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity

inferredcites →https://doi.org/10.1093/emboj/18.8.2196openalex-snapshot

Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

inferredcites →https://doi.org/10.1101/gad.12.17.2735openalex-snapshot

Pax9 -deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities

inferredcites →https://doi.org/10.1101/gad.1693008openalex-snapshot

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

inferredcites →https://doi.org/10.1101/gad.1823109openalex-snapshot

The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells

inferredcites →https://doi.org/10.1101/gad.219202openalex-snapshot

Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling

inferredcites →https://doi.org/10.1126/science.1075620openalex-snapshot

Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3

inferredcites →https://doi.org/10.1126/science.1096049openalex-snapshot

A Dual Role for Hox Genes in Limb Anterior-Posterior Asymmetry

inferredcites →https://doi.org/10.1159/000324747openalex-snapshot

Regulation of Bmp4 Expression in Odontogenic Mesenchyme: From Simple to Complex

inferredcites →https://doi.org/10.1242/bio.023218openalex-snapshot

A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development

inferredcites →https://doi.org/10.1242/dev.02172openalex-snapshot

IncreasingFgf4expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss ofFgf8function

inferredcites →https://doi.org/10.1242/dev.02529openalex-snapshot

Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling

inferredcites →https://doi.org/10.1242/dev.042911openalex-snapshot

RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

inferredcites →https://doi.org/10.1242/dev.051789openalex-snapshot

Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb

inferredcites →https://doi.org/10.1242/dev.099028openalex-snapshot

Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis

inferredcites →https://doi.org/10.1242/dev.124.22.4523openalex-snapshot

Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop

inferredcites →https://doi.org/10.1242/dev.127.11.2461openalex-snapshot

The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development

inferredcites →https://doi.org/10.1242/dev.173328openalex-snapshot

Molecular signatures identify immature mesenchymal progenitors in early mouse limb buds that respond differentially to morphogen signaling

inferredcites →https://doi.org/10.1242/jcs.181271openalex-snapshot

HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development

inferredcites →https://doi.org/10.1371/journal.pgen.1000901openalex-snapshot

Distinct Roles of Hand2 in Initiating Polarity and Posterior Shh Expression during the Onset of Mouse Limb Bud Development

inferredcites →https://doi.org/10.1371/journal.pgen.1003467openalex-snapshot

Tbx2 Terminates Shh/Fgf Signaling in the Developing Mouse Limb Bud by Direct Repression of Gremlin1

inferredcites →https://doi.org/10.1371/journal.pgen.1004072openalex-snapshot

GATA6 Is a Crucial Regulator of Shh in the Limb Bud

inferredcites →https://doi.org/10.1371/journal.pgen.1007738openalex-snapshot

Unraveling the transcriptional regulation of TWIST1 in limb development

inferredcites →https://doi.org/10.1387/ijdb.051984lpopenalex-snapshot

Genetic interaction of Gli3 and Alx4 during limb development

inferredcites →https://doi.org/10.3727/096504016x14685034103833openalex-snapshot

Overexpression of Aristaless-Like Homeobox-4 Inhibits Proliferation, Invasion, and EMT in Hepatocellular Carcinoma Cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.70675/059b4951z271fz4649za800z1b92769ff8e2openalex-snapshot

Role of SWI/SNF chromatin-remodeling complexes in tumorigenesis : insights in dedifferentiated melanoma and renal medullary carcinoma

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