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Hepatocellular Carcinoma‐Associated Protein TD26 Interacts and Enhances Sterol Regulatory Element‐Binding Protein 1 Activity to Promote Tumor Cell Proliferation and Growth

https://doi.org/10.1002/hep.30030
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/dmrr.2919openalex-snapshot
ANGPTL8 (betatrophin) role in diabetes and metabolic diseases
inferredcites →https://doi.org/10.1002/hep.28574openalex-snapshot
Metallothionein‐1G facilitates sorafenib resistance through inhibition of ferroptosis
inferredcites →https://doi.org/10.1002/ijc.20363openalex-snapshot
Identification of genes differentially expressed in human hepatocellular carcinoma by a modified suppression subtractive hybridization method
inferredcites →https://doi.org/10.1007/s00125-014-3346-1openalex-snapshot
An explanation for recent discrepancies in levels of human circulating betatrophin
inferredcites →https://doi.org/10.1007/s00261-017-1209-1openalex-snapshot
Epidemiology of hepatocellular carcinoma: target population for surveillance and diagnosis
inferredcites →https://doi.org/10.1016/0092-8674(94)90234-8openalex-snapshot
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
inferredcites →https://doi.org/10.1016/j.abb.2010.06.004openalex-snapshot
Sterol metabolism and SREBP activation
inferredcites →https://doi.org/10.1016/j.canlet.2015.06.019openalex-snapshot
Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma
inferredcites →https://doi.org/10.1016/j.cell.2014.09.027openalex-snapshot
ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion
inferredcites →https://doi.org/10.1016/j.chembiol.2009.07.007openalex-snapshot
A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP
inferredcites →https://doi.org/10.1016/j.cmet.2008.07.007openalex-snapshot
SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
inferredcites →https://doi.org/10.1016/j.cmet.2010.12.004openalex-snapshot
Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques
inferredcites →https://doi.org/10.1016/j.cmet.2011.03.009openalex-snapshot
AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
inferredcites →https://doi.org/10.1016/j.cmet.2011.06.002openalex-snapshot
Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
inferredcites →https://doi.org/10.1016/j.cmet.2012.09.002openalex-snapshot
Expanding Roles for SREBP in Metabolism
inferredcites →https://doi.org/10.1016/j.ymgme.2016.04.007openalex-snapshot
The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and differentially affects cleavage of ANGPTL3
inferredcites →https://doi.org/10.1016/s0899-9007(99)00266-xopenalex-snapshot
Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology
inferredcites →https://doi.org/10.1038/nature07943openalex-snapshot
The cancer genome
inferredcites →https://doi.org/10.1038/nature08987openalex-snapshot
International network of cancer genome projects
inferredcites →https://doi.org/10.1038/nrc1478openalex-snapshot
Why do cancers have high aerobic glycolysis?
inferredcites →https://doi.org/10.1038/nrc2222openalex-snapshot
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
inferredcites →https://doi.org/10.1038/nrendo.2017.91openalex-snapshot
SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology
inferredcites →https://doi.org/10.1038/onc.2015.123openalex-snapshot
Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells
inferredcites →https://doi.org/10.1038/s41467-017-02355-wopenalex-snapshot
ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ
inferredcites →https://doi.org/10.1038/srep10949openalex-snapshot
Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance
inferredcites →https://doi.org/10.1053/j.gastro.2008.02.090openalex-snapshot
Diagnosis and Treatment of Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1053/j.gastro.2010.12.006openalex-snapshot
Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1056/nejmoa0708857openalex-snapshot
Sorafenib in Advanced Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1073/pnas.1217552109openalex-snapshot
Atypical angiopoietin-like protein that regulates ANGPTL3
inferredcites →https://doi.org/10.1097/01.mco.0000232894.28674.30openalex-snapshot
Increased lipogenesis in cancer cells: new players, novel targets
inferredcites →https://doi.org/10.1111/cas.12085openalex-snapshot
Cancer metabolism: Key players in metabolic reprogramming
inferredcites →https://doi.org/10.1111/j.1365-2036.2009.04200.xopenalex-snapshot
Review article: the management of hepatocellular carcinoma
inferredcites →https://doi.org/10.1124/jpet.110.175786openalex-snapshot
Activation of Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Mediates Acquired Resistance to Sorafenib in Hepatocellular Carcinoma Cells
inferredcites →https://doi.org/10.1126/scisignal.2000446openalex-snapshot
EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy
inferredcites →https://doi.org/10.1152/ajpendo.00084.2012openalex-snapshot
Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism
inferredcites →https://doi.org/10.1158/0008-5472.can-13-0382-topenalex-snapshot
An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
inferredcites →https://doi.org/10.1158/1535-7163.mct-10-0802openalex-snapshot
Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation
inferredcites →https://doi.org/10.1172/jci0215593openalex-snapshot
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
inferredcites →https://doi.org/10.1186/s40170-016-0156-6openalex-snapshot
Metabolic requirements for cancer cell proliferation
inferredcites →https://doi.org/10.1371/journal.pone.0147367openalex-snapshot
Circulating ANGPTL8/Betatrophin Is Increased in Obesity and Reduced after Exercise Training
inferredcites →https://doi.org/10.18632/oncotarget.10721openalex-snapshot
Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells
inferredcites →https://doi.org/10.18632/oncotarget.21852openalex-snapshot
Circulating betatrophin is associated with insulin resistance in humans: cross-sectional and interventional studiesin vivoandin vitro
inferredcites →https://doi.org/10.3390/ijms15057124openalex-snapshot
SREBP-1 Has a Prognostic Role and Contributes to Invasion and Metastasis in Human Hepatocellular Carcinoma
inferredcites →https://doi.org/10.3390/ijms151223640openalex-snapshot
Emerging Regulation and Function of Betatrophin
inferredcites →https://doi.org/10.3748/wjg.v21.i37.10662openalex-snapshot
Plasma betatrophin levels in patients with liver cirrhosis
inferredcites →https://doi.org/10.3748/wjg.v22.i45.9933openalex-snapshot
Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects
inferredcites →https://doi.org/10.3892/or.2015.4380openalex-snapshot
Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo
inferredcites →https://doi.org/10.4161/auto.26126openalex-snapshot
Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism
inferredcites →https://doi.org/10.4161/cbt.5.8.2883openalex-snapshot
Growth arrest induced by C75, A fatty acid synthase inhibitor, Was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Linggui Zhugan Decoction Delayed the Progression of NAFLD-HCC by Regulating Fatty Acid Metabolism Through AKT/mTOR/SREBP-1/SCD-1 Signaling Pathway
inferred← citeshttps://doi.org/10.1002/advs.202305902openalex-snapshot
A Mammalian Conserved Circular RNA CircLARP1B Regulates Hepatocellular Carcinoma Metastasis and Lipid Metabolism
inferred← citeshttps://doi.org/10.1002/jcp.30534openalex-snapshot
Emerging roles of angiopoietin‐like proteins in inflammation: Mechanisms and potential as pharmacological targets
inferred← citeshttps://doi.org/10.1002/mog2.70081openalex-snapshot
Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies
inferred← citeshttps://doi.org/10.1002/path.5530openalex-snapshot
ZHX2 inhibits SREBP1c ‐mediated de novo lipogenesis in hepatocellular carcinoma via miR ‐24‐3p
inferred← citeshttps://doi.org/10.1007/s00592-024-02335-9openalex-snapshot
Hepatokines: unveiling the molecular and cellular mechanisms connecting hepatic tissue to insulin resistance and inflammation
inferred← citeshttps://doi.org/10.1007/s10555-023-10156-5openalex-snapshot
Regulation and targeting of SREBP-1 in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s11033-021-06270-8openalex-snapshot
ANGPTL8 roles in proliferation, metabolic diseases, hypothyroidism, polycystic ovary syndrome, and signaling pathways
inferred← citeshttps://doi.org/10.1007/s12272-022-01419-wopenalex-snapshot
Non-alcoholic fatty liver disease and liver secretome
inferred← citeshttps://doi.org/10.1016/j.bbr.2025.115782openalex-snapshot
The impact of a high-fat diet (HFD) on mouse behavior, neurotransmitters, inflammation, and gut-brain axis metabolism under hypoxic conditions
inferred← citeshttps://doi.org/10.1016/j.canlet.2019.08.014openalex-snapshot
Clinical lipidomics in understanding of lung cancer: Opportunity and challenge
inferred← citeshttps://doi.org/10.1016/j.canlet.2025.217469openalex-snapshot
LCAT deficiency promotes hepatocellular carcinoma progression and lenvatinib resistance by promoting triglyceride catabolism and fatty acid oxidation
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.114986openalex-snapshot
Cadmium exposure impairs skeletal muscle function by altering lipid signature and inducing inflammation in C57BL/6J mice
inferred← citeshttps://doi.org/10.1016/j.envint.2021.106406openalex-snapshot
Cadmium exposure impairs pancreatic β-cell function and exaggerates diabetes by disrupting lipid metabolism
inferred← citeshttps://doi.org/10.1016/j.genrep.2021.101306openalex-snapshot
The effect of ANGPTL8 protein on proliferation and apoptosis in HepG2 hepatocellular carcinoma cell line
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e27739openalex-snapshot
Role of the angiopoietin-like protein family in the progression of NAFLD
inferred← citeshttps://doi.org/10.1016/j.jare.2022.08.006openalex-snapshot
ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2/ERK signaling pathways
inferred← citeshttps://doi.org/10.1016/j.jep.2024.118663openalex-snapshot
A study on the effects of metacinnabar (β-HgS) on weight and appetite recovery in stressed mice
inferred← citeshttps://doi.org/10.1016/j.jhep.2020.10.030openalex-snapshot
Hepatokines and adipokines in NASH-related hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.jhep.2025.08.022openalex-snapshot
Alcohol activates ATF4/LPLA2-mediated BMP metabolism to enhance HBV-induced hepatocellular carcinogenesis
inferred← citeshttps://doi.org/10.1016/j.jhepr.2023.100811openalex-snapshot
Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.molmet.2020.101131openalex-snapshot
LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases
inferred← citeshttps://doi.org/10.1016/j.molmet.2022.101540openalex-snapshot
A novel lncRNA RP11-386G11.10 reprograms lipid metabolism to promote hepatocellular carcinoma progression
inferred← citeshttps://doi.org/10.1038/s41388-022-02477-6openalex-snapshot
The NQO1/p53/SREBP1 axis promotes hepatocellular carcinoma progression and metastasis by regulating Snail stability
inferred← citeshttps://doi.org/10.1038/s41418-024-01422-2openalex-snapshot
Angiopoietin-like protein 8 directs DNA damage responses towards apoptosis by stabilizing PARP1-DNA condensates
inferred← citeshttps://doi.org/10.1038/s41419-025-07707-9openalex-snapshot
MARCH8 suppresses hepatocellular carcinoma by promoting SREBP1 degradation and modulating fatty acid de novo synthesis
inferred← citeshttps://doi.org/10.1038/s41419-025-08250-3openalex-snapshot
Targeting CREB3L2-mediated lipid metabolism overcomes lenvatinib resistance and attenuates the progression of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1089/hum.2018.095openalex-snapshot
Oncolytic Activity of a Novel Influenza A Virus Carrying Granulocyte-Macrophage Colony-Stimulating Factor in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1093/cvr/cvad089openalex-snapshot
Vascular smooth muscle cells specific deletion of angiopoietin-like protein 8 prevents angiotensin II-promoted hypertension and cardiovascular hypertrophy
inferred← citeshttps://doi.org/10.1096/fj.202503400rropenalex-snapshot
Time‐Dependent Multisystem Effects of Small Independent Space ( SIS ) Exposure in Mice: Integrative Analysis of Behavior, Neuroendocrine, Gut Microbiota, and Hippocampal Function
inferred← citeshttps://doi.org/10.1111/cns.70433openalex-snapshot
A Study of Sex Differences in the Biological Pathways of Stress Regulation in Mice
inferred← citeshttps://doi.org/10.1155/ije/9009628openalex-snapshot
Adipokine in Metabolic Liver Disease: Adipo–Brain–Liver Cross talk
inferred← citeshttps://doi.org/10.1158/0008-5472.can-22-2156openalex-snapshot
PRP19 Enhances Esophageal Squamous Cell Carcinoma Progression by Reprogramming SREBF1-Dependent Fatty Acid Metabolism
inferred← citeshttps://doi.org/10.1186/s12882-021-02268-3openalex-snapshot
Using circulating O-sulfotyrosine in the differential diagnosis of acute kidney injury and chronic kidney disease
inferred← citeshttps://doi.org/10.1186/s12891-025-08725-6openalex-snapshot
High-fat diet-induced osteoporosis in mice under hypoxic conditions
inferred← citeshttps://doi.org/10.1186/s12944-021-01572-zopenalex-snapshot
Revealing potential lipid biomarkers in clear cell renal cell carcinoma using targeted quantitative lipidomics
inferred← citeshttps://doi.org/10.1186/s13046-021-02211-2openalex-snapshot
Lipid reprogramming induced by the TFEB-ERRα axis enhanced membrane fluidity to promote EC progression
inferred← citeshttps://doi.org/10.1186/s13578-025-01487-7openalex-snapshot
Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome
inferred← citeshttps://doi.org/10.1530/joe-19-0447openalex-snapshot
Betatrophin knockdown induces beiging and mitochondria biogenesis of white adipocytes
inferred← citeshttps://doi.org/10.18632/aging.205142openalex-snapshot
Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression
inferred← citeshttps://doi.org/10.20517/mtod.2025.03openalex-snapshot
Lipid metabolism in liver transplantation: from challenge to chance
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5305970/v1openalex-snapshot
DysUFMylation of SREBP1 promotes the progression of hepatocellular carcinoma by reprogramming lipid metabolism
inferred← citeshttps://doi.org/10.21203/rs.3.rs-882595/v1openalex-snapshot
Lipid Reprogramming Induced by TFEB-ERRα Axis Enhanced Membrane Fluidity to Promote EC Progression
inferred← citeshttps://doi.org/10.2147/ott.s282906openalex-snapshot
Biological Behavior and Lipid Metabolism of Colon Cancer Cells are Regulated by a Combination of Sterol Regulatory Element-Binding Protein 1 and ATP Citrate Lyase
inferred← citeshttps://doi.org/10.3340/jkns.2021.0298openalex-snapshot
EID3 Promotes Glioma Cell Proliferation and Survival by Inactivating AMPKα1
inferred← citeshttps://doi.org/10.3389/fcvm.2023.1119005openalex-snapshot
The regulatory role of metabolic organ-secreted factors in the nonalcoholic fatty liver disease and cardiovascular disease
inferred← citeshttps://doi.org/10.3389/fphar.2025.1528671openalex-snapshot
Research advances in traditional Chinese medicine formulae and active components targeting lipid metabolism for hepatocellular carcinoma therapy
inferred← citeshttps://doi.org/10.3389/fphys.2023.1275485openalex-snapshot
Emerging insights into the roles of ANGPTL8 beyond glucose and lipid metabolism
inferred← citeshttps://doi.org/10.3390/biomedicines9121903openalex-snapshot
Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism
inferred← citeshttps://doi.org/10.3390/foods12081707openalex-snapshot
The Study of Yak Colostrum Nutritional Content Based on Foodomics
inferred← citeshttps://doi.org/10.3390/ijms22094495openalex-snapshot
Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC
inferred← citeshttps://doi.org/10.3390/life12101563openalex-snapshot
Identification of Two GDSL-Type Esterase/Lipase Genes Related to Tissue-Specific Lipolysis in Dendrobium catenatum by Multi-Omics Analysis
inferred← citeshttps://doi.org/10.6084/m9.figshare.17006877openalex-snapshot
Additional file 1 of Revealing potential lipid biomarkers in clear cell renal cell carcinoma using targeted quantitative lipidomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.17006880openalex-snapshot
Additional file 2 of Revealing potential lipid biomarkers in clear cell renal cell carcinoma using targeted quantitative lipidomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.17006883openalex-snapshot
Additional file 3 of Revealing potential lipid biomarkers in clear cell renal cell carcinoma using targeted quantitative lipidomics
inferred← citeshttps://doi.org/10.62347/yavk1315openalex-snapshot
Will AMPK be a potential therapeutic target for hepatocellular carcinoma?
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