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ZHX2 inhibits SREBP1c ‐mediated de novo lipogenesis in hepatocellular carcinoma via miR ‐24‐3p
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/hep.21825openalex-snapshot
The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha-fetoprotein regulator 2
inferredcites →https://doi.org/10.1002/hep.27396openalex-snapshot
4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N‐Ras proto‐oncogenes in mice
inferredcites →https://doi.org/10.1002/hep.27969openalex-snapshot
World‐wide relative contribution of hepatitis B and C viruses in hepatocellular carcinoma
inferredcites →https://doi.org/10.1002/hep.28368openalex-snapshot
Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study
inferredcites →https://doi.org/10.1002/hep.30030openalex-snapshot
Hepatocellular Carcinoma‐Associated Protein TD26 Interacts and Enhances Sterol Regulatory Element‐Binding Protein 1 Activity to Promote Tumor Cell Proliferation and Growth
inferredcites →https://doi.org/10.1002/ijc.31595openalex-snapshot
HBV suppresses ZHX2 expression to promote proliferation of HCC through miR‐155 activation
inferredcites →https://doi.org/10.1002/jcb.28568openalex-snapshot
Overexpression miR‐24‐3p repressed Bim expression to confer tamoxifen resistance in breast cancer
inferredcites →https://doi.org/10.1007/s00335-019-09811-6openalex-snapshot
Liver size and lipid content differences between BALB/c and BALB/cJ mice on a high-fat diet are due, in part, to Zhx2
inferredcites →https://doi.org/10.1016/j.ajpath.2017.02.016openalex-snapshot
miR-24-3p Is Overexpressed in Hodgkin Lymphoma and Protects Hodgkin and Reed-Sternberg Cells from Apoptosis
inferredcites →https://doi.org/10.1016/j.biocel.2014.08.021openalex-snapshot
Reduced nucleic ZHX2 involves in oncogenic activation of glypican 3 in human hepatocellular carcinoma
inferredcites →https://doi.org/10.1016/j.canlet.2014.10.011openalex-snapshot
The emerging roles of microRNAs in cancer metabolism
inferredcites →https://doi.org/10.1016/j.ccell.2017.11.011openalex-snapshot
mTORC2 Promotes Tumorigenesis via Lipid Synthesis
inferredcites →https://doi.org/10.1016/j.cell.2011.02.013openalex-snapshot
Hallmarks of Cancer: The Next Generation
inferredcites →https://doi.org/10.1016/j.cmet.2017.01.016openalex-snapshot
Lipid Metabolism Fuels Cancer’s Spread
inferredcites →https://doi.org/10.1016/j.ebiom.2020.102676openalex-snapshot
ZHX2 restricts hepatocellular carcinoma by suppressing stem cell-like traits through KDM2A-mediated H3K36 demethylation
inferredcites →https://doi.org/10.1016/j.ejca.2004.12.037openalex-snapshot
Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma
inferredcites →https://doi.org/10.1016/j.jhep.2015.07.039openalex-snapshot
CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways
inferredcites →https://doi.org/10.1016/j.semcancer.2011.01.001openalex-snapshot
Zhx2 and Zbtb20: Novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer
inferredcites →https://doi.org/10.1038/nature11743openalex-snapshot
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
inferredcites →https://doi.org/10.1038/nrc.2016.89openalex-snapshot
The multifaceted roles of fatty acid synthesis in cancer
inferredcites →https://doi.org/10.1038/s41418-019-0453-zopenalex-snapshot
Tumor suppressor ZHX2 inhibits NAFLD–HCC progression via blocking LPL-mediated lipid uptake
inferredcites →https://doi.org/10.1038/srep44847openalex-snapshot
The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells
inferredcites →https://doi.org/10.1053/j.gastro.2010.12.006openalex-snapshot
Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1053/j.gastro.2012.02.049openalex-snapshot
Zinc Fingers and Homeoboxes 2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Represses Expression of Cyclins A and E
inferredcites →https://doi.org/10.1073/pnas.0408555102openalex-snapshot
Hereditary persistence of α-fetoprotein and H19 expression in liver of BALB/cJ mice is due to a retrovirus insertion in the Zhx2 gene
inferredcites →https://doi.org/10.1073/pnas.1307237110openalex-snapshot
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
inferredcites →https://doi.org/10.1093/molbev/msu323openalex-snapshot
Functional Conservation of Both CDS- and 3′-UTR-Located MicroRNA Binding Sites between Species
inferredcites →https://doi.org/10.1111/j.1582-4934.2008.00233.xopenalex-snapshot
ZHX2 is a repressor of α‐fetoprotein expression in human hepatoma cell lines
inferredcites →https://doi.org/10.1128/mcb.24.18.8288-8300.2004openalex-snapshot
Selective Coactivator Interactions in Gene Activation by SREBP-1a and -1c
inferredcites →https://doi.org/10.1158/0008-5472.can-09-3871openalex-snapshot
De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
inferredcites →https://doi.org/10.1158/0008-5472.can-18-0655openalex-snapshot
A Polysome-Based microRNA Screen Identifies miR-24-3p as a Novel Promigratory miRNA in Mesothelioma
inferredcites →https://doi.org/10.1159/000481244openalex-snapshot
Systemic Therapy for Hepatocellular Carcinoma: 2017 Update
inferredcites →https://doi.org/10.1161/circgenetics.109.902320openalex-snapshot
Quantitative Trait Locus Mapping and Identification of Zhx2 as a Novel Regulator of Plasma Lipid Metabolism
inferredcites →https://doi.org/10.1172/jci0215593openalex-snapshot
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
inferredcites →https://doi.org/10.1172/jci15593openalex-snapshot
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
inferredcites →https://doi.org/10.18632/oncotarget.24403openalex-snapshot
Prognostic role of elevated mir-24-3p in breast cancer and its association with the metastatic process
inferredcites →https://doi.org/10.18632/oncotarget.2832openalex-snapshot
ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA
inferredcites →https://doi.org/10.20517/2394-5079.2018.51openalex-snapshot
Fat and hepatocellular carcinoma
inferredcites →https://doi.org/10.25405/ncl.34294743openalex-snapshot
Microarray expression profiling identifies genes, including cytokines, and biofunctions, as diapedesis, associated with a brain metastasis from a papillary thyroid carcinoma
inferredcites →https://doi.org/10.3233/cbm-190514openalex-snapshot
ZHX2 inhibits proliferation and promotes apoptosis of human lung cancer cells through targeting p38MAPK pathway
inferredcites →https://doi.org/10.3390/cancers10110447openalex-snapshot
Lipid Metabolic Reprogramming in Hepatocellular Carcinoma
inferredcites →https://doi.org/10.3892/ijo.2015.2855openalex-snapshot
Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer
inferredcites →https://doi.org/10.4149/neo_2018_180806n593openalex-snapshot
Targeting genes and signaling pathways of transcriptional suppressor ZHX2 in hepatocellular carcinoma: a Chromatin Immunoprecipitation-sequencing (ChIP-seq) investigation
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4665445openalex-extracted
Linggui Zhugan Decoction Delayed the Progression of NAFLD-HCC by Regulating Fatty Acid Metabolism Through AKT/mTOR/SREBP-1/SCD-1 Signaling Pathway
inferred← citeshttps://doi.org/10.1002/2211-5463.13391openalex-snapshot
Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells
inferred← citeshttps://doi.org/10.1002/hep.32165openalex-snapshot
The transcription factor zinc fingers and homeoboxes 2 alleviates NASH by transcriptional activation of phosphatase and tensin homolog
inferred← citeshttps://doi.org/10.1002/hep4.2106openalex-snapshot
Zinc fingers and homeoboxes 2 is required for diethylnitrosamine‐induced liver tumor formation in C57BL/6 mice
inferred← citeshttps://doi.org/10.1002/mc.23801openalex-snapshot
STAMBPL1, transcriptionally regulated by SREBP1, promotes malignant behaviors of hepatocellular carcinoma cells via Wnt/β‐catenin signaling pathway
inferred← citeshttps://doi.org/10.1007/s00018-025-05801-xopenalex-snapshot
Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation
inferred← citeshttps://doi.org/10.1007/s00204-025-04052-wopenalex-snapshot
Lipogenesis and MASLD: re-thinking the role of SREBPs
inferred← citeshttps://doi.org/10.1007/s12672-024-01069-yopenalex-snapshot
Role of lipid metabolism in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s42764-022-00078-xopenalex-snapshot
MicroRNA-mediated reprogramming of glucose, fatty acid and amino acid metabolism in cancer
inferred← citeshttps://doi.org/10.1016/j.bbrc.2026.153846openalex-snapshot
MicroRNA clusters as regulators in progressive fatty liver disease Spectrum: from mechanistic insights to therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.116021openalex-snapshot
Targeting metabolic reprogramming in hepatocellular carcinoma to overcome therapeutic resistance: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.cbd.2024.101202openalex-snapshot
miRNA-seq analysis of liver tissue from largemouth bass (Micropterus salmoides) in response to oxytetracycline and enzyme-treated soy protein
inferred← citeshttps://doi.org/10.1016/j.drup.2025.101275openalex-snapshot
Hypoxia-induced upregulation of HIF1A-AS3 promotes MSC transition to cancer-associated fibroblasts and confers drug resistance in gastric cancer
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.177890openalex-snapshot
Effectiveness and safety of the SREBP1/2 inhibitor, fatostatin, in a preclinical model of metabolic dysfunction-associated steatotic liver disease progression
inferred← citeshttps://doi.org/10.1016/j.fct.2024.114631openalex-snapshot
Toosendanin induces hepatotoxicity via disrupting LXRα/Lipin1/SREBP1 mediated lipid metabolism
inferred← citeshttps://doi.org/10.1016/j.tem.2023.02.007openalex-snapshot
ncRNA-mediated fatty acid metabolism reprogramming in HCC
inferred← citeshttps://doi.org/10.1038/s41401-021-00819-wopenalex-snapshot
The miR-23–27–24 cluster: an emerging target in NAFLD pathogenesis
inferred← citeshttps://doi.org/10.1038/s41420-022-01234-8openalex-snapshot
LINC01468 drives NAFLD-HCC progression through CUL4A-linked degradation of SHIP2
inferred← citeshttps://doi.org/10.1038/s41420-023-01548-1openalex-snapshot
Cooperative regulation of Zhx1 and hnRNPA1 drives the cardiac progenitor-specific transcriptional activation during cardiomyocyte differentiation
inferred← citeshttps://doi.org/10.1038/s41420-023-01593-wopenalex-snapshot
Characterization of circSEC11A as a novel regulator of Iodine-125 radioactive seed-induced anticancer effects in hepatocellular carcinoma via targeting ZHX2/GADD34 axis
inferred← citeshttps://doi.org/10.1038/s41467-023-43439-0openalex-snapshot
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury
inferred← citeshttps://doi.org/10.1055/s-0041-1731709openalex-snapshot
Role of Lipogenesis Rewiring in Hepatocellular Carcinoma.
inferred← citeshttps://doi.org/10.1096/fj.202101975ropenalex-snapshot
Mesencephalic astrocyte‐derived neurotrophic factor alleviates non‐alcoholic steatohepatitis induced by Western diet in mice
inferred← citeshttps://doi.org/10.1111/jcmm.70441openalex-snapshot
IRX5 Promoted SREBP1 ‐Mediated de Novo Fatty Acid Synthesis via HMGN4 in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1158/0008-5472.can-22-0917openalex-snapshot
Metabolic Reprogramming in Hematologic Malignancies: Advances and Clinical Perspectives
inferred← citeshttps://doi.org/10.1159/000540483openalex-snapshot
METTL3 and IGF2BP1-Mediated m6A Modification of ZHX2 Promotes Tumor Property of Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.12677/md.2025.153036openalex-snapshot
Advances in the Study of Exosomal MicroRNAs in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.15212/amm-2024-0057openalex-snapshot
Bioinformatics-based analysis of fatty acid metabolic reprogramming in hepatocellular carcinoma: cellular heterogeneity, therapeutic targets, and drug discovery
inferred← citeshttps://doi.org/10.15212/amm-2025-0001openalex-snapshot
Therapeutic strategies targeting SREBP transcription factors: an update to 2024
inferred← citeshttps://doi.org/10.2147/jhc.s450423openalex-snapshot
Lipid Metabolism as a Potential Target of Liver Cancer
inferred← citeshttps://doi.org/10.3389/fonc.2021.796152openalex-snapshot
Inhibition of SREBP-1 Activation by a Novel Small-Molecule Inhibitor Enhances the Sensitivity of Hepatocellular Carcinoma Tissue to Radiofrequency Ablation
inferred← citeshttps://doi.org/10.3389/fonc.2022.952371openalex-snapshot
Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer
inferred← citeshttps://doi.org/10.3389/fphar.2023.1336216openalex-snapshot
Pharmacological therapy of metabolic dysfunction-associated steatotic liver disease-driven hepatocellular carcinoma
inferred← citeshttps://doi.org/10.3389/fphys.2023.1129889openalex-snapshot
The functions and roles of C2H2 zinc finger proteins in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.3390/biomedicines11123280openalex-snapshot
SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies
inferred← citeshttps://doi.org/10.3390/cancers13153740openalex-snapshot
The Emerging Factors and Treatment Options for NAFLD-Related Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.3390/ijms231911167openalex-snapshot
Zinc Fingers and Homeobox Family in Cancer: A Double-Edged Sword
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