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Berberine: A potential adjunct for the treatment of gastrointestinal cancers?
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2 of the 103 references listed on this page are in the Retraction Watch database as retracted (export 2026-11-04): 10.1093/carcin/bgl043 (notice 2018-04-20), 10.1371/journal.pone.0123478 (notice 2025-07-14).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jamaoncol.2016.5688openalex-snapshotGlobal, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015
inferredcites →https://doi.org/10.1002/ijc.10338openalex-snapshotAnticachectic effects of the natural herb Coptidis rhizoma and berberine on mice bearing colon 26/clone 20 adenocarcinoma
inferredcites →https://doi.org/10.1002/ijc.30292openalex-snapshotInforming etiologic research priorities for squamous cell esophageal cancer in Africa: A review of setting‐specific exposures to known and putative risk factors
inferredcites →https://doi.org/10.1002/jcb.22198openalex-snapshotThe combination of berberine and irradiation enhances anti‐cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells
inferredcites →https://doi.org/10.1002/mc.22179openalex-snapshotBerberine regulates AMP‐activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice
inferredcites →https://doi.org/10.1002/ptr.3586openalex-snapshotBerberine Inhibits Pulmonary Metastasis through Down‐regulation of MMP in Metastatic B16F‐10 Melanoma Cells
inferredcites →https://doi.org/10.1007/s00044-013-0844-5openalex-snapshotSynergistic effects of berberines with antibiotics on clinical multi-drug resistant isolates of methicillin-resistant Staphylococcus aureus (MRSA)
inferredcites →https://doi.org/10.1007/s00204-006-0169-yopenalex-snapshotBerberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL
inferredcites →https://doi.org/10.1016/j.bcp.2011.11.008openalex-snapshotBerberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression
inferredcites →https://doi.org/10.1016/j.canlet.2009.01.033openalex-snapshotBerberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-κB, u-PA and MMP-2 and -9
inferredcites →https://doi.org/10.1016/j.canlet.2016.02.032openalex-snapshotHelicobacter pylori upregulates Nanog and Oct4 via Wnt/β-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer
inferredcites →https://doi.org/10.1016/j.ejphar.2013.02.041openalex-snapshotEffect of berberine on cell cycle arrest and cell survival during cerebral ischemia and reperfusion and correlations with p53/cyclin D1 and PI3K/Akt
inferredcites →https://doi.org/10.1016/j.neulet.2017.06.048openalex-snapshotThe neuroprotective effects of Berberine against amyloid β-protein-induced apoptosis in primary cultured hippocampal neurons via mitochondria-related caspase pathway
inferredcites →https://doi.org/10.1016/j.pharep.2017.06.006openalex-snapshotBerberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation
inferredcites →https://doi.org/10.1016/j.phrs.2016.04.021openalex-snapshotThe effects of a nutraceutical combination on plasma lipids and glucose: A systematic review and meta -analysis of randomized controlled trials
inferredcites →https://doi.org/10.1016/j.taap.2005.11.010openalex-snapshotInhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2
inferredcites →https://doi.org/10.1016/j.tiv.2010.07.017openalex-snapshotCytotoxicity of berberine on human cervical carcinoma HeLa cells through mitochondria, death receptor and MAPK pathways, and in-silico drug-target prediction
inferredcites →https://doi.org/10.1016/j.tox.2017.01.006openalex-snapshotIncreased microRNA 21 expression contributes to arsenic induced skin lesions, skin cancers and respiratory distress in chronically exposed individuals
inferredcites →https://doi.org/10.1016/s0006-2952(02)00982-6openalex-snapshotInvolvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid
inferredcites →https://doi.org/10.1021/jf2012584openalex-snapshotGrowth Suppression of HER2-Overexpressing Breast Cancer Cells by Berberine via Modulation of the HER2/PI3K/Akt Signaling Pathway
inferredcites →https://doi.org/10.1021/jf302832nopenalex-snapshotBerberine, an Isoquinoline Alkaloid, Inhibits the Metastatic Potential of Breast Cancer Cells via Akt Pathway Modulation
inferredcites →https://doi.org/10.1046/j.1365-2567.2003.01673.xopenalex-snapshotInduction of interleukin‐12 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid, deviates CD4+ T cells from a Th2 to a Th1 response
inferredcites →https://doi.org/10.1074/jbc.m109.033795openalex-snapshotBerberine Inhibits Metastasis of Nasopharyngeal Carcinoma 5-8F Cells by Targeting Rho Kinase-mediated Ezrin Phosphorylation at Threonine 567
inferredcites →https://doi.org/10.1093/carcin/bgl043openalex-snapshotRETRACTED: Berberine inhibits growth, induces G1arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki–Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP
inferredcites →https://doi.org/10.1124/dmd.106.011361openalex-snapshotPharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry
inferredcites →https://doi.org/10.1159/000266127openalex-snapshotUkrain Affects Pancreas Cancer Cell Phenotype in vitro by Targeting MMP-9 and Intra-/Extracellular SPARC Expression
inferredcites →https://doi.org/10.1248/bpb.21.814openalex-snapshotInhibitory Effect of Coptidis Rhizoma and Scutellariae Radix on Azoxymethane-Induced Aberrant Crypt Foci Formation in Rat Colon.
inferredcites →https://doi.org/10.1371/journal.pone.0037939openalex-snapshotBiophysical Characterization of the Strong Stabilization of the RNA Triplex poly(U)•poly(A)*poly(U) by 9-O-(ω-amino) Alkyl Ether Berberine Analogs
inferredcites →https://doi.org/10.1371/journal.pone.0134044openalex-snapshotProtection of Gastrointestinal Mucosa from Acute Heavy Alcohol Consumption: The Effect of Berberine and Its Correlation with TLR2, 4/IL1β-TNFα Signaling
inferredcites →https://doi.org/10.3390/molecules13122975openalex-snapshotBerberine Suppresses TNF-α-induced MMP-9 and Cell Invasion through Inhibition of AP-1 Activity in MDA-MB-231 Human Breast Cancer Cells
inferredcites →https://doi.org/10.3892/ijo_00000234openalex-snapshotInduction of apoptosis in human leukemia U937 cells by anthocyanins through down-regulation of Bcl-2 and activation of caspases
inferredcites →https://doi.org/10.3892/ijo_00000299openalex-snapshotInvolvement of reactive oxygen species and caspase-dependent pathway in berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cells
inferredcites →https://doi.org/10.4161/cbt.26426openalex-snapshotBerberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1007/s40011-021-01310-6openalex-snapshotExogenous Elicitors Enhanced Berberine Production in the Cell Suspension Cultures of Tinospora cordifolia (Willd.) Miers ex Hook F. &Thoms.
inferred← citeshttps://doi.org/10.1016/j.apsb.2020.06.014openalex-snapshotBerberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5
inferred← citeshttps://doi.org/10.1016/j.envpol.2021.117865openalex-snapshotBerberine improves intestinal barrier function and reduces inflammation, immunosuppression, and oxidative stress by regulating the NF-κB/MAPK signaling pathway in deoxynivalenol-challenged piglets
inferred← citeshttps://doi.org/10.1016/j.fitote.2019.104293openalex-snapshotGut microbial transformation, a potential improving factor in the therapeutic activities of four groups of natural compounds isolated from herbal medicines
inferred← citeshttps://doi.org/10.1016/j.fitote.2024.106342openalex-snapshotChemical constituents, anti-rheumatic potential, and anti-inflammatory properties of the aqueous extract from the aerial parts of Aristolochia esperanzae Kuntze
inferred← citeshttps://doi.org/10.1016/j.jep.2020.113206openalex-snapshotBerberine inhibits intestinal epithelial barrier dysfunction in colon caused by peritoneal dialysis fluid by improving cell migration
inferred← citeshttps://doi.org/10.1016/j.jep.2021.114771openalex-snapshotCoptis chinensis and dried ginger herb combination inhibits gastric tumor growth by interfering with glucose metabolism via LDHA and SLC2A1
inferred← citeshttps://doi.org/10.1016/j.procbio.2021.02.004openalex-snapshotPhytochemicals intended for anticancer effects at preclinical levels to clinical practice: Assessment of formulations at nanoscale for non-small cell lung cancer (NSCLC) therapy
inferred← citeshttps://doi.org/10.1097/cm9.0000000000002696openalex-snapshotEfficacy and safety of triple therapy containing berberine, amoxicillin, and vonoprazan for Helicobacter pylori initial treatment: A randomized controlled trial
inferred← citeshttps://doi.org/10.1177/1934578x231161414openalex-snapshotResearch Progress on the Anti-Tumor Mechanism and Reversal of Multidrug Resistance of Zuojin Pill and its Main Components, Evodiamine and Berberine
inferred← citeshttps://doi.org/10.21037/tp-21-81openalex-snapshotThe protective effect and mechanism of epidermal growth factor on necrotizing enterocolitis in a neonatal rat model
inferred← citeshttps://doi.org/10.2147/dddt.s384607openalex-snapshotMetabolomics Study of Shaoyao Plants Decoction on the Proximal and Distal Colon in Mice with Dextran Sulfate Sodium-Induced Colitis by UPLC-Q-TOF-MS
inferred← citeshttps://doi.org/10.2147/dddt.s487371openalex-snapshotZuojin Pill Alleviates Precancerous Lesions of Gastric Cancer by Modulating the MEK/ERK/c-Myc Pathway: An Integrated Approach of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Validation
inferred← citeshttps://doi.org/10.3389/fphar.2022.842295openalex-snapshotTraditional Chinese Medicines as Effective Reversals of Epithelial-Mesenchymal Transition Induced-Metastasis of Colorectal Cancer: Molecular Targets and Mechanisms
inferred← citeshttps://doi.org/10.3389/fphar.2024.1284371openalex-snapshotCynanchum paniculatum (Bunge) Kitag. ex H.Hara inhibits pancreatic cancer progression by inducing caspase-dependent apoptosis and suppressing TGF-β-mediated epithelial-mesenchymal transition
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